Systemic exposure to a common periodontal pathogen and missing teeth are associated with metabolic syndrome.
Identifieur interne : 000C99 ( PubMed/Corpus ); précédent : 000C98; suivant : 000D00Systemic exposure to a common periodontal pathogen and missing teeth are associated with metabolic syndrome.
Auteurs : K. Hyv Rinen ; A. Salminen ; V. Salomaa ; P J PussinenSource :
- Acta diabetologica [ 1432-5233 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Aggregatibacter actinomycetemcomitans (immunology), Aggregatibacter actinomycetemcomitans (isolation & purification), Antibodies, Bacterial (blood), Antibodies, Bacterial (immunology), Cohort Studies, Female, Finland (epidemiology), Humans, Male, Metabolic Syndrome (epidemiology), Metabolic Syndrome (etiology), Metabolic Syndrome (immunology), Middle Aged, Periodontitis (complications), Periodontitis (immunology), Periodontitis (microbiology), Porphyromonas gingivalis (immunology), Porphyromonas gingivalis (isolation & purification), Tooth (chemistry), Tooth (microbiology), Tooth Loss (microbiology).
- MESH :
- chemical , blood : Antibodies, Bacterial.
- chemistry : Tooth.
- complications : Periodontitis.
- epidemiology : Finland, Metabolic Syndrome.
- etiology : Metabolic Syndrome.
- immunology : Aggregatibacter actinomycetemcomitans, Antibodies, Bacterial, Metabolic Syndrome, Periodontitis, Porphyromonas gingivalis.
- isolation & purification : Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis.
- microbiology : Periodontitis, Tooth, Tooth Loss.
- Aged, Cohort Studies, Female, Humans, Male, Middle Aged.
Abstract
Periodontitis is a common chronic infection of tooth-supporting tissues leading to tooth loss. Two of the major periodontal pathogens are Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis. Clinically diagnosed periodontitis has been associated with metabolic syndrome (MetS). The aim of the study was to investigate the association of serum antibody levels against A. actinomycetemcomitans and P. gingivalis and the number of missing teeth with MetS. The population was the PAIS subcohort of the FINRISK '97 study (n = 1,354). The subjects were men aged 45-74 years, and they participated in this cardiovascular risk factor survey in Finland. A total of 534 (39 %) subjects had MetS defined according to the guidelines of the International Diabetes Federation. Serum antibody levels against the pathogens were measured by multiserotype ELISA. A. actinomycetemcomitans antibody levels and the number of missing teeth were significantly higher in subjects with a large waist circumference or with low serum high-density lipoprotein cholesterol. The number of missing teeth was also higher among subjects with a high serum triglyceride concentration or high plasma glucose concentration. Seropositivity for A. actinomycetemcomitans was significantly associated with MetS with an odds ratio (OR) 1.42 (95 % confidence interval 1.09-1.85, p = 0.009). More than four missing teeth and complete edentulousness were also significantly associated with MetS with ORs 1.69 (1.26-2.27, p < 0.001) and 1.93 (1.30-2.86, p = 0.001), respectively. Missing teeth and systemic exposure to A. actinomycetemcomitans were associated with several components of Mets. Infection with this common pathogen or the host response against it is associated with the presence of MetS.
DOI: 10.1007/s00592-014-0586-y
PubMed: 24791962
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Systemic exposure to a common periodontal pathogen and missing teeth are associated with metabolic syndrome.</title><author><name sortKey="Hyv Rinen, K" sort="Hyv Rinen, K" uniqKey="Hyv Rinen K" first="K" last="Hyv Rinen">K. Hyv Rinen</name><affiliation><nlm:affiliation>Institute of Dentistry, University of Helsinki, P.O. Box 63, 00014, Helsinki, Finland, kati.hyvarinen@helsinki.fi.</nlm:affiliation></affiliation></author><author><name sortKey="Salminen, A" sort="Salminen, A" uniqKey="Salminen A" first="A" last="Salminen">A. Salminen</name></author><author><name sortKey="Salomaa, V" sort="Salomaa, V" uniqKey="Salomaa V" first="V" last="Salomaa">V. Salomaa</name></author><author><name sortKey="Pussinen, P J" sort="Pussinen, P J" uniqKey="Pussinen P" first="P J" last="Pussinen">P J Pussinen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:24791962</idno><idno type="pmid">24791962</idno><idno type="doi">10.1007/s00592-014-0586-y</idno><idno type="wicri:Area/PubMed/Corpus">000C99</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C99</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Systemic exposure to a common periodontal pathogen and missing teeth are associated with metabolic syndrome.</title><author><name sortKey="Hyv Rinen, K" sort="Hyv Rinen, K" uniqKey="Hyv Rinen K" first="K" last="Hyv Rinen">K. Hyv Rinen</name><affiliation><nlm:affiliation>Institute of Dentistry, University of Helsinki, P.O. Box 63, 00014, Helsinki, Finland, kati.hyvarinen@helsinki.fi.</nlm:affiliation></affiliation></author><author><name sortKey="Salminen, A" sort="Salminen, A" uniqKey="Salminen A" first="A" last="Salminen">A. Salminen</name></author><author><name sortKey="Salomaa, V" sort="Salomaa, V" uniqKey="Salomaa V" first="V" last="Salomaa">V. Salomaa</name></author><author><name sortKey="Pussinen, P J" sort="Pussinen, P J" uniqKey="Pussinen P" first="P J" last="Pussinen">P J Pussinen</name></author></analytic><series><title level="j">Acta diabetologica</title><idno type="eISSN">1432-5233</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aggregatibacter actinomycetemcomitans (immunology)</term><term>Aggregatibacter actinomycetemcomitans (isolation & purification)</term><term>Antibodies, Bacterial (blood)</term><term>Antibodies, Bacterial (immunology)</term><term>Cohort Studies</term><term>Female</term><term>Finland (epidemiology)</term><term>Humans</term><term>Male</term><term>Metabolic Syndrome (epidemiology)</term><term>Metabolic Syndrome (etiology)</term><term>Metabolic Syndrome (immunology)</term><term>Middle Aged</term><term>Periodontitis (complications)</term><term>Periodontitis (immunology)</term><term>Periodontitis (microbiology)</term><term>Porphyromonas gingivalis (immunology)</term><term>Porphyromonas gingivalis (isolation & purification)</term><term>Tooth (chemistry)</term><term>Tooth (microbiology)</term><term>Tooth Loss (microbiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Bacterial</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Tooth</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Periodontitis</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Finland</term><term>Metabolic Syndrome</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Metabolic Syndrome</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Aggregatibacter actinomycetemcomitans</term><term>Antibodies, Bacterial</term><term>Metabolic Syndrome</term><term>Periodontitis</term><term>Porphyromonas gingivalis</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Aggregatibacter actinomycetemcomitans</term><term>Porphyromonas gingivalis</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Periodontitis</term><term>Tooth</term><term>Tooth Loss</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Periodontitis is a common chronic infection of tooth-supporting tissues leading to tooth loss. Two of the major periodontal pathogens are Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis. Clinically diagnosed periodontitis has been associated with metabolic syndrome (MetS). The aim of the study was to investigate the association of serum antibody levels against A. actinomycetemcomitans and P. gingivalis and the number of missing teeth with MetS. The population was the PAIS subcohort of the FINRISK '97 study (n = 1,354). The subjects were men aged 45-74 years, and they participated in this cardiovascular risk factor survey in Finland. A total of 534 (39 %) subjects had MetS defined according to the guidelines of the International Diabetes Federation. Serum antibody levels against the pathogens were measured by multiserotype ELISA. A. actinomycetemcomitans antibody levels and the number of missing teeth were significantly higher in subjects with a large waist circumference or with low serum high-density lipoprotein cholesterol. The number of missing teeth was also higher among subjects with a high serum triglyceride concentration or high plasma glucose concentration. Seropositivity for A. actinomycetemcomitans was significantly associated with MetS with an odds ratio (OR) 1.42 (95 % confidence interval 1.09-1.85, p = 0.009). More than four missing teeth and complete edentulousness were also significantly associated with MetS with ORs 1.69 (1.26-2.27, p < 0.001) and 1.93 (1.30-2.86, p = 0.001), respectively. Missing teeth and systemic exposure to A. actinomycetemcomitans were associated with several components of Mets. Infection with this common pathogen or the host response against it is associated with the presence of MetS.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24791962</PMID><DateCompleted><Year>2015</Year><Month>11</Month><Day>25</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-5233</ISSN><JournalIssue CitedMedium="Internet"><Volume>52</Volume><Issue>1</Issue><PubDate><Year>2015</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Acta diabetologica</Title><ISOAbbreviation>Acta Diabetol</ISOAbbreviation></Journal><ArticleTitle>Systemic exposure to a common periodontal pathogen and missing teeth are associated with metabolic syndrome.</ArticleTitle><Pagination><MedlinePgn>179-82</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00592-014-0586-y</ELocationID><Abstract><AbstractText>Periodontitis is a common chronic infection of tooth-supporting tissues leading to tooth loss. Two of the major periodontal pathogens are Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis. Clinically diagnosed periodontitis has been associated with metabolic syndrome (MetS). The aim of the study was to investigate the association of serum antibody levels against A. actinomycetemcomitans and P. gingivalis and the number of missing teeth with MetS. The population was the PAIS subcohort of the FINRISK '97 study (n = 1,354). The subjects were men aged 45-74 years, and they participated in this cardiovascular risk factor survey in Finland. A total of 534 (39 %) subjects had MetS defined according to the guidelines of the International Diabetes Federation. Serum antibody levels against the pathogens were measured by multiserotype ELISA. A. actinomycetemcomitans antibody levels and the number of missing teeth were significantly higher in subjects with a large waist circumference or with low serum high-density lipoprotein cholesterol. The number of missing teeth was also higher among subjects with a high serum triglyceride concentration or high plasma glucose concentration. Seropositivity for A. actinomycetemcomitans was significantly associated with MetS with an odds ratio (OR) 1.42 (95 % confidence interval 1.09-1.85, p = 0.009). More than four missing teeth and complete edentulousness were also significantly associated with MetS with ORs 1.69 (1.26-2.27, p < 0.001) and 1.93 (1.30-2.86, p = 0.001), respectively. Missing teeth and systemic exposure to A. actinomycetemcomitans were associated with several components of Mets. Infection with this common pathogen or the host response against it is associated with the presence of MetS.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hyvärinen</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Institute of Dentistry, University of Helsinki, P.O. Box 63, 00014, Helsinki, Finland, kati.hyvarinen@helsinki.fi.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salminen</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Salomaa</LastName><ForeName>V</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Pussinen</LastName><ForeName>P J</ForeName><Initials>PJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>05</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Acta Diabetol</MedlineTA><NlmUniqueID>9200299</NlmUniqueID><ISSNLinking>0940-5429</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000907">Antibodies, Bacterial</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016976" MajorTopicYN="N">Aggregatibacter actinomycetemcomitans</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000907" MajorTopicYN="N">Antibodies, Bacterial</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005387" MajorTopicYN="N">Finland</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D024821" MajorTopicYN="N">Metabolic Syndrome</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010518" MajorTopicYN="N">Periodontitis</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016966" MajorTopicYN="N">Porphyromonas gingivalis</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014070" MajorTopicYN="N">Tooth</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016388" MajorTopicYN="N">Tooth Loss</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>01</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>04</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>5</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>5</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24791962</ArticleId><ArticleId IdType="doi">10.1007/s00592-014-0586-y</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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