Interleukin‐1β and Interleukin‐6 Expression and Gene Polymorphisms in Subjects with Peri‐Implant Disease
Identifieur interne : 002959 ( Istex/Corpus ); précédent : 002958; suivant : 002960Interleukin‐1β and Interleukin‐6 Expression and Gene Polymorphisms in Subjects with Peri‐Implant Disease
Auteurs : Rafaela F. Melo ; Beatriz M. V. Lopes ; Jamil A. Shibli ; Elcio Marcantonio Junior ; Rosemary Adriana C. Marcantonio ; Gl Ria M. Thompson GalliSource :
- Clinical Implant Dentistry and Related Research [ 1523-0899 ] ; 2012-12.
English descriptors
- KwdEn :
- Allele, Allelic distribution, Araraquara, Bone loss, Clin, Clin implant dent relat, Clin periodontol, Clinical implant dentistry, Crevicular, Cytokine, Dental implants, Diseased implants, Early bone loss, Edentulous patients, Gene polymorphism, Gene polymorphisms, Genetic polymorphisms, Genotype, Gingival crevicular, Healthy implants, Healthy teeth, Heterozygote genotype, Il1b, Implant, Oral mucosa, Osseointegrated, Osseointegrated implants, Paulo, Periodontal, Periodontal disease, Periodontitis, Periodontol, Periodontology, Polymorphism, Positive allele, Positive genotype, Unesp, Unesp paulo state university.
- Teeft :
- Allele, Allelic distribution, Araraquara, Bone loss, Clin, Clin implant dent relat, Clin periodontol, Clinical implant dentistry, Crevicular, Cytokine, Dental implants, Diseased implants, Early bone loss, Edentulous patients, Gene polymorphism, Gene polymorphisms, Genetic polymorphisms, Genotype, Gingival crevicular, Healthy implants, Healthy teeth, Heterozygote genotype, Il1b, Implant, Oral mucosa, Osseointegrated, Osseointegrated implants, Paulo, Periodontal, Periodontal disease, Periodontitis, Periodontol, Periodontology, Polymorphism, Positive allele, Positive genotype, Unesp, Unesp paulo state university.
Abstract
Background: Polymorphisms found in the IL‐1 family genes have been associated with susceptibility of periodontal disease. However, very little is known about the relationship between polymorphisms on inflammatory mediators' genes and peri‐implant disease.
Url:
DOI: 10.1111/j.1708-8208.2010.00325.x
Links to Exploration step
ISTEX:54664B4909FBD48D5DC5F1DE242DCB5208DF7621Le document en format XML
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Melo</name><affiliation><mods:affiliation>Doctor of Dental Surgery, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil;</mods:affiliation></affiliation></author><author><name sortKey="Lopes, Beatriz M V" sort="Lopes, Beatriz M V" uniqKey="Lopes B" first="Beatriz M. V." last="Lopes">Beatriz M. V. Lopes</name><affiliation><mods:affiliation>Doctor of Dental Surgery, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil;</mods:affiliation></affiliation></author><author><name sortKey="Shibli, Jamil A" sort="Shibli, Jamil A" uniqKey="Shibli J" first="Jamil A." last="Shibli">Jamil A. Shibli</name><affiliation><mods:affiliation>assistant professor, Department of Periodontology, Dental Research Division and Oral Implantology Clinic, Guarulhos University, São Paulo, Brazil;</mods:affiliation></affiliation></author><author><name sortKey="Marcantonio Junior, Elcio" sort="Marcantonio Junior, Elcio" uniqKey="Marcantonio Junior E" first="Elcio" last="Marcantonio Junior">Elcio Marcantonio Junior</name><affiliation><mods:affiliation>professor, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil;</mods:affiliation></affiliation></author><author><name sortKey="Marcantonio, Rosemary Adriana C" sort="Marcantonio, Rosemary Adriana C" uniqKey="Marcantonio R" first="Rosemary Adriana C." last="Marcantonio">Rosemary Adriana C. Marcantonio</name><affiliation><mods:affiliation>professor, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil;</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: adriana@foar.unesp.br</mods:affiliation></affiliation></author><author><name sortKey="Galli, Gl Ria M Thompson" sort="Galli, Gl Ria M Thompson" uniqKey="Galli G" first="Gl Ria M. Thompson" last="Galli">Gl Ria M. Thompson Galli</name><affiliation><mods:affiliation>postdoctoral research associate, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Implant Dentistry and Related Research</title><title level="j" type="alt">CLINICAL IMPLANT DENTISTRY RELATED RESEARCH</title><idno type="ISSN">1523-0899</idno><idno type="eISSN">1708-8208</idno><imprint><biblScope unit="vol">14</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="905">905</biblScope><biblScope unit="page" to="914">914</biblScope><biblScope unit="page-count">10</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2012-12">2012-12</date></imprint><idno type="ISSN">1523-0899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1523-0899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Allele</term><term>Allelic distribution</term><term>Araraquara</term><term>Bone loss</term><term>Clin</term><term>Clin implant dent relat</term><term>Clin periodontol</term><term>Clinical implant dentistry</term><term>Crevicular</term><term>Cytokine</term><term>Dental implants</term><term>Diseased implants</term><term>Early bone loss</term><term>Edentulous patients</term><term>Gene polymorphism</term><term>Gene polymorphisms</term><term>Genetic polymorphisms</term><term>Genotype</term><term>Gingival crevicular</term><term>Healthy implants</term><term>Healthy teeth</term><term>Heterozygote genotype</term><term>Il1b</term><term>Implant</term><term>Oral mucosa</term><term>Osseointegrated</term><term>Osseointegrated implants</term><term>Paulo</term><term>Periodontal</term><term>Periodontal disease</term><term>Periodontitis</term><term>Periodontol</term><term>Periodontology</term><term>Polymorphism</term><term>Positive allele</term><term>Positive genotype</term><term>Unesp</term><term>Unesp paulo state university</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Allele</term><term>Allelic distribution</term><term>Araraquara</term><term>Bone loss</term><term>Clin</term><term>Clin implant dent relat</term><term>Clin periodontol</term><term>Clinical implant dentistry</term><term>Crevicular</term><term>Cytokine</term><term>Dental implants</term><term>Diseased implants</term><term>Early bone loss</term><term>Edentulous patients</term><term>Gene polymorphism</term><term>Gene polymorphisms</term><term>Genetic polymorphisms</term><term>Genotype</term><term>Gingival crevicular</term><term>Healthy implants</term><term>Healthy teeth</term><term>Heterozygote genotype</term><term>Il1b</term><term>Implant</term><term>Oral mucosa</term><term>Osseointegrated</term><term>Osseointegrated implants</term><term>Paulo</term><term>Periodontal</term><term>Periodontal disease</term><term>Periodontitis</term><term>Periodontol</term><term>Periodontology</term><term>Polymorphism</term><term>Positive allele</term><term>Positive genotype</term><term>Unesp</term><term>Unesp paulo state university</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Background: Polymorphisms found in the IL‐1 family genes have been associated with susceptibility of periodontal disease. However, very little is known about the relationship between polymorphisms on inflammatory mediators' genes and peri‐implant disease.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>polymorphism</json:string><json:string>implant</json:string><json:string>allele</json:string><json:string>il1b</json:string><json:string>genotype</json:string><json:string>clin</json:string><json:string>healthy implants</json:string><json:string>periodontal</json:string><json:string>periodontol</json:string><json:string>crevicular</json:string><json:string>paulo</json:string><json:string>araraquara</json:string><json:string>cytokine</json:string><json:string>healthy teeth</json:string><json:string>bone loss</json:string><json:string>periodontal disease</json:string><json:string>osseointegrated</json:string><json:string>gene polymorphisms</json:string><json:string>periodontology</json:string><json:string>unesp</json:string><json:string>periodontitis</json:string><json:string>clin periodontol</json:string><json:string>unesp paulo state university</json:string><json:string>osseointegrated implants</json:string><json:string>clinical implant dentistry</json:string><json:string>positive allele</json:string><json:string>heterozygote genotype</json:string><json:string>gene polymorphism</json:string><json:string>gingival crevicular</json:string><json:string>early bone loss</json:string><json:string>oral mucosa</json:string><json:string>dental implants</json:string><json:string>edentulous patients</json:string><json:string>positive genotype</json:string><json:string>allelic distribution</json:string><json:string>clin implant dent relat</json:string><json:string>diseased implants</json:string><json:string>genetic polymorphisms</json:string></teeft></keywords><author><json:item><name>Rafaela F. Melo DDS, PhD</name><affiliations><json:string>Doctor of Dental Surgery, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil;</json:string></affiliations></json:item><json:item><name>Beatriz M. V. Lopes DDS, PhD</name><affiliations><json:string>Doctor of Dental Surgery, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil;</json:string></affiliations></json:item><json:item><name>Jamil A. Shibli PhD</name><affiliations><json:string>assistant professor, Department of Periodontology, Dental Research Division and Oral Implantology Clinic, Guarulhos University, São Paulo, Brazil;</json:string></affiliations></json:item><json:item><name>Elcio Marcantonio Junior PhD</name><affiliations><json:string>professor, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil;</json:string></affiliations></json:item><json:item><name>Rosemary Adriana C. Marcantonio PhD</name><affiliations><json:string>professor, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil;</json:string><json:string>E-mail: adriana@foar.unesp.br</json:string></affiliations></json:item><json:item><name>Glória M. Thompson Galli PhD</name><affiliations><json:string>postdoctoral research associate, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>genetic</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>gingival crevicular fluid</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>implant</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>interleukin‐1</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>interleukin‐6</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>polymorphism</value></json:item></subject><articleId><json:string>CID325</json:string></articleId><arkIstex>ark:/67375/WNG-ZWSL87D2-1</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Background: Polymorphisms found in the IL‐1 family genes have been associated with susceptibility of periodontal disease. However, very little is known about the relationship between polymorphisms on inflammatory mediators' genes and peri‐implant disease.</abstract><qualityIndicators><score>7.396</score><pdfWordCount>5069</pdfWordCount><pdfCharCount>32326</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>10</pdfPageCount><pdfPageSize>585 x 783 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>33</abstractWordCount><abstractCharCount>255</abstractCharCount><keywordCount>6</keywordCount></qualityIndicators><title>Interleukin‐1β and Interleukin‐6 Expression and Gene Polymorphisms in Subjects with Peri‐Implant Disease</title><pmid><json:string>21414132</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Clinical Implant Dentistry and Related Research</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1708-8208</json:string></doi><issn><json:string>1523-0899</json:string></issn><eissn><json:string>1708-8208</json:string></eissn><publisherId><json:string>CID</json:string></publisherId><volume>14</volume><issue>6</issue><pages><first>905</first><last>914</last><total>10</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>ARTICLE</value></json:item></subject></host><namedEntities><unitex><date><json:string>2012</json:string></date><geogName></geogName><orgName><json:string>Wiley Periodicals, Inc.</json:string><json:string>São Paulo Research Foundation, São Paulo, Brazil</json:string><json:string>BioSource International</json:string><json:string>São Paulo State University</json:string><json:string>Related Research, Volume</json:string><json:string>Graph Pad Software, Inc.</json:string><json:string>American Academy of Periodontology</json:string><json:string>Ethics Committee on Research</json:string><json:string>National Council for Scienti</json:string><json:string>Department of Periodontology, Dental Research Division and Oral</json:string><json:string>Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil Reprint</json:string><json:string>Guarulhos University</json:string><json:string>Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Shimpuku</json:string><json:string>Marcantonio Junior</json:string><json:string>Hultin</json:string><json:string>Fishman</json:string><json:string>Moreira</json:string><json:string>M. V. Lopes</json:string><json:string>Adriana C. Marcantonio</json:string><json:string>Panagakos</json:string><json:string>Lachmann</json:string><json:string>Rosemary Adriana</json:string><json:string>Jamil A. Shibli</json:string><json:string>Gruica</json:string><json:string>Polymorphisms</json:string><json:string>Campos</json:string><json:string>Feloutzis</json:string><json:string>Kornman</json:string><json:string>Murata</json:string><json:string>C. 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V.</forename><surname>Lopes</surname><roleName type="degree">DDS, PhD</roleName></persName><affiliation>Doctor of Dental Surgery, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil;<address><country key="BR"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Jamil A.</forename><surname>Shibli</surname><roleName type="degree">PhD</roleName></persName><affiliation>assistant professor, Department of Periodontology, Dental Research Division and Oral Implantology Clinic, Guarulhos University, São Paulo, Brazil;<address><country key="BR"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Elcio</forename><surname>Marcantonio Junior</surname><roleName type="degree">PhD</roleName></persName><affiliation>professor, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil;<address><country key="BR"></country></address></affiliation></author><author xml:id="author-0004" role="corresp"><persName><forename type="first">Rosemary Adriana C.</forename><surname>Marcantonio</surname><roleName type="degree">PhD</roleName></persName><affiliation>professor, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil;<address><country key="BR"></country></address></affiliation><affiliation>Dr. Rosemary Adriana C. Marcantonio, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Rua Humaitá, 1680. Araraquara, SP 14801‐903, Brazil; e‐mail: adriana@foar.unesp.br</affiliation></author><author xml:id="author-0005"><persName><forename type="first">Glória M. Thompson</forename><surname>Galli</surname><roleName type="degree">PhD</roleName></persName><affiliation>postdoctoral research associate, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil<address><country key="BR"></country></address></affiliation></author><idno type="istex">54664B4909FBD48D5DC5F1DE242DCB5208DF7621</idno><idno type="ark">ark:/67375/WNG-ZWSL87D2-1</idno><idno type="DOI">10.1111/j.1708-8208.2010.00325.x</idno><idno type="unit">CID325</idno><idno type="toTypesetVersion">file:CID.CID325.pdf</idno></analytic><monogr><title level="j" type="main">Clinical Implant Dentistry and Related Research</title><title level="j" type="alt">CLINICAL IMPLANT DENTISTRY RELATED RESEARCH</title><idno type="pISSN">1523-0899</idno><idno type="eISSN">1708-8208</idno><idno type="book-DOI">10.1111/(ISSN)1708-8208</idno><idno type="book-part-DOI">10.1111/cid.2012.14.issue-6</idno><idno type="product">CID</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">14</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="905">905</biblScope><biblScope unit="page" to="914">914</biblScope><biblScope unit="page-count">10</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2012-12"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>ABSTRACT</head><p><hi rend="bold">Background:</hi> Polymorphisms found in the IL‐1 family genes have been associated with susceptibility of periodontal disease. However, very little is known about the relationship between polymorphisms on inflammatory mediators' genes and peri‐implant disease.</p><p><hi rend="bold">Purpose:</hi> The aim of the present study was to evaluate interleukin‐1β (IL‐1β) and interleukin‐6 (IL‐6) concentration in the crevicular fluid, and the impact of gene polymorphisms on healthy and diseased implants in comparison with healthy teeth.</p><p><hi rend="bold">Materials and Methods:</hi> We examined 47 implants and teeth in 47 patients grouped as: 31 healthy implants, 16 implants with peri‐implantitis, 31 healthy teeth from patients with healthy implants, and 16 healthy teeth from patients with peri‐implantitis. Clinical parameters were recorded from all implants and teeth. Gingival crevicular fluid was collected to evaluate the concentration of IL‐1β and IL‐6. Cells from buccal mucosa were collected and their genomic DNA extracted for identification of the following polymorphisms: <hi rend="italic">IL1B</hi>+3954, <hi rend="italic">IL1B</hi>‐511, and <hi rend="italic">IL6</hi>‐174.</p><p><hi rend="bold">Results:</hi> Clinical evaluation demonstrated that implants with peri‐implantitis had less favorable indexes for probing depth (PD), relative clinical attachment level (CAL), bleeding on probing, and suppuration when compared with healthy implants and, for PD and CAL when compared with healthy teeth. There was no significant difference in the concentration of IL‐1β and IL‐6 detected between groups. There were no statistically significant differences between alleles and polymorphisms distribution on the studied population.</p><p><hi rend="bold">Conclusions:</hi> There was no correlation between the concentration of IL‐1β and IL‐6 in the crevicular sulcular fluid present in healthy or diseased osseointegrated implants in comparison with healthy teeth. The studied gene polymorphisms had no influence on peri‐implant disease.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">genetic</term><term xml:id="k2">gingival crevicular fluid</term><term xml:id="k3">implant</term><term xml:id="k4">interleukin‐1</term><term xml:id="k5">interleukin‐6</term><term xml:id="k6">polymorphism</term></keywords><keywords rend="tocHeading1"><term>ARTICLES</term></keywords><keywords rend="articleCategory"><term>ARTICLE</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/54664B4909FBD48D5DC5F1DE242DCB5208DF7621/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1708-8208</doi><issn type="print">1523-0899</issn><issn type="electronic">1708-8208</issn><idGroup><id type="product" value="CID"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="CLINICAL IMPLANT DENTISTRY RELATED RESEARCH">Clinical Implant Dentistry and Related Research</title></titleGroup></publicationMeta><publicationMeta level="part" position="12106"><doi>10.1111/cid.2012.14.issue-6</doi><copyright ownership="publisher">Copyright © 2012 Wiley Periodicals, Inc.</copyright><numberingGroup><numbering number="14" type="journalVolume">14</numbering><numbering type="journalIssue">6</numbering></numberingGroup><coverDate startDate="2012-12">December 2012</coverDate></publicationMeta><publicationMeta level="unit" position="150" status="forIssue" type="article"><doi origin="wiley">10.1111/j.1708-8208.2010.00325.x</doi><idGroup><id type="unit" value="CID325"></id></idGroup><countGroup><count type="pageTotal" number="10"></count></countGroup><titleGroup><title type="tocHeading1">ARTICLES</title><title type="articleCategory">ARTICLE</title></titleGroup><copyright>© 2011 Wiley Periodicals, Inc.</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:3.1.9 mode:FullText" date="2012-12-02"></event><event date="2012-12-03" type="xmlCorrected"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-03-17"></event><event type="firstOnline" date="2011-03-17"></event><event type="publishedOnlineFinalForm" date="2012-12-03"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-15"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.3.4 mode:FullText" date="2015-02-25"></event></eventGroup><numberingGroup><numbering type="pageFirst">905</numbering><numbering type="pageLast">914</numbering></numberingGroup><correspondenceTo>Dr. Rosemary Adriana C. Marcantonio, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Rua Humaitá, 1680. Araraquara, SP 14801‐903, Brazil; e‐mail: <email>adriana@foar.unesp.br</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:CID.CID325.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="5"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="41"></count><count type="wordTotal" number="5728"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Interleukin‐1β and Interleukin‐6 Expression and Gene Polymorphisms in Subjects with Peri‐Implant Disease</title><title type="shortAuthors">Clinical Implant Dentistry and Related Research, Volume *, Number *, 2011</title><title type="short">Interleukin‐1β and Interleukin‐6 Expression and Gene Polymorphisms in Subjects with Peri‐Implant Disease</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Rafaela F.</givenNames><familyName>Melo</familyName><degrees>DDS, PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>Beatriz M. V.</givenNames><familyName>Lopes</familyName><degrees>DDS, PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>Jamil A.</givenNames><familyName>Shibli</familyName><degrees>PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a4"><personName><givenNames>Elcio</givenNames><familyName>Marcantonio Junior</familyName><degrees>PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a5" corresponding="yes"><personName><givenNames>Rosemary Adriana C.</givenNames><familyName>Marcantonio</familyName><degrees>PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a6"><personName><givenNames>Glória M. Thompson</givenNames><familyName>Galli</familyName><degrees>PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="BR"><unparsedAffiliation>Doctor of Dental Surgery, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil;</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="BR"><unparsedAffiliation>Doctor of Dental Surgery, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil;</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="BR"><unparsedAffiliation>assistant professor, Department of Periodontology, Dental Research Division and Oral Implantology Clinic, Guarulhos University, São Paulo, Brazil;</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="BR"><unparsedAffiliation>professor, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil;</unparsedAffiliation></affiliation><affiliation xml:id="a5" countryCode="BR"><unparsedAffiliation>professor, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil;</unparsedAffiliation></affiliation><affiliation xml:id="a6" countryCode="BR"><unparsedAffiliation>postdoctoral research associate, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">genetic</keyword><keyword xml:id="k2">gingival crevicular fluid</keyword><keyword xml:id="k3">implant</keyword><keyword xml:id="k4">interleukin‐1</keyword><keyword xml:id="k5">interleukin‐6</keyword><keyword xml:id="k6">polymorphism</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">ABSTRACT</title><p><b>Background:</b> Polymorphisms found in the IL‐1 family genes have been associated with susceptibility of periodontal disease. However, very little is known about the relationship between polymorphisms on inflammatory mediators' genes and peri‐implant disease.</p><p><b>Purpose:</b> The aim of the present study was to evaluate interleukin‐1β (IL‐1β) and interleukin‐6 (IL‐6) concentration in the crevicular fluid, and the impact of gene polymorphisms on healthy and diseased implants in comparison with healthy teeth.</p><p><b>Materials and Methods:</b> We examined 47 implants and teeth in 47 patients grouped as: 31 healthy implants, 16 implants with peri‐implantitis, 31 healthy teeth from patients with healthy implants, and 16 healthy teeth from patients with peri‐implantitis. Clinical parameters were recorded from all implants and teeth. Gingival crevicular fluid was collected to evaluate the concentration of IL‐1β and IL‐6. Cells from buccal mucosa were collected and their genomic DNA extracted for identification of the following polymorphisms: <i>IL1B</i>+3954, <i>IL1B</i>‐511, and <i>IL6</i>‐174.</p><p><b>Results:</b> Clinical evaluation demonstrated that implants with peri‐implantitis had less favorable indexes for probing depth (PD), relative clinical attachment level (CAL), bleeding on probing, and suppuration when compared with healthy implants and, for PD and CAL when compared with healthy teeth. There was no significant difference in the concentration of IL‐1β and IL‐6 detected between groups. There were no statistically significant differences between alleles and polymorphisms distribution on the studied population.</p><p><b>Conclusions:</b> There was no correlation between the concentration of IL‐1β and IL‐6 in the crevicular sulcular fluid present in healthy or diseased osseointegrated implants in comparison with healthy teeth. The studied gene polymorphisms had no influence on peri‐implant disease.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Interleukin‐1β and Interleukin‐6 Expression and Gene Polymorphisms in Subjects with Peri‐Implant Disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Interleukin‐1β and Interleukin‐6 Expression and Gene Polymorphisms in Subjects with Peri‐Implant Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Interleukin‐1β and Interleukin‐6 Expression and Gene Polymorphisms in Subjects with Peri‐Implant Disease</title></titleInfo><name type="personal"><namePart type="given">Rafaela F.</namePart><namePart type="family">Melo</namePart><namePart type="termsOfAddress">DDS, PhD</namePart><affiliation>Doctor of Dental Surgery, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Beatriz M. V.</namePart><namePart type="family">Lopes</namePart><namePart type="termsOfAddress">DDS, PhD</namePart><affiliation>Doctor of Dental Surgery, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jamil A.</namePart><namePart type="family">Shibli</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>assistant professor, Department of Periodontology, Dental Research Division and Oral Implantology Clinic, Guarulhos University, São Paulo, Brazil;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elcio</namePart><namePart type="family">Marcantonio Junior</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>professor, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rosemary Adriana C.</namePart><namePart type="family">Marcantonio</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>professor, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil;</affiliation><affiliation>E-mail: adriana@foar.unesp.br</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Glória M. Thompson</namePart><namePart type="family">Galli</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>postdoctoral research associate, UNESP – São Paulo State University, Department of Periodontology, Araraquara Dental School, Araraquara, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2012-12</dateIssued><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">1</extent><extent unit="tables">5</extent><extent unit="formulas">0</extent><extent unit="references">41</extent><extent unit="linksCrossRef">0</extent><extent unit="words">5728</extent></physicalDescription><abstract>Background: Polymorphisms found in the IL‐1 family genes have been associated with susceptibility of periodontal disease. However, very little is known about the relationship between polymorphisms on inflammatory mediators' genes and peri‐implant disease.</abstract><abstract>Purpose: The aim of the present study was to evaluate interleukin‐1β (IL‐1β) and interleukin‐6 (IL‐6) concentration in the crevicular fluid, and the impact of gene polymorphisms on healthy and diseased implants in comparison with healthy teeth.</abstract><abstract>Materials and Methods: We examined 47 implants and teeth in 47 patients grouped as: 31 healthy implants, 16 implants with peri‐implantitis, 31 healthy teeth from patients with healthy implants, and 16 healthy teeth from patients with peri‐implantitis. Clinical parameters were recorded from all implants and teeth. Gingival crevicular fluid was collected to evaluate the concentration of IL‐1β and IL‐6. Cells from buccal mucosa were collected and their genomic DNA extracted for identification of the following polymorphisms: IL1B+3954, IL1B‐511, and IL6‐174.</abstract><abstract>Results: Clinical evaluation demonstrated that implants with peri‐implantitis had less favorable indexes for probing depth (PD), relative clinical attachment level (CAL), bleeding on probing, and suppuration when compared with healthy implants and, for PD and CAL when compared with healthy teeth. There was no significant difference in the concentration of IL‐1β and IL‐6 detected between groups. There were no statistically significant differences between alleles and polymorphisms distribution on the studied population.</abstract><abstract>Conclusions: There was no correlation between the concentration of IL‐1β and IL‐6 in the crevicular sulcular fluid present in healthy or diseased osseointegrated implants in comparison with healthy teeth. The studied gene polymorphisms had no influence on peri‐implant disease.</abstract><subject lang="en"><genre>keywords</genre><topic>genetic</topic><topic>gingival crevicular fluid</topic><topic>implant</topic><topic>interleukin‐1</topic><topic>interleukin‐6</topic><topic>polymorphism</topic></subject><relatedItem type="host"><titleInfo><title>Clinical Implant Dentistry and Related Research</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>ARTICLE</topic></subject><identifier type="ISSN">1523-0899</identifier><identifier type="eISSN">1708-8208</identifier><identifier type="DOI">10.1111/(ISSN)1708-8208</identifier><identifier type="PublisherID">CID</identifier><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>905</start><end>914</end><total>10</total></extent></part></relatedItem><identifier type="istex">54664B4909FBD48D5DC5F1DE242DCB5208DF7621</identifier><identifier type="ark">ark:/67375/WNG-ZWSL87D2-1</identifier><identifier type="DOI">10.1111/j.1708-8208.2010.00325.x</identifier><identifier type="ArticleID">CID325</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2012 Wiley Periodicals, Inc.© 2011 Wiley Periodicals, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/54664B4909FBD48D5DC5F1DE242DCB5208DF7621/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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