Predictors of carcinomatous invasion of the mandible
Identifieur interne : 000085 ( Istex/Corpus ); précédent : 000084; suivant : 000086Predictors of carcinomatous invasion of the mandible
Auteurs : Terance T. Tsue ; Timothy M. Mcculloch ; Douglas A. Girod ; David J. Couper ; Ernest A. Weymuller Jr ; Michael G. GlennSource :
- Head & Neck [ 1043-3074 ] ; 1994-03.
English descriptors
- KwdEn :
- Actual increase, Alveolar ridgehetromolar trigone, Bone invasion, Bone involvement, Bone scanning, Bony, Bony invasion, Bony involvement, Cancer history, Carcinoma, Carcinomatous invasion, Cell carcinoma, Chief complaint, Chief complaints, Clinical size estimate, Clinical size estimates, Cortical invasion, Cortical involvement, Craniomawcillofac surg, Decalcification specimens, Decision guide, Decision tree, Decision tree guide, Diagnostic workup, Edentulous patients, Exam, False negatives, Head neck, Head neck surg, Highest priority, Important part, Intraoral carcinoma, Invasion, John wiley sons, Lesion, Lymphatic channels, Magnetic resonance imaging, Mandible, Mandibular, Mandibular continuity, Mandibular cortex, Mandibular invasion, Mandibular invasion head neck, Mandibular invasion status, Mandibular involvement, Mandibular periosteum, Mandibular specimens, Mandibulectomy, Mcgregor, Multivariate, Multivariate analysis, Neck surgeon, Neck surgery, Negative mandibular invasion, Nodal, Oral cancer, Oral cavity, Osseous invasion, Osseous involvement, Pacific grove, Partitioning, Partitioning analysis, Pathologic, Pathologic exam, Physical exam, Positive mandibular invasion, Postoperative, Postoperative variables, Predictive, Predictive accuracy, Predictive association, Predictive variables, Preoperative, Preoperative evaluation, Preoperative variables, Present study, Previous studies, Primary tumor location, Primary tumor sites, Propensity, Reactive changes, Recent advances, Resection, Scan, Scan results, Sensory deficit, Specific category, Squamous, Squamous carcinoma, Squamous carcinomas, Squamous cell carcinoma, Study group, Study period, Surg, Surg gynecol obstet, Surgical, Surgical oncologic effectiveness, Tumor characteristics, Tumor fixation, Tumor size, Washington school.
- Teeft :
- Actual increase, Alveolar ridgehetromolar trigone, Bone invasion, Bone involvement, Bone scanning, Bony, Bony invasion, Bony involvement, Cancer history, Carcinoma, Carcinomatous invasion, Cell carcinoma, Chief complaint, Chief complaints, Clinical size estimate, Clinical size estimates, Cortical invasion, Cortical involvement, Craniomawcillofac surg, Decalcification specimens, Decision guide, Decision tree, Decision tree guide, Diagnostic workup, Edentulous patients, Exam, False negatives, Head neck, Head neck surg, Highest priority, Important part, Intraoral carcinoma, Invasion, John wiley sons, Lesion, Lymphatic channels, Magnetic resonance imaging, Mandible, Mandibular, Mandibular continuity, Mandibular cortex, Mandibular invasion, Mandibular invasion head neck, Mandibular invasion status, Mandibular involvement, Mandibular periosteum, Mandibular specimens, Mandibulectomy, Mcgregor, Multivariate, Multivariate analysis, Neck surgeon, Neck surgery, Negative mandibular invasion, Nodal, Oral cancer, Oral cavity, Osseous invasion, Osseous involvement, Pacific grove, Partitioning, Partitioning analysis, Pathologic, Pathologic exam, Physical exam, Positive mandibular invasion, Postoperative, Postoperative variables, Predictive, Predictive accuracy, Predictive association, Predictive variables, Preoperative, Preoperative evaluation, Preoperative variables, Present study, Previous studies, Primary tumor location, Primary tumor sites, Propensity, Reactive changes, Recent advances, Resection, Scan, Scan results, Sensory deficit, Specific category, Squamous, Squamous carcinoma, Squamous carcinomas, Squamous cell carcinoma, Study group, Study period, Surg, Surg gynecol obstet, Surgical, Surgical oncologic effectiveness, Tumor characteristics, Tumor fixation, Tumor size, Washington school.
Abstract
The preoperative assessment of mandibular invasion by oral or oropharyngeal squamous cell carcinoma poses a challenge for the head and neck surgeon. A study of 64 composite resection patients was performed to determine which variables in the patient's history, physical exam, and diagnostic workup had a predictive association with carcinomatous mandibular invasion. Four postoperative variables were included in this analysis. Thirty‐nine percent of the mandibular specimens demonstrated cancerous involvement. A multivariate recursive partitioning statistical analysis was performed to create a decision tree. Branching was based on the two statistically predictive variables: computed tomographic (CT) scan results and primary tumor location. The guide provides improved predictive accuracy with a 100% negative predictive value (NPV) and a 46% positive predictive value (PPV). This decision guide should help the surgeon provide accurate patient counseling, anticipate reconstructive needs, and maximize surgical oncologic effectiveness. © 1994 John Wiley & Sons, Inc.
Url:
DOI: 10.1002/hed.2880160204
Links to Exploration step
ISTEX:01AA128DBF36C6133EAE12712C431242BF37AF15Le document en format XML
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Mcculloch</name><affiliation><mods:affiliation>Department of Otolaryngology, Division of Head and Neck Oncology (Dr. McCulloch), University of Iowa Hospitals and Clinics, Iowa City, Iowa</mods:affiliation></affiliation></author><author><name sortKey="Girod, Douglas A" sort="Girod, Douglas A" uniqKey="Girod D" first="Douglas A." last="Girod">Douglas A. Girod</name><affiliation><mods:affiliation>Department of Otolaryngology‐Head and Neck Surgery, Oakland Naval Hospital, Oakland, California</mods:affiliation></affiliation></author><author><name sortKey="Couper, David J" sort="Couper, David J" uniqKey="Couper D" first="David J." last="Couper">David J. 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Tsue</name><affiliation><mods:affiliation>Department of Otolaryngology‐Head and Neck Surgery, University of Washington School of Medicine, Seattle, Washington</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Department of Otolaryngology‐Head and Neck Surgery, University of Washington School of Medicine RL‐30, Seattle, WA 98195</mods:affiliation></affiliation></author><author><name sortKey="Mcculloch, Timothy M" sort="Mcculloch, Timothy M" uniqKey="Mcculloch T" first="Timothy M." last="Mcculloch">Timothy M. Mcculloch</name><affiliation><mods:affiliation>Department of Otolaryngology, Division of Head and Neck Oncology (Dr. McCulloch), University of Iowa Hospitals and Clinics, Iowa City, Iowa</mods:affiliation></affiliation></author><author><name sortKey="Girod, Douglas A" sort="Girod, Douglas A" uniqKey="Girod D" first="Douglas A." last="Girod">Douglas A. Girod</name><affiliation><mods:affiliation>Department of Otolaryngology‐Head and Neck Surgery, Oakland Naval Hospital, Oakland, California</mods:affiliation></affiliation></author><author><name sortKey="Couper, David J" sort="Couper, David J" uniqKey="Couper D" first="David J." last="Couper">David J. Couper</name><affiliation><mods:affiliation>Department of Biostatistics, University of Washington School of Public Health and Community Medicine, Seattle, Washington</mods:affiliation></affiliation></author><author><name sortKey="Weymuller Jr, Ernest A" sort="Weymuller Jr, Ernest A" uniqKey="Weymuller Jr E" first="Ernest A." last="Weymuller Jr">Ernest A. Weymuller Jr</name><affiliation><mods:affiliation>Department of Otolaryngology‐Head and Neck Surgery, University of Washington School of Medicine, Seattle, Washington</mods:affiliation></affiliation></author><author><name sortKey="Glenn, Michael G" sort="Glenn, Michael G" uniqKey="Glenn M" first="Michael G." last="Glenn">Michael G. 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xml:lang="en"><term>Actual increase</term><term>Alveolar ridgehetromolar trigone</term><term>Bone invasion</term><term>Bone involvement</term><term>Bone scanning</term><term>Bony</term><term>Bony invasion</term><term>Bony involvement</term><term>Cancer history</term><term>Carcinoma</term><term>Carcinomatous invasion</term><term>Cell carcinoma</term><term>Chief complaint</term><term>Chief complaints</term><term>Clinical size estimate</term><term>Clinical size estimates</term><term>Cortical invasion</term><term>Cortical involvement</term><term>Craniomawcillofac surg</term><term>Decalcification specimens</term><term>Decision guide</term><term>Decision tree</term><term>Decision tree guide</term><term>Diagnostic workup</term><term>Edentulous patients</term><term>Exam</term><term>False negatives</term><term>Head neck</term><term>Head neck surg</term><term>Highest priority</term><term>Important part</term><term>Intraoral carcinoma</term><term>Invasion</term><term>John wiley sons</term><term>Lesion</term><term>Lymphatic channels</term><term>Magnetic resonance imaging</term><term>Mandible</term><term>Mandibular</term><term>Mandibular continuity</term><term>Mandibular cortex</term><term>Mandibular invasion</term><term>Mandibular invasion head neck</term><term>Mandibular invasion status</term><term>Mandibular involvement</term><term>Mandibular periosteum</term><term>Mandibular specimens</term><term>Mandibulectomy</term><term>Mcgregor</term><term>Multivariate</term><term>Multivariate analysis</term><term>Neck surgeon</term><term>Neck surgery</term><term>Negative mandibular invasion</term><term>Nodal</term><term>Oral cancer</term><term>Oral cavity</term><term>Osseous invasion</term><term>Osseous involvement</term><term>Pacific grove</term><term>Partitioning</term><term>Partitioning analysis</term><term>Pathologic</term><term>Pathologic exam</term><term>Physical exam</term><term>Positive mandibular invasion</term><term>Postoperative</term><term>Postoperative variables</term><term>Predictive</term><term>Predictive accuracy</term><term>Predictive association</term><term>Predictive variables</term><term>Preoperative</term><term>Preoperative evaluation</term><term>Preoperative variables</term><term>Present study</term><term>Previous studies</term><term>Primary tumor location</term><term>Primary tumor sites</term><term>Propensity</term><term>Reactive changes</term><term>Recent advances</term><term>Resection</term><term>Scan</term><term>Scan results</term><term>Sensory deficit</term><term>Specific category</term><term>Squamous</term><term>Squamous carcinoma</term><term>Squamous carcinomas</term><term>Squamous cell carcinoma</term><term>Study group</term><term>Study period</term><term>Surg</term><term>Surg gynecol obstet</term><term>Surgical</term><term>Surgical oncologic effectiveness</term><term>Tumor characteristics</term><term>Tumor fixation</term><term>Tumor size</term><term>Washington school</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Actual increase</term><term>Alveolar ridgehetromolar trigone</term><term>Bone invasion</term><term>Bone involvement</term><term>Bone scanning</term><term>Bony</term><term>Bony invasion</term><term>Bony involvement</term><term>Cancer history</term><term>Carcinoma</term><term>Carcinomatous invasion</term><term>Cell carcinoma</term><term>Chief complaint</term><term>Chief complaints</term><term>Clinical size estimate</term><term>Clinical size estimates</term><term>Cortical invasion</term><term>Cortical involvement</term><term>Craniomawcillofac surg</term><term>Decalcification specimens</term><term>Decision guide</term><term>Decision tree</term><term>Decision tree guide</term><term>Diagnostic workup</term><term>Edentulous patients</term><term>Exam</term><term>False negatives</term><term>Head neck</term><term>Head neck surg</term><term>Highest priority</term><term>Important part</term><term>Intraoral carcinoma</term><term>Invasion</term><term>John wiley sons</term><term>Lesion</term><term>Lymphatic channels</term><term>Magnetic resonance imaging</term><term>Mandible</term><term>Mandibular</term><term>Mandibular continuity</term><term>Mandibular cortex</term><term>Mandibular invasion</term><term>Mandibular invasion head neck</term><term>Mandibular invasion status</term><term>Mandibular involvement</term><term>Mandibular periosteum</term><term>Mandibular specimens</term><term>Mandibulectomy</term><term>Mcgregor</term><term>Multivariate</term><term>Multivariate analysis</term><term>Neck surgeon</term><term>Neck surgery</term><term>Negative mandibular invasion</term><term>Nodal</term><term>Oral cancer</term><term>Oral cavity</term><term>Osseous invasion</term><term>Osseous involvement</term><term>Pacific grove</term><term>Partitioning</term><term>Partitioning analysis</term><term>Pathologic</term><term>Pathologic exam</term><term>Physical exam</term><term>Positive mandibular invasion</term><term>Postoperative</term><term>Postoperative variables</term><term>Predictive</term><term>Predictive accuracy</term><term>Predictive association</term><term>Predictive variables</term><term>Preoperative</term><term>Preoperative evaluation</term><term>Preoperative variables</term><term>Present study</term><term>Previous studies</term><term>Primary tumor location</term><term>Primary tumor sites</term><term>Propensity</term><term>Reactive changes</term><term>Recent advances</term><term>Resection</term><term>Scan</term><term>Scan results</term><term>Sensory deficit</term><term>Specific category</term><term>Squamous</term><term>Squamous carcinoma</term><term>Squamous carcinomas</term><term>Squamous cell carcinoma</term><term>Study group</term><term>Study period</term><term>Surg</term><term>Surg gynecol obstet</term><term>Surgical</term><term>Surgical oncologic effectiveness</term><term>Tumor characteristics</term><term>Tumor fixation</term><term>Tumor size</term><term>Washington school</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The preoperative assessment of mandibular invasion by oral or oropharyngeal squamous cell carcinoma poses a challenge for the head and neck surgeon. A study of 64 composite resection patients was performed to determine which variables in the patient's history, physical exam, and diagnostic workup had a predictive association with carcinomatous mandibular invasion. Four postoperative variables were included in this analysis. Thirty‐nine percent of the mandibular specimens demonstrated cancerous involvement. A multivariate recursive partitioning statistical analysis was performed to create a decision tree. Branching was based on the two statistically predictive variables: computed tomographic (CT) scan results and primary tumor location. The guide provides improved predictive accuracy with a 100% negative predictive value (NPV) and a 46% positive predictive value (PPV). This decision guide should help the surgeon provide accurate patient counseling, anticipate reconstructive needs, and maximize surgical oncologic effectiveness. © 1994 John Wiley & Sons, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>mandibular</json:string><json:string>mandible</json:string><json:string>mandibular invasion</json:string><json:string>surg</json:string><json:string>resection</json:string><json:string>multivariate</json:string><json:string>preoperative</json:string><json:string>exam</json:string><json:string>carcinoma</json:string><json:string>squamous</json:string><json:string>bony invasion</json:string><json:string>postoperative</json:string><json:string>partitioning</json:string><json:string>mandibulectomy</json:string><json:string>scan results</json:string><json:string>propensity</json:string><json:string>decision tree</json:string><json:string>squamous cell carcinoma</json:string><json:string>mcgregor</json:string><json:string>postoperative variables</json:string><json:string>nodal</json:string><json:string>study group</json:string><json:string>mandibular involvement</json:string><json:string>cell carcinoma</json:string><json:string>primary tumor location</json:string><json:string>pathologic</json:string><json:string>bony involvement</json:string><json:string>neck surgeon</json:string><json:string>positive mandibular invasion</json:string><json:string>negative mandibular invasion</json:string><json:string>head neck</json:string><json:string>diagnostic workup</json:string><json:string>predictive variables</json:string><json:string>head neck surg</json:string><json:string>preoperative variables</json:string><json:string>carcinomatous invasion</json:string><json:string>tumor size</json:string><json:string>reactive changes</json:string><json:string>surgical</json:string><json:string>invasion</json:string><json:string>predictive accuracy</json:string><json:string>chief complaints</json:string><json:string>mandibular invasion head neck</json:string><json:string>partitioning analysis</json:string><json:string>preoperative evaluation</json:string><json:string>washington school</json:string><json:string>neck surgery</json:string><json:string>cortical invasion</json:string><json:string>decision guide</json:string><json:string>chief complaint</json:string><json:string>magnetic resonance imaging</json:string><json:string>squamous carcinomas</json:string><json:string>previous studies</json:string><json:string>bone involvement</json:string><json:string>physical exam</json:string><json:string>oral cancer</json:string><json:string>intraoral carcinoma</json:string><json:string>oral cavity</json:string><json:string>scan</json:string><json:string>mandibular invasion status</json:string><json:string>recent advances</json:string><json:string>craniomawcillofac surg</json:string><json:string>edentulous patients</json:string><json:string>sensory deficit</json:string><json:string>pathologic exam</json:string><json:string>tumor characteristics</json:string><json:string>pacific grove</json:string><json:string>lymphatic channels</json:string><json:string>clinical size estimate</json:string><json:string>specific category</json:string><json:string>clinical size estimates</json:string><json:string>primary tumor sites</json:string><json:string>alveolar ridgehetromolar trigone</json:string><json:string>cortical involvement</json:string><json:string>study period</json:string><json:string>mandibular periosteum</json:string><json:string>decalcification specimens</json:string><json:string>mandibular cortex</json:string><json:string>multivariate analysis</json:string><json:string>false negatives</json:string><json:string>decision tree guide</json:string><json:string>important part</json:string><json:string>surgical oncologic effectiveness</json:string><json:string>actual increase</json:string><json:string>squamous carcinoma</json:string><json:string>tumor fixation</json:string><json:string>osseous involvement</json:string><json:string>bone invasion</json:string><json:string>bone scanning</json:string><json:string>osseous invasion</json:string><json:string>highest priority</json:string><json:string>mandibular continuity</json:string><json:string>surg gynecol obstet</json:string><json:string>john wiley sons</json:string><json:string>cancer history</json:string><json:string>mandibular specimens</json:string><json:string>predictive association</json:string><json:string>present study</json:string><json:string>lesion</json:string><json:string>predictive</json:string><json:string>bony</json:string></teeft></keywords><author><json:item><name>Dr. Terance T. Tsue MD</name><affiliations><json:string>Department of Otolaryngology‐Head and Neck Surgery, University of Washington School of Medicine, Seattle, Washington</json:string><json:string>Correspondence address: Department of Otolaryngology‐Head and Neck Surgery, University of Washington School of Medicine RL‐30, Seattle, WA 98195</json:string></affiliations></json:item><json:item><name>Dr. Timothy M. McCulloch MD</name><affiliations><json:string>Department of Otolaryngology, Division of Head and Neck Oncology (Dr. McCulloch), University of Iowa Hospitals and Clinics, Iowa City, Iowa</json:string></affiliations></json:item><json:item><name>Dr. Douglas A. Girod MD</name><affiliations><json:string>Department of Otolaryngology‐Head and Neck Surgery, Oakland Naval Hospital, Oakland, California</json:string></affiliations></json:item><json:item><name>Dr. David J. Couper MS</name><affiliations><json:string>Department of Biostatistics, University of Washington School of Public Health and Community Medicine, Seattle, Washington</json:string></affiliations></json:item><json:item><name>Dr. Ernest A. Weymuller Jr MD</name><affiliations><json:string>Department of Otolaryngology‐Head and Neck Surgery, University of Washington School of Medicine, Seattle, Washington</json:string></affiliations></json:item><json:item><name>Dr. Michael G. Glenn MD</name><affiliations><json:string>Department of Otolaryngology‐Head and Neck Surgery, University of Washington School of Medicine, Seattle, Washington</json:string></affiliations></json:item></author><articleId><json:string>HED2880160204</json:string></articleId><arkIstex>ark:/67375/WNG-GM6RWTKG-S</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The preoperative assessment of mandibular invasion by oral or oropharyngeal squamous cell carcinoma poses a challenge for the head and neck surgeon. A study of 64 composite resection patients was performed to determine which variables in the patient's history, physical exam, and diagnostic workup had a predictive association with carcinomatous mandibular invasion. Four postoperative variables were included in this analysis. Thirty‐nine percent of the mandibular specimens demonstrated cancerous involvement. A multivariate recursive partitioning statistical analysis was performed to create a decision tree. Branching was based on the two statistically predictive variables: computed tomographic (CT) scan results and primary tumor location. The guide provides improved predictive accuracy with a 100% negative predictive value (NPV) and a 46% positive predictive value (PPV). This decision guide should help the surgeon provide accurate patient counseling, anticipate reconstructive needs, and maximize surgical oncologic effectiveness. © 1994 John Wiley & Sons, Inc.</abstract><qualityIndicators><score>8.752</score><pdfWordCount>5077</pdfWordCount><pdfCharCount>34069</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>11</pdfPageCount><pdfPageSize>594 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>146</abstractWordCount><abstractCharCount>1072</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Predictors of carcinomatous invasion of the mandible</title><pmid><json:string>8021130</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Head & Neck</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1097-0347</json:string></doi><issn><json:string>1043-3074</json:string></issn><eissn><json:string>1097-0347</json:string></eissn><publisherId><json:string>HED</json:string></publisherId><volume>16</volume><issue>2</issue><pages><first>116</first><last>126</last><total>11</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Article</value></json:item></subject></host><namedEntities><unitex><date><json:string>1994</json:string><json:string>1949</json:string></date><geogName></geogName><orgName><json:string>University of Washington School of Medicine</json:string><json:string>Sons, Inc.</json:string><json:string>Harborview Medical Center</json:string><json:string>and Department of Otolaryngology, Division of Head and Neck</json:string><json:string>Apple Computer Co., Cupertino</json:string><json:string>and Department of Biostatistics</json:string><json:string>University of Iowa Hospitals</json:string><json:string>Department of Otolaryngology-Head and Neck</json:string><json:string>Statistical Sciences Inc., Seattle</json:string><json:string>University of Washington School of Public Health</json:string><json:string>Oakland Naval Hospital, Oakland, California</json:string><json:string>Claris Corporation, Santa Clara</json:string><json:string>University of Washington Medical Center</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Girod</json:string><json:string>David J. Couper</json:string><json:string>Our</json:string><json:string>Douglas A. Girod</json:string><json:string>Timothy M. McCulloch</json:string><json:string>Tumors</json:string><json:string>John Wiley</json:string><json:string>Lynne Werner</json:string><json:string>Minh Phan</json:string><json:string>Couper</json:string><json:string>Study</json:string><json:string>History</json:string><json:string>Ernest A. Weymuller</json:string><json:string>McCulloch</json:string><json:string>Michael G. Glenn</json:string><json:string>Physical</json:string><json:string>Tsue</json:string></persName><placeName><json:string>Iowa City</json:string><json:string>Seattle</json:string><json:string>WA</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Marchetta et al.</json:string><json:string>Ator et al.</json:string><json:string>Carter et al.</json:string><json:string>Totsuka et al.</json:string><json:string>Gilbert et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-GM6RWTKG-S</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - surgery</json:string><json:string>2 - otorhinolaryngology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - otorhinolaryngology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Otorhinolaryngology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1994</publicationDate><copyrightDate>1994</copyrightDate><doi><json:string>10.1002/hed.2880160204</json:string></doi><id>01AA128DBF36C6133EAE12712C431242BF37AF15</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/01AA128DBF36C6133EAE12712C431242BF37AF15/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/01AA128DBF36C6133EAE12712C431242BF37AF15/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/01AA128DBF36C6133EAE12712C431242BF37AF15/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Predictors of carcinomatous invasion of the mandible</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><availability><licence>Copyright © 1994 Wiley Periodicals, Inc., A Wiley Company</licence></availability><date type="published" when="1994-03"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main" xml:lang="en">Predictors of carcinomatous invasion of the mandible</title><title level="a" type="short" xml:lang="en">Mandibular Invasion</title><author xml:id="author-0000" role="corresp"><persName><addName>Dr.</addName><forename type="first">Terance T.</forename><surname>Tsue</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Otolaryngology‐Head and Neck Surgery, University of Washington School of Medicine, Seattle, Washington<address><country key="US"></country></address></affiliation><affiliation>Department of Otolaryngology‐Head and Neck Surgery, University of Washington School of Medicine RL‐30, Seattle, WA 98195</affiliation></author><author xml:id="author-0001"><persName><addName>Dr.</addName><forename type="first">Timothy M.</forename><surname>McCulloch</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Otolaryngology, Division of Head and Neck Oncology (Dr. McCulloch), University of Iowa Hospitals and Clinics, Iowa City, Iowa<address><country key="US"></country></address></affiliation></author><author xml:id="author-0002"><persName><addName>Dr.</addName><forename type="first">Douglas A.</forename><surname>Girod</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Otolaryngology‐Head and Neck Surgery, Oakland Naval Hospital, Oakland, California<address><country key="US"></country></address></affiliation></author><author xml:id="author-0003"><persName><addName>Dr.</addName><forename type="first">David J.</forename><surname>Couper</surname><roleName type="degree">MS</roleName></persName><affiliation>Department of Biostatistics, University of Washington School of Public Health and Community Medicine, Seattle, Washington<address><country key="US"></country></address></affiliation></author><author xml:id="author-0004"><persName><addName>Dr.</addName><genName>Jr</genName><forename type="first">Ernest A.</forename><surname>Weymuller</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Otolaryngology‐Head and Neck Surgery, University of Washington School of Medicine, Seattle, Washington<address><country key="US"></country></address></affiliation></author><author xml:id="author-0005"><persName><addName>Dr.</addName><forename type="first">Michael G.</forename><surname>Glenn</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Otolaryngology‐Head and Neck Surgery, University of Washington School of Medicine, Seattle, Washington<address><country key="US"></country></address></affiliation></author><idno type="istex">01AA128DBF36C6133EAE12712C431242BF37AF15</idno><idno type="ark">ark:/67375/WNG-GM6RWTKG-S</idno><idno type="DOI">10.1002/hed.2880160204</idno><idno type="unit">HED2880160204</idno><idno type="toTypesetVersion">file:HED.HED2880160204.pdf</idno></analytic><monogr><title level="j" type="main">Head & Neck</title><title level="j" type="alt">HEAD AND NECK</title><idno type="pISSN">1043-3074</idno><idno type="eISSN">1097-0347</idno><idno type="book-DOI">10.1002/(ISSN)1097-0347</idno><idno type="book-part-DOI">10.1002/hed.v16:2</idno><idno type="product">HED</idno><imprint><biblScope unit="vol">16</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="116">116</biblScope><biblScope unit="page" to="126">126</biblScope><biblScope unit="page-count">11</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1994-03"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>The preoperative assessment of mandibular invasion by oral or oropharyngeal squamous cell carcinoma poses a challenge for the head and neck surgeon. A study of 64 composite resection patients was performed to determine which variables in the patient's history, physical exam, and diagnostic workup had a predictive association with carcinomatous mandibular invasion. Four postoperative variables were included in this analysis. Thirty‐nine percent of the mandibular specimens demonstrated cancerous involvement.</p><p>A multivariate recursive partitioning statistical analysis was performed to create a decision tree. Branching was based on the two statistically predictive variables: computed tomographic (CT) scan results and primary tumor location. The guide provides improved predictive accuracy with a 100% negative predictive value (NPV) and a 46% positive predictive value (PPV). This decision guide should help the surgeon provide accurate patient counseling, anticipate reconstructive needs, and maximize surgical oncologic effectiveness. © 1994 John Wiley & Sons, Inc.</p></abstract><textClass><keywords rend="articleCategory"><term>Article</term></keywords><keywords rend="tocHeading1"><term>Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/01AA128DBF36C6133EAE12712C431242BF37AF15/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription 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number="11"></count></countGroup><titleGroup><title type="articleCategory">Article</title><title type="tocHeading1">Articles</title></titleGroup><copyright ownership="publisher">Copyright © 1994 Wiley Periodicals, Inc., A Wiley Company</copyright><eventGroup><event type="manuscriptAccepted" date="1993-08-10"></event><event type="firstOnline" date="2006-07-18"></event><event type="publishedOnlineFinalForm" date="2006-07-18"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-27"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-23"></event></eventGroup><numberingGroup><numbering type="pageFirst">116</numbering><numbering type="pageLast">126</numbering></numberingGroup><correspondenceTo>Department of Otolaryngology‐Head and Neck Surgery, University of Washington School of Medicine RL‐30, Seattle, WA 98195</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:HED.HED2880160204.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="7"></count><count type="referenceTotal" number="42"></count></countGroup><titleGroup><title type="main" xml:lang="en">Predictors of carcinomatous invasion of the mandible</title><title type="short" xml:lang="en">Mandibular Invasion</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><honorifics>Dr.</honorifics><givenNames>Terance T.</givenNames><familyName>Tsue</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><honorifics>Dr.</honorifics><givenNames>Timothy M.</givenNames><familyName>McCulloch</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><honorifics>Dr.</honorifics><givenNames>Douglas A.</givenNames><familyName>Girod</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af4"><personName><honorifics>Dr.</honorifics><givenNames>David J.</givenNames><familyName>Couper</familyName><degrees>MS</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><honorifics>Dr.</honorifics><givenNames>Ernest A.</givenNames><familyName>Weymuller</familyName><nameSuffix>Jr</nameSuffix><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><honorifics>Dr.</honorifics><givenNames>Michael G.</givenNames><familyName>Glenn</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Department of Otolaryngology‐Head and Neck Surgery, University of Washington School of Medicine, Seattle, Washington</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Department of Otolaryngology, Division of Head and Neck Oncology (Dr. McCulloch), University of Iowa Hospitals and Clinics, Iowa City, Iowa</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Department of Otolaryngology‐Head and Neck Surgery, Oakland Naval Hospital, Oakland, California</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="US" type="organization"><unparsedAffiliation>Department of Biostatistics, University of Washington School of Public Health and Community Medicine, Seattle, Washington</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The preoperative assessment of mandibular invasion by oral or oropharyngeal squamous cell carcinoma poses a challenge for the head and neck surgeon. A study of 64 composite resection patients was performed to determine which variables in the patient's history, physical exam, and diagnostic workup had a predictive association with carcinomatous mandibular invasion. Four postoperative variables were included in this analysis. Thirty‐nine percent of the mandibular specimens demonstrated cancerous involvement.</p><p>A multivariate recursive partitioning statistical analysis was performed to create a decision tree. Branching was based on the two statistically predictive variables: computed tomographic (CT) scan results and primary tumor location. The guide provides improved predictive accuracy with a 100% negative predictive value (NPV) and a 46% positive predictive value (PPV). This decision guide should help the surgeon provide accurate patient counseling, anticipate reconstructive needs, and maximize surgical oncologic effectiveness. © 1994 John Wiley & Sons, Inc.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Predictors of carcinomatous invasion of the mandible</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Mandibular Invasion</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Predictors of carcinomatous invasion of the mandible</title></titleInfo><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="given">Terance T.</namePart><namePart type="family">Tsue</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Otolaryngology‐Head and Neck Surgery, University of Washington School of Medicine, Seattle, Washington</affiliation><affiliation>Correspondence address: Department of Otolaryngology‐Head and Neck Surgery, University of Washington School of Medicine RL‐30, Seattle, WA 98195</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="given">Timothy M.</namePart><namePart type="family">McCulloch</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Otolaryngology, Division of Head and Neck Oncology (Dr. McCulloch), University of Iowa Hospitals and Clinics, Iowa City, Iowa</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="given">Douglas A.</namePart><namePart type="family">Girod</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Otolaryngology‐Head and Neck Surgery, Oakland Naval Hospital, Oakland, California</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="given">David J.</namePart><namePart type="family">Couper</namePart><namePart type="termsOfAddress">MS</namePart><affiliation>Department of Biostatistics, University of Washington School of Public Health and Community Medicine, Seattle, Washington</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="given">Ernest A.</namePart><namePart type="family">Weymuller Jr</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Otolaryngology‐Head and Neck Surgery, University of Washington School of Medicine, Seattle, Washington</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="given">Michael G.</namePart><namePart type="family">Glenn</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Otolaryngology‐Head and Neck Surgery, University of Washington School of Medicine, Seattle, Washington</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">1994-03</dateIssued><dateValid encoding="w3cdtf">1993-08-10</dateValid><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">2</extent><extent unit="tables">7</extent><extent unit="references">42</extent></physicalDescription><abstract lang="en">The preoperative assessment of mandibular invasion by oral or oropharyngeal squamous cell carcinoma poses a challenge for the head and neck surgeon. A study of 64 composite resection patients was performed to determine which variables in the patient's history, physical exam, and diagnostic workup had a predictive association with carcinomatous mandibular invasion. Four postoperative variables were included in this analysis. Thirty‐nine percent of the mandibular specimens demonstrated cancerous involvement. A multivariate recursive partitioning statistical analysis was performed to create a decision tree. Branching was based on the two statistically predictive variables: computed tomographic (CT) scan results and primary tumor location. The guide provides improved predictive accuracy with a 100% negative predictive value (NPV) and a 46% positive predictive value (PPV). 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