Bone responses to zirconia implants with a thin carbonate‐containing hydroxyapatite coating using a molecular precursor method
Identifieur interne : 001479 ( Istex/Corpus ); précédent : 001478; suivant : 001480Bone responses to zirconia implants with a thin carbonate‐containing hydroxyapatite coating using a molecular precursor method
Auteurs : Masatsugu Hirota ; Tohru Hayakawa ; Chikahiro Ohkubo ; Mitsunobu Sato ; Hiroki Hara ; Takeshi Toyama ; Yasuhiro TanakaSource :
- Journal of Biomedical Materials Research Part B: Applied Biomaterials [ 1552-4973 ] ; 2014-08.
Abstract
Thin carbonate‐containing hydroxyapatite (CA) films coating partially stabilized zirconia (Y‐TZP) were prepared (CA‐Y‐TZP) to establish a metal‐free implant system. CA was coated using a molecular precursor method. The CA film was deposited on the surface of Y‐TZP using a precursor solution, which was a mixture of a calcium–ethylenediaminetetraacetic acid (EDTA) complex and phosphate compounds. The deposited CA film was characterized by X‐ray diffraction, Fourier transform infrared spectroscopy, and energy dispersive X‐ray spectroscopy measurements. A focus ion beam system technique revealed that the thickness of the CA film was less than 1.0 µm. Biological evaluations of CA‐Y‐TZP were performed by immersion experiments in simulated body fluid (SBF) and implantation experiments in the tibiae and femoral condyles of rabbits. In the SBF immersion experiment, apatite deposition progressed more on CA‐Y‐TZP at the early stage of immersion than on Y‐TZP without the CA coating. Animal experiments revealed that bone formation on CA‐Y‐TZP was similar with than on Y‐TZP. Histomorphometrical evaluations showed a significantly higher bone‐to‐implant contact ratio and bone mass on CA‐Y‐TZP after implantation into the femoral trabecular bone of rabbits. Therefore, CA‐Y‐TZP appears to be applicable as a metal‐free implant. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1277–1288, 2014.
Url:
DOI: 10.1002/jbm.b.33112
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Ohkubo</name><affiliation><mods:affiliation>Department of Removable Prosthodontics, Tsurumi University School of Dental Medicine, Kanagawa, Japan</mods:affiliation></affiliation></author><author><name sortKey="Sato, Mitsunobu" sort="Sato, Mitsunobu" uniqKey="Sato M" first="Mitsunobu" last="Sato">Mitsunobu Sato</name><affiliation><mods:affiliation>Division of Liberal Arts, Kogakuin University, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Hara, Hiroki" sort="Hara, Hiroki" uniqKey="Hara H" first="Hiroki" last="Hara">Hiroki Hara</name><affiliation><mods:affiliation>Division of Liberal Arts, Kogakuin University, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Toyama, Takeshi" sort="Toyama, Takeshi" uniqKey="Toyama T" first="Takeshi" last="Toyama">Takeshi Toyama</name><affiliation><mods:affiliation>Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Tanaka, Yasuhiro" sort="Tanaka, Yasuhiro" uniqKey="Tanaka Y" first="Yasuhiro" last="Tanaka">Yasuhiro Tanaka</name><affiliation><mods:affiliation>Department of Advance Materials Science, Faculty of Engineering, Kagawa University, Engineering Materials Science, Kagawa, Japan</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:2AB767347CDED8AB2D46985BF28D00B26FF2425B</idno><date when="2014" year="2014">2014</date><idno type="doi">10.1002/jbm.b.33112</idno><idno type="url">https://api.istex.fr/document/2AB767347CDED8AB2D46985BF28D00B26FF2425B/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001479</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001479</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Bone responses to zirconia implants with a thin carbonate‐containing hydroxyapatite coating using a molecular precursor method</title><author><name sortKey="Hirota, Masatsugu" sort="Hirota, Masatsugu" uniqKey="Hirota M" first="Masatsugu" last="Hirota">Masatsugu Hirota</name><affiliation><mods:affiliation>Department of Removable Prosthodontics, Tsurumi University School of Dental Medicine, Kanagawa, Japan</mods:affiliation></affiliation></author><author><name sortKey="Hayakawa, Tohru" sort="Hayakawa, Tohru" uniqKey="Hayakawa T" first="Tohru" last="Hayakawa">Tohru Hayakawa</name><affiliation><mods:affiliation>Department of Dental Engineering, Tsurumi University School of Dental Medicine, Kanagawa, Japan</mods:affiliation></affiliation></author><author><name sortKey="Ohkubo, Chikahiro" sort="Ohkubo, Chikahiro" uniqKey="Ohkubo C" first="Chikahiro" last="Ohkubo">Chikahiro Ohkubo</name><affiliation><mods:affiliation>Department of Removable Prosthodontics, Tsurumi University School of Dental Medicine, Kanagawa, Japan</mods:affiliation></affiliation></author><author><name sortKey="Sato, Mitsunobu" sort="Sato, Mitsunobu" uniqKey="Sato M" first="Mitsunobu" last="Sato">Mitsunobu Sato</name><affiliation><mods:affiliation>Division of Liberal Arts, Kogakuin University, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Hara, Hiroki" sort="Hara, Hiroki" uniqKey="Hara H" first="Hiroki" last="Hara">Hiroki Hara</name><affiliation><mods:affiliation>Division of Liberal Arts, Kogakuin University, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Toyama, Takeshi" sort="Toyama, Takeshi" uniqKey="Toyama T" first="Takeshi" last="Toyama">Takeshi Toyama</name><affiliation><mods:affiliation>Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Tanaka, Yasuhiro" sort="Tanaka, Yasuhiro" uniqKey="Tanaka Y" first="Yasuhiro" last="Tanaka">Yasuhiro Tanaka</name><affiliation><mods:affiliation>Department of Advance Materials Science, Faculty of Engineering, Kagawa University, Engineering Materials Science, Kagawa, Japan</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Biomedical Materials Research Part B: Applied Biomaterials</title><title level="j" type="alt">JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B: APPLIED BIOMATERIALS</title><idno type="ISSN">1552-4973</idno><idno type="eISSN">1552-4981</idno><imprint><biblScope unit="vol">102</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1277">1277</biblScope><biblScope unit="page" to="1288">1288</biblScope><biblScope unit="page-count">12</biblScope><date type="published" when="2014-08">2014-08</date></imprint><idno type="ISSN">1552-4973</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1552-4973</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Thin carbonate‐containing hydroxyapatite (CA) films coating partially stabilized zirconia (Y‐TZP) were prepared (CA‐Y‐TZP) to establish a metal‐free implant system. CA was coated using a molecular precursor method. The CA film was deposited on the surface of Y‐TZP using a precursor solution, which was a mixture of a calcium–ethylenediaminetetraacetic acid (EDTA) complex and phosphate compounds. The deposited CA film was characterized by X‐ray diffraction, Fourier transform infrared spectroscopy, and energy dispersive X‐ray spectroscopy measurements. A focus ion beam system technique revealed that the thickness of the CA film was less than 1.0 µm. Biological evaluations of CA‐Y‐TZP were performed by immersion experiments in simulated body fluid (SBF) and implantation experiments in the tibiae and femoral condyles of rabbits. In the SBF immersion experiment, apatite deposition progressed more on CA‐Y‐TZP at the early stage of immersion than on Y‐TZP without the CA coating. Animal experiments revealed that bone formation on CA‐Y‐TZP was similar with than on Y‐TZP. Histomorphometrical evaluations showed a significantly higher bone‐to‐implant contact ratio and bone mass on CA‐Y‐TZP after implantation into the femoral trabecular bone of rabbits. Therefore, CA‐Y‐TZP appears to be applicable as a metal‐free implant. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1277–1288, 2014.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Masatsugu Hirota</name><affiliations><json:string>Department of Removable Prosthodontics, Tsurumi University School of Dental Medicine, Kanagawa, Japan</json:string></affiliations></json:item><json:item><name>Tohru Hayakawa</name><affiliations><json:string>Department of Dental Engineering, Tsurumi University School of Dental Medicine, Kanagawa, Japan</json:string></affiliations></json:item><json:item><name>Chikahiro Ohkubo</name><affiliations><json:string>Department of Removable Prosthodontics, Tsurumi University School of Dental Medicine, Kanagawa, Japan</json:string></affiliations></json:item><json:item><name>Mitsunobu Sato</name><affiliations><json:string>Division of Liberal Arts, Kogakuin University, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Hiroki Hara</name><affiliations><json:string>Division of Liberal Arts, Kogakuin University, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Takeshi Toyama</name><affiliations><json:string>Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Yasuhiro Tanaka</name><affiliations><json:string>Department of Advance Materials Science, Faculty of Engineering, Kagawa University, Engineering Materials Science, Kagawa, Japan</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>dental implants</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>partially stabilized zirconia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>apatite coating</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>simulated body fluid</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>bone</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>implant contact</value></json:item></subject><articleId><json:string>JBMB33112</json:string></articleId><arkIstex>ark:/67375/WNG-WTZFFJT1-X</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Thin carbonate‐containing hydroxyapatite (CA) films coating partially stabilized zirconia (Y‐TZP) were prepared (CA‐Y‐TZP) to establish a metal‐free implant system. CA was coated using a molecular precursor method. The CA film was deposited on the surface of Y‐TZP using a precursor solution, which was a mixture of a calcium–ethylenediaminetetraacetic acid (EDTA) complex and phosphate compounds. The deposited CA film was characterized by X‐ray diffraction, Fourier transform infrared spectroscopy, and energy dispersive X‐ray spectroscopy measurements. A focus ion beam system technique revealed that the thickness of the CA film was less than 1.0 µm. Biological evaluations of CA‐Y‐TZP were performed by immersion experiments in simulated body fluid (SBF) and implantation experiments in the tibiae and femoral condyles of rabbits. In the SBF immersion experiment, apatite deposition progressed more on CA‐Y‐TZP at the early stage of immersion than on Y‐TZP without the CA coating. Animal experiments revealed that bone formation on CA‐Y‐TZP was similar with than on Y‐TZP. Histomorphometrical evaluations showed a significantly higher bone‐to‐implant contact ratio and bone mass on CA‐Y‐TZP after implantation into the femoral trabecular bone of rabbits. Therefore, CA‐Y‐TZP appears to be applicable as a metal‐free implant. © 2014 Wiley Periodicals, Inc. 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type="first">Masatsugu</forename><surname>Hirota</surname></persName><affiliation><orgName>Department of Removable Prosthodontics</orgName><orgName>Tsurumi University School of Dental Medicine</orgName><address><settlement type="city">Kanagawa</settlement><country key="JP">Japan</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Tohru</forename><surname>Hayakawa</surname></persName><affiliation><orgName>Department of Dental Engineering</orgName><orgName>Tsurumi University School of Dental Medicine</orgName><address><region>Kanagawa</region><country key="JP">Japan</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Chikahiro</forename><surname>Ohkubo</surname></persName><affiliation><orgName>Department of Removable Prosthodontics</orgName><orgName>Tsurumi University School of Dental Medicine</orgName><address><settlement type="city">Kanagawa</settlement><country key="JP">Japan</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Mitsunobu</forename><surname>Sato</surname></persName><affiliation><orgName>Division of Liberal Arts</orgName><orgName>Kogakuin University</orgName><address><settlement type="city">Tokyo</settlement><country key="JP">Japan</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Hiroki</forename><surname>Hara</surname></persName><affiliation><orgName>Division of Liberal Arts</orgName><orgName>Kogakuin University</orgName><address><settlement type="city">Tokyo</settlement><country key="JP">Japan</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Takeshi</forename><surname>Toyama</surname></persName><affiliation><orgName>Department of Materials and Applied Chemistry</orgName><orgName>College of Science and Technology, Nihon University</orgName><address><settlement type="city">Tokyo</settlement><country key="JP">Japan</country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Yasuhiro</forename><surname>Tanaka</surname></persName><affiliation><orgName>Department of Advance Materials Science, Faculty of Engineering, Kagawa University</orgName><orgName>Engineering Materials Science</orgName><address><street>Kagawa</street><country key="JP">Japan</country></address></affiliation></author><idno type="istex">2AB767347CDED8AB2D46985BF28D00B26FF2425B</idno><idno type="ark">ark:/67375/WNG-WTZFFJT1-X</idno><idno type="DOI">10.1002/jbm.b.33112</idno><idno type="unit">JBMB33112</idno><idno type="toTypesetVersion">file:JBM.JBMB33112.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Biomedical Materials Research Part B: Applied Biomaterials</title><title level="j" type="alt">JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B: APPLIED BIOMATERIALS</title><idno type="pISSN">1552-4973</idno><idno type="eISSN">1552-4981</idno><idno type="book-DOI">10.1002/(ISSN)1552-4981</idno><idno type="book-part-DOI">10.1002/jbm.b.v102.6</idno><idno type="product">JBM</idno><imprint><biblScope unit="vol">102</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1277">1277</biblScope><biblScope unit="page" to="1288">1288</biblScope><biblScope unit="page-count">12</biblScope><date type="published" when="2014-08"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract style="main"><head>Abstract</head><p>Thin carbonate‐containing hydroxyapatite (CA) films coating partially stabilized zirconia (Y‐TZP) were prepared (CA‐Y‐TZP) to establish a metal‐free implant system. CA was coated using a molecular precursor method. The CA film was deposited on the surface of Y‐TZP using a precursor solution, which was a mixture of a calcium–ethylenediaminetetraacetic acid (EDTA) complex and phosphate compounds. The deposited CA film was characterized by X‐ray diffraction, Fourier transform infrared spectroscopy, and energy dispersive X‐ray spectroscopy measurements. A focus ion beam system technique revealed that the thickness of the CA film was less than 1.0 µm. Biological evaluations of CA‐Y‐TZP were performed by immersion experiments in simulated body fluid (SBF) and implantation experiments in the tibiae and femoral condyles of rabbits. In the SBF immersion experiment, apatite deposition progressed more on CA‐Y‐TZP at the early stage of immersion than on Y‐TZP without the CA coating. Animal experiments revealed that bone formation on CA‐Y‐TZP was similar with than on Y‐TZP. Histomorphometrical evaluations showed a significantly higher bone‐to‐implant contact ratio and bone mass on CA‐Y‐TZP after implantation into the femoral trabecular bone of rabbits. Therefore, CA‐Y‐TZP appears to be applicable as a metal‐free implant. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1277–1288, 2014.</p></abstract><textClass><keywords><term xml:id="jbmb33112-kwd-0001">dental implants</term><term xml:id="jbmb33112-kwd-0002">partially stabilized zirconia</term><term xml:id="jbmb33112-kwd-0003">apatite coating</term><term xml:id="jbmb33112-kwd-0004">simulated body fluid</term><term xml:id="jbmb33112-kwd-0005">bone</term><term xml:id="jbmb33112-kwd-0006">implant contact</term></keywords><keywords rend="articleCategory"><term>Original Report</term></keywords><keywords rend="tocHeading1"><term>Original Research Reports</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en" xml:id="jbmb33112"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1002/(ISSN)1552-4981</doi><issn type="print">1552-4973</issn><issn type="electronic">1552-4981</issn><idGroup><id type="product" value="JBM"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B: APPLIED BIOMATERIALS">Journal of Biomedical Materials Research Part B: Applied Biomaterials</title><title type="short">J. 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Res.</title></titleGroup></publicationMeta><publicationMeta level="part" position="60"><doi>10.1002/jbm.b.v102.6</doi><copyright ownership="publisher">© 2014 Wiley Periodicals, Inc.</copyright><numberingGroup><numbering type="journalVolume" number="102">102</numbering><numbering type="journalIssue">6</numbering></numberingGroup><coverDate startDate="2014-08">August 2014</coverDate></publicationMeta><publicationMeta level="unit" position="180" type="article" status="forIssue"><doi>10.1002/jbm.b.33112</doi><idGroup><id type="unit" value="JBMB33112"></id></idGroup><countGroup><count type="pageTotal" number="12"></count></countGroup><titleGroup><title type="articleCategory">Original Report</title><title type="tocHeading1">Original Research Reports</title></titleGroup><copyright ownership="publisher">© 2014 Wiley Periodicals, Inc.</copyright><eventGroup><event type="manuscriptReceived" date="2013-09-17"></event><event type="manuscriptRevised" date="2013-12-16"></event><event type="manuscriptAccepted" date="2014-01-07"></event><event type="xmlCreated" agent="Cenveo Publisher Services" date="2014-01-13"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.3.2 mode:FullText" date="2014-07-04"></event><event type="publishedOnlineEarlyUnpaginated" date="2014-01-21"></event><event type="firstOnline" date="2014-01-21"></event><event type="publishedOnlineFinalForm" date="2014-07-04"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-09"></event></eventGroup><numberingGroup><numbering type="pageFirst">1277</numbering><numbering type="pageLast">1288</numbering></numberingGroup><correspondenceTo><b>Correspondence to:</b> M. Hirota (e‐mail: <email>hirota-masatsugu@tsurumi-u.ac.jp</email>)</correspondenceTo><selfCitationGroup><citation xml:id="jbmb33112-cit-0040" type="self"><b>How to cite this article:</b> <author><familyName>Hirota</familyName> <givenNames>M</givenNames></author>, <author><familyName>Hayakawa</familyName> <givenNames>T</givenNames></author>, <author><familyName>Ohkubo</familyName> <givenNames>C</givenNames></author>, <author><familyName>Sato</familyName> <givenNames>M</givenNames></author>, <author><familyName>Hara</familyName> <givenNames>H</givenNames></author>, <author><familyName>Toyama</familyName> <givenNames>T</givenNames></author>, <author><familyName>Tanaka</familyName> <givenNames>Y</givenNames></author>. <pubYear year="2014">2014</pubYear>. <articleTitle>Bone responses to zirconia implants with a thin carbonate‐containing hydroxyapatite coating using a molecular precursor method</articleTitle>. <journalTitle>J Biomed Mater Res Part B</journalTitle> 2014:<vol>102B</vol>:<pageFirst>1277</pageFirst>–<pageLast>1288</pageLast>.
</citation></selfCitationGroup><linkGroup><link type="toTypesetVersion" href="file:JBM.JBMB33112.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Bone responses to zirconia implants with a thin carbonate‐containing hydroxyapatite coating using a molecular precursor method</title><title type="short">BONE RESPONSES TO ZIRCONIA IMPLANTS WITH A THIN CA COATING</title><title type="shortAuthors">HIROTA ET AL.</title></titleGroup><creators><creator affiliationRef="#jbmb33112-aff-0001" creatorRole="author" xml:id="jbmb33112-cr-0001"><personName><givenNames>Masatsugu</givenNames><familyName>Hirota</familyName></personName></creator><creator affiliationRef="#jbmb33112-aff-0002" creatorRole="author" xml:id="jbmb33112-cr-0002"><personName><givenNames>Tohru</givenNames><familyName>Hayakawa</familyName></personName></creator><creator affiliationRef="#jbmb33112-aff-0001" creatorRole="author" xml:id="jbmb33112-cr-0003"><personName><givenNames>Chikahiro</givenNames><familyName>Ohkubo</familyName></personName></creator><creator affiliationRef="#jbmb33112-aff-0003" creatorRole="author" xml:id="jbmb33112-cr-0004"><personName><givenNames>Mitsunobu</givenNames><familyName>Sato</familyName></personName></creator><creator affiliationRef="#jbmb33112-aff-0003" creatorRole="author" xml:id="jbmb33112-cr-0005"><personName><givenNames>Hiroki</givenNames><familyName>Hara</familyName></personName></creator><creator affiliationRef="#jbmb33112-aff-0004" creatorRole="author" xml:id="jbmb33112-cr-0006"><personName><givenNames>Takeshi</givenNames><familyName>Toyama</familyName></personName></creator><creator affiliationRef="#jbmb33112-aff-0005" creatorRole="author" xml:id="jbmb33112-cr-0007"><personName><givenNames>Yasuhiro</givenNames><familyName>Tanaka</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="JP" type="organization" xml:id="jbmb33112-aff-0001"><orgDiv>Department of Removable Prosthodontics</orgDiv><orgName>Tsurumi University School of Dental Medicine</orgName><address><city>Kanagawa</city><country>Japan</country></address></affiliation><affiliation countryCode="JP" type="organization" xml:id="jbmb33112-aff-0002"><orgDiv>Department of Dental Engineering</orgDiv><orgName>Tsurumi University School of Dental Medicine</orgName><address><countryPart>Kanagawa</countryPart><country>Japan</country></address></affiliation><affiliation countryCode="JP" type="organization" xml:id="jbmb33112-aff-0003"><orgDiv>Division of Liberal Arts</orgDiv><orgName>Kogakuin University</orgName><address><city>Tokyo</city><country>Japan</country></address></affiliation><affiliation countryCode="JP" type="organization" xml:id="jbmb33112-aff-0004"><orgDiv>Department of Materials and Applied Chemistry</orgDiv><orgName>College of Science and Technology, Nihon University</orgName><address><city>Tokyo</city><country>Japan</country></address></affiliation><affiliation countryCode="JP" type="organization" xml:id="jbmb33112-aff-0005"><orgName>Engineering Materials Science</orgName><orgDiv>Department of Advance Materials Science, Faculty of Engineering, Kagawa University</orgDiv><address><street>Kagawa</street><country>Japan</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="jbmb33112-kwd-0001">dental implants</keyword><keyword xml:id="jbmb33112-kwd-0002">partially stabilized zirconia</keyword><keyword xml:id="jbmb33112-kwd-0003">apatite coating</keyword><keyword xml:id="jbmb33112-kwd-0004">simulated body fluid</keyword><keyword xml:id="jbmb33112-kwd-0005">bone</keyword><keyword xml:id="jbmb33112-kwd-0006">implant contact</keyword></keywordGroup><abstractGroup><abstract type="main"><title type="main">Abstract</title><p>Thin carbonate‐containing hydroxyapatite (CA) films coating partially stabilized zirconia (Y‐TZP) were prepared (CA‐Y‐TZP) to establish a metal‐free implant system. CA was coated using a molecular precursor method. The CA film was deposited on the surface of Y‐TZP using a precursor solution, which was a mixture of a calcium–ethylenediaminetetraacetic acid (EDTA) complex and phosphate compounds. The deposited CA film was characterized by X‐ray diffraction, Fourier transform infrared spectroscopy, and energy dispersive X‐ray spectroscopy measurements. A focus ion beam system technique revealed that the thickness of the CA film was less than 1.0 µm. Biological evaluations of CA‐Y‐TZP were performed by immersion experiments in simulated body fluid (SBF) and implantation experiments in the tibiae and femoral condyles of rabbits. In the SBF immersion experiment, apatite deposition progressed more on CA‐Y‐TZP at the early stage of immersion than on Y‐TZP without the CA coating. Animal experiments revealed that bone formation on CA‐Y‐TZP was similar with than on Y‐TZP. Histomorphometrical evaluations showed a significantly higher bone‐to‐implant contact ratio and bone mass on CA‐Y‐TZP after implantation into the femoral trabecular bone of rabbits. Therefore, CA‐Y‐TZP appears to be applicable as a metal‐free implant. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1277–1288, 2014.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Bone responses to zirconia implants with a thin carbonate‐containing hydroxyapatite coating using a molecular precursor method</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>BONE RESPONSES TO ZIRCONIA IMPLANTS WITH A THIN CA COATING</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Bone responses to zirconia implants with a thin carbonate‐containing hydroxyapatite coating using a molecular precursor method</title></titleInfo><name type="personal"><namePart type="given">Masatsugu</namePart><namePart type="family">Hirota</namePart><affiliation>Department of Removable Prosthodontics, Tsurumi University School of Dental Medicine, Kanagawa, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tohru</namePart><namePart type="family">Hayakawa</namePart><affiliation>Department of Dental Engineering, Tsurumi University School of Dental Medicine, Kanagawa, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chikahiro</namePart><namePart type="family">Ohkubo</namePart><affiliation>Department of Removable Prosthodontics, Tsurumi University School of Dental Medicine, Kanagawa, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mitsunobu</namePart><namePart type="family">Sato</namePart><affiliation>Division of Liberal Arts, Kogakuin University, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hiroki</namePart><namePart type="family">Hara</namePart><affiliation>Division of Liberal Arts, Kogakuin University, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Takeshi</namePart><namePart type="family">Toyama</namePart><affiliation>Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yasuhiro</namePart><namePart type="family">Tanaka</namePart><affiliation>Department of Advance Materials Science, Faculty of Engineering, Kagawa University, Engineering Materials Science, Kagawa, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2014-08</dateIssued><dateCreated encoding="w3cdtf">2014-01-13</dateCreated><dateCaptured encoding="w3cdtf">2013-09-17</dateCaptured><dateValid encoding="w3cdtf">2014-01-07</dateValid><edition>How to cite this article: Hirota M, Hayakawa T, Ohkubo C, Sato M, Hara H, Toyama T, Tanaka Y. 2014. Bone responses to zirconia implants with a thin carbonate‐containing hydroxyapatite coating using a molecular precursor method. J Biomed Mater Res Part B 2014:102B:1277–1288.</edition><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Thin carbonate‐containing hydroxyapatite (CA) films coating partially stabilized zirconia (Y‐TZP) were prepared (CA‐Y‐TZP) to establish a metal‐free implant system. CA was coated using a molecular precursor method. The CA film was deposited on the surface of Y‐TZP using a precursor solution, which was a mixture of a calcium–ethylenediaminetetraacetic acid (EDTA) complex and phosphate compounds. The deposited CA film was characterized by X‐ray diffraction, Fourier transform infrared spectroscopy, and energy dispersive X‐ray spectroscopy measurements. A focus ion beam system technique revealed that the thickness of the CA film was less than 1.0 µm. Biological evaluations of CA‐Y‐TZP were performed by immersion experiments in simulated body fluid (SBF) and implantation experiments in the tibiae and femoral condyles of rabbits. In the SBF immersion experiment, apatite deposition progressed more on CA‐Y‐TZP at the early stage of immersion than on Y‐TZP without the CA coating. Animal experiments revealed that bone formation on CA‐Y‐TZP was similar with than on Y‐TZP. Histomorphometrical evaluations showed a significantly higher bone‐to‐implant contact ratio and bone mass on CA‐Y‐TZP after implantation into the femoral trabecular bone of rabbits. Therefore, CA‐Y‐TZP appears to be applicable as a metal‐free implant. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1277–1288, 2014.</abstract><subject><genre>keywords</genre><topic>dental implants</topic><topic>partially stabilized zirconia</topic><topic>apatite coating</topic><topic>simulated body fluid</topic><topic>bone</topic><topic>implant contact</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Biomedical Materials Research Part B: Applied Biomaterials</title></titleInfo><titleInfo type="abbreviated"><title>J. Biomed. Mater. Res.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Original Report</topic></subject><identifier type="ISSN">1552-4973</identifier><identifier type="eISSN">1552-4981</identifier><identifier type="DOI">10.1002/(ISSN)1552-4981</identifier><identifier type="PublisherID">JBM</identifier><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>102</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>1277</start><end>1288</end><total>12</total></extent></part></relatedItem><identifier type="istex">2AB767347CDED8AB2D46985BF28D00B26FF2425B</identifier><identifier type="ark">ark:/67375/WNG-WTZFFJT1-X</identifier><identifier type="DOI">10.1002/jbm.b.33112</identifier><identifier type="ArticleID">JBMB33112</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2014 Wiley Periodicals, Inc.© 2014 Wiley Periodicals, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/2AB767347CDED8AB2D46985BF28D00B26FF2425B/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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