Formation of Bone around Titanium Implants Placed into Zero Wall Defects: Pilot Project Using Reinforced e‐PTFE Membrane and Autogenous Bone Grafts
Identifieur interne : 000804 ( Istex/Corpus ); précédent : 000803; suivant : 000805Formation of Bone around Titanium Implants Placed into Zero Wall Defects: Pilot Project Using Reinforced e‐PTFE Membrane and Autogenous Bone Grafts
Auteurs : Ken Akimoto ; William Becker ; Karl Donath ; Burton E. Becker ; Raquel SanchezSource :
- Clinical Implant Dentistry and Related Research [ 1523-0899 ] ; 1999-10.
English descriptors
- KwdEn :
- Autogenous, Autogenous bone, Autogenous bone chips, Autogenous bone graft, Autogenous bone grafts, Autogenous bone particles, Barrier membrane, Barrier membranes, Becker, Block sections, Bone formation, Bone grafts, Bone healing, Bone height, Bone regeneration, Clinical implant dentistry, Collagen fibers, Connective tissue, Control sites, Cortical bone, Defect, Edentulous patients, Extraction sockets, First implant thread, Flap closure, Graft, Graft group, Grafted, Grafted bone, Greater bone formation, Histologic, Histologic evaluation, Histomorphometric, Histomorphometric measurements, Implant, Implant dehiscences, Implant surface, Implant threads, Lingual surface, Membrane, Membrane bone graft, Mucoperiosteal flaps, Normal healing, Oral maxillofac implants, Oral prophylaxis, Original bone, Osseointegrated implants, Periodont restor dent, Pilot project, Pilot study, Poor contact, Present study, Private practice, Pure titanium implants, Regenerated, Regenerated bone, Regeneration, Small number, Standard implant, Statistical analysis, Tissue regeneration, Titanium, Titanium frame, Titanium implants, Vertical mattress sutures.
- Teeft :
- Autogenous, Autogenous bone, Autogenous bone chips, Autogenous bone graft, Autogenous bone grafts, Autogenous bone particles, Barrier membrane, Barrier membranes, Becker, Block sections, Bone formation, Bone grafts, Bone healing, Bone height, Bone regeneration, Clinical implant dentistry, Collagen fibers, Connective tissue, Control sites, Cortical bone, Defect, Edentulous patients, Extraction sockets, First implant thread, Flap closure, Graft, Graft group, Grafted, Grafted bone, Greater bone formation, Histologic, Histologic evaluation, Histomorphometric, Histomorphometric measurements, Implant, Implant dehiscences, Implant surface, Implant threads, Lingual surface, Membrane, Membrane bone graft, Mucoperiosteal flaps, Normal healing, Oral maxillofac implants, Oral prophylaxis, Original bone, Osseointegrated implants, Periodont restor dent, Pilot project, Pilot study, Poor contact, Present study, Private practice, Pure titanium implants, Regenerated, Regenerated bone, Regeneration, Small number, Standard implant, Statistical analysis, Tissue regeneration, Titanium, Titanium frame, Titanium implants, Vertical mattress sutures.
Abstract
Background: Guided bone regeneration (GBR) frequently is used to augment implants with various types of bone defects. The defects often are grafted with different materials, yet there is insufficient evidence that these materials enhance bone‐to‐implant contacts. Purpose: The purpose of this pilot project was to test the principle of GBR to promote bone formation adjacent to commercially pure titanium implants placed within zero‐wall defects. Histologic and histomorphometric measurements were used to evaluate new bone formation. Materials and Methods: Under appropriate anesthesia, deep, wide defects were created within the mandibles of two large dogs. Buccolingual bone was removed to the depth of the defects leaving only the mesial and distal walls. Of the eight implants placed, three were augmented with titanium‐reinforced expanded polytetrafluoroethylene (e‐PTFE) barriers and autogenous bone chips. Three sites were augmented with barrier membranes only, and two sites were not augmented or grafted and served as controls. Seven months after surgery the dogs were sacrificed and block sections were taken for histologic evaluation. Results: Histologic and histomorphometric measurements were used to evaluate new bone formation. Results from this evaluation revealed bone formation at the membrane‐only sites and the membrane‐plus‐bone grafted sites. The bone grafts were completely incorporated by the newly formed marginal compact bone. For all treated sites, there was poor bone‐to‐implant contact. Histomorphometric measurements showed a trend toward greater bone formation at membrane‐treated sites compared with control sites. However, autogenous bone grafting did not seem to affect the amount of newly regenerated bone. Conclusions: Within the limits of this pilot project, findings show trends toward bone healing, indicating constant and enhanced bone regeneration over the exposed implant. Bone contact to the implant surface generally was poor.
Url:
DOI: 10.1111/j.1708-8208.1999.tb00098.x
Links to Exploration step
ISTEX:10534B0630F33A98A1AA8FDCA8361BBD59261E0ALe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Formation of Bone around Titanium Implants Placed into Zero Wall Defects: Pilot Project Using Reinforced e‐PTFE Membrane and Autogenous Bone Grafts</title><author><name sortKey="Akimoto, Ken" sort="Akimoto, Ken" uniqKey="Akimoto K" first="Ken" last="Akimoto">Ken Akimoto</name><affiliation><mods:affiliation>Private Practice, Tokyo Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: kenaki@dd.catv.ne.jp</mods:affiliation></affiliation></author><author><name sortKey="Becker, William" sort="Becker, William" uniqKey="Becker W" first="William" last="Becker">William Becker</name><affiliation><mods:affiliation>Private Practice, Tucson, Arizona, and Department of Periodontics, University of Texas, Houston, Texas</mods:affiliation></affiliation></author><author><name sortKey="Donath, Karl" sort="Donath, Karl" uniqKey="Donath K" first="Karl" last="Donath">Karl Donath</name><affiliation><mods:affiliation>Institute for Pathology, University of Hamburg, Hamburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Becker, Burton E" sort="Becker, Burton E" uniqKey="Becker B" first="Burton E." last="Becker">Burton E. Becker</name><affiliation><mods:affiliation>Private Practice, Tucson, Arizona, and Department of Periodontics, University of Texas, Houston, Texas</mods:affiliation></affiliation></author><author><name sortKey="Sanchez, Raquel" sort="Sanchez, Raquel" uniqKey="Sanchez R" first="Raquel" last="Sanchez">Raquel Sanchez</name><affiliation><mods:affiliation>W.L. 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Becker</name><affiliation><mods:affiliation>Private Practice, Tucson, Arizona, and Department of Periodontics, University of Texas, Houston, Texas</mods:affiliation></affiliation></author><author><name sortKey="Sanchez, Raquel" sort="Sanchez, Raquel" uniqKey="Sanchez R" first="Raquel" last="Sanchez">Raquel Sanchez</name><affiliation><mods:affiliation>W.L. Gore and Associates, Flagstaff, Arizona</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Implant Dentistry and Related Research</title><title level="j" type="alt">CLINICAL IMPLANT DENTISTRY RELATED RESEARCH</title><idno type="ISSN">1523-0899</idno><idno type="eISSN">1708-8208</idno><imprint><biblScope unit="vol">1</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="98">98</biblScope><biblScope unit="page" to="104">104</biblScope><biblScope unit="page-count">7</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1999-10">1999-10</date></imprint><idno type="ISSN">1523-0899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1523-0899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autogenous</term><term>Autogenous bone</term><term>Autogenous bone chips</term><term>Autogenous bone graft</term><term>Autogenous bone grafts</term><term>Autogenous bone particles</term><term>Barrier membrane</term><term>Barrier membranes</term><term>Becker</term><term>Block sections</term><term>Bone formation</term><term>Bone grafts</term><term>Bone healing</term><term>Bone height</term><term>Bone regeneration</term><term>Clinical implant dentistry</term><term>Collagen fibers</term><term>Connective tissue</term><term>Control sites</term><term>Cortical bone</term><term>Defect</term><term>Edentulous patients</term><term>Extraction sockets</term><term>First implant thread</term><term>Flap closure</term><term>Graft</term><term>Graft group</term><term>Grafted</term><term>Grafted bone</term><term>Greater bone formation</term><term>Histologic</term><term>Histologic evaluation</term><term>Histomorphometric</term><term>Histomorphometric measurements</term><term>Implant</term><term>Implant dehiscences</term><term>Implant surface</term><term>Implant threads</term><term>Lingual surface</term><term>Membrane</term><term>Membrane bone graft</term><term>Mucoperiosteal flaps</term><term>Normal healing</term><term>Oral maxillofac implants</term><term>Oral prophylaxis</term><term>Original bone</term><term>Osseointegrated implants</term><term>Periodont restor dent</term><term>Pilot project</term><term>Pilot study</term><term>Poor contact</term><term>Present study</term><term>Private practice</term><term>Pure titanium implants</term><term>Regenerated</term><term>Regenerated bone</term><term>Regeneration</term><term>Small number</term><term>Standard implant</term><term>Statistical analysis</term><term>Tissue regeneration</term><term>Titanium</term><term>Titanium frame</term><term>Titanium implants</term><term>Vertical mattress sutures</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Autogenous</term><term>Autogenous bone</term><term>Autogenous bone chips</term><term>Autogenous bone graft</term><term>Autogenous bone grafts</term><term>Autogenous bone particles</term><term>Barrier membrane</term><term>Barrier membranes</term><term>Becker</term><term>Block sections</term><term>Bone formation</term><term>Bone grafts</term><term>Bone healing</term><term>Bone height</term><term>Bone regeneration</term><term>Clinical implant dentistry</term><term>Collagen fibers</term><term>Connective tissue</term><term>Control sites</term><term>Cortical bone</term><term>Defect</term><term>Edentulous patients</term><term>Extraction sockets</term><term>First implant thread</term><term>Flap closure</term><term>Graft</term><term>Graft group</term><term>Grafted</term><term>Grafted bone</term><term>Greater bone formation</term><term>Histologic</term><term>Histologic evaluation</term><term>Histomorphometric</term><term>Histomorphometric measurements</term><term>Implant</term><term>Implant dehiscences</term><term>Implant surface</term><term>Implant threads</term><term>Lingual surface</term><term>Membrane</term><term>Membrane bone graft</term><term>Mucoperiosteal flaps</term><term>Normal healing</term><term>Oral maxillofac implants</term><term>Oral prophylaxis</term><term>Original bone</term><term>Osseointegrated implants</term><term>Periodont restor dent</term><term>Pilot project</term><term>Pilot study</term><term>Poor contact</term><term>Present study</term><term>Private practice</term><term>Pure titanium implants</term><term>Regenerated</term><term>Regenerated bone</term><term>Regeneration</term><term>Small number</term><term>Standard implant</term><term>Statistical analysis</term><term>Tissue regeneration</term><term>Titanium</term><term>Titanium frame</term><term>Titanium implants</term><term>Vertical mattress sutures</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Guided bone regeneration (GBR) frequently is used to augment implants with various types of bone defects. The defects often are grafted with different materials, yet there is insufficient evidence that these materials enhance bone‐to‐implant contacts. Purpose: The purpose of this pilot project was to test the principle of GBR to promote bone formation adjacent to commercially pure titanium implants placed within zero‐wall defects. Histologic and histomorphometric measurements were used to evaluate new bone formation. Materials and Methods: Under appropriate anesthesia, deep, wide defects were created within the mandibles of two large dogs. Buccolingual bone was removed to the depth of the defects leaving only the mesial and distal walls. Of the eight implants placed, three were augmented with titanium‐reinforced expanded polytetrafluoroethylene (e‐PTFE) barriers and autogenous bone chips. Three sites were augmented with barrier membranes only, and two sites were not augmented or grafted and served as controls. Seven months after surgery the dogs were sacrificed and block sections were taken for histologic evaluation. Results: Histologic and histomorphometric measurements were used to evaluate new bone formation. Results from this evaluation revealed bone formation at the membrane‐only sites and the membrane‐plus‐bone grafted sites. The bone grafts were completely incorporated by the newly formed marginal compact bone. For all treated sites, there was poor bone‐to‐implant contact. Histomorphometric measurements showed a trend toward greater bone formation at membrane‐treated sites compared with control sites. However, autogenous bone grafting did not seem to affect the amount of newly regenerated bone. Conclusions: Within the limits of this pilot project, findings show trends toward bone healing, indicating constant and enhanced bone regeneration over the exposed implant. Bone contact to the implant surface generally was poor.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>implant</json:string><json:string>autogenous</json:string><json:string>bone formation</json:string><json:string>implant surface</json:string><json:string>becker</json:string><json:string>bone regeneration</json:string><json:string>graft</json:string><json:string>grafted</json:string><json:string>regenerated</json:string><json:string>histomorphometric</json:string><json:string>histologic</json:string><json:string>regeneration</json:string><json:string>oral maxillofac implants</json:string><json:string>collagen fibers</json:string><json:string>autogenous bone grafts</json:string><json:string>regenerated bone</json:string><json:string>histomorphometric measurements</json:string><json:string>pilot project</json:string><json:string>implant threads</json:string><json:string>defect</json:string><json:string>titanium implants</json:string><json:string>autogenous bone graft</json:string><json:string>tissue regeneration</json:string><json:string>osseointegrated implants</json:string><json:string>titanium</json:string><json:string>control sites</json:string><json:string>bone height</json:string><json:string>bone grafts</json:string><json:string>clinical implant dentistry</json:string><json:string>titanium frame</json:string><json:string>present study</json:string><json:string>autogenous bone chips</json:string><json:string>pure titanium implants</json:string><json:string>periodont restor dent</json:string><json:string>membrane</json:string><json:string>oral prophylaxis</json:string><json:string>mucoperiosteal flaps</json:string><json:string>standard implant</json:string><json:string>implant dehiscences</json:string><json:string>poor contact</json:string><json:string>histologic evaluation</json:string><json:string>barrier membrane</json:string><json:string>bone healing</json:string><json:string>vertical mattress sutures</json:string><json:string>connective tissue</json:string><json:string>autogenous bone</json:string><json:string>barrier membranes</json:string><json:string>cortical bone</json:string><json:string>first implant thread</json:string><json:string>flap closure</json:string><json:string>autogenous bone particles</json:string><json:string>graft group</json:string><json:string>lingual surface</json:string><json:string>original bone</json:string><json:string>statistical analysis</json:string><json:string>small number</json:string><json:string>pilot study</json:string><json:string>grafted bone</json:string><json:string>membrane bone graft</json:string><json:string>normal healing</json:string><json:string>extraction sockets</json:string><json:string>greater bone formation</json:string><json:string>edentulous patients</json:string><json:string>private practice</json:string><json:string>block sections</json:string></teeft></keywords><author><json:item><name>Ken Akimoto DDS, MS</name><affiliations><json:string>Private Practice, Tokyo Japan</json:string><json:string>E-mail: kenaki@dd.catv.ne.jp</json:string></affiliations></json:item><json:item><name>William Becker DDS, MS</name><affiliations><json:string>Private Practice, Tucson, Arizona, and Department of Periodontics, University of Texas, Houston, Texas</json:string></affiliations></json:item><json:item><name>Karl Donath MD, PhD</name><affiliations><json:string>Institute for Pathology, University of Hamburg, Hamburg, Germany</json:string></affiliations></json:item><json:item><name>Burton E. Becker DDS</name><affiliations><json:string>Private Practice, Tucson, Arizona, and Department of Periodontics, University of Texas, Houston, Texas</json:string></affiliations></json:item><json:item><name>Raquel Sanchez</name><affiliations><json:string>W.L. Gore and Associates, Flagstaff, Arizona</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>autogenous bone grafts</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>guided bone regeneration</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>histomorphometric findings</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pilot study</value></json:item></subject><articleId><json:string>CID98</json:string></articleId><arkIstex>ark:/67375/WNG-KSSQZ134-W</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>caseStudy</json:string></originalGenre><abstract>Background: Guided bone regeneration (GBR) frequently is used to augment implants with various types of bone defects. The defects often are grafted with different materials, yet there is insufficient evidence that these materials enhance bone‐to‐implant contacts. Purpose: The purpose of this pilot project was to test the principle of GBR to promote bone formation adjacent to commercially pure titanium implants placed within zero‐wall defects. Histologic and histomorphometric measurements were used to evaluate new bone formation. Materials and Methods: Under appropriate anesthesia, deep, wide defects were created within the mandibles of two large dogs. Buccolingual bone was removed to the depth of the defects leaving only the mesial and distal walls. Of the eight implants placed, three were augmented with titanium‐reinforced expanded polytetrafluoroethylene (e‐PTFE) barriers and autogenous bone chips. Three sites were augmented with barrier membranes only, and two sites were not augmented or grafted and served as controls. Seven months after surgery the dogs were sacrificed and block sections were taken for histologic evaluation. Results: Histologic and histomorphometric measurements were used to evaluate new bone formation. Results from this evaluation revealed bone formation at the membrane‐only sites and the membrane‐plus‐bone grafted sites. The bone grafts were completely incorporated by the newly formed marginal compact bone. For all treated sites, there was poor bone‐to‐implant contact. Histomorphometric measurements showed a trend toward greater bone formation at membrane‐treated sites compared with control sites. However, autogenous bone grafting did not seem to affect the amount of newly regenerated bone. Conclusions: Within the limits of this pilot project, findings show trends toward bone healing, indicating constant and enhanced bone regeneration over the exposed implant. Bone contact to the implant surface generally was poor.</abstract><qualityIndicators><score>7.819</score><pdfWordCount>2819</pdfWordCount><pdfCharCount>17530</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>7</pdfPageCount><pdfPageSize>576 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>278</abstractWordCount><abstractCharCount>1971</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>Formation of Bone around Titanium Implants Placed into Zero Wall Defects: Pilot Project Using Reinforced e‐PTFE Membrane and Autogenous Bone Grafts</title><pmid><json:string>11359304</json:string></pmid><genre><json:string>case-report</json:string></genre><host><title>Clinical Implant Dentistry and Related Research</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1708-8208</json:string></doi><issn><json:string>1523-0899</json:string></issn><eissn><json:string>1708-8208</json:string></eissn><publisherId><json:string>CID</json:string></publisherId><volume>1</volume><issue>2</issue><pages><first>98</first><last>104</last><total>7</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1999</json:string><json:string>2-9-7</json:string></date><geogName></geogName><orgName><json:string>Related Research, Volume</json:string><json:string>American Psychological Society</json:string><json:string>Decker Inc.</json:string><json:string>Institute for Pathology, University of Hamburg, Hamburg, Germany</json:string><json:string>Associates, Inc.</json:string><json:string>Related Research, Volume I , Number</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Ken Akimoto</json:string><json:string>Associates</json:string><json:string>Dahlin</json:string><json:string>Karl Donath</json:string><json:string>W.L. Gore</json:string><json:string>William Becker</json:string><json:string>Raquel Sanchez</json:string><json:string>Burton E. Becker</json:string></persName><placeName><json:string>Japan</json:string><json:string>Gothenburg</json:string><json:string>Tokyo</json:string><json:string>Chicago</json:string><json:string>Sweden</json:string><json:string>Tucson</json:string></placeName><ref_url></ref_url><ref_bibl></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-KSSQZ134-W</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - dentistry, oral surgery & medicine</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - dentistry</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Dentistry</json:string><json:string>3 - General Dentistry</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Dentistry</json:string><json:string>3 - Oral Surgery</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1999</publicationDate><copyrightDate>1999</copyrightDate><doi><json:string>10.1111/j.1708-8208.1999.tb00098.x</json:string></doi><id>10534B0630F33A98A1AA8FDCA8361BBD59261E0A</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/10534B0630F33A98A1AA8FDCA8361BBD59261E0A/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/10534B0630F33A98A1AA8FDCA8361BBD59261E0A/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/10534B0630F33A98A1AA8FDCA8361BBD59261E0A/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Formation of Bone around Titanium Implants Placed into Zero Wall Defects: Pilot Project Using Reinforced e‐PTFE Membrane and Autogenous Bone Grafts</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1999-10"></date></publicationStmt><notesStmt><note type="content-type" subtype="case-report" source="caseStudy" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-29919SZJ-6">case-report</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="case-report"><analytic><title level="a" type="main">Formation of Bone around Titanium Implants Placed into Zero Wall Defects: Pilot Project Using Reinforced e‐PTFE Membrane and Autogenous Bone Grafts</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Ken</forename><surname>Akimoto</surname><roleName type="degree">DDS, MS</roleName></persName><affiliation>Private Practice, Tokyo Japan<address><country key="JP"></country></address></affiliation><affiliation>Reprint requests: Ken Akimoto, DDS, MS, 2‐9‐7 Tomigaya, Shibuya, Tokyo 151‐0063 Japan; e‐mail: kenaki@dd.catv.ne.jp</affiliation></author><author xml:id="author-0001"><persName><forename type="first">William</forename><surname>Becker</surname><roleName type="degree">DDS, MS</roleName></persName><affiliation>Private Practice, Tucson, Arizona, and Department of Periodontics, University of Texas, Houston, Texas</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Karl</forename><surname>Donath</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Institute for Pathology, University of Hamburg, Hamburg, Germany<address><country key="DE"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Burton E.</forename><surname>Becker</surname><roleName type="degree">DDS</roleName></persName><affiliation>Private Practice, Tucson, Arizona, and Department of Periodontics, University of Texas, Houston, Texas</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Raquel</forename><surname>Sanchez</surname></persName><affiliation>W.L. Gore and Associates, Flagstaff, Arizona<address><country key="US"></country></address></affiliation></author><idno type="istex">10534B0630F33A98A1AA8FDCA8361BBD59261E0A</idno><idno type="ark">ark:/67375/WNG-KSSQZ134-W</idno><idno type="DOI">10.1111/j.1708-8208.1999.tb00098.x</idno><idno type="unit">CID98</idno><idno type="toTypesetVersion">file:CID.CID98.pdf</idno></analytic><monogr><title level="j" type="main">Clinical Implant Dentistry and Related Research</title><title level="j" type="alt">CLINICAL IMPLANT DENTISTRY RELATED RESEARCH</title><idno type="pISSN">1523-0899</idno><idno type="eISSN">1708-8208</idno><idno type="book-DOI">10.1111/(ISSN)1708-8208</idno><idno type="book-part-DOI">10.1111/cid.1999.1.issue-2</idno><idno type="product">CID</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">1</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="98">98</biblScope><biblScope unit="page" to="104">104</biblScope><biblScope unit="page-count">7</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1999-10"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>ABSTRACT</head><p>
<hi rend="italic">Background</hi>: Guided bone regeneration (GBR) frequently is used to augment implants with various types of bone defects. The defects often are grafted with different materials, yet there is insufficient evidence that these materials enhance bone‐to‐implant contacts.</p><p>
<hi rend="italic">Purpose</hi>: The purpose of this pilot project was to test the principle of GBR to promote bone formation adjacent to commercially pure titanium implants placed within zero‐wall defects. Histologic and histomorphometric measurements were used to evaluate new bone formation.</p><p>
<hi rend="italic">Materials and Methods</hi>: Under appropriate anesthesia, deep, wide defects were created within the mandibles of two large dogs. Buccolingual bone was removed to the depth of the defects leaving only the mesial and distal walls. Of the eight implants placed, three were augmented with titanium‐reinforced expanded polytetrafluoroethylene (e‐PTFE) barriers and autogenous bone chips. Three sites were augmented with barrier membranes only, and two sites were not augmented or grafted and served as controls. Seven months after surgery the dogs were sacrificed and block sections were taken for histologic evaluation.</p><p>
<hi rend="italic">Results</hi>: Histologic and histomorphometric measurements were used to evaluate new bone formation. Results from this evaluation revealed bone formation at the membrane‐only sites and the membrane‐plus‐bone grafted sites. The bone grafts were completely incorporated by the newly formed marginal compact bone. For all treated sites, there was poor bone‐to‐implant contact. Histomorphometric measurements showed a trend toward greater bone formation at membrane‐treated sites compared with control sites. However, autogenous bone grafting did not seem to affect the amount of newly regenerated bone.</p><p>
<hi rend="italic">Conclusions</hi>: Within the limits of this pilot project, findings show trends toward bone healing, indicating constant and enhanced bone regeneration over the exposed implant. Bone contact to the implant surface generally was poor.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">autogenous bone grafts</term><term xml:id="k2">guided bone regeneration</term><term xml:id="k3">histomorphometric findings</term><term xml:id="k4">pilot study</term></keywords><keywords rend="tocHeading1"><term>CASE REPORT</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/10534B0630F33A98A1AA8FDCA8361BBD59261E0A/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1708-8208</doi><issn type="print">1523-0899</issn><issn type="electronic">1708-8208</issn><idGroup><id type="product" value="CID"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="CLINICAL IMPLANT DENTISTRY RELATED RESEARCH">Clinical Implant Dentistry and Related Research</title></titleGroup></publicationMeta><publicationMeta level="part" position="10002"><doi origin="wiley">10.1111/cid.1999.1.issue-2</doi><numberingGroup><numbering type="journalVolume" number="1">1</numbering><numbering type="journalIssue" number="2">2</numbering></numberingGroup><coverDate startDate="1999-10">October 1999</coverDate></publicationMeta><publicationMeta level="unit" type="caseStudy" position="0009800" status="forIssue"><doi origin="wiley">10.1111/j.1708-8208.1999.tb00098.x</doi><idGroup><id type="unit" value="CID98"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1">CASE REPORT</title></titleGroup><eventGroup><event type="firstOnline" date="2007-04-10"></event><event type="publishedOnlineFinalForm" date="2007-04-10"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-13"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-15"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-17"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="98">98</numbering><numbering type="pageLast" number="104">104</numbering></numberingGroup><correspondenceTo>Reprint requests: Ken Akimoto, DDS, MS, 2‐9‐7 Tomigaya, Shibuya, Tokyo 151‐0063 Japan; e‐mail: <email>kenaki@dd.catv.ne.jp</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:CID.CID98.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="referenceTotal" number="17"></count><count type="linksCrossRef" number="6"></count></countGroup><titleGroup><title type="main">Formation of Bone around Titanium Implants Placed into Zero Wall Defects: Pilot Project Using Reinforced e‐PTFE Membrane and Autogenous Bone Grafts</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>Ken</givenNames><familyName>Akimoto</familyName><degrees>DDS, MS</degrees></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>William</givenNames><familyName>Becker</familyName><degrees>DDS, MS</degrees></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>Karl</givenNames><familyName>Donath</familyName><degrees>MD, PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a2"><personName><givenNames>Burton E.</givenNames><familyName>Becker</familyName><degrees>DDS</degrees></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a4"><personName><givenNames>Raquel</givenNames><familyName>Sanchez</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="JP"><unparsedAffiliation>Private Practice, Tokyo Japan</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Private Practice, Tucson, Arizona, and Department of Periodontics, University of Texas, Houston, Texas</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="DE"><unparsedAffiliation>Institute for Pathology, University of Hamburg, Hamburg, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="US"><unparsedAffiliation>W.L. Gore and Associates, Flagstaff, Arizona</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">autogenous bone grafts</keyword><keyword xml:id="k2">guided bone regeneration</keyword><keyword xml:id="k3">histomorphometric findings</keyword><keyword xml:id="k4">pilot study</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">ABSTRACT</title><p> <i>Background</i>: Guided bone regeneration (GBR) frequently is used to augment implants with various types of bone defects. The defects often are grafted with different materials, yet there is insufficient evidence that these materials enhance bone‐to‐implant contacts.</p><p> <i>Purpose</i>: The purpose of this pilot project was to test the principle of GBR to promote bone formation adjacent to commercially pure titanium implants placed within zero‐wall defects. Histologic and histomorphometric measurements were used to evaluate new bone formation.</p><p> <i>Materials and Methods</i>: Under appropriate anesthesia, deep, wide defects were created within the mandibles of two large dogs. Buccolingual bone was removed to the depth of the defects leaving only the mesial and distal walls. Of the eight implants placed, three were augmented with titanium‐reinforced expanded polytetrafluoroethylene (e‐PTFE) barriers and autogenous bone chips. Three sites were augmented with barrier membranes only, and two sites were not augmented or grafted and served as controls. Seven months after surgery the dogs were sacrificed and block sections were taken for histologic evaluation.</p><p> <i>Results</i>: Histologic and histomorphometric measurements were used to evaluate new bone formation. Results from this evaluation revealed bone formation at the membrane‐only sites and the membrane‐plus‐bone grafted sites. The bone grafts were completely incorporated by the newly formed marginal compact bone. For all treated sites, there was poor bone‐to‐implant contact. Histomorphometric measurements showed a trend toward greater bone formation at membrane‐treated sites compared with control sites. However, autogenous bone grafting did not seem to affect the amount of newly regenerated bone.</p><p> <i>Conclusions</i>: Within the limits of this pilot project, findings show trends toward bone healing, indicating constant and enhanced bone regeneration over the exposed implant. Bone contact to the implant surface generally was poor.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Formation of Bone around Titanium Implants Placed into Zero Wall Defects: Pilot Project Using Reinforced e‐PTFE Membrane and Autogenous Bone Grafts</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Formation of Bone around Titanium Implants Placed into Zero Wall Defects: Pilot Project Using Reinforced e‐PTFE Membrane and Autogenous Bone Grafts</title></titleInfo><name type="personal"><namePart type="given">Ken</namePart><namePart type="family">Akimoto</namePart><namePart type="termsOfAddress">DDS, MS</namePart><affiliation>Private Practice, Tokyo Japan</affiliation><affiliation>E-mail: kenaki@dd.catv.ne.jp</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">William</namePart><namePart type="family">Becker</namePart><namePart type="termsOfAddress">DDS, MS</namePart><affiliation>Private Practice, Tucson, Arizona, and Department of Periodontics, University of Texas, Houston, Texas</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Karl</namePart><namePart type="family">Donath</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Institute for Pathology, University of Hamburg, Hamburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Burton E.</namePart><namePart type="family">Becker</namePart><namePart type="termsOfAddress">DDS</namePart><affiliation>Private Practice, Tucson, Arizona, and Department of Periodontics, University of Texas, Houston, Texas</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Raquel</namePart><namePart type="family">Sanchez</namePart><affiliation>W.L. Gore and Associates, Flagstaff, Arizona</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="case-report" displayLabel="caseStudy" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-29919SZJ-6">case-report</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1999-10</dateIssued><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="references">17</extent><extent unit="linksCrossRef">6</extent></physicalDescription><abstract lang="en">Background: Guided bone regeneration (GBR) frequently is used to augment implants with various types of bone defects. The defects often are grafted with different materials, yet there is insufficient evidence that these materials enhance bone‐to‐implant contacts. Purpose: The purpose of this pilot project was to test the principle of GBR to promote bone formation adjacent to commercially pure titanium implants placed within zero‐wall defects. Histologic and histomorphometric measurements were used to evaluate new bone formation. Materials and Methods: Under appropriate anesthesia, deep, wide defects were created within the mandibles of two large dogs. Buccolingual bone was removed to the depth of the defects leaving only the mesial and distal walls. Of the eight implants placed, three were augmented with titanium‐reinforced expanded polytetrafluoroethylene (e‐PTFE) barriers and autogenous bone chips. Three sites were augmented with barrier membranes only, and two sites were not augmented or grafted and served as controls. Seven months after surgery the dogs were sacrificed and block sections were taken for histologic evaluation. Results: Histologic and histomorphometric measurements were used to evaluate new bone formation. Results from this evaluation revealed bone formation at the membrane‐only sites and the membrane‐plus‐bone grafted sites. The bone grafts were completely incorporated by the newly formed marginal compact bone. For all treated sites, there was poor bone‐to‐implant contact. Histomorphometric measurements showed a trend toward greater bone formation at membrane‐treated sites compared with control sites. However, autogenous bone grafting did not seem to affect the amount of newly regenerated bone. Conclusions: Within the limits of this pilot project, findings show trends toward bone healing, indicating constant and enhanced bone regeneration over the exposed implant. Bone contact to the implant surface generally was poor.</abstract><subject lang="en"><genre>keywords</genre><topic>autogenous bone grafts</topic><topic>guided bone regeneration</topic><topic>histomorphometric findings</topic><topic>pilot study</topic></subject><relatedItem type="host"><titleInfo><title>Clinical Implant Dentistry and Related Research</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">1523-0899</identifier><identifier type="eISSN">1708-8208</identifier><identifier type="DOI">10.1111/(ISSN)1708-8208</identifier><identifier type="PublisherID">CID</identifier><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>98</start><end>104</end><total>7</total></extent></part></relatedItem><identifier type="istex">10534B0630F33A98A1AA8FDCA8361BBD59261E0A</identifier><identifier type="ark">ark:/67375/WNG-KSSQZ134-W</identifier><identifier type="DOI">10.1111/j.1708-8208.1999.tb00098.x</identifier><identifier type="ArticleID">CID98</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/10534B0630F33A98A1AA8FDCA8361BBD59261E0A/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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