Combination therapy including serratiopeptidase improves outcomes of mechanical-antibiotic treatment of periimplantitis.
Identifieur interne : 000078 ( PubMed/Curation ); précédent : 000077; suivant : 000079Combination therapy including serratiopeptidase improves outcomes of mechanical-antibiotic treatment of periimplantitis.
Auteurs : G. Sannino [Italie] ; P. Gigola ; M. Puttini ; F. Pera ; C. PassarielloSource :
- International journal of immunopathology and pharmacology [ 0394-6320 ]
Descripteurs français
- KwdFr :
- Anti-inflammatoires non stéroïdiens (effets indésirables), Antibactériens (usage thérapeutique), Association de médicaments, Association thérapeutique, Cicatrisation de plaie (), Débridement, Facteurs temps, Humains, Peptide hydrolases (usage thérapeutique), Péri-implantite (), Péri-implantite (diagnostic), Péri-implantite (traitement médicamenteux), Résultat thérapeutique, Études rétrospectives.
- MESH :
- diagnostic : Péri-implantite.
- effets indésirables : Anti-inflammatoires non stéroïdiens.
- traitement médicamenteux : Péri-implantite.
- usage thérapeutique : Antibactériens, Peptide hydrolases.
- Association de médicaments, Association thérapeutique, Cicatrisation de plaie, Débridement, Facteurs temps, Humains, Péri-implantite, Résultat thérapeutique, Études rétrospectives.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (therapeutic use), Anti-Inflammatory Agents, Non-Steroidal (adverse effects), Combined Modality Therapy, Debridement, Drug Therapy, Combination, Humans, Peptide Hydrolases (therapeutic use), Peri-Implantitis (diagnosis), Peri-Implantitis (drug therapy), Peri-Implantitis (surgery), Retrospective Studies, Time Factors, Treatment Outcome, Wound Healing (drug effects).
- MESH :
- chemical , adverse effects : Anti-Inflammatory Agents, Non-Steroidal.
- chemical , therapeutic use : Anti-Bacterial Agents, Peptide Hydrolases.
- diagnosis : Peri-Implantitis.
- drug effects : Wound Healing.
- drug therapy : Peri-Implantitis.
- surgery : Peri-Implantitis.
- Combined Modality Therapy, Debridement, Drug Therapy, Combination, Humans, Retrospective Studies, Time Factors, Treatment Outcome.
Abstract
This study was designed as a retrospective analysis of clinical outcomes of cases of periimplantitis treated by mechanical debridement and the administration of antibiotics combined or not with the administration of either the proteolytic enzyme serratiopeptidase (SPEP) or non-steroidal anti-inflammatory drugs (NSAIDs). Clinical charts of 544 partially edentulous patients treated for periimplantitis between June 1996 and December 2010 were analyzed to obtain clinical data of the affected implants just before the beginning of treatment and 12 months later to evaluate the outcomes of combined mechanical antibiotic treatment alone or in combination with the co-administration of the anti-inflammatory SPEP or NSAIDs. The comparative analysis revealed that therapeutic outcomes were significantly different in the three groups. Failure rate in the group that received SPEP (6 percent) was significantly lower compared to the group that received NSAIDS (16.9 percent; P less than 0.01) and to the group that received no anti-inflammatory therapy (18.9 percent; P less than 0.01). Treatment including SPEP was associated with significantly better healing also when successful treatments alone were considered. The data reported in this paper strongly support the hypothesis that SPEP is a valid addition to protocols for the combined therapy of peri-implantitis. In fact, it allows to enhance success rates significantly and also favors better tissue repair around successfully treated implants as compared to other regimens.
DOI: 10.1177/039463201302600332
PubMed: 24067485
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Pera</name></author><author><name sortKey="Passariello, C" sort="Passariello, C" uniqKey="Passariello C" first="C" last="Passariello">C. 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Sannino</name><affiliation wicri:level="1"><nlm:affiliation>Department of Prosthodontics, University of Rome Tor Vergata, School of Dentistry, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Prosthodontics, University of Rome Tor Vergata, School of Dentistry, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Gigola, P" sort="Gigola, P" uniqKey="Gigola P" first="P" last="Gigola">P. Gigola</name></author><author><name sortKey="Puttini, M" sort="Puttini, M" uniqKey="Puttini M" first="M" last="Puttini">M. Puttini</name></author><author><name sortKey="Pera, F" sort="Pera, F" uniqKey="Pera F" first="F" last="Pera">F. Pera</name></author><author><name sortKey="Passariello, C" sort="Passariello, C" uniqKey="Passariello C" first="C" last="Passariello">C. 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Clinical charts of 544 partially edentulous patients treated for periimplantitis between June 1996 and December 2010 were analyzed to obtain clinical data of the affected implants just before the beginning of treatment and 12 months later to evaluate the outcomes of combined mechanical antibiotic treatment alone or in combination with the co-administration of the anti-inflammatory SPEP or NSAIDs. The comparative analysis revealed that therapeutic outcomes were significantly different in the three groups. Failure rate in the group that received SPEP (6 percent) was significantly lower compared to the group that received NSAIDS (16.9 percent; P less than 0.01) and to the group that received no anti-inflammatory therapy (18.9 percent; P less than 0.01). Treatment including SPEP was associated with significantly better healing also when successful treatments alone were considered. The data reported in this paper strongly support the hypothesis that SPEP is a valid addition to protocols for the combined therapy of peri-implantitis. In fact, it allows to enhance success rates significantly and also favors better tissue repair around successfully treated implants as compared to other regimens.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24067485</PMID><DateCompleted><Year>2014</Year><Month>03</Month><Day>28</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0394-6320</ISSN><JournalIssue CitedMedium="Print"><Volume>26</Volume><Issue>3</Issue><PubDate><MedlineDate>2013 Jul-Sep</MedlineDate></PubDate></JournalIssue><Title>International journal of immunopathology and pharmacology</Title><ISOAbbreviation>Int J Immunopathol Pharmacol</ISOAbbreviation></Journal><ArticleTitle>Combination therapy including serratiopeptidase improves outcomes of mechanical-antibiotic treatment of periimplantitis.</ArticleTitle><Pagination><MedlinePgn>825-31</MedlinePgn></Pagination><Abstract><AbstractText>This study was designed as a retrospective analysis of clinical outcomes of cases of periimplantitis treated by mechanical debridement and the administration of antibiotics combined or not with the administration of either the proteolytic enzyme serratiopeptidase (SPEP) or non-steroidal anti-inflammatory drugs (NSAIDs). Clinical charts of 544 partially edentulous patients treated for periimplantitis between June 1996 and December 2010 were analyzed to obtain clinical data of the affected implants just before the beginning of treatment and 12 months later to evaluate the outcomes of combined mechanical antibiotic treatment alone or in combination with the co-administration of the anti-inflammatory SPEP or NSAIDs. The comparative analysis revealed that therapeutic outcomes were significantly different in the three groups. Failure rate in the group that received SPEP (6 percent) was significantly lower compared to the group that received NSAIDS (16.9 percent; P less than 0.01) and to the group that received no anti-inflammatory therapy (18.9 percent; P less than 0.01). Treatment including SPEP was associated with significantly better healing also when successful treatments alone were considered. The data reported in this paper strongly support the hypothesis that SPEP is a valid addition to protocols for the combined therapy of peri-implantitis. In fact, it allows to enhance success rates significantly and also favors better tissue repair around successfully treated implants as compared to other regimens.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sannino</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Prosthodontics, University of Rome Tor Vergata, School of Dentistry, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gigola</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Puttini</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Pera</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Passariello</LastName><ForeName>C</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016422">Letter</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Int J Immunopathol Pharmacol</MedlineTA><NlmUniqueID>8911335</NlmUniqueID><ISSNLinking>0394-6320</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000894">Anti-Inflammatory Agents, Non-Steroidal</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.-</RegistryNumber><NameOfSubstance UI="D010447">Peptide Hydrolases</NameOfSubstance></Chemical><Chemical><RegistryNumber>NL053ABE4J</RegistryNumber><NameOfSubstance UI="C022640">serratiopeptidase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000894" MajorTopicYN="N">Anti-Inflammatory Agents, Non-Steroidal</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003131" MajorTopicYN="N">Combined Modality Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003646" MajorTopicYN="Y">Debridement</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010447" MajorTopicYN="N">Peptide Hydrolases</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057873" MajorTopicYN="N">Peri-Implantitis</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014945" MajorTopicYN="N">Wound Healing</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>9</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>9</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>3</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24067485</ArticleId><ArticleId IdType="pii">32</ArticleId><ArticleId IdType="doi">10.1177/039463201302600332</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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