Patient-specific analysis of periodontal and peri-implant microbiomes.
Identifieur interne : 000020 ( PubMed/Corpus ); précédent : 000019; suivant : 000021Patient-specific analysis of periodontal and peri-implant microbiomes.
Auteurs : S M Dabdoub ; A A Tsigarida ; P S KumarSource :
- Journal of dental research [ 1544-0591 ] ; 2013.
English descriptors
- KwdEn :
- Anaerobiosis, Biodiversity, Biofilms, Chimera (genetics), DNA, Bacterial (analysis), Dental Implants (microbiology), Dental Plaque (microbiology), Ecosystem, Gram-Negative Anaerobic Bacteria (classification), Gram-Positive Bacteria (classification), Humans, Jaw, Edentulous, Partially (microbiology), Jaw, Edentulous, Partially (rehabilitation), Microbiota (genetics), Peri-Implantitis (microbiology), Periodontal Diseases (microbiology), Periodontitis (microbiology), Periodontium (microbiology), RNA, Bacterial (analysis), RNA, Ribosomal, 16S (analysis), Sequence Analysis, DNA, Stomatitis (microbiology).
- MESH :
- chemical , analysis : DNA, Bacterial, RNA, Bacterial, RNA, Ribosomal, 16S.
- classification : Gram-Negative Anaerobic Bacteria, Gram-Positive Bacteria.
- genetics : Chimera, Microbiota.
- chemical , microbiology : Dental Implants, Dental Plaque, Jaw, Edentulous, Partially, Peri-Implantitis, Periodontal Diseases, Periodontitis, Periodontium, Stomatitis.
- rehabilitation : Jaw, Edentulous, Partially.
- Anaerobiosis, Biodiversity, Biofilms, Ecosystem, Humans, Sequence Analysis, DNA.
Abstract
Periodontally involved teeth have been implicated as 'microbial reservoirs' in the etiology of peri-implant diseases. Therefore, the purpose of this investigation was to use a deep-sequencing approach to identify the degree of congruence between adjacent peri-implant and periodontal microbiomes in states of health and disease. Subgingival and peri-implant biofilm samples were collected from 81 partially edentulous individuals with periodontal and peri-implant health and disease. Bacterial DNA was isolated, and the 16S rRNA gene was amplified and sequenced by pyrotag sequencing. Chimera-depleted sequences were compared against a locally hosted curated database for bacterial identification. Statistical significance was determined by paired Student's t tests between tooth-implant pairs. The 1.9 million sequences identified represented 523 species. Sixty percent of individuals shared less than 50% of all species between their periodontal and peri-implant biofilms, and 85% of individuals shared less than 8% of abundant species between tooth and implant. Additionally, the periodontal microbiome demonstrated significantly higher diversity than the implant, and distinct bacterial lineages were associated with health and disease in each ecosystem. Analysis of our data suggests that simple geographic proximity is not a sufficient determinant of colonization of topographically distinct niches, and that the peri-implant and periodontal microbiomes represent microbiologically distinct ecosystems.
DOI: 10.1177/0022034513504950
PubMed: 24158341
Links to Exploration step
pubmed:24158341Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Patient-specific analysis of periodontal and peri-implant microbiomes.</title><author><name sortKey="Dabdoub, S M" sort="Dabdoub, S M" uniqKey="Dabdoub S" first="S M" last="Dabdoub">S M Dabdoub</name><affiliation><nlm:affiliation>Division of Periodontology, College of Dentistry, The Ohio State University, Columbus, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tsigarida, A A" sort="Tsigarida, A A" uniqKey="Tsigarida A" first="A A" last="Tsigarida">A A Tsigarida</name></author><author><name sortKey="Kumar, P S" sort="Kumar, P S" uniqKey="Kumar P" first="P S" last="Kumar">P S Kumar</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:24158341</idno><idno type="pmid">24158341</idno><idno type="doi">10.1177/0022034513504950</idno><idno type="wicri:Area/PubMed/Corpus">000020</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000020</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Patient-specific analysis of periodontal and peri-implant microbiomes.</title><author><name sortKey="Dabdoub, S M" sort="Dabdoub, S M" uniqKey="Dabdoub S" first="S M" last="Dabdoub">S M Dabdoub</name><affiliation><nlm:affiliation>Division of Periodontology, College of Dentistry, The Ohio State University, Columbus, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tsigarida, A A" sort="Tsigarida, A A" uniqKey="Tsigarida A" first="A A" last="Tsigarida">A A Tsigarida</name></author><author><name sortKey="Kumar, P S" sort="Kumar, P S" uniqKey="Kumar P" first="P S" last="Kumar">P S Kumar</name></author></analytic><series><title level="j">Journal of dental research</title><idno type="eISSN">1544-0591</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anaerobiosis</term><term>Biodiversity</term><term>Biofilms</term><term>Chimera (genetics)</term><term>DNA, Bacterial (analysis)</term><term>Dental Implants (microbiology)</term><term>Dental Plaque (microbiology)</term><term>Ecosystem</term><term>Gram-Negative Anaerobic Bacteria (classification)</term><term>Gram-Positive Bacteria (classification)</term><term>Humans</term><term>Jaw, Edentulous, Partially (microbiology)</term><term>Jaw, Edentulous, Partially (rehabilitation)</term><term>Microbiota (genetics)</term><term>Peri-Implantitis (microbiology)</term><term>Periodontal Diseases (microbiology)</term><term>Periodontitis (microbiology)</term><term>Periodontium (microbiology)</term><term>RNA, Bacterial (analysis)</term><term>RNA, Ribosomal, 16S (analysis)</term><term>Sequence Analysis, DNA</term><term>Stomatitis (microbiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>DNA, Bacterial</term><term>RNA, Bacterial</term><term>RNA, Ribosomal, 16S</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Gram-Negative Anaerobic Bacteria</term><term>Gram-Positive Bacteria</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chimera</term><term>Microbiota</term></keywords><keywords scheme="MESH" type="chemical" qualifier="microbiology" xml:lang="en"><term>Dental Implants</term><term>Dental Plaque</term><term>Jaw, Edentulous, Partially</term><term>Peri-Implantitis</term><term>Periodontal Diseases</term><term>Periodontitis</term><term>Periodontium</term><term>Stomatitis</term></keywords><keywords scheme="MESH" qualifier="rehabilitation" xml:lang="en"><term>Jaw, Edentulous, Partially</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Anaerobiosis</term><term>Biodiversity</term><term>Biofilms</term><term>Ecosystem</term><term>Humans</term><term>Sequence Analysis, DNA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Periodontally involved teeth have been implicated as 'microbial reservoirs' in the etiology of peri-implant diseases. Therefore, the purpose of this investigation was to use a deep-sequencing approach to identify the degree of congruence between adjacent peri-implant and periodontal microbiomes in states of health and disease. Subgingival and peri-implant biofilm samples were collected from 81 partially edentulous individuals with periodontal and peri-implant health and disease. Bacterial DNA was isolated, and the 16S rRNA gene was amplified and sequenced by pyrotag sequencing. Chimera-depleted sequences were compared against a locally hosted curated database for bacterial identification. Statistical significance was determined by paired Student's t tests between tooth-implant pairs. The 1.9 million sequences identified represented 523 species. Sixty percent of individuals shared less than 50% of all species between their periodontal and peri-implant biofilms, and 85% of individuals shared less than 8% of abundant species between tooth and implant. Additionally, the periodontal microbiome demonstrated significantly higher diversity than the implant, and distinct bacterial lineages were associated with health and disease in each ecosystem. Analysis of our data suggests that simple geographic proximity is not a sufficient determinant of colonization of topographically distinct niches, and that the peri-implant and periodontal microbiomes represent microbiologically distinct ecosystems.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24158341</PMID><DateCompleted><Year>2014</Year><Month>01</Month><Day>24</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1544-0591</ISSN><JournalIssue CitedMedium="Internet"><Volume>92</Volume><Issue>12 Suppl</Issue><PubDate><Year>2013</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Journal of dental research</Title><ISOAbbreviation>J. Dent. Res.</ISOAbbreviation></Journal><ArticleTitle>Patient-specific analysis of periodontal and peri-implant microbiomes.</ArticleTitle><Pagination><MedlinePgn>168S-75S</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1177/0022034513504950</ELocationID><Abstract><AbstractText>Periodontally involved teeth have been implicated as 'microbial reservoirs' in the etiology of peri-implant diseases. Therefore, the purpose of this investigation was to use a deep-sequencing approach to identify the degree of congruence between adjacent peri-implant and periodontal microbiomes in states of health and disease. Subgingival and peri-implant biofilm samples were collected from 81 partially edentulous individuals with periodontal and peri-implant health and disease. Bacterial DNA was isolated, and the 16S rRNA gene was amplified and sequenced by pyrotag sequencing. Chimera-depleted sequences were compared against a locally hosted curated database for bacterial identification. Statistical significance was determined by paired Student's t tests between tooth-implant pairs. The 1.9 million sequences identified represented 523 species. Sixty percent of individuals shared less than 50% of all species between their periodontal and peri-implant biofilms, and 85% of individuals shared less than 8% of abundant species between tooth and implant. Additionally, the periodontal microbiome demonstrated significantly higher diversity than the implant, and distinct bacterial lineages were associated with health and disease in each ecosystem. Analysis of our data suggests that simple geographic proximity is not a sufficient determinant of colonization of topographically distinct niches, and that the peri-implant and periodontal microbiomes represent microbiologically distinct ecosystems.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dabdoub</LastName><ForeName>S M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Division of Periodontology, College of Dentistry, The Ohio State University, Columbus, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsigarida</LastName><ForeName>A A</ForeName><Initials>AA</Initials></Author><Author ValidYN="Y"><LastName>Kumar</LastName><ForeName>P S</ForeName><Initials>PS</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 DE022579</GrantID><Acronym>DE</Acronym><Agency>NIDCR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01-DE022579</GrantID><Acronym>DE</Acronym><Agency>NIDCR NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>10</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Dent Res</MedlineTA><NlmUniqueID>0354343</NlmUniqueID><ISSNLinking>0022-0345</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004269">DNA, Bacterial</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015921">Dental Implants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012329">RNA, Bacterial</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012336">RNA, Ribosomal, 16S</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Ann Periodontol. 1999 Dec;4(1):1-6</RefSource><PMID Version="1">10863370</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Periodontol. 2009 Jul;36(7):604-9</RefSource><PMID Version="1">19538334</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Oral Implants Res. 2000 Dec;11(6):511-20</RefSource><PMID Version="1">11168244</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Oral Implants Res. 2001 Jun;12(3):189-95</RefSource><PMID Version="1">11359474</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Periodontol. 1985 Jul;12(6):465-76</RefSource><PMID Version="1">3894435</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Oral Implants Res. 1990 Dec;1(1):8-12</RefSource><PMID Version="1">2099212</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Oral Implants Res. 2009 Aug;20(8):817-26</RefSource><PMID Version="1">19508342</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Methods. 2010 May;7(5):335-6</RefSource><PMID Version="1">20383131</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Periodontol. 2011 Mar;38 Suppl 11:188-202</RefSource><PMID Version="1">21323715</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2011;6(6):e20956</RefSource><PMID Version="1">21738596</PMID></CommentsCorrections><CommentsCorrections 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MajorTopicYN="N">Anaerobiosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044822" MajorTopicYN="N">Biodiversity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018441" MajorTopicYN="N">Biofilms</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002678" MajorTopicYN="N">Chimera</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004269" MajorTopicYN="N">DNA, Bacterial</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015921" MajorTopicYN="N">Dental Implants</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003773" MajorTopicYN="N">Dental Plaque</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017753" 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UI="D057873" MajorTopicYN="N">Peri-Implantitis</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010510" MajorTopicYN="N">Periodontal Diseases</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010518" MajorTopicYN="N">Periodontitis</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010519" MajorTopicYN="N">Periodontium</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012329" MajorTopicYN="N">RNA, Bacterial</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012336" MajorTopicYN="N">RNA, Ribosomal, 16S</DescriptorName><QualifierName UI="Q000032" 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