Effect of occlusal rehabilitation on spatial memory and hippocampal neurons after long‐term loss of molars in rats
Identifieur interne : 002C21 ( Istex/Corpus ); précédent : 002C20; suivant : 002C22Effect of occlusal rehabilitation on spatial memory and hippocampal neurons after long‐term loss of molars in rats
Auteurs : S. Sakamoto ; T. Hara ; A. Kurozumi ; M. Oka ; C. Kuroda-Ishimine ; D. Araki ; S. Iida ; S. MinagiSource :
- Journal of Oral Rehabilitation [ 0305-182X ] ; 2014-10.
Abstract
Experimental loss of occlusal support caused by the extraction or grinding of molar teeth has been reported to foment the impairment of learning and memory in laboratory animals. The purpose of this study was to examine the effect of occlusal reconstruction after long‐term loss of molars on spatial memory by using 8‐arm radial maze and by assessing histopathological changes of neuron density in the hippocampus. Experimental dentures were inserted into the oral cavities of molarless rats to recover the occlusal support. Age‐matched groups of control, molarless and denture‐wearing rats were trained to perform the maze tasks. The difference of the error incidence in the maze task was evaluated between three groups. The difference of neuron density between three groups was also evaluated at the end of the maze task. Serum corticosterone levels were also measured to estimate the chronic stress, which could be caused by extraction, insertion of the experimental denture or any experimental procedure. The error incidence in the denture‐wearing group was significantly higher than that of the control group, but significantly lower than that of the molarless group. Significant differences of neuron density were observed between three groups in each of the hippocampal CA1, CA3 and DG subfields. No significant difference of the serum corticosterone levels between three groups could be observed. From the results of this study, it was suggested that the recovery of occlusal support would bring amelioration of cognitive impairment concomitant with long period loss of molars in rats.
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DOI: 10.1111/joor.12198
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Hara</name><affiliation><mods:affiliation>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence: Tetsuya Hara, Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2‐5‐1 Shikata‐cho, Kita‐ku, Okayama 700‐8525, Japan.E‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: harat@md.okayama-u.ac.jp</mods:affiliation></affiliation></author><author><name sortKey="Kurozumi, A" sort="Kurozumi, A" uniqKey="Kurozumi A" first="A." last="Kurozumi">A. 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Sakamoto</name><affiliation><mods:affiliation>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</mods:affiliation></affiliation></author><author><name sortKey="Hara, T" sort="Hara, T" uniqKey="Hara T" first="T." last="Hara">T. Hara</name><affiliation><mods:affiliation>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence: Tetsuya Hara, Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2‐5‐1 Shikata‐cho, Kita‐ku, Okayama 700‐8525, Japan.E‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: harat@md.okayama-u.ac.jp</mods:affiliation></affiliation></author><author><name sortKey="Kurozumi, A" sort="Kurozumi, A" uniqKey="Kurozumi A" first="A." last="Kurozumi">A. Kurozumi</name><affiliation><mods:affiliation>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</mods:affiliation></affiliation></author><author><name sortKey="Oka, M" sort="Oka, M" uniqKey="Oka M" first="M." last="Oka">M. Oka</name><affiliation><mods:affiliation>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kuroda Shimine, C" sort="Kuroda Shimine, C" uniqKey="Kuroda Shimine C" first="C." last="Kuroda-Ishimine">C. Kuroda-Ishimine</name><affiliation><mods:affiliation>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</mods:affiliation></affiliation></author><author><name sortKey="Araki, D" sort="Araki, D" uniqKey="Araki D" first="D." last="Araki">D. Araki</name><affiliation><mods:affiliation>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</mods:affiliation></affiliation></author><author><name sortKey="Iida, S" sort="Iida, S" uniqKey="Iida S" first="S." last="Iida">S. Iida</name><affiliation><mods:affiliation>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</mods:affiliation></affiliation></author><author><name sortKey="Minagi, S" sort="Minagi, S" uniqKey="Minagi S" first="S." last="Minagi">S. Minagi</name><affiliation><mods:affiliation>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Oral Rehabilitation</title><title level="j" type="alt">JOURNAL OF ORAL REHABILITATION</title><idno type="ISSN">0305-182X</idno><idno type="eISSN">1365-2842</idno><imprint><biblScope unit="vol">41</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="715">715</biblScope><biblScope unit="page" to="722">722</biblScope><biblScope unit="page-count">8</biblScope><date type="published" when="2014-10">2014-10</date></imprint><idno type="ISSN">0305-182X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0305-182X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Experimental loss of occlusal support caused by the extraction or grinding of molar teeth has been reported to foment the impairment of learning and memory in laboratory animals. The purpose of this study was to examine the effect of occlusal reconstruction after long‐term loss of molars on spatial memory by using 8‐arm radial maze and by assessing histopathological changes of neuron density in the hippocampus. Experimental dentures were inserted into the oral cavities of molarless rats to recover the occlusal support. Age‐matched groups of control, molarless and denture‐wearing rats were trained to perform the maze tasks. The difference of the error incidence in the maze task was evaluated between three groups. The difference of neuron density between three groups was also evaluated at the end of the maze task. Serum corticosterone levels were also measured to estimate the chronic stress, which could be caused by extraction, insertion of the experimental denture or any experimental procedure. The error incidence in the denture‐wearing group was significantly higher than that of the control group, but significantly lower than that of the molarless group. Significant differences of neuron density were observed between three groups in each of the hippocampal CA1, CA3 and DG subfields. No significant difference of the serum corticosterone levels between three groups could be observed. From the results of this study, it was suggested that the recovery of occlusal support would bring amelioration of cognitive impairment concomitant with long period loss of molars in rats.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>S. Sakamoto</name><affiliations><json:string>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</json:string></affiliations></json:item><json:item><name>T. Hara</name><affiliations><json:string>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</json:string><json:string>Correspondence: Tetsuya Hara, Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2‐5‐1 Shikata‐cho, Kita‐ku, Okayama 700‐8525, Japan.E‐mail:</json:string><json:string>E-mail: harat@md.okayama-u.ac.jp</json:string></affiliations></json:item><json:item><name>A. Kurozumi</name><affiliations><json:string>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</json:string></affiliations></json:item><json:item><name>M. 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Iida</name><affiliations><json:string>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</json:string></affiliations></json:item><json:item><name>S. Minagi</name><affiliations><json:string>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>dental occlusal wear</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>toothless</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hippocampus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>neurons</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>maze learning</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>rats</value></json:item></subject><articleId><json:string>JOOR12198</json:string></articleId><arkIstex>ark:/67375/WNG-MM3JPRZ9-6</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Experimental loss of occlusal support caused by the extraction or grinding of molar teeth has been reported to foment the impairment of learning and memory in laboratory animals. The purpose of this study was to examine the effect of occlusal reconstruction after long‐term loss of molars on spatial memory by using 8‐arm radial maze and by assessing histopathological changes of neuron density in the hippocampus. Experimental dentures were inserted into the oral cavities of molarless rats to recover the occlusal support. Age‐matched groups of control, molarless and denture‐wearing rats were trained to perform the maze tasks. The difference of the error incidence in the maze task was evaluated between three groups. The difference of neuron density between three groups was also evaluated at the end of the maze task. Serum corticosterone levels were also measured to estimate the chronic stress, which could be caused by extraction, insertion of the experimental denture or any experimental procedure. The error incidence in the denture‐wearing group was significantly higher than that of the control group, but significantly lower than that of the molarless group. Significant differences of neuron density were observed between three groups in each of the hippocampal CA1, CA3 and DG subfields. No significant difference of the serum corticosterone levels between three groups could be observed. 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E‐mail: harat@md.okayama-u.ac.jp</affiliation></author><author xml:id="author-0002"><persName><forename type="first">A.</forename><surname>Kurozumi</surname></persName><affiliation><orgName>Department of Occlusal and Oral Functional Rehabilitation</orgName><orgName>Graduate School of Medicine, Dentistry and Pharmaceutical Sciences</orgName><orgName>Okayama University</orgName><address><settlement type="city">Okayama</settlement><country key="JP">Japan</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">M.</forename><surname>Oka</surname></persName><affiliation><orgName>Department of Occlusal and Oral Functional Rehabilitation</orgName><orgName>Graduate School of Medicine, Dentistry and Pharmaceutical Sciences</orgName><orgName>Okayama University</orgName><address><settlement type="city">Okayama</settlement><country key="JP">Japan</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">C.</forename><surname>Kuroda‐Ishimine</surname></persName><affiliation><orgName>Department of Occlusal and Oral Functional Rehabilitation</orgName><orgName>Graduate School of Medicine, Dentistry and Pharmaceutical Sciences</orgName><orgName>Okayama University</orgName><address><settlement type="city">Okayama</settlement><country key="JP">Japan</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">D.</forename><surname>Araki</surname></persName><affiliation><orgName>Department of Occlusal and Oral Functional Rehabilitation</orgName><orgName>Graduate School of Medicine, Dentistry and Pharmaceutical Sciences</orgName><orgName>Okayama University</orgName><address><settlement type="city">Okayama</settlement><country key="JP">Japan</country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">S.</forename><surname>Iida</surname></persName><affiliation><orgName>Department of Occlusal and Oral Functional Rehabilitation</orgName><orgName>Graduate School of Medicine, Dentistry and Pharmaceutical Sciences</orgName><orgName>Okayama University</orgName><address><settlement type="city">Okayama</settlement><country key="JP">Japan</country></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">S.</forename><surname>Minagi</surname></persName><affiliation><orgName>Department of Occlusal and Oral Functional Rehabilitation</orgName><orgName>Graduate School of Medicine, Dentistry and Pharmaceutical Sciences</orgName><orgName>Okayama University</orgName><address><settlement type="city">Okayama</settlement><country key="JP">Japan</country></address></affiliation></author><idno type="istex">59DA6EB7B42111111420C8BF77B314825C4DC0CF</idno><idno type="ark">ark:/67375/WNG-MM3JPRZ9-6</idno><idno type="DOI">10.1111/joor.12198</idno><idno type="unit">JOOR12198</idno><idno type="toTypesetVersion">file:JOOR.JOOR12198.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Oral Rehabilitation</title><title level="j" type="alt">JOURNAL OF ORAL REHABILITATION</title><idno type="pISSN">0305-182X</idno><idno type="eISSN">1365-2842</idno><idno type="book-DOI">10.1111/(ISSN)1365-2842</idno><idno type="book-part-DOI">10.1111/joor.2014.41.issue-10</idno><idno type="product">JOOR</idno><imprint><biblScope unit="vol">41</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="715">715</biblScope><biblScope unit="page" to="722">722</biblScope><biblScope unit="page-count">8</biblScope><date type="published" when="2014-10"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract style="main" xml:id="joor12198-abs-0001"><head>Summary</head><p>Experimental loss of occlusal support caused by the extraction or grinding of molar teeth has been reported to foment the impairment of learning and memory in laboratory animals. The purpose of this study was to examine the effect of occlusal reconstruction after long‐term loss of molars on spatial memory by using 8‐arm radial maze and by assessing histopathological changes of neuron density in the hippocampus. Experimental dentures were inserted into the oral cavities of molarless rats to recover the occlusal support. Age‐matched groups of control, molarless and denture‐wearing rats were trained to perform the maze tasks. The difference of the error incidence in the maze task was evaluated between three groups. The difference of neuron density between three groups was also evaluated at the end of the maze task. Serum corticosterone levels were also measured to estimate the chronic stress, which could be caused by extraction, insertion of the experimental denture or any experimental procedure. The error incidence in the denture‐wearing group was significantly higher than that of the control group, but significantly lower than that of the molarless group. Significant differences of neuron density were observed between three groups in each of the hippocampal <hi rend="fc">CA</hi>1, <hi rend="fc">CA</hi>3 and <hi rend="fc">DG</hi> subfields. No significant difference of the serum corticosterone levels between three groups could be observed. From the results of this study, it was suggested that the recovery of occlusal support would bring amelioration of cognitive impairment concomitant with long period loss of molars in rats.</p></abstract><textClass><keywords><term xml:id="joor12198-kwd-0001">dental occlusal wear</term><term xml:id="joor12198-kwd-0002">toothless</term><term xml:id="joor12198-kwd-0003">hippocampus</term><term xml:id="joor12198-kwd-0004">neurons</term><term xml:id="joor12198-kwd-0005">maze learning</term><term xml:id="joor12198-kwd-0006">rats</term></keywords><keywords rend="articleCategory"><term>Original Article</term></keywords><keywords rend="tocHeading1"><term>Original Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="joor12198" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1365-2842</doi><issn type="print">0305-182X</issn><issn type="electronic">1365-2842</issn><idGroup><id type="product" value="JOOR"></id></idGroup><titleGroup><title sort="JOURNAL OF ORAL REHABILITATION" type="main">Journal of Oral Rehabilitation</title><title type="short">J Oral Rehabil</title></titleGroup></publicationMeta><publicationMeta level="part" position="100"><doi origin="wiley">10.1111/joor.2014.41.issue-10</doi><copyright ownership="publisher">Copyright © 2014 John Wiley & Sons Ltd</copyright><numberingGroup><numbering type="journalVolume" number="41">41</numbering><numbering type="journalIssue">10</numbering></numberingGroup><coverDate startDate="2014-10">October 2014</coverDate></publicationMeta><publicationMeta level="unit" position="10" status="forIssue" type="article"><doi>10.1111/joor.12198</doi><idGroup><id type="unit" value="JOOR12198"></id></idGroup><countGroup><count number="8" type="pageTotal"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Articles</title></titleGroup><copyright ownership="publisher">© 2014 John Wiley & Sons Ltd</copyright><eventGroup><event date="2014-05-11" type="manuscriptAccepted"></event><event agent="SPS" date="2014-05-21" type="xmlCreated"></event><event type="publishedOnlineEarlyUnpaginated" date="2014-06-07"></event><event type="firstOnline" date="2014-06-07"></event><event type="publishedOnlineFinalForm" date="2014-09-12"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-07"></event></eventGroup><numberingGroup><numbering type="pageFirst">715</numbering><numbering type="pageLast">722</numbering></numberingGroup><correspondenceTo><lineatedText><line>Correspondence: Tetsuya Hara, Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2‐5‐1 Shikata‐cho, Kita‐ku, Okayama 700‐8525, Japan.</line><line>E‐mail: <email>harat@md.okayama-u.ac.jp</email></line></lineatedText></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JOOR.JOOR12198.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Effect of occlusal rehabilitation on spatial memory and hippocampal neurons after long‐term loss of molars in rats</title><title type="shortAuthors">S. Sakamoto <i>et al</i>.</title></titleGroup><creators><creator affiliationRef="#joor12198-aff-0001" creatorRole="author" xml:id="joor12198-cr-0001"><personName><givenNames>S.</givenNames> <familyName>Sakamoto</familyName></personName></creator><creator affiliationRef="#joor12198-aff-0001" corresponding="yes" creatorRole="author" xml:id="joor12198-cr-0002"><personName><givenNames>T.</givenNames> <familyName>Hara</familyName></personName></creator><creator affiliationRef="#joor12198-aff-0001" creatorRole="author" xml:id="joor12198-cr-0003"><personName><givenNames>A.</givenNames> <familyName>Kurozumi</familyName></personName></creator><creator affiliationRef="#joor12198-aff-0001" creatorRole="author" xml:id="joor12198-cr-0004"><personName><givenNames>M.</givenNames> <familyName>Oka</familyName></personName></creator><creator affiliationRef="#joor12198-aff-0001" creatorRole="author" xml:id="joor12198-cr-0005"><personName><givenNames>C.</givenNames> <familyName>Kuroda‐Ishimine</familyName></personName></creator><creator affiliationRef="#joor12198-aff-0001" creatorRole="author" xml:id="joor12198-cr-0006"><personName><givenNames>D.</givenNames> <familyName>Araki</familyName></personName></creator><creator affiliationRef="#joor12198-aff-0001" creatorRole="author" xml:id="joor12198-cr-0007"><personName><givenNames>S.</givenNames> <familyName>Iida</familyName></personName></creator><creator affiliationRef="#joor12198-aff-0001" creatorRole="author" xml:id="joor12198-cr-0008"><personName><givenNames>S.</givenNames> <familyName>Minagi</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="JP" type="organization" xml:id="joor12198-aff-0001"><orgDiv>Department of Occlusal and Oral Functional Rehabilitation</orgDiv> <orgDiv>Graduate School of Medicine, Dentistry and Pharmaceutical Sciences</orgDiv> <orgName>Okayama University</orgName> <address><city>Okayama</city> <country>Japan</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="joor12198-kwd-0001">dental occlusal wear</keyword><keyword xml:id="joor12198-kwd-0002">toothless</keyword><keyword xml:id="joor12198-kwd-0003">hippocampus</keyword><keyword xml:id="joor12198-kwd-0004">neurons</keyword><keyword xml:id="joor12198-kwd-0005">maze learning</keyword><keyword xml:id="joor12198-kwd-0006">rats</keyword></keywordGroup><fundingInfo><fundingAgency>JSPS KAKENHI</fundingAgency><fundingNumber>#21592448</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:id="joor12198-abs-0001"><title type="main">Summary</title><p>Experimental loss of occlusal support caused by the extraction or grinding of molar teeth has been reported to foment the impairment of learning and memory in laboratory animals. The purpose of this study was to examine the effect of occlusal reconstruction after long‐term loss of molars on spatial memory by using 8‐arm radial maze and by assessing histopathological changes of neuron density in the hippocampus. Experimental dentures were inserted into the oral cavities of molarless rats to recover the occlusal support. Age‐matched groups of control, molarless and denture‐wearing rats were trained to perform the maze tasks. The difference of the error incidence in the maze task was evaluated between three groups. The difference of neuron density between three groups was also evaluated at the end of the maze task. Serum corticosterone levels were also measured to estimate the chronic stress, which could be caused by extraction, insertion of the experimental denture or any experimental procedure. The error incidence in the denture‐wearing group was significantly higher than that of the control group, but significantly lower than that of the molarless group. Significant differences of neuron density were observed between three groups in each of the hippocampal <fc>CA</fc>1, <fc>CA</fc>3 and <fc>DG</fc> subfields. No significant difference of the serum corticosterone levels between three groups could be observed. From the results of this study, it was suggested that the recovery of occlusal support would bring amelioration of cognitive impairment concomitant with long period loss of molars in rats.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Effect of occlusal rehabilitation on spatial memory and hippocampal neurons after long‐term loss of molars in rats</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Effect of occlusal rehabilitation on spatial memory and hippocampal neurons after long‐term loss of molars in rats</title></titleInfo><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Sakamoto</namePart><affiliation>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Hara</namePart><affiliation>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</affiliation><affiliation>Correspondence: Tetsuya Hara, Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2‐5‐1 Shikata‐cho, Kita‐ku, Okayama 700‐8525, Japan.E‐mail:</affiliation><affiliation>E-mail: harat@md.okayama-u.ac.jp</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Kurozumi</namePart><affiliation>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Oka</namePart><affiliation>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Kuroda‐Ishimine</namePart><affiliation>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Araki</namePart><affiliation>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Iida</namePart><affiliation>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Minagi</namePart><affiliation>Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2014-10</dateIssued><dateCreated encoding="w3cdtf">2014-05-21</dateCreated><dateValid encoding="w3cdtf">2014-05-11</dateValid><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Experimental loss of occlusal support caused by the extraction or grinding of molar teeth has been reported to foment the impairment of learning and memory in laboratory animals. The purpose of this study was to examine the effect of occlusal reconstruction after long‐term loss of molars on spatial memory by using 8‐arm radial maze and by assessing histopathological changes of neuron density in the hippocampus. Experimental dentures were inserted into the oral cavities of molarless rats to recover the occlusal support. Age‐matched groups of control, molarless and denture‐wearing rats were trained to perform the maze tasks. The difference of the error incidence in the maze task was evaluated between three groups. The difference of neuron density between three groups was also evaluated at the end of the maze task. Serum corticosterone levels were also measured to estimate the chronic stress, which could be caused by extraction, insertion of the experimental denture or any experimental procedure. The error incidence in the denture‐wearing group was significantly higher than that of the control group, but significantly lower than that of the molarless group. Significant differences of neuron density were observed between three groups in each of the hippocampal CA1, CA3 and DG subfields. No significant difference of the serum corticosterone levels between three groups could be observed. From the results of this study, it was suggested that the recovery of occlusal support would bring amelioration of cognitive impairment concomitant with long period loss of molars in rats.</abstract><note type="funding">JSPS KAKENHI - No. #21592448; </note><subject><genre>keywords</genre><topic>dental occlusal wear</topic><topic>toothless</topic><topic>hippocampus</topic><topic>neurons</topic><topic>maze learning</topic><topic>rats</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Oral Rehabilitation</title></titleInfo><titleInfo type="abbreviated"><title>J Oral Rehabil</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Original Article</topic></subject><identifier type="ISSN">0305-182X</identifier><identifier type="eISSN">1365-2842</identifier><identifier type="DOI">10.1111/(ISSN)1365-2842</identifier><identifier type="PublisherID">JOOR</identifier><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>41</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>715</start><end>722</end><total>8</total></extent></part></relatedItem><identifier type="istex">59DA6EB7B42111111420C8BF77B314825C4DC0CF</identifier><identifier type="ark">ark:/67375/WNG-MM3JPRZ9-6</identifier><identifier type="DOI">10.1111/joor.12198</identifier><identifier type="ArticleID">JOOR12198</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2014 John Wiley & Sons Ltd© 2014 John Wiley & Sons Ltd</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/59DA6EB7B42111111420C8BF77B314825C4DC0CF/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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