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Role of salivary epithelial toll‐like receptors 2 and 4 in modulating innate immune responses in chronic periodontitis

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Role of salivary epithelial toll‐like receptors 2 and 4 in modulating innate immune responses in chronic periodontitis

Auteurs : V. Swaminathan [États-Unis] ; S. Prakasam [États-Unis] ; V. Puri [États-Unis] ; M. Srinivasan [États-Unis]

Source :

Journal of Periodontal Research [ 0022-3484 ] ; 2013-12.

RBID : ISTEX:B7A477E9D3C5D3A05A238FC0D8411B5B27324AE2

English descriptors

Abstract

Chronic periodontitis is initiated by sequential colonization with a broad array of bacteria and is perpetuated by an immune‐inflammatory response to the changing biofilm. Host recognition of microbes is largely mediated by toll‐like receptors (TLRs), which interact with conserved pathogen‐associated molecular patterns. Based on ligand recognition, TLR‐2 and TLR‐4 interact with most periodontal pathogens. Extracrevicular bacterial reservoirs, such as the oral epithelial cells, contribute to the persistence of periodontitis. Human saliva is a rich source of oral epithelial cells that express functional TLRs. In this study we investigated the role of salivary epithelial cell (SEC) TLR‐2 and TLR‐4 in patients with generalized chronic periodontitis.

Url:

https://api.istex.fr/document/B7A477E9D3C5D3A05A238FC0D8411B5B27324AE2/fulltext/pdf

DOI: 10.1111/jre.12066

Affiliations:

États-Unis

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ISTEX:B7A477E9D3C5D3A05A238FC0D8411B5B27324AE2

Le document en format XML

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<term>Buccal</term>
<term>Chronic periodontitis</term>
<term>Clin</term>
<term>Clinical attachment loss</term>
<term>Control subjects</term>
<term>Cytokine</term>
<term>Cytokine secretion</term>
<term>Epithelial</term>
<term>Epithelial cells</term>
<term>Epithelium</term>
<term>Exfoliated</term>
<term>Exfoliation</term>
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<term>Mucosal surfaces</term>
<term>Oral cavity</term>
<term>Oral epithelial cells</term>
<term>Oral mucosa</term>
<term>Oral mucosal epithelial cells</term>
<term>Pathogen</term>
<term>Peptidoglycan</term>
<term>Peptidoglycan recognition proteins</term>
<term>Periodontal</term>
<term>Periodontal disease</term>
<term>Periodontal pathogens</term>
<term>Periodontitis</term>
<term>Periodontol</term>
<term>Periodontopathic bacteria</term>
<term>Pgrp4 mrnas</term>
<term>Porphyromonas gingivalis</term>
<term>Protein peptide</term>
<term>Receptor</term>
<term>Relative quantities</term>
<term>Saliva</term>
<term>Salivary</term>
<term>Salivary epithelial cells</term>
<term>Small proline</term>
<term>Sprr2a</term>
<term>Time point</term>
<term>Tlr2</term>
<term>Tlr2 mrna</term>
<term>Tlr4</term>
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<term>Control subjects</term>
<term>Cytokine</term>
<term>Cytokine secretion</term>
<term>Epithelial</term>
<term>Epithelial cells</term>
<term>Epithelium</term>
<term>Exfoliated</term>
<term>Exfoliation</term>
<term>Gingivalis</term>
<term>Healthy controls</term>
<term>Healthy subjects</term>
<term>Host response</term>
<term>Human saliva</term>
<term>John wiley sons</term>
<term>Ligand</term>
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<term>Microbial products</term>
<term>Molecular patterns</term>
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<term>Mucosal</term>
<term>Mucosal epithelial cells</term>
<term>Mucosal surfaces</term>
<term>Oral cavity</term>
<term>Oral epithelial cells</term>
<term>Oral mucosa</term>
<term>Oral mucosal epithelial cells</term>
<term>Pathogen</term>
<term>Peptidoglycan</term>
<term>Peptidoglycan recognition proteins</term>
<term>Periodontal</term>
<term>Periodontal disease</term>
<term>Periodontal pathogens</term>
<term>Periodontitis</term>
<term>Periodontol</term>
<term>Periodontopathic bacteria</term>
<term>Pgrp4 mrnas</term>
<term>Porphyromonas gingivalis</term>
<term>Protein peptide</term>
<term>Receptor</term>
<term>Relative quantities</term>
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<term>Salivary</term>
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<term>Time point</term>
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<front><div type="abstract">Chronic periodontitis is initiated by sequential colonization with a broad array of bacteria and is perpetuated by an immune‐inflammatory response to the changing biofilm. Host recognition of microbes is largely mediated by toll‐like receptors (TLRs), which interact with conserved pathogen‐associated molecular patterns. Based on ligand recognition, TLR‐2 and TLR‐4 interact with most periodontal pathogens. Extracrevicular bacterial reservoirs, such as the oral epithelial cells, contribute to the persistence of periodontitis. Human saliva is a rich source of oral epithelial cells that express functional TLRs. In this study we investigated the role of salivary epithelial cell (SEC) TLR‐2 and TLR‐4 in patients with generalized chronic periodontitis.</div>
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Role of salivary epithelial toll‐like receptors 2 and 4 in modulating innate immune responses in chronic periodontitis

Role of salivary epithelial toll‐like receptors 2 and 4 in modulating innate immune responses in chronic periodontitis

Source :

English descriptors

Abstract

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