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Crestal remodelling and osseointegration at surface‐modified commercially pure titanium and titanium alloy implants in a canine model

Identifieur interne : 001217 ( Istex/Corpus ); précédent : 001216; suivant : 001218

Crestal remodelling and osseointegration at surface‐modified commercially pure titanium and titanium alloy implants in a canine model

Auteurs : Jaebum Lee ; Steve Hurson ; Hatem Tadros ; Peter Schüpbach ; Cristiano Susin ; Ulf M. E. Wikesjö

Source :

RBID : ISTEX:25432B76DF845F5E11DD0D6F01CB02701B026412

English descriptors

Abstract

Ti‐6Al‐7Nb alloys exhibit enhanced mechanical properties and corrosion resistance and may represent an improvement to present commercially pure (CP) titanium oral implant technology.

Url:
DOI: 10.1111/j.1600-051X.2012.01905.x

Links to Exploration step

ISTEX:25432B76DF845F5E11DD0D6F01CB02701B026412

Le document en format XML

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<forename type="first">Jaebum</forename>
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<affiliation>Address: Jaebum Lee Laboratory for Applied Periodontal and Craniofacial Regeneration Department of Periodontics and Oral Biology Georgia Health Sciences University College of Dental Medicine 1120 15th Street AD1432 Augusta, GA 30912 USA E‐mail: jaelee@georgiahealth.edu</affiliation>
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<forename type="first">Steve</forename>
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<orgName>Research and Development</orgName>
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<forename type="first">Hatem</forename>
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<address>
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<forename type="first">Peter</forename>
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<settlement type="city">Horgen</settlement>
<country key="CH">Switzerland</country>
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</affiliation>
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<head>Abstract</head>
Background
<p>
<hi rend="fc">Ti</hi>
‐6
<hi rend="fc">Al</hi>
‐7
<hi rend="fc">Nb</hi>
alloys exhibit enhanced mechanical properties and corrosion resistance and may represent an improvement to present commercially pure (
<hi rend="fc">CP</hi>
) titanium oral implant technology.</p>
Objectives
<p>To evaluate crestal remodelling and osseointegration at
<hi rend="fc">CP</hi>
titanium compared with
<hi rend="fc">Ti</hi>
‐6
<hi rend="fc">Al</hi>
‐7
<hi rend="fc">Nb</hi>
alloy oral implants using a canine model.</p>
Methods
<p>Two threaded anodized
<hi rend="fc">CP</hi>
titanium and two
<hi rend="fc">Ti</hi>
‐6
<hi rend="fc">Al</hi>
‐7
<hi rend="fc">Nb</hi>
alloy anodized oral implants (ø4.5 × 6.1 mm) were placed into each jaw quadrant in the edentulated posterior mandible in six adult male Hound Labrador mongrel dogs. Abutments were placed onto the implants, and the mucogingival flaps were adapted and sutured for transmucosal wound healing. Block biopsies were collected for histometric analysis following an 8‐week healing interval.</p>
Results
<p>Healing was uneventful. Bone density outside and within the root of the threads averaged (±
<hi rend="fc">SE</hi>
) 49.0 ± 4.5% and 38.7 ± 5.1% for
<hi rend="fc">CP</hi>
titanium implants and 43.2 ± 3.6% and 34.2 ± 4.8% for
<hi rend="fc">Ti</hi>
‐6
<hi rend="fc">Al</hi>
‐7
<hi rend="fc">Nb</hi>
alloy implants. Mean osseointegration reached 68.0 ± 4.4% and 62.8 ± 2.5% for
<hi rend="fc">CP</hi>
titanium and
<hi rend="fc">Ti</hi>
‐6
<hi rend="fc">Al</hi>
‐7
<hi rend="fc">Nb</hi>
alloy implants, respectively. Although crestal resorption at lingual sites averaged 0.2 ± 0.1 mm for both technologies, crestal resorption at buccal sites averaged 0.9 ± 0.2 and 1.0 ± 0.6 mm for
<hi rend="fc">CP</hi>
titanium and
<hi rend="fc">Ti</hi>
‐6
<hi rend="fc">Al</hi>
‐7
<hi rend="fc">Nb</hi>
alloy implants, respectively. There were no statistically significant differences between implant technologies for any parameter assessed. Notably, advanced/advancing buccal crestal resorption exposing the implant threads was observed in 50% of the implants (four of six animals) regardless of implant technology; osteoclastic resorption still observed at 8 weeks following implant placement.</p>
Conclusion
<p>Within the limitations of study, anodized
<hi rend="fc">Ti</hi>
‐6
<hi rend="fc">Al</hi>
‐7
<hi rend="fc">Nb</hi>
alloy implants may represent a feasible alternative to benchmark anodized
<hi rend="fc">CP</hi>
titanium implants. Remodelling of the buccal crestal plate resulting in advanced bone loss appears a major impediment to oral implant osseointegration and possibly, in extension, implant maintenance.</p>
</abstract>
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<term xml:id="jcpe1905-kwd-0004">platform shift</term>
<term xml:id="jcpe1905-kwd-0005">Ti‐6Al‐7Nb alloy</term>
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<title type="main">Background</title>
<p>
<fc>Ti</fc>
‐6
<fc>Al</fc>
‐7
<fc>Nb</fc>
alloys exhibit enhanced mechanical properties and corrosion resistance and may represent an improvement to present commercially pure (
<fc>CP</fc>
) titanium oral implant technology.</p>
</section>
<section xml:id="jcpe1905-sec-0002">
<title type="main">Objectives</title>
<p>To evaluate crestal remodelling and osseointegration at
<fc>CP</fc>
titanium compared with
<fc>Ti</fc>
‐6
<fc>Al</fc>
‐7
<fc>Nb</fc>
alloy oral implants using a canine model.</p>
</section>
<section xml:id="jcpe1905-sec-0003">
<title type="main">Methods</title>
<p>Two threaded anodized
<fc>CP</fc>
titanium and two
<fc>Ti</fc>
‐6
<fc>Al</fc>
‐7
<fc>Nb</fc>
alloy anodized oral implants (ø4.5 × 6.1 mm) were placed into each jaw quadrant in the edentulated posterior mandible in six adult male Hound Labrador mongrel dogs. Abutments were placed onto the implants, and the mucogingival flaps were adapted and sutured for transmucosal wound healing. Block biopsies were collected for histometric analysis following an 8‐week healing interval.</p>
</section>
<section xml:id="jcpe1905-sec-0004">
<title type="main">Results</title>
<p>Healing was uneventful. Bone density outside and within the root of the threads averaged (±
<fc>SE</fc>
) 49.0 ± 4.5% and 38.7 ± 5.1% for
<fc>CP</fc>
titanium implants and 43.2 ± 3.6% and 34.2 ± 4.8% for
<fc>Ti</fc>
‐6
<fc>Al</fc>
‐7
<fc>Nb</fc>
alloy implants. Mean osseointegration reached 68.0 ± 4.4% and 62.8 ± 2.5% for
<fc>CP</fc>
titanium and
<fc>Ti</fc>
‐6
<fc>Al</fc>
‐7
<fc>Nb</fc>
alloy implants, respectively. Although crestal resorption at lingual sites averaged 0.2 ± 0.1 mm for both technologies, crestal resorption at buccal sites averaged 0.9 ± 0.2 and 1.0 ± 0.6 mm for
<fc>CP</fc>
titanium and
<fc>Ti</fc>
‐6
<fc>Al</fc>
‐7
<fc>Nb</fc>
alloy implants, respectively. There were no statistically significant differences between implant technologies for any parameter assessed. Notably, advanced/advancing buccal crestal resorption exposing the implant threads was observed in 50% of the implants (four of six animals) regardless of implant technology; osteoclastic resorption still observed at 8 weeks following implant placement.</p>
</section>
<section xml:id="jcpe1905-sec-0005">
<title type="main">Conclusion</title>
<p>Within the limitations of study, anodized
<fc>Ti</fc>
‐6
<fc>Al</fc>
‐7
<fc>Nb</fc>
alloy implants may represent a feasible alternative to benchmark anodized
<fc>CP</fc>
titanium implants. Remodelling of the buccal crestal plate resulting in advanced bone loss appears a major impediment to oral implant osseointegration and possibly, in extension, implant maintenance.</p>
</section>
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<b>Conflict of interest and source of funding statement</b>
</p>
<p>Drs. Ulf ME Wikesjö and Peter Schüpbach serve as consultants to Nobel Biocare AB. Steve Hurson is an employee of Nobel Biocare USA. Hatem Tadros was an employee of Nobel Biocare USA at the time of study.</p>
<p>This study was supported by a grant from Nobel Biocare AB, Göteborg, Sweden.</p>
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<abstract>Ti‐6Al‐7Nb alloys exhibit enhanced mechanical properties and corrosion resistance and may represent an improvement to present commercially pure (CP) titanium oral implant technology.</abstract>
<abstract>To evaluate crestal remodelling and osseointegration at CP titanium compared with Ti‐6Al‐7Nb alloy oral implants using a canine model.</abstract>
<abstract>Two threaded anodized CP titanium and two Ti‐6Al‐7Nb alloy anodized oral implants (ø4.5 × 6.1 mm) were placed into each jaw quadrant in the edentulated posterior mandible in six adult male Hound Labrador mongrel dogs. Abutments were placed onto the implants, and the mucogingival flaps were adapted and sutured for transmucosal wound healing. Block biopsies were collected for histometric analysis following an 8‐week healing interval.</abstract>
<abstract>Healing was uneventful. Bone density outside and within the root of the threads averaged (±SE) 49.0 ± 4.5% and 38.7 ± 5.1% for CP titanium implants and 43.2 ± 3.6% and 34.2 ± 4.8% for Ti‐6Al‐7Nb alloy implants. Mean osseointegration reached 68.0 ± 4.4% and 62.8 ± 2.5% for CP titanium and Ti‐6Al‐7Nb alloy implants, respectively. Although crestal resorption at lingual sites averaged 0.2 ± 0.1 mm for both technologies, crestal resorption at buccal sites averaged 0.9 ± 0.2 and 1.0 ± 0.6 mm for CP titanium and Ti‐6Al‐7Nb alloy implants, respectively. There were no statistically significant differences between implant technologies for any parameter assessed. Notably, advanced/advancing buccal crestal resorption exposing the implant threads was observed in 50% of the implants (four of six animals) regardless of implant technology; osteoclastic resorption still observed at 8 weeks following implant placement.</abstract>
<abstract>Within the limitations of study, anodized Ti‐6Al‐7Nb alloy implants may represent a feasible alternative to benchmark anodized CP titanium implants. Remodelling of the buccal crestal plate resulting in advanced bone loss appears a major impediment to oral implant osseointegration and possibly, in extension, implant maintenance.</abstract>
<note type="funding">Nobel Biocare</note>
<subject>
<genre>keywords</genre>
<topic>bone remodelling</topic>
<topic>commercially pure titanium</topic>
<topic>osseointegration</topic>
<topic>platform shift</topic>
<topic>Ti‐6Al‐7Nb alloy</topic>
</subject>
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<title>Journal of Clinical Periodontology</title>
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<title>J Clin Periodontol</title>
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<subject>
<genre>article-category</genre>
<topic>Animal Experiment</topic>
</subject>
<identifier type="ISSN">0303-6979</identifier>
<identifier type="eISSN">1600-051X</identifier>
<identifier type="DOI">10.1111/(ISSN)1600-051X</identifier>
<identifier type="PublisherID">JCPE</identifier>
<part>
<date>2012</date>
<detail type="volume">
<caption>vol.</caption>
<number>39</number>
</detail>
<detail type="issue">
<caption>no.</caption>
<number>8</number>
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<extent unit="pages">
<start>781</start>
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<total>8</total>
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<identifier type="istex">25432B76DF845F5E11DD0D6F01CB02701B026412</identifier>
<identifier type="ark">ark:/67375/WNG-F1H69MN1-Z</identifier>
<identifier type="DOI">10.1111/j.1600-051X.2012.01905.x</identifier>
<identifier type="ArticleID">JCPE1905</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2012 John Wiley & Sons A/S© 2012 John Wiley & Sons A/S</accessCondition>
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