Is Marginal Bone Loss around Oral Implants the Result of a Provoked Foreign Body Reaction?
Identifieur interne : 001A76 ( Istex/Corpus ); précédent : 001A75; suivant : 001A77Is Marginal Bone Loss around Oral Implants the Result of a Provoked Foreign Body Reaction?
Auteurs : Tomas Albrektsson ; Christer Dahlin ; Torsten Jemt ; Lars Sennerby ; Alberto Turri ; Ann WennerbergSource :
- Clinical Implant Dentistry and Related Research [ 1523-0899 ] ; 2014-04.
Abstract
When a foreign body is placed in bone or soft tissue, an inflammatory reaction inevitably develops. Hence, osseointegration is but a foreign body response to the implant, which according to classic pathology is a chronic inflammatory response and characterized by bone embedding/separation of the implant from the body.
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DOI: 10.1111/cid.12142
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first="Alberto" last="Turri">Alberto Turri</name><affiliation><mods:affiliation>Department of Biomaterials, Göteborg University, Göteborg, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>The Brånemark Clinic, Public Dental Health Service, Göteborg, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Wennerberg, Ann" sort="Wennerberg, Ann" uniqKey="Wennerberg A" first="Ann" last="Wennerberg">Ann Wennerberg</name><affiliation><mods:affiliation>Department of Prosthodontics, Malmö University, Malmö, Sweden</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Implant Dentistry and Related Research</title><title level="j" type="alt">CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH</title><idno type="ISSN">1523-0899</idno><idno type="eISSN">1708-8208</idno><imprint><biblScope unit="vol">16</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" 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Hence, osseointegration is but a foreign body response to the implant, which according to classic pathology is a chronic inflammatory response and characterized by bone embedding/separation of the implant from the body.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Tomas Albrektsson MD, PhD, RCPSG</name><affiliations><json:string>Department of Biomaterials, Göteborg University, Göteborg, Sweden</json:string><json:string>Department of Prosthodontics, Malmö University, Malmö, Sweden</json:string><json:string>E-mail: tomas.albrektsson@gu.se</json:string></affiliations></json:item><json:item><name>Christer Dahlin DDS, PhD</name><affiliations><json:string>Department of Biomaterials, Göteborg University, Göteborg, Sweden</json:string><json:string>Department of Oral& Maxillofacial Surgery, NU Hospital Group, Trollhättan, Sweden</json:string></affiliations></json:item><json:item><name>Torsten Jemt DDS, PhD</name><affiliations><json:string>Department of Prosthetic Dentistry/Dental Material Science, University of Göteborg, Göteborg, Sweden</json:string><json:string>The Brånemark Clinic, Public Dental Health Service, Göteborg, Sweden</json:string></affiliations></json:item><json:item><name>Lars Sennerby DDS, PhD</name><affiliations><json:string>Department of Oral and Maxillofacial Surgery, Göteborg University, Göteborg, Sweden</json:string></affiliations></json:item><json:item><name>Alberto Turri DDS, PhD cand</name><affiliations><json:string>Department of Biomaterials, Göteborg University, Göteborg, Sweden</json:string><json:string>The Brånemark Clinic, Public Dental Health Service, Göteborg, Sweden</json:string></affiliations></json:item><json:item><name>Ann Wennerberg DDS, PhD</name><affiliations><json:string>Department of Prosthodontics, Malmö University, Malmö, Sweden</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>bone loss</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dental implants</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>foreign body reaction</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>osseointegration</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>peri‐implantitis</value></json:item></subject><articleId><json:string>CID12142</json:string></articleId><arkIstex>ark:/67375/WNG-XZMDCJJ7-B</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>When a foreign body is placed in bone or soft tissue, an inflammatory reaction inevitably develops. 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e‐mail: tomas.albrektsson@gu.se</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Christer</forename><surname>Dahlin</surname><roleName type="degree">DDS, PhD</roleName></persName><affiliation><orgName>Department of Biomaterials</orgName><orgName>Göteborg University</orgName><address><settlement type="city">Göteborg</settlement><country key="SE">Sweden</country></address></affiliation><affiliation><orgName>Department of Oral& Maxillofacial Surgery</orgName><orgName>NU Hospital Group</orgName><address><settlement type="city">Trollhättan</settlement><country key="SE">Sweden</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Torsten</forename><surname>Jemt</surname><roleName type="degree">DDS, PhD</roleName></persName><affiliation><orgName>Department of Prosthetic Dentistry/Dental Material Science</orgName><orgName>University of Göteborg</orgName><address><settlement type="city">Göteborg</settlement><country key="SE">Sweden</country></address></affiliation><affiliation><orgName>The Brånemark Clinic</orgName><orgName>Public Dental Health Service</orgName><address><settlement type="city">Göteborg</settlement><country key="SE">Sweden</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Lars</forename><surname>Sennerby</surname><roleName type="degree">DDS, PhD</roleName></persName><affiliation><orgName>Department of Oral and Maxillofacial Surgery</orgName><orgName>Göteborg University</orgName><address><settlement type="city">Göteborg</settlement><country key="SE">Sweden</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Alberto</forename><surname>Turri</surname><roleName type="degree">DDS, PhD cand</roleName></persName><affiliation><orgName>Department of Biomaterials</orgName><orgName>Göteborg University</orgName><address><settlement type="city">Göteborg</settlement><country key="SE">Sweden</country></address></affiliation><affiliation><orgName>The Brånemark Clinic</orgName><orgName>Public Dental Health Service</orgName><address><settlement type="city">Göteborg</settlement><country key="SE">Sweden</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Ann</forename><surname>Wennerberg</surname><roleName type="degree">DDS, PhD</roleName></persName><affiliation><orgName>Department of Prosthodontics</orgName><orgName>Malmö University</orgName><address><settlement type="city">Malmö</settlement><country key="SE">Sweden</country></address></affiliation></author><idno type="istex">36AF7A4A8DD2C74DF22206D697C89162A4942625</idno><idno type="ark">ark:/67375/WNG-XZMDCJJ7-B</idno><idno type="DOI">10.1111/cid.12142</idno><idno type="unit">CID12142</idno><idno type="toTypesetVersion">file://CID.CID12142.pdf</idno></analytic><monogr><title level="j" type="main">Clinical Implant Dentistry and Related Research</title><title level="j" type="alt">CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH</title><idno type="pISSN">1523-0899</idno><idno type="eISSN">1708-8208</idno><idno type="book-DOI">10.1111/(ISSN)1708-8208</idno><idno type="book-part-DOI">10.1111/cid.2014.16.issue-2</idno><idno type="product">CID</idno><imprint><biblScope unit="vol">16</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="155">155</biblScope><biblScope unit="page" to="165">165</biblScope><biblScope unit="page-count">11</biblScope><date type="published" when="2014-04"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract style="main"><head>Abstract</head>
Background
<p>When a foreign body is placed in bone or soft tissue, an inflammatory reaction inevitably develops. Hence, osseointegration is but a foreign body response to the implant, which according to classic pathology is a chronic inflammatory response and characterized by bone embedding/separation of the implant from the body.</p>
Purpose
<p>The aim of this paper is to suggest an alternative way of looking at the reason for marginal bone loss as a complication to treatment rather than a disease process.</p>
Materials and Methods
<p>The present paper is authored as a narrative review contribution.</p>
Results
<p>The implant‐enveloping bone has sparse blood circulation and is lacking proper innervation in clear contrast to natural teeth that are anchored in bone by a periodontal ligament rich in blood vessels and nerves. Fortunately, a balanced, steady state situation of the inevitable foreign body response will be established for the great majority of implants, seen as maintained osseointegration with no or only very little marginal bone loss. Marginal bone resorption around the implant is the result of different tissue reactions coupled to the foreign body response and is not primarily related to biofilm‐mediated infectious processes as in the pathogenesis of periodontitis around teeth. This means that initial marginal bone resorption around implants represents a reaction to treatment and is not at all a disease process. There is clear evidence that the initial foreign body response to the implant can be sustained and aggravated by various factors related to implant hardware, patient characteristics, surgical and/or prosthodontic mishaps, which may lead to significant marginal bone loss and possibly to implant failure. Admittedly, once severe marginal bone loss has developed, a secondary biofilm‐mediated infection may follow as a complication to the already established bone loss.</p>
Conclusions
<p>The present authors regard researchers seeing marginal bone loss as a periodontitis‐like disease to be on the wrong track; the onset of marginal bone loss around oral implants depends in reality on a dis‐balanced foreign body response.</p></abstract><textClass><keywords><term xml:id="cid12142-kwd-0001">bone loss</term><term xml:id="cid12142-kwd-0002">dental implants</term><term xml:id="cid12142-kwd-0003">foreign body reaction</term><term xml:id="cid12142-kwd-0004">osseointegration</term><term xml:id="cid12142-kwd-0005">peri‐implantitis</term></keywords><keywords rend="tocHeading1"><term>ARTICLES</term></keywords><keywords rend="articleCategory"><term>ARTICLE</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body" wicri:toSee="Element #text"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="cid12142" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley">10.1111/(ISSN)1708-8208</doi><issn type="print">1523-0899</issn><issn type="electronic">1708-8208</issn><idGroup><id type="product" value="CID"></id></idGroup><titleGroup><title sort="CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH" type="main">Clinical Implant Dentistry and Related Research</title><title type="short">Clinical Implant Dentistry and Related Research</title></titleGroup></publicationMeta><publicationMeta level="part" position="04102"><doi>10.1111/cid.2014.16.issue-2</doi><copyright ownership="publisher">Copyright © 2014 Wiley Periodicals, Inc.</copyright><numberingGroup><numbering number="16" type="journalVolume">16</numbering><numbering type="journalIssue">2</numbering></numberingGroup><coverDate startDate="2014-04">April 2014</coverDate></publicationMeta><publicationMeta level="unit" position="10" status="forIssue" type="article"><doi>10.1111/cid.12142</doi><idGroup><id type="unit" value="CID12142"></id></idGroup><countGroup><count number="11" type="pageTotal"></count></countGroup><titleGroup><title type="tocHeading1">ARTICLES</title><title type="articleCategory">ARTICLE</title></titleGroup><copyright ownership="publisher">© 2013 Wiley Periodicals, Inc.</copyright><eventGroup><event agent="bestset" date="2013-08-05" type="xmlCreated"></event><event type="publishedOnlineEarlyUnpaginated" date="2013-09-04"></event><event type="firstOnline" date="2013-09-04"></event><event type="publishedOnlineFinalForm" date="2014-04-25"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-08"></event></eventGroup><numberingGroup><numbering type="pageFirst">155</numbering><numbering type="pageLast">165</numbering></numberingGroup><correspondenceTo>Reprint requests: Professor Tomas Albrektsson, Department of Biomaterials, Sahlgrenska Academy, PO Box 412, Göteborg SE 405 30, Sweden; e‐mail: <email>tomas.albrektsson@gu.se</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file://CID.CID12142.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="short">Osseointegration as a Foreign Body Reaction</title><title type="main">Is Marginal Bone Loss around Oral Implants the Result of a Provoked Foreign Body Reaction?</title></titleGroup><creators><creator affiliationRef="#cid12142-aff-0001 #cid12142-aff-0002" corresponding="yes" creatorRole="author" xml:id="cid12142-cr-0001"><personName><givenNames>Tomas</givenNames><familyName>Albrektsson</familyName><degrees>MD, PhD, RCPSG</degrees></personName></creator><creator affiliationRef="#cid12142-aff-0001 #cid12142-aff-0003" creatorRole="author" xml:id="cid12142-cr-0002"><personName><givenNames>Christer</givenNames><familyName>Dahlin</familyName><degrees>DDS, PhD</degrees></personName></creator><creator affiliationRef="#cid12142-aff-0004 #cid12142-aff-0005" creatorRole="author" xml:id="cid12142-cr-0003"><personName><givenNames>Torsten</givenNames><familyName>Jemt</familyName><degrees>DDS, PhD</degrees></personName></creator><creator affiliationRef="#cid12142-aff-0006" creatorRole="author" xml:id="cid12142-cr-0004"><personName><givenNames>Lars</givenNames><familyName>Sennerby</familyName><degrees>DDS, PhD</degrees></personName></creator><creator affiliationRef="#cid12142-aff-0001 #cid12142-aff-0005" creatorRole="author" xml:id="cid12142-cr-0005"><personName><givenNames>Alberto</givenNames><familyName>Turri</familyName><degrees>DDS, PhD cand</degrees></personName></creator><creator affiliationRef="#cid12142-aff-0002" creatorRole="author" xml:id="cid12142-cr-0006"><personName><givenNames>Ann</givenNames><familyName>Wennerberg</familyName><degrees>DDS, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation countryCode="SE" xml:id="cid12142-aff-0001"><orgDiv>Department of Biomaterials</orgDiv><orgName>Göteborg University</orgName><address><city>Göteborg</city><country>Sweden</country></address></affiliation><affiliation countryCode="SE" xml:id="cid12142-aff-0002"><orgDiv>Department of Prosthodontics</orgDiv><orgName>Malmö University</orgName><address><city>Malmö</city><country>Sweden</country></address></affiliation><affiliation countryCode="SE" xml:id="cid12142-aff-0003"><orgDiv>Department of Oral& Maxillofacial Surgery</orgDiv><orgName>NU Hospital Group</orgName><address><city>Trollhättan</city><country>Sweden</country></address></affiliation><affiliation countryCode="SE" xml:id="cid12142-aff-0004"><orgDiv>Department of Prosthetic Dentistry/Dental Material Science</orgDiv><orgName>University of Göteborg</orgName><address><city>Göteborg</city><country>Sweden</country></address></affiliation><affiliation countryCode="SE" xml:id="cid12142-aff-0005"><orgDiv>The Brånemark Clinic</orgDiv><orgName>Public Dental Health Service</orgName><address><city>Göteborg</city><country>Sweden</country></address></affiliation><affiliation countryCode="SE" xml:id="cid12142-aff-0006"><orgDiv>Department of Oral and Maxillofacial Surgery</orgDiv><orgName>Göteborg University</orgName><address><city>Göteborg</city><country>Sweden</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="cid12142-kwd-0001">bone loss</keyword><keyword xml:id="cid12142-kwd-0002">dental implants</keyword><keyword xml:id="cid12142-kwd-0003">foreign body reaction</keyword><keyword xml:id="cid12142-kwd-0004">osseointegration</keyword><keyword xml:id="cid12142-kwd-0005">peri‐implantitis</keyword></keywordGroup><fundingInfo><fundingAgency>Sylván Foundation</fundingAgency></fundingInfo><abstractGroup><abstract type="main"><title type="main">Abstract</title><section xml:id="cid12142-sec-0001"><title type="main">Background</title><p>When a foreign body is placed in bone or soft tissue, an inflammatory reaction inevitably develops. Hence, osseointegration is but a foreign body response to the implant, which according to classic pathology is a chronic inflammatory response and characterized by bone embedding/separation of the implant from the body.</p></section><section xml:id="cid12142-sec-0002"><title type="main">Purpose</title><p>The aim of this paper is to suggest an alternative way of looking at the reason for marginal bone loss as a complication to treatment rather than a disease process.</p></section><section xml:id="cid12142-sec-0003"><title type="main">Materials and Methods</title><p>The present paper is authored as a narrative review contribution.</p></section><section xml:id="cid12142-sec-0004"><title type="main">Results</title><p>The implant‐enveloping bone has sparse blood circulation and is lacking proper innervation in clear contrast to natural teeth that are anchored in bone by a periodontal ligament rich in blood vessels and nerves. Fortunately, a balanced, steady state situation of the inevitable foreign body response will be established for the great majority of implants, seen as maintained osseointegration with no or only very little marginal bone loss. Marginal bone resorption around the implant is the result of different tissue reactions coupled to the foreign body response and is not primarily related to biofilm‐mediated infectious processes as in the pathogenesis of periodontitis around teeth. This means that initial marginal bone resorption around implants represents a reaction to treatment and is not at all a disease process. There is clear evidence that the initial foreign body response to the implant can be sustained and aggravated by various factors related to implant hardware, patient characteristics, surgical and/or prosthodontic mishaps, which may lead to significant marginal bone loss and possibly to implant failure. Admittedly, once severe marginal bone loss has developed, a secondary biofilm‐mediated infection may follow as a complication to the already established bone loss.</p></section><section xml:id="cid12142-sec-0005"><title type="main">Conclusions</title><p>The present authors regard researchers seeing marginal bone loss as a periodontitis‐like disease to be on the wrong track; the onset of marginal bone loss around oral implants depends in reality on a dis‐balanced foreign body response.</p></section></abstract></abstractGroup></contentMeta></header> </component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Is Marginal Bone Loss around Oral Implants the Result of a Provoked Foreign Body Reaction?</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Osseointegration as a Foreign Body Reaction</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Is Marginal Bone Loss around Oral Implants the Result of a Provoked Foreign Body Reaction?</title></titleInfo><name type="personal"><namePart type="given">Tomas</namePart><namePart type="family">Albrektsson</namePart><namePart type="termsOfAddress">MD, PhD, RCPSG</namePart><affiliation>Department of Biomaterials, Göteborg University, Göteborg, Sweden</affiliation><affiliation>Department of Prosthodontics, Malmö University, Malmö, Sweden</affiliation><affiliation>E-mail: tomas.albrektsson@gu.se</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christer</namePart><namePart type="family">Dahlin</namePart><namePart type="termsOfAddress">DDS, PhD</namePart><affiliation>Department of Biomaterials, Göteborg University, Göteborg, Sweden</affiliation><affiliation>Department of Oral& Maxillofacial Surgery, NU Hospital Group, Trollhättan, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Torsten</namePart><namePart type="family">Jemt</namePart><namePart type="termsOfAddress">DDS, PhD</namePart><affiliation>Department of Prosthetic Dentistry/Dental Material Science, University of Göteborg, Göteborg, Sweden</affiliation><affiliation>The Brånemark Clinic, Public Dental Health Service, Göteborg, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lars</namePart><namePart type="family">Sennerby</namePart><namePart type="termsOfAddress">DDS, PhD</namePart><affiliation>Department of Oral and Maxillofacial Surgery, Göteborg University, Göteborg, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alberto</namePart><namePart type="family">Turri</namePart><namePart type="termsOfAddress">DDS, PhD cand</namePart><affiliation>Department of Biomaterials, Göteborg University, Göteborg, Sweden</affiliation><affiliation>The Brånemark Clinic, Public Dental Health Service, Göteborg, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ann</namePart><namePart type="family">Wennerberg</namePart><namePart type="termsOfAddress">DDS, PhD</namePart><affiliation>Department of Prosthodontics, Malmö University, Malmö, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2014-04</dateIssued><dateCreated encoding="w3cdtf">2013-08-05</dateCreated><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>When a foreign body is placed in bone or soft tissue, an inflammatory reaction inevitably develops. Hence, osseointegration is but a foreign body response to the implant, which according to classic pathology is a chronic inflammatory response and characterized by bone embedding/separation of the implant from the body.</abstract><abstract>The aim of this paper is to suggest an alternative way of looking at the reason for marginal bone loss as a complication to treatment rather than a disease process.</abstract><abstract>The present paper is authored as a narrative review contribution.</abstract><abstract>The implant‐enveloping bone has sparse blood circulation and is lacking proper innervation in clear contrast to natural teeth that are anchored in bone by a periodontal ligament rich in blood vessels and nerves. Fortunately, a balanced, steady state situation of the inevitable foreign body response will be established for the great majority of implants, seen as maintained osseointegration with no or only very little marginal bone loss. Marginal bone resorption around the implant is the result of different tissue reactions coupled to the foreign body response and is not primarily related to biofilm‐mediated infectious processes as in the pathogenesis of periodontitis around teeth. This means that initial marginal bone resorption around implants represents a reaction to treatment and is not at all a disease process. There is clear evidence that the initial foreign body response to the implant can be sustained and aggravated by various factors related to implant hardware, patient characteristics, surgical and/or prosthodontic mishaps, which may lead to significant marginal bone loss and possibly to implant failure. Admittedly, once severe marginal bone loss has developed, a secondary biofilm‐mediated infection may follow as a complication to the already established bone loss.</abstract><abstract>The present authors regard researchers seeing marginal bone loss as a periodontitis‐like disease to be on the wrong track; the onset of marginal bone loss around oral implants depends in reality on a dis‐balanced foreign body response.</abstract><note type="funding">Sylván Foundation</note><subject><genre>keywords</genre><topic>bone loss</topic><topic>dental implants</topic><topic>foreign body reaction</topic><topic>osseointegration</topic><topic>peri‐implantitis</topic></subject><relatedItem type="host"><titleInfo><title>Clinical Implant Dentistry and Related Research</title></titleInfo><titleInfo type="abbreviated"><title>Clinical Implant Dentistry and Related Research</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>ARTICLE</topic></subject><identifier type="ISSN">1523-0899</identifier><identifier type="eISSN">1708-8208</identifier><identifier type="DOI">10.1111/(ISSN)1708-8208</identifier><identifier type="PublisherID">CID</identifier><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>155</start><end>165</end><total>11</total></extent></part></relatedItem><identifier type="istex">36AF7A4A8DD2C74DF22206D697C89162A4942625</identifier><identifier type="ark">ark:/67375/WNG-XZMDCJJ7-B</identifier><identifier type="DOI">10.1111/cid.12142</identifier><identifier type="ArticleID">CID12142</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2014 Wiley Periodicals, Inc.© 2013 Wiley Periodicals, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/36AF7A4A8DD2C74DF22206D697C89162A4942625/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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