Molecular and Structural Assessment of Alveolar Bone During Tooth Eruption and Function in the Miniature Pig, Sus Scrofa
Identifieur interne : 003472 ( Istex/Corpus ); précédent : 003471; suivant : 003473Molecular and Structural Assessment of Alveolar Bone During Tooth Eruption and Function in the Miniature Pig, Sus Scrofa
Auteurs : Kuang-Dah Yeh ; Tracy PopowicsSource :
- Anatomia, Histologia, Embryologia [ 0340-2096 ] ; 2011-08.
English descriptors
- KwdEn :
- Alveolar, Alveolar bone, Anat, Apposition, Biol, Blackwell verlag gmbh anat, Bone, Bone forms, Bone matrix, Bone miner, Bone samples, Bone structure, Brolamellar, Brolamellar bone, Brolamellar structure, Cancellous bone, Diastema, Diastema region, Embryol, Eruption, Eruptive stages, Functional occlusion, Gene expression, Gmbh, Histol, Intraosseous eruption, Lamellar, Lamellar bone, Ligand, Mandibular, Matrix, Molar, Mucosal, Mucosal penetration stage, Occlusal, Occlusal loads, Occlusion, Oral biol, Orthodontic tooth movement, Osteoblast, Osteoclast, Osteoclast cell counts, Osteoclast formation, Osteoclast numbers, Osteons, Osteoprotegerin, Periodontal, Periodontal ligament, Popowics, Porcine, Present study, Primary osteons, Primer, Primer sequences, Rankl, Rankl expression, Receptor activator, Resorption, Reticular, Runx2, Structural assessment, Tooth eruption, Tooth root, Tooth roots, Verlag.
- Teeft :
- Alveolar, Alveolar bone, Anat, Apposition, Biol, Blackwell verlag gmbh anat, Bone, Bone forms, Bone matrix, Bone miner, Bone samples, Bone structure, Brolamellar, Brolamellar bone, Brolamellar structure, Cancellous bone, Diastema, Diastema region, Embryol, Eruption, Eruptive stages, Functional occlusion, Gene expression, Gmbh, Histol, Intraosseous eruption, Lamellar, Lamellar bone, Ligand, Mandibular, Matrix, Molar, Mucosal, Mucosal penetration stage, Occlusal, Occlusal loads, Occlusion, Oral biol, Orthodontic tooth movement, Osteoblast, Osteoclast, Osteoclast cell counts, Osteoclast formation, Osteoclast numbers, Osteons, Osteoprotegerin, Periodontal, Periodontal ligament, Popowics, Porcine, Present study, Primary osteons, Primer, Primer sequences, Rankl, Rankl expression, Receptor activator, Resorption, Reticular, Runx2, Structural assessment, Tooth eruption, Tooth root, Tooth roots, Verlag.
Abstract
With 5 figures and 2 tables
Url:
DOI: 10.1111/j.1439-0264.2011.01067.x
Links to Exploration step
ISTEX:6A9DF431C540CC4E11161A59BB318C7DB7A0043CLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular and Structural Assessment of Alveolar Bone During Tooth Eruption and Function in the Miniature Pig, Sus Scrofa</title><author><name sortKey="Yeh, Kuang Ah" sort="Yeh, Kuang Ah" uniqKey="Yeh K" first="Kuang-Dah" last="Yeh">Kuang-Dah Yeh</name><affiliation><mods:affiliation>Addresses of authors: Hualien Armed Forces General Hospital, Hualien, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation> Department of Oral Biology, University of Washington, Seattle, WA 98195, USA</mods:affiliation></affiliation></author><author><name sortKey="Popowics, Tracy" sort="Popowics, Tracy" uniqKey="Popowics T" first="Tracy" last="Popowics">Tracy Popowics</name><affiliation><mods:affiliation> Department of Oral Biology, University of Washington, Seattle, WA 98195, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: popowics@u.washington.edu</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6A9DF431C540CC4E11161A59BB318C7DB7A0043C</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1111/j.1439-0264.2011.01067.x</idno><idno type="url">https://api.istex.fr/document/6A9DF431C540CC4E11161A59BB318C7DB7A0043C/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003472</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">003472</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Molecular and Structural Assessment of Alveolar Bone During Tooth Eruption and Function in the Miniature Pig, <hi rend="italic">Sus Scrofa</hi></title><author><name sortKey="Yeh, Kuang Ah" sort="Yeh, Kuang Ah" uniqKey="Yeh K" first="Kuang-Dah" last="Yeh">Kuang-Dah Yeh</name><affiliation><mods:affiliation>Addresses of authors: Hualien Armed Forces General Hospital, Hualien, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation> Department of Oral Biology, University of Washington, Seattle, WA 98195, USA</mods:affiliation></affiliation></author><author><name sortKey="Popowics, Tracy" sort="Popowics, Tracy" uniqKey="Popowics T" first="Tracy" last="Popowics">Tracy Popowics</name><affiliation><mods:affiliation> Department of Oral Biology, University of Washington, Seattle, WA 98195, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: popowics@u.washington.edu</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Anatomia, Histologia, Embryologia</title><title level="j" type="alt">ANATOMIA HISTOLOGIA EMBRYOLOGIA</title><idno type="ISSN">0340-2096</idno><idno type="eISSN">1439-0264</idno><imprint><biblScope unit="vol">40</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="283">283</biblScope><biblScope unit="page" to="291">291</biblScope><biblScope unit="page-count">9</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-08">2011-08</date></imprint><idno type="ISSN">0340-2096</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0340-2096</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alveolar</term><term>Alveolar bone</term><term>Anat</term><term>Apposition</term><term>Biol</term><term>Blackwell verlag gmbh anat</term><term>Bone</term><term>Bone forms</term><term>Bone matrix</term><term>Bone miner</term><term>Bone samples</term><term>Bone structure</term><term>Brolamellar</term><term>Brolamellar bone</term><term>Brolamellar structure</term><term>Cancellous bone</term><term>Diastema</term><term>Diastema region</term><term>Embryol</term><term>Eruption</term><term>Eruptive stages</term><term>Functional occlusion</term><term>Gene expression</term><term>Gmbh</term><term>Histol</term><term>Intraosseous eruption</term><term>Lamellar</term><term>Lamellar bone</term><term>Ligand</term><term>Mandibular</term><term>Matrix</term><term>Molar</term><term>Mucosal</term><term>Mucosal penetration stage</term><term>Occlusal</term><term>Occlusal loads</term><term>Occlusion</term><term>Oral biol</term><term>Orthodontic tooth movement</term><term>Osteoblast</term><term>Osteoclast</term><term>Osteoclast cell counts</term><term>Osteoclast formation</term><term>Osteoclast numbers</term><term>Osteons</term><term>Osteoprotegerin</term><term>Periodontal</term><term>Periodontal ligament</term><term>Popowics</term><term>Porcine</term><term>Present study</term><term>Primary osteons</term><term>Primer</term><term>Primer sequences</term><term>Rankl</term><term>Rankl expression</term><term>Receptor activator</term><term>Resorption</term><term>Reticular</term><term>Runx2</term><term>Structural assessment</term><term>Tooth eruption</term><term>Tooth root</term><term>Tooth roots</term><term>Verlag</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Alveolar</term><term>Alveolar bone</term><term>Anat</term><term>Apposition</term><term>Biol</term><term>Blackwell verlag gmbh anat</term><term>Bone</term><term>Bone forms</term><term>Bone matrix</term><term>Bone miner</term><term>Bone samples</term><term>Bone structure</term><term>Brolamellar</term><term>Brolamellar bone</term><term>Brolamellar structure</term><term>Cancellous bone</term><term>Diastema</term><term>Diastema region</term><term>Embryol</term><term>Eruption</term><term>Eruptive stages</term><term>Functional occlusion</term><term>Gene expression</term><term>Gmbh</term><term>Histol</term><term>Intraosseous eruption</term><term>Lamellar</term><term>Lamellar bone</term><term>Ligand</term><term>Mandibular</term><term>Matrix</term><term>Molar</term><term>Mucosal</term><term>Mucosal penetration stage</term><term>Occlusal</term><term>Occlusal loads</term><term>Occlusion</term><term>Oral biol</term><term>Orthodontic tooth movement</term><term>Osteoblast</term><term>Osteoclast</term><term>Osteoclast cell counts</term><term>Osteoclast formation</term><term>Osteoclast numbers</term><term>Osteons</term><term>Osteoprotegerin</term><term>Periodontal</term><term>Periodontal ligament</term><term>Popowics</term><term>Porcine</term><term>Present study</term><term>Primary osteons</term><term>Primer</term><term>Primer sequences</term><term>Rankl</term><term>Rankl expression</term><term>Receptor activator</term><term>Resorption</term><term>Reticular</term><term>Runx2</term><term>Structural assessment</term><term>Tooth eruption</term><term>Tooth root</term><term>Tooth roots</term><term>Verlag</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">With 5 figures and 2 tables</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>alveolar bone</json:string><json:string>osteoclast</json:string><json:string>diastema</json:string><json:string>rankl</json:string><json:string>tooth eruption</json:string><json:string>occlusal</json:string><json:string>anat</json:string><json:string>runx2</json:string><json:string>brolamellar</json:string><json:string>popowics</json:string><json:string>osteoblast</json:string><json:string>tooth root</json:string><json:string>resorption</json:string><json:string>structural assessment</json:string><json:string>porcine</json:string><json:string>histol</json:string><json:string>blackwell verlag gmbh anat</json:string><json:string>biol</json:string><json:string>gmbh</json:string><json:string>verlag</json:string><json:string>rankl expression</json:string><json:string>embryol</json:string><json:string>osteons</json:string><json:string>eruption</json:string><json:string>lamellar</json:string><json:string>mucosal</json:string><json:string>periodontal</json:string><json:string>primer</json:string><json:string>reticular</json:string><json:string>brolamellar bone</json:string><json:string>mandibular</json:string><json:string>osteoprotegerin</json:string><json:string>tooth roots</json:string><json:string>mucosal penetration stage</json:string><json:string>oral biol</json:string><json:string>primary osteons</json:string><json:string>apposition</json:string><json:string>molar</json:string><json:string>osteoclast cell counts</json:string><json:string>osteoclast numbers</json:string><json:string>bone samples</json:string><json:string>gene expression</json:string><json:string>matrix</json:string><json:string>diastema region</json:string><json:string>bone matrix</json:string><json:string>brolamellar structure</json:string><json:string>bone miner</json:string><json:string>bone structure</json:string><json:string>receptor activator</json:string><json:string>ligand</json:string><json:string>bone forms</json:string><json:string>lamellar bone</json:string><json:string>occlusal loads</json:string><json:string>functional occlusion</json:string><json:string>cancellous bone</json:string><json:string>periodontal ligament</json:string><json:string>primer sequences</json:string><json:string>osteoclast formation</json:string><json:string>intraosseous eruption</json:string><json:string>eruptive stages</json:string><json:string>present study</json:string><json:string>orthodontic tooth movement</json:string><json:string>alveolar</json:string><json:string>bone</json:string><json:string>occlusion</json:string></teeft></keywords><author><json:item><name>Kuang‐Dah Yeh</name><affiliations><json:string>Addresses of authors: Hualien Armed Forces General Hospital, Hualien, Taiwan</json:string><json:string>Department of Oral Biology, University of Washington, Seattle, WA 98195, USA</json:string></affiliations></json:item><json:item><name>Tracy Popowics</name><affiliations><json:string>Department of Oral Biology, University of Washington, Seattle, WA 98195, USA</json:string><json:string>E-mail: popowics@u.washington.edu</json:string></affiliations></json:item></author><articleId><json:string>AHE1067</json:string></articleId><arkIstex>ark:/67375/WNG-K5JMR87K-1</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The development of alveolar bone adjacent to the tooth root during tooth eruption is not well understood. This study tested the hypothesis that predominantly woven bone forms adjacent to tooth roots during tooth eruption, but that this immature structure transitions to lamellar bone when the tooth comes into function. Additionally, bone resorption was predicted to play a key role in transitioning immature bone to more mature, load‐bearing tissue. Miniature pigs were compared at two occlusal stages, 13 weeks (n = 3), corresponding with the mucosal penetration stage of M1 tooth eruption, and 23 weeks (n = 3), corresponding with early occlusion of M1/M1. Bone samples for RNA extraction and qRT‐PCR analysis were harvested from the diastema and adjacent to M1 roots on one side. Following euthanasia, bone samples for haematoxylin and eosin and TRAP staining were harvested from these regions on the other side. In contrast to expectations, both erupting and functioning molars had reticular fibrolamellar structure in alveolar bone adjacent to M1. However, the woven bone matrix in older pigs was thicker and had denser primary osteons. Gene expression data and osteoclast cell counts showed a tendency for more bone resorptive activity near the molars than at distant sites, but no differences between eruptive stages. Thus, although resorption does occur, it is not a primary mechanism in the transition in alveolar bone from eruption to function. Incremental growth of existing woven bone and filling in of primary osteons within the mineralized scaffold generated the fortification necessary to support an erupted and functioning tooth.</abstract><qualityIndicators><score>7.072</score><pdfWordCount>5305</pdfWordCount><pdfCharCount>33782</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>9</pdfPageCount><pdfPageSize>595.276 x 796.535 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>6</abstractWordCount><abstractCharCount>27</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Molecular and Structural Assessment of Alveolar Bone During Tooth Eruption and Function in the Miniature Pig, Sus Scrofa</title><pmid><json:string>21434979</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Anatomia, Histologia, Embryologia</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1439-0264</json:string></doi><issn><json:string>0340-2096</json:string></issn><eissn><json:string>1439-0264</json:string></eissn><publisherId><json:string>AHE</json:string></publisherId><volume>40</volume><issue>4</issue><pages><first>283</first><last>291</last><total>9</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>ORIGINAL ARTICLE</value></json:item></subject></host><namedEntities><unitex><date><json:string>2011</json:string><json:string>5000</json:string><json:string>2010</json:string></date><geogName></geogName><orgName><json:string>Department of Oral Biology, University of Washington, Seattle, WA</json:string><json:string>University of Washington Animal Care</json:string><json:string>Sinclair Research, St Louis, MO, USA</json:string><json:string>NIH</json:string></orgName><orgName_funder><json:string>NIH</json:string></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Martha Somerman</json:string><json:string>T. Popowics</json:string><json:string>Susan Herring</json:string></persName><placeName><json:string>Switzerland</json:string><json:string>Germany</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Burr, 1993</json:string><json:string>Ducy et al., 1997</json:string><json:string>Zou et al., 2004</json:string><json:string>Rubin et al., 2002a</json:string><json:string>Gori et al., 2000</json:string><json:string>Van Wesenbeeck et al., 2002</json:string><json:string>Franceschi and Xiao, 2003</json:string><json:string>Marks and Cahill, 1986</json:string><json:string>Chen et al., 1993</json:string><json:string>Yeh and 283 Molecular and Structural Assessment of Alveolar Bone During Tooth Eruption Popowics, 2010</json:string><json:string>Frost, 1987</json:string><json:string>Yasuda et al., 1998, 1999</json:string><json:string>Mavropoulos et al., 2004</json:string><json:string>Claudino et al., 2010</json:string><json:string>Ducy, 2000</json:string><json:string>Liu et al., 2005</json:string><json:string>Francillon-Viellot et al., 1990</json:string><json:string>Ogasawara et al., 2004</json:string><json:string>Huja et al., 2006</json:string><json:string>Komori, 2010</json:string><json:string>Liu et al., 2010</json:string><json:string>Powell et al., 1973</json:string><json:string>Verna et al., 2004</json:string><json:string>Kon et al., 2001</json:string><json:string>Zeng et al., 2006</json:string><json:string>Terespolsky et al., 2002</json:string><json:string>Bosch et al., 2006</json:string><json:string>Rubin et al., 2000, 2002b</json:string><json:string>Wise et al., 1999, 2005</json:string><json:string>Taylor and Lee, 2003</json:string><json:string>Saffar et al., 1997</json:string><json:string>Heinrich et al., 2005</json:string><json:string>Walker et al., 2008</json:string><json:string>Pilipili et al., 1998</json:string><json:string>Wise et al., 2002</json:string><json:string>Ogata, 2008</json:string><json:string>Fazzalari et al., 2001</json:string><json:string>Deguchi et al., 2008</json:string><json:string>Dixon et al., 1997</json:string><json:string>Kim et al., 2006</json:string><json:string>Katagiri and Takahashi, 2002</json:string><json:string>Vignery and Baron, 1980</json:string><json:string>Yeh et al., 2010</json:string><json:string>Zhang et al., 2009</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-K5JMR87K-1</json:string></ark><categories><wos><json:string>1 - 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Summary
<p>The development of alveolar bone adjacent to the tooth root during tooth eruption is not well understood. This study tested the hypothesis that predominantly woven bone forms adjacent to tooth roots during tooth eruption, but that this immature structure transitions to lamellar bone when the tooth comes into function. Additionally, bone resorption was predicted to play a key role in transitioning immature bone to more mature, load‐bearing tissue. Miniature pigs were compared at two occlusal stages, 13 weeks (<hi rend="italic">n</hi> = 3), corresponding with the mucosal penetration stage of M<hi rend="subscript">1</hi> tooth eruption, and 23 weeks (<hi rend="italic">n</hi> = 3), corresponding with early occlusion of M<hi rend="superscript">1</hi>/M<hi rend="subscript">1</hi>. Bone samples for RNA extraction and qRT‐PCR analysis were harvested from the diastema and adjacent to M<hi rend="subscript">1</hi> roots on one side. Following euthanasia, bone samples for haematoxylin and eosin and TRAP staining were harvested from these regions on the other side. In contrast to expectations, both erupting and functioning molars had reticular fibrolamellar structure in alveolar bone adjacent to M<hi rend="subscript">1</hi>. However, the woven bone matrix in older pigs was thicker and had denser primary osteons. Gene expression data and osteoclast cell counts showed a tendency for more bone resorptive activity near the molars than at distant sites, but no differences between eruptive stages. Thus, although resorption does occur, it is not a primary mechanism in the transition in alveolar bone from eruption to function. Incremental growth of existing woven bone and filling in of primary osteons within the mineralized scaffold generated the fortification necessary to support an erupted and functioning tooth.</p></abstract><textClass><keywords rend="tocHeading1"><term>ORIGINAL ARTICLES</term></keywords><keywords rend="articleCategory"><term>ORIGINAL ARTICLE</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/6A9DF431C540CC4E11161A59BB318C7DB7A0043C/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1439-0264</doi><issn type="print">0340-2096</issn><issn type="electronic">1439-0264</issn><idGroup><id type="product" value="AHE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ANATOMIA HISTOLOGIA EMBRYOLOGIA">Anatomia, Histologia, Embryologia</title></titleGroup></publicationMeta><publicationMeta level="part" position="08104"><doi origin="wiley">10.1111/ahe.2011.40.issue-4</doi><numberingGroup><numbering type="journalVolume" number="40">40</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="2011-08">August 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="6" status="forIssue"><doi origin="wiley">10.1111/j.1439-0264.2011.01067.x</doi><idGroup><id type="unit" value="AHE1067"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="tocHeading1">ORIGINAL ARTICLES</title><title type="articleCategory">ORIGINAL ARTICLE</title></titleGroup><copyright>© 2011 Blackwell Verlag GmbH</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.5.2 mode:FullText" date="2011-07-13"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-03-22"></event><event type="firstOnline" date="2011-03-22"></event><event type="publishedOnlineFinalForm" date="2011-07-13"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-01"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="283">283</numbering><numbering type="pageLast" number="291">291</numbering></numberingGroup><correspondenceTo>
Tel.:+1 206 221 5350; fax: +1 206 685 3162; e‐mail: <email>popowics@u.washington.edu</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:AHE.AHE1067.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received May 2010; accepted for publication January 2011</unparsedEditorialHistory><countGroup><count type="figureTotal" number="5"></count><count type="tableTotal" number="2"></count></countGroup><titleGroup><title type="main">Molecular and Structural Assessment of Alveolar Bone During Tooth Eruption and Function in the Miniature Pig, <i>Sus Scrofa</i></title><title type="shortAuthors">K.‐D. Yeh and T. Popowics</title><title type="short">Molecular and Structural Assessment of Alveolar Bone During Tooth Eruption</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2"><personName><givenNames>Kuang‐Dah</givenNames><familyName>Yeh</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2" corresponding="yes"><personName><givenNames>Tracy</givenNames><familyName>Popowics</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Addresses of authors: Hualien Armed Forces General Hospital, Hualien, Taiwan</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="US"><unparsedAffiliation> Department of Oral Biology, University of Washington, Seattle, WA 98195, USA</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><section xml:id="sec-sum-1"><p>With 5 figures and 2 tables</p></section><section xml:id="abs1-1"><title type="main">Summary</title><p>The development of alveolar bone adjacent to the tooth root during tooth eruption is not well understood. This study tested the hypothesis that predominantly woven bone forms adjacent to tooth roots during tooth eruption, but that this immature structure transitions to lamellar bone when the tooth comes into function. Additionally, bone resorption was predicted to play a key role in transitioning immature bone to more mature, load‐bearing tissue. Miniature pigs were compared at two occlusal stages, 13 weeks (<i>n</i> = 3), corresponding with the mucosal penetration stage of M<sub>1</sub> tooth eruption, and 23 weeks (<i>n</i> = 3), corresponding with early occlusion of M<sup>1</sup>/M<sub>1</sub>. Bone samples for RNA extraction and qRT‐PCR analysis were harvested from the diastema and adjacent to M<sub>1</sub> roots on one side. Following euthanasia, bone samples for haematoxylin and eosin and TRAP staining were harvested from these regions on the other side. In contrast to expectations, both erupting and functioning molars had reticular fibrolamellar structure in alveolar bone adjacent to M<sub>1</sub>. However, the woven bone matrix in older pigs was thicker and had denser primary osteons. Gene expression data and osteoclast cell counts showed a tendency for more bone resorptive activity near the molars than at distant sites, but no differences between eruptive stages. Thus, although resorption does occur, it is not a primary mechanism in the transition in alveolar bone from eruption to function. Incremental growth of existing woven bone and filling in of primary osteons within the mineralized scaffold generated the fortification necessary to support an erupted and functioning tooth.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Molecular and Structural Assessment of Alveolar Bone During Tooth Eruption and Function in the Miniature Pig, Sus Scrofa</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Molecular and Structural Assessment of Alveolar Bone During Tooth Eruption</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Molecular and Structural Assessment of Alveolar Bone During Tooth Eruption and Function in the Miniature Pig, Sus Scrofa</title></titleInfo><name type="personal"><namePart type="given">Kuang‐Dah</namePart><namePart type="family">Yeh</namePart><affiliation>Addresses of authors: Hualien Armed Forces General Hospital, Hualien, Taiwan</affiliation><affiliation> Department of Oral Biology, University of Washington, Seattle, WA 98195, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tracy</namePart><namePart type="family">Popowics</namePart><affiliation> Department of Oral Biology, University of Washington, Seattle, WA 98195, USA</affiliation><affiliation>E-mail: popowics@u.washington.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2011-08</dateIssued><edition>Received May 2010; accepted for publication January 2011</edition><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">5</extent><extent unit="tables">2</extent></physicalDescription><abstract>With 5 figures and 2 tables</abstract><abstract lang="en">The development of alveolar bone adjacent to the tooth root during tooth eruption is not well understood. This study tested the hypothesis that predominantly woven bone forms adjacent to tooth roots during tooth eruption, but that this immature structure transitions to lamellar bone when the tooth comes into function. Additionally, bone resorption was predicted to play a key role in transitioning immature bone to more mature, load‐bearing tissue. Miniature pigs were compared at two occlusal stages, 13 weeks (n = 3), corresponding with the mucosal penetration stage of M1 tooth eruption, and 23 weeks (n = 3), corresponding with early occlusion of M1/M1. Bone samples for RNA extraction and qRT‐PCR analysis were harvested from the diastema and adjacent to M1 roots on one side. Following euthanasia, bone samples for haematoxylin and eosin and TRAP staining were harvested from these regions on the other side. In contrast to expectations, both erupting and functioning molars had reticular fibrolamellar structure in alveolar bone adjacent to M1. However, the woven bone matrix in older pigs was thicker and had denser primary osteons. Gene expression data and osteoclast cell counts showed a tendency for more bone resorptive activity near the molars than at distant sites, but no differences between eruptive stages. Thus, although resorption does occur, it is not a primary mechanism in the transition in alveolar bone from eruption to function. Incremental growth of existing woven bone and filling in of primary osteons within the mineralized scaffold generated the fortification necessary to support an erupted and functioning tooth.</abstract><relatedItem type="host"><titleInfo><title>Anatomia, Histologia, Embryologia</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>ORIGINAL ARTICLE</topic></subject><identifier type="ISSN">0340-2096</identifier><identifier type="eISSN">1439-0264</identifier><identifier type="DOI">10.1111/(ISSN)1439-0264</identifier><identifier type="PublisherID">AHE</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>283</start><end>291</end><total>9</total></extent></part></relatedItem><identifier type="istex">6A9DF431C540CC4E11161A59BB318C7DB7A0043C</identifier><identifier type="ark">ark:/67375/WNG-K5JMR87K-1</identifier><identifier type="DOI">10.1111/j.1439-0264.2011.01067.x</identifier><identifier type="ArticleID">AHE1067</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2011 Blackwell Verlag GmbH</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/6A9DF431C540CC4E11161A59BB318C7DB7A0043C/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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