Cyclosporine A up-regulates Sonic hedgehog in gingiva: role of the up-regulation on gingival cell proliferation.
Identifieur interne : 000636 ( PubMed/Checkpoint ); précédent : 000635; suivant : 000637Cyclosporine A up-regulates Sonic hedgehog in gingiva: role of the up-regulation on gingival cell proliferation.
Auteurs : Y. Chung [République populaire de Chine] ; E. FuSource :
- Journal of periodontal research [ 1600-0765 ] ; 2014.
Descripteurs français
- KwdFr :
- Alcaloïdes de Veratrum (pharmacologie), Animaux, Antigène nucléaire de prolifération cellulaire (), Antigène nucléaire de prolifération cellulaire (analyse), Ciclosporine (pharmacologie), Doigts de zinc (), Fibroblastes (), Gencive (), Gencive (cytologie), Humains, Lignée cellulaire, Mitogènes (pharmacologie), Modèles animaux, Mâchoire édentée (anatomopathologie), Mâle, Prolifération cellulaire (), Protéine à doigts de zinc GLI1, Protéines Hedgehog (), Protéines Hedgehog (analyse), Protéines Hedgehog (antagonistes et inhibiteurs), Protéines oncogènes (), Rat Sprague-Dawley, Rats, Régulation positive, Techniques de culture cellulaire, Transactivateurs ().
- MESH :
- analyse : Antigène nucléaire de prolifération cellulaire, Protéines Hedgehog.
- anatomopathologie : Mâchoire édentée.
- antagonistes et inhibiteurs : Protéines Hedgehog.
- cytologie : Gencive.
- pharmacologie : Alcaloïdes de Veratrum, Ciclosporine, Mitogènes.
- Animaux, Antigène nucléaire de prolifération cellulaire, Doigts de zinc, Fibroblastes, Gencive, Humains, Lignée cellulaire, Modèles animaux, Mâle, Prolifération cellulaire, Protéine à doigts de zinc GLI1, Protéines Hedgehog, Protéines oncogènes, Rat Sprague-Dawley, Rats, Régulation positive, Techniques de culture cellulaire, Transactivateurs.
English descriptors
- KwdEn :
- Animals, Cell Culture Techniques, Cell Line, Cell Proliferation (drug effects), Cyclosporine (pharmacology), Fibroblasts (drug effects), Gingiva (cytology), Gingiva (drug effects), Hedgehog Proteins (analysis), Hedgehog Proteins (antagonists & inhibitors), Hedgehog Proteins (drug effects), Humans, Jaw, Edentulous (pathology), Male, Mitogens (pharmacology), Models, Animal, Oncogene Proteins (drug effects), Proliferating Cell Nuclear Antigen (analysis), Proliferating Cell Nuclear Antigen (drug effects), Rats, Rats, Sprague-Dawley, Trans-Activators (drug effects), Up-Regulation, Veratrum Alkaloids (pharmacology), Zinc Finger Protein GLI1, Zinc Fingers (drug effects).
- MESH :
- chemical , analysis : Hedgehog Proteins, Proliferating Cell Nuclear Antigen.
- chemical , antagonists & inhibitors : Hedgehog Proteins.
- chemical , drug effects : Hedgehog Proteins, Oncogene Proteins, Proliferating Cell Nuclear Antigen, Trans-Activators.
- chemical , pharmacology : Cyclosporine, Mitogens, Veratrum Alkaloids.
- cytology : Gingiva.
- drug effects : Cell Proliferation, Fibroblasts, Gingiva, Zinc Fingers.
- pathology : Jaw, Edentulous.
- Animals, Cell Culture Techniques, Cell Line, Humans, Male, Models, Animal, Rats, Rats, Sprague-Dawley, Up-Regulation, Zinc Finger Protein GLI1.
Abstract
Sonic hedgehog protein (SHH) is a mitogen that stimulates cell proliferation. Cyclosporine A enhances the proliferation of gingival cells; however, the relationships of SHH to cyclosporine A or to cyclosporine A-enhanced gingival cell proliferation have not been described.
DOI: 10.1111/jre.12168
PubMed: 24823913
Affiliations:
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Chung</name><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, China; Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri-Service General Hospital, Taipei, Taiwan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, China; Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri-Service General Hospital, Taipei, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author><author><name sortKey="Fu, E" sort="Fu, E" uniqKey="Fu E" first="E" last="Fu">E. Fu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24823913</idno><idno type="pmid">24823913</idno><idno type="doi">10.1111/jre.12168</idno><idno type="wicri:Area/PubMed/Corpus">000A99</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A99</idno><idno type="wicri:Area/PubMed/Curation">000A99</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A99</idno><idno type="wicri:Area/PubMed/Checkpoint">000A99</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000A99</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cyclosporine A up-regulates Sonic hedgehog in gingiva: role of the up-regulation on gingival cell proliferation.</title><author><name sortKey="Chung, Y" sort="Chung, Y" uniqKey="Chung Y" first="Y" last="Chung">Y. Chung</name><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, China; Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri-Service General Hospital, Taipei, Taiwan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, China; Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri-Service General Hospital, Taipei, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author><author><name sortKey="Fu, E" sort="Fu, E" uniqKey="Fu E" first="E" last="Fu">E. Fu</name></author></analytic><series><title level="j">Journal of periodontal research</title><idno type="eISSN">1600-0765</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Culture Techniques</term><term>Cell Line</term><term>Cell Proliferation (drug effects)</term><term>Cyclosporine (pharmacology)</term><term>Fibroblasts (drug effects)</term><term>Gingiva (cytology)</term><term>Gingiva (drug effects)</term><term>Hedgehog Proteins (analysis)</term><term>Hedgehog Proteins (antagonists & inhibitors)</term><term>Hedgehog Proteins (drug effects)</term><term>Humans</term><term>Jaw, Edentulous (pathology)</term><term>Male</term><term>Mitogens (pharmacology)</term><term>Models, Animal</term><term>Oncogene Proteins (drug effects)</term><term>Proliferating Cell Nuclear Antigen (analysis)</term><term>Proliferating Cell Nuclear Antigen (drug effects)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Trans-Activators (drug effects)</term><term>Up-Regulation</term><term>Veratrum Alkaloids (pharmacology)</term><term>Zinc Finger Protein GLI1</term><term>Zinc Fingers (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alcaloïdes de Veratrum (pharmacologie)</term><term>Animaux</term><term>Antigène nucléaire de prolifération cellulaire ()</term><term>Antigène nucléaire de prolifération cellulaire (analyse)</term><term>Ciclosporine (pharmacologie)</term><term>Doigts de zinc ()</term><term>Fibroblastes ()</term><term>Gencive ()</term><term>Gencive (cytologie)</term><term>Humains</term><term>Lignée cellulaire</term><term>Mitogènes (pharmacologie)</term><term>Modèles animaux</term><term>Mâchoire édentée (anatomopathologie)</term><term>Mâle</term><term>Prolifération cellulaire ()</term><term>Protéine à doigts de zinc GLI1</term><term>Protéines Hedgehog ()</term><term>Protéines Hedgehog (analyse)</term><term>Protéines Hedgehog (antagonistes et inhibiteurs)</term><term>Protéines oncogènes ()</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Régulation positive</term><term>Techniques de culture cellulaire</term><term>Transactivateurs ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Hedgehog Proteins</term><term>Proliferating Cell Nuclear Antigen</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Hedgehog Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Hedgehog Proteins</term><term>Oncogene Proteins</term><term>Proliferating Cell Nuclear Antigen</term><term>Trans-Activators</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Cyclosporine</term><term>Mitogens</term><term>Veratrum Alkaloids</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigène nucléaire de prolifération cellulaire</term><term>Protéines Hedgehog</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mâchoire édentée</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protéines Hedgehog</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Gencive</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Gingiva</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term><term>Fibroblasts</term><term>Gingiva</term><term>Zinc Fingers</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Jaw, Edentulous</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Alcaloïdes de Veratrum</term><term>Ciclosporine</term><term>Mitogènes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Culture Techniques</term><term>Cell Line</term><term>Humans</term><term>Male</term><term>Models, Animal</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Up-Regulation</term><term>Zinc Finger Protein GLI1</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Antigène nucléaire de prolifération cellulaire</term><term>Doigts de zinc</term><term>Fibroblastes</term><term>Gencive</term><term>Humains</term><term>Lignée cellulaire</term><term>Modèles animaux</term><term>Mâle</term><term>Prolifération cellulaire</term><term>Protéine à doigts de zinc GLI1</term><term>Protéines Hedgehog</term><term>Protéines oncogènes</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Régulation positive</term><term>Techniques de culture cellulaire</term><term>Transactivateurs</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sonic hedgehog protein (SHH) is a mitogen that stimulates cell proliferation. Cyclosporine A enhances the proliferation of gingival cells; however, the relationships of SHH to cyclosporine A or to cyclosporine A-enhanced gingival cell proliferation have not been described.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24823913</PMID><DateCompleted><Year>2015</Year><Month>10</Month><Day>06</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-0765</ISSN><JournalIssue CitedMedium="Internet"><Volume>49</Volume><Issue>6</Issue><PubDate><Year>2014</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Journal of periodontal research</Title><ISOAbbreviation>J. Periodont. Res.</ISOAbbreviation></Journal><ArticleTitle>Cyclosporine A up-regulates Sonic hedgehog in gingiva: role of the up-regulation on gingival cell proliferation.</ArticleTitle><Pagination><MedlinePgn>810-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/jre.12168</ELocationID><Abstract><AbstractText Label="BACKGROUND AND OBJECTIVE" NlmCategory="OBJECTIVE">Sonic hedgehog protein (SHH) is a mitogen that stimulates cell proliferation. Cyclosporine A enhances the proliferation of gingival cells; however, the relationships of SHH to cyclosporine A or to cyclosporine A-enhanced gingival cell proliferation have not been described.</AbstractText><AbstractText Label="MATERIAL AND METHODS" NlmCategory="METHODS">Here, we investigated SHH expression in gingiva in vitro and in vivo after cyclosporine A treatment and tested the effect of SHH inhibition on cyclosporine A-enhanced gingival fibroblast proliferation in vitro.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In human gingival fibroblasts, cyclosporine A treatment increased the expression of SHH transcripts and SHH protein, and stimulated cell proliferation; the addition of cyclopamine, an SHH signaling inhibitor, suppressed cyclosporine A-enhanced cell proliferation. Up-regulated expression of SHH and up-regulation of proliferating cell nuclear antigen transcripts and protein were observed in the edentulous gingiva of cyclosporine A-treated rats.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Cyclosporine A up-regulates gingival SHH expression in vitro and in vivo, and the inhibition of the SHH pathway counteracts the stimulatory effect of cyclosporine A on gingival fibroblast proliferation. Therefore, we suggest that SHH mediates a novel molecular mechanism for cyclosporine A-induced gingival complications.</AbstractText><CopyrightInformation>© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chung</LastName><ForeName>Y</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, China; Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri-Service General Hospital, Taipei, Taiwan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fu</LastName><ForeName>E</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>05</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Periodontal Res</MedlineTA><NlmUniqueID>0055107</NlmUniqueID><ISSNLinking>0022-3484</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053823">Hedgehog Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008934">Mitogens</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015513">Oncogene Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018809">Proliferating Cell Nuclear Antigen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C509239">SHH protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015534">Trans-Activators</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014704">Veratrum Alkaloids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000071676">Zinc Finger Protein GLI1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C546888">sonic hedgehog protein, rat</NameOfSubstance></Chemical><Chemical><RegistryNumber>83HN0GTJ6D</RegistryNumber><NameOfSubstance UI="D016572">Cyclosporine</NameOfSubstance></Chemical><Chemical><RegistryNumber>ZH658AJ192</RegistryNumber><NameOfSubstance UI="C000541">cyclopamine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018929" MajorTopicYN="N">Cell Culture Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016572" MajorTopicYN="N">Cyclosporine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005347" MajorTopicYN="N">Fibroblasts</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005881" MajorTopicYN="N">Gingiva</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053823" MajorTopicYN="N">Hedgehog Proteins</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007575" MajorTopicYN="N">Jaw, Edentulous</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008934" MajorTopicYN="N">Mitogens</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D023421" MajorTopicYN="N">Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015513" MajorTopicYN="N">Oncogene Proteins</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018809" MajorTopicYN="N">Proliferating Cell Nuclear Antigen</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015534" MajorTopicYN="N">Trans-Activators</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015854" MajorTopicYN="N">Up-Regulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014704" MajorTopicYN="N">Veratrum Alkaloids</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000071676" MajorTopicYN="N">Zinc Finger Protein GLI1</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016335" MajorTopicYN="N">Zinc Fingers</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">cell proliferation</Keyword><Keyword MajorTopicYN="N">cyclosporine</Keyword><Keyword MajorTopicYN="N">fibroblasts</Keyword><Keyword MajorTopicYN="N">sonic hedgehog</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>12</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>5</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>5</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>10</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24823913</ArticleId><ArticleId IdType="doi">10.1111/jre.12168</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Fu, E" sort="Fu, E" uniqKey="Fu E" first="E" last="Fu">E. Fu</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Chung, Y" sort="Chung, Y" uniqKey="Chung Y" first="Y" last="Chung">Y. Chung</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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