EdenteV2, Hal, Checkpoint, bibRecord, 000013

Expression of MMP-2, 9 and 13 in newly formed bone after sinus augmentation using inorganic bovine bone in human

Identifieur interne : 000013 ( Hal/Checkpoint ); précédent : 000012; suivant : 000014

Expression of MMP-2, 9 and 13 in newly formed bone after sinus augmentation using inorganic bovine bone in human

Auteurs : J. Bassil ; K. Senni ; S. Changotade [France] ; B. Baroukh ; C. Kassis ; N. Naaman ; G. Godeau

Source :

Journal of Periodontal Research [ 0022-3484 ] ; 2011.

RBID : Hal:hal-00704086

English descriptors

mix :
- FLOOR ELEVATION, GELATINASE, INTERSTITIAL COLLAGENASE, MATRIX METALLOPROTEINASES, MAXILLARY, OSSIFICATION, OSTEOCLASTS, RESORPTION, RIDGE AUGMENTATION, TISSUE, bone graft, bone substitute, collagenase.

Abstract

Background and Objective: The aim of the present study was to analyse the expression of MMP-2, MMP-9 and MMP-13 in newly formed bone following maxillary sinus augmentation using inorganic bovine bone substitute, because these MMPs play a major role in bone remodeling and bone resorption. Material and Methods: Deproteinized bovine bone (Bio-Oss (R)) was used to fill cavities after elevating the sinus mucosa. Twenty patients with edentulous posterior maxilla were treated with 20 sinus-augmentation procedures using a two-stage technique. Forty-nine Straumann (R) endosseous implants were used to complete the implant-prosthetic rehabilitation. One cylinder-shaped bone biopsy from each patient was taken from the augmented maxillary region using trephine burs at the second stage of surgery, 8 months after grafting. A biopsy was also taken as a control from the upper molar region from six different patients who did not undergo the sinus procedure. All biopsies were subjected to biochemical analysis and staining for TRAP. Results: No implant losses or failures occurred. The large number of TRAP-positive multinucleated osteoclasts in resorption lacunae indicated that the resorption was very active in all grafts, in contrast with the control group. Zymography and western blot analysis demonstrated a significantly increased expression of MMP-2, MMP-9 and MMP-13 in the newly formed bone compared with controls (p < 0.05). Conclusion: The quantity of osteoclastic cells and the increased expression of proteolytic enzymes suggest that 8 months after grafting, inorganic bovine bone is slowly resorbing and is the site of important remodeling of the newly formed bone by means of resorption and synthesis.

Url:

https://hal.archives-ouvertes.fr/hal-00704086

DOI: 10.1111/j.1600-0765.2011.01400.x

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000006
to stream Hal, to step Curation: 000006

Links to Exploration step

Hal:hal-00704086

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Expression of MMP-2, 9 and 13 in newly formed bone after sinus augmentation using inorganic bovine bone in human</title>
<author><name sortKey="Bassil, J" sort="Bassil, J" uniqKey="Bassil J" first="J." last="Bassil">J. Bassil</name>
</author>
<author><name sortKey="Senni, K" sort="Senni, K" uniqKey="Senni K" first="K." last="Senni">K. Senni</name>
</author>
<author><name sortKey="Changotade, S" sort="Changotade, S" uniqKey="Changotade S" first="S." last="Changotade">S. Changotade</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-152356" status="VALID">          <orgName>Chimie, Structures et Propriétés de Biomatériaux et d'Agents Thérapeutiques</orgName>
          <orgName type="acronym">CSPBAT</orgName>
          <desc>            <address>              <addrLine>Institut Galilée, Université Paris 13, 99 avenue Jean-Baptiste Clément, F-93430 Villetaneuse</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-paris13.fr/cspbat/</ref>
          </desc>
          <listRelation>            <relation active="#struct-303141" type="direct"></relation>
            <relation active="#struct-303171" type="direct"></relation>
            <relation active="#struct-305778" type="direct"></relation>
            <relation name="UMR7244" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-303141" type="direct"><org type="institution" xml:id="struct-303141" status="VALID">          <orgName>Université Paris 13</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-303171" type="direct"><org type="regroupinstitution" xml:id="struct-303171" status="VALID">          <orgName>Université Sorbonne Paris Cité</orgName>
          <orgName type="acronym">USPC</orgName>
          <date type="start">2010</date>
          <desc>            <address>              <addrLine>Université Sorbonne Paris Cité | 100-104, avenue de France | 75013 Paris</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.sorbonne-paris-cite.fr/fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-305778" type="direct"><org type="institution" xml:id="struct-305778" status="INCOMING">          <orgName>Institut Galilée</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR7244" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="university">Université Paris 13</orgName>
</affiliation>
</author>
<author><name sortKey="Baroukh, B" sort="Baroukh, B" uniqKey="Baroukh B" first="B." last="Baroukh">B. Baroukh</name>
</author>
<author><name sortKey="Kassis, C" sort="Kassis, C" uniqKey="Kassis C" first="C." last="Kassis">C. Kassis</name>
</author>
<author><name sortKey="Naaman, N" sort="Naaman, N" uniqKey="Naaman N" first="N." last="Naaman">N. Naaman</name>
</author>
<author><name sortKey="Godeau, G" sort="Godeau, G" uniqKey="Godeau G" first="G." last="Godeau">G. Godeau</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-00704086</idno>
<idno type="halId">hal-00704086</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00704086</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-00704086</idno>
<idno type="doi">10.1111/j.1600-0765.2011.01400.x</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Hal/Corpus">000006</idno>
<idno type="wicri:Area/Hal/Curation">000006</idno>
<idno type="wicri:Area/Hal/Checkpoint">000013</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000013</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Expression of MMP-2, 9 and 13 in newly formed bone after sinus augmentation using inorganic bovine bone in human</title>
<author><name sortKey="Bassil, J" sort="Bassil, J" uniqKey="Bassil J" first="J." last="Bassil">J. Bassil</name>
</author>
<author><name sortKey="Senni, K" sort="Senni, K" uniqKey="Senni K" first="K." last="Senni">K. Senni</name>
</author>
<author><name sortKey="Changotade, S" sort="Changotade, S" uniqKey="Changotade S" first="S." last="Changotade">S. Changotade</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-152356" status="VALID">          <orgName>Chimie, Structures et Propriétés de Biomatériaux et d'Agents Thérapeutiques</orgName>
          <orgName type="acronym">CSPBAT</orgName>
          <desc>            <address>              <addrLine>Institut Galilée, Université Paris 13, 99 avenue Jean-Baptiste Clément, F-93430 Villetaneuse</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-paris13.fr/cspbat/</ref>
          </desc>
          <listRelation>            <relation active="#struct-303141" type="direct"></relation>
            <relation active="#struct-303171" type="direct"></relation>
            <relation active="#struct-305778" type="direct"></relation>
            <relation name="UMR7244" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-303141" type="direct"><org type="institution" xml:id="struct-303141" status="VALID">          <orgName>Université Paris 13</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-303171" type="direct"><org type="regroupinstitution" xml:id="struct-303171" status="VALID">          <orgName>Université Sorbonne Paris Cité</orgName>
          <orgName type="acronym">USPC</orgName>
          <date type="start">2010</date>
          <desc>            <address>              <addrLine>Université Sorbonne Paris Cité | 100-104, avenue de France | 75013 Paris</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.sorbonne-paris-cite.fr/fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-305778" type="direct"><org type="institution" xml:id="struct-305778" status="INCOMING">          <orgName>Institut Galilée</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR7244" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="university">Université Paris 13</orgName>
</affiliation>
</author>
<author><name sortKey="Baroukh, B" sort="Baroukh, B" uniqKey="Baroukh B" first="B." last="Baroukh">B. Baroukh</name>
</author>
<author><name sortKey="Kassis, C" sort="Kassis, C" uniqKey="Kassis C" first="C." last="Kassis">C. Kassis</name>
</author>
<author><name sortKey="Naaman, N" sort="Naaman, N" uniqKey="Naaman N" first="N." last="Naaman">N. Naaman</name>
</author>
<author><name sortKey="Godeau, G" sort="Godeau, G" uniqKey="Godeau G" first="G." last="Godeau">G. Godeau</name>
</author>
</analytic>
<idno type="DOI">10.1111/j.1600-0765.2011.01400.x</idno>
<series><title level="j">Journal of Periodontal Research</title>
<idno type="ISSN">0022-3484</idno>
<imprint><date type="datePub">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>FLOOR ELEVATION</term>
<term>GELATINASE</term>
<term>INTERSTITIAL COLLAGENASE</term>
<term>MATRIX METALLOPROTEINASES</term>
<term>MAXILLARY</term>
<term>OSSIFICATION</term>
<term>OSTEOCLASTS</term>
<term>RESORPTION</term>
<term>RIDGE AUGMENTATION</term>
<term>TISSUE</term>
<term>bone graft</term>
<term>bone substitute</term>
<term>collagenase</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background and Objective: The aim of the present study was to analyse the expression of MMP-2, MMP-9 and MMP-13 in newly formed bone following maxillary sinus augmentation using inorganic bovine bone substitute, because these MMPs play a major role in bone remodeling and bone resorption. Material and Methods: Deproteinized bovine bone (Bio-Oss (R)) was used to fill cavities after elevating the sinus mucosa. Twenty patients with edentulous posterior maxilla were treated with 20 sinus-augmentation procedures using a two-stage technique. Forty-nine Straumann (R) endosseous implants were used to complete the implant-prosthetic rehabilitation. One cylinder-shaped bone biopsy from each patient was taken from the augmented maxillary region using trephine burs at the second stage of surgery, 8 months after grafting. A biopsy was also taken as a control from the upper molar region from six different patients who did not undergo the sinus procedure. All biopsies were subjected to biochemical analysis and staining for TRAP. Results: No implant losses or failures occurred. The large number of TRAP-positive multinucleated osteoclasts in resorption lacunae indicated that the resorption was very active in all grafts, in contrast with the control group. Zymography and western blot analysis demonstrated a significantly increased expression of MMP-2, MMP-9 and MMP-13 in the newly formed bone compared with controls (p < 0.05). Conclusion: The quantity of osteoclastic cells and the increased expression of proteolytic enzymes suggest that 8 months after grafting, inorganic bovine bone is slowly resorbing and is the site of important remodeling of the newly formed bone by means of resorption and synthesis.</div>
</front>
</TEI>
<hal api="V3">          <titleStmt>            <title xml:lang="en">Expression of MMP-2, 9 and 13 in newly formed bone after sinus augmentation using inorganic bovine bone in human</title>
            <author role="aut">              <persName>                <forename type="first">J.</forename>
                <surname>Bassil</surname>
              </persName>
              <idno type="halauthorid">431981</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">K.</forename>
                <surname>Senni</surname>
              </persName>
              <idno type="halauthorid">431979</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">S.</forename>
                <surname>Changotade</surname>
              </persName>
              <idno type="halauthorid">730002</idno>
              <affiliation ref="#struct-152356"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">B.</forename>
                <surname>Baroukh</surname>
              </persName>
              <idno type="halauthorid">140767</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">C.</forename>
                <surname>Kassis</surname>
              </persName>
              <idno type="halauthorid">730004</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">N.</forename>
                <surname>Naaman</surname>
              </persName>
              <idno type="halauthorid">472255</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">G.</forename>
                <surname>Godeau</surname>
              </persName>
              <idno type="halauthorid">71600</idno>
            </author>
            <editor role="depositor">              <persName>                <forename>Géraldine</forename>
                <surname>Rohman</surname>
              </persName>
              <email type="md5">94acaa17007f12f2fab572876118506e</email>
              <email type="domain">univ-paris13.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>            <edition n="v1" type="current">              <date type="whenSubmitted">2012-06-04 18:00:33</date>
              <date type="whenModified">2017-11-06 10:49:47</date>
              <date type="whenReleased">2012-06-04 18:01:24</date>
              <date type="whenProduced">2011</date>
            </edition>
            <respStmt>              <resp>contributor</resp>
              <name key="143548">                <persName>                  <forename>Géraldine</forename>
                  <surname>Rohman</surname>
                </persName>
                <email type="md5">94acaa17007f12f2fab572876118506e</email>
                <email type="domain">univ-paris13.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>            <distributor>CCSD</distributor>
            <idno type="halId">hal-00704086</idno>
            <idno type="halUri">https://hal.archives-ouvertes.fr/hal-00704086</idno>
            <idno type="halBibtex">bassil:hal-00704086</idno>
            <idno type="halRefHtml">Journal of Periodontal Research, Wiley, 2011, 46 (6), pp.756-762. 〈10.1111/j.1600-0765.2011.01400.x〉</idno>
            <idno type="halRef">Journal of Periodontal Research, Wiley, 2011, 46 (6), pp.756-762. 〈10.1111/j.1600-0765.2011.01400.x〉</idno>
          </publicationStmt>
          <seriesStmt>            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-PARIS13">Université Paris-Nord - Paris XIII</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="CSPBAT" p="UNIV-PARIS13">Chimie, Structures, Propriétés de Biomatériaux et d’Agents Thérapeutiques</idno>
            <idno type="stamp" n="USPC">Université Sorbonne Paris Cité</idno>
          </seriesStmt>
          <notesStmt>            <note type="commentary">1 - Article</note>
            <note type="audience" n="1">Not set</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">Expression of MMP-2, 9 and 13 in newly formed bone after sinus augmentation using inorganic bovine bone in human</title>
                <author role="aut">                  <persName>                    <forename type="first">J.</forename>
                    <surname>Bassil</surname>
                  </persName>
                  <idno type="halauthorid">431981</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">K.</forename>
                    <surname>Senni</surname>
                  </persName>
                  <idno type="halauthorid">431979</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">S.</forename>
                    <surname>Changotade</surname>
                  </persName>
                  <idno type="halauthorid">730002</idno>
                  <affiliation ref="#struct-152356"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">B.</forename>
                    <surname>Baroukh</surname>
                  </persName>
                  <idno type="halauthorid">140767</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">C.</forename>
                    <surname>Kassis</surname>
                  </persName>
                  <idno type="halauthorid">730004</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">N.</forename>
                    <surname>Naaman</surname>
                  </persName>
                  <idno type="halauthorid">472255</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">G.</forename>
                    <surname>Godeau</surname>
                  </persName>
                  <idno type="halauthorid">71600</idno>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">15980</idno>
                <idno type="issn">0022-3484</idno>
                <idno type="eissn">1600-0765</idno>
                <title level="j">Journal of Periodontal Research</title>
                <imprint>                  <publisher>Wiley</publisher>
                  <biblScope unit="volume">46</biblScope>
                  <biblScope unit="issue">6</biblScope>
                  <biblScope unit="pp">756-762</biblScope>
                  <date type="datePub">2011</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1111/j.1600-0765.2011.01400.x</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <keywords scheme="author">                <term xml:lang="en">bone graft</term>
                <term xml:lang="en">bone substitute</term>
                <term xml:lang="en">collagenase</term>
                <term xml:lang="en">INTERSTITIAL COLLAGENASE</term>
                <term xml:lang="en">MATRIX METALLOPROTEINASES</term>
                <term xml:lang="en">RIDGE AUGMENTATION</term>
                <term xml:lang="en">FLOOR ELEVATION</term>
                <term xml:lang="en">TISSUE</term>
                <term xml:lang="en">RESORPTION</term>
                <term xml:lang="en">OSTEOCLASTS</term>
                <term xml:lang="en">MAXILLARY</term>
                <term xml:lang="en">OSSIFICATION</term>
                <term xml:lang="en">GELATINASE</term>
              </keywords>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">Background and Objective: The aim of the present study was to analyse the expression of MMP-2, MMP-9 and MMP-13 in newly formed bone following maxillary sinus augmentation using inorganic bovine bone substitute, because these MMPs play a major role in bone remodeling and bone resorption. Material and Methods: Deproteinized bovine bone (Bio-Oss (R)) was used to fill cavities after elevating the sinus mucosa. Twenty patients with edentulous posterior maxilla were treated with 20 sinus-augmentation procedures using a two-stage technique. Forty-nine Straumann (R) endosseous implants were used to complete the implant-prosthetic rehabilitation. One cylinder-shaped bone biopsy from each patient was taken from the augmented maxillary region using trephine burs at the second stage of surgery, 8 months after grafting. A biopsy was also taken as a control from the upper molar region from six different patients who did not undergo the sinus procedure. All biopsies were subjected to biochemical analysis and staining for TRAP. Results: No implant losses or failures occurred. The large number of TRAP-positive multinucleated osteoclasts in resorption lacunae indicated that the resorption was very active in all grafts, in contrast with the control group. Zymography and western blot analysis demonstrated a significantly increased expression of MMP-2, MMP-9 and MMP-13 in the newly formed bone compared with controls (p < 0.05). Conclusion: The quantity of osteoclastic cells and the increased expression of proteolytic enzymes suggest that 8 months after grafting, inorganic bovine bone is slowly resorbing and is the site of important remodeling of the newly formed bone by means of resorption and synthesis.</abstract>
          </profileDesc>
        </hal>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Hal/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000013 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Hal/Checkpoint/biblio.hfd -nk 000013 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    EdenteV2
   |flux=    Hal
   |étape=   Checkpoint
   |type=    RBID
   |clé=     Hal:hal-00704086
   |texte=   Expression of MMP-2, 9 and 13 in newly formed bone after sinus augmentation using inorganic bovine bone in human
}}

This area was generated with Dilib version V0.6.32.
Data generation: Thu Nov 30 15:26:48 2017. Site generation: Tue Mar 8 16:36:20 2022

	Serveur d'exploration sur le patient édenté
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le patient édenté

Expression of MMP-2, 9 and 13 in newly formed bone after sinus augmentation using inorganic bovine bone in human

Expression of MMP-2, 9 and 13 in newly formed bone after sinus augmentation using inorganic bovine bone in human

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri