Early molecular assessment of osseointegration in humans.
Identifieur interne : 000618 ( PubMed/Checkpoint ); précédent : 000617; suivant : 000619Early molecular assessment of osseointegration in humans.
Auteurs : Ghadeer N. Thalji [États-Unis] ; Salvador Nares ; Lyndon F. CooperSource :
- Clinical oral implants research [ 1600-0501 ] ; 2014.
Descripteurs français
- KwdFr :
- Activation des macrophages (génétique), Adulte d'âge moyen, Analyse de profil d'expression de gènes (), Antigènes CD20 (génétique), Chimiokines CC (génétique), Collagène (génétique), Conception de prothèse dentaire, Femelle, Humains, Implants dentaires, Interface os-implant (anatomie et histologie), Marqueurs biologiques (analyse), Matrice extracellulaire (génétique), Matériaux dentaires (), Mâle, Néovascularisation physiologique (génétique), Ostéo-intégration (génétique), Propriétés de surface, Protéines de tissu nerveux (génétique), Protéines membranaires (génétique), Récepteurs immunologiques (génétique), Récepteurs éboueurs de classe A (génétique), Sujet âgé, Systèmes de transport d'acides aminés neutres (génétique), Titane (), Transcription génétique (génétique).
- MESH :
- analyse : Marqueurs biologiques.
- anatomie et histologie : Interface os-implant.
- génétique : Activation des macrophages, Antigènes CD20, Chimiokines CC, Collagène, Matrice extracellulaire, Néovascularisation physiologique, Ostéo-intégration, Protéines de tissu nerveux, Protéines membranaires, Récepteurs immunologiques, Récepteurs éboueurs de classe A, Systèmes de transport d'acides aminés neutres, Transcription génétique.
- Adulte d'âge moyen, Analyse de profil d'expression de gènes, Conception de prothèse dentaire, Femelle, Humains, Implants dentaires, Matériaux dentaires, Mâle, Propriétés de surface, Sujet âgé, Titane.
English descriptors
- KwdEn :
- Aged, Amino Acid Transport Systems, Neutral (genetics), Antigens, CD20 (genetics), Biomarkers (analysis), Bone-Implant Interface (anatomy & histology), Chemokines, CC (genetics), Collagen (genetics), Dental Implants, Dental Materials (chemistry), Dental Prosthesis Design, Extracellular Matrix (genetics), Female, Gene Expression Profiling (methods), Humans, Macrophage Activation (genetics), Male, Membrane Proteins (genetics), Middle Aged, Neovascularization, Physiologic (genetics), Nerve Tissue Proteins (genetics), Osseointegration (genetics), Receptors, Immunologic (genetics), Scavenger Receptors, Class A (genetics), Surface Properties, Titanium (chemistry), Transcription, Genetic (genetics).
- MESH :
- chemical , analysis : Biomarkers.
- chemical , chemistry : Dental Materials, Titanium.
- chemical , genetics : Amino Acid Transport Systems, Neutral, Antigens, CD20, Chemokines, CC, Collagen, Membrane Proteins, Nerve Tissue Proteins, Receptors, Immunologic, Scavenger Receptors, Class A.
- anatomy & histology : Bone-Implant Interface.
- genetics : Extracellular Matrix, Macrophage Activation, Neovascularization, Physiologic, Osseointegration, Transcription, Genetic.
- methods : Gene Expression Profiling.
- Aged, Dental Implants, Dental Prosthesis Design, Female, Humans, Male, Middle Aged, Surface Properties.
Abstract
To determine the early temporal-wide genome transcription regulation by the surface topography at the bone-implant interface of implants bearing microroughened or superimposed nanosurface topology.
DOI: 10.1111/clr.12266
PubMed: 24118318
Affiliations:
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pubmed:24118318Le document en format XML
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Thalji</name><affiliation wicri:level="4"><nlm:affiliation>Department of Prosthodontics, University of Iowa, Iowa City, IA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Prosthodontics, University of Iowa, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Nares, Salvador" sort="Nares, Salvador" uniqKey="Nares S" first="Salvador" last="Nares">Salvador Nares</name></author><author><name sortKey="Cooper, Lyndon F" sort="Cooper, Lyndon F" uniqKey="Cooper L" first="Lyndon F" last="Cooper">Lyndon F. 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(genetics)</term><term>Nerve Tissue Proteins (genetics)</term><term>Osseointegration (genetics)</term><term>Receptors, Immunologic (genetics)</term><term>Scavenger Receptors, Class A (genetics)</term><term>Surface Properties</term><term>Titanium (chemistry)</term><term>Transcription, Genetic (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des macrophages (génétique)</term><term>Adulte d'âge moyen</term><term>Analyse de profil d'expression de gènes ()</term><term>Antigènes CD20 (génétique)</term><term>Chimiokines CC (génétique)</term><term>Collagène (génétique)</term><term>Conception de prothèse dentaire</term><term>Femelle</term><term>Humains</term><term>Implants dentaires</term><term>Interface os-implant (anatomie et histologie)</term><term>Marqueurs biologiques (analyse)</term><term>Matrice extracellulaire (génétique)</term><term>Matériaux dentaires ()</term><term>Mâle</term><term>Néovascularisation physiologique (génétique)</term><term>Ostéo-intégration (génétique)</term><term>Propriétés de surface</term><term>Protéines de tissu nerveux (génétique)</term><term>Protéines membranaires (génétique)</term><term>Récepteurs immunologiques (génétique)</term><term>Récepteurs éboueurs de classe A (génétique)</term><term>Sujet âgé</term><term>Systèmes de transport d'acides aminés neutres (génétique)</term><term>Titane ()</term><term>Transcription génétique (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Dental Materials</term><term>Titanium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Amino Acid Transport Systems, Neutral</term><term>Antigens, CD20</term><term>Chemokines, CC</term><term>Collagen</term><term>Membrane Proteins</term><term>Nerve Tissue Proteins</term><term>Receptors, 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membranaires</term><term>Récepteurs immunologiques</term><term>Récepteurs éboueurs de classe A</term><term>Systèmes de transport d'acides aminés neutres</term><term>Transcription génétique</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Gene Expression Profiling</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Dental Implants</term><term>Dental Prosthesis Design</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Surface Properties</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse de profil d'expression de gènes</term><term>Conception de prothèse dentaire</term><term>Femelle</term><term>Humains</term><term>Implants dentaires</term><term>Matériaux dentaires</term><term>Mâle</term><term>Propriétés de surface</term><term>Sujet âgé</term><term>Titane</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine the early temporal-wide genome transcription regulation by the surface topography at the bone-implant interface of implants bearing microroughened or superimposed nanosurface topology.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24118318</PMID><DateCompleted><Year>2016</Year><Month>09</Month><Day>13</Day></DateCompleted><DateRevised><Year>2014</Year><Month>10</Month><Day>04</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-0501</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>11</Issue><PubDate><Year>2014</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Clinical oral implants research</Title><ISOAbbreviation>Clin Oral Implants Res</ISOAbbreviation></Journal><ArticleTitle>Early molecular assessment of osseointegration in humans.</ArticleTitle><Pagination><MedlinePgn>1273-85</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/clr.12266</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine the early temporal-wide genome transcription regulation by the surface topography at the bone-implant interface of implants bearing microroughened or superimposed nanosurface topology.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Four commercially pure titanium implants (2.2 × 5.0 mm) with either a moderately roughened surface (TiOblast) or super-imposed nanoscale topography (Osseospeed) were placed (n = 2/surface) in edentulous sites of eleven systemically healthy subjects and subsequently removed after 3 and 7 days. Total RNA was isolated from cells adherent to retrieved implants. A whole-genome microarray using the Affymetrix Human gene 1.1 ST Array was used to describe the gene expression profiles that were differentially regulated by the implant surfaces.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">There were no significant differences when comparing the two implant surfaces at each time point. However, the microarray identified several genes that were differentially regulated at day 7 vs. day 3 for both implant surfaces. Functionally relevant categories related to the extracellular matrix (ECM), collagen fibril organization, and angiogenesis were upregulated at both surfaces (day7 vs. day3). Abundant upregulation of several differential markers of alternative activated macrophages was observed (e.g., MRC1, MSR1, MS4A4A, SLC38A6, and CCL18). The biological processes involved with the inflammatory/immune response gene expression were concomitantly downregulated.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Gene regulation implicating collagen fibrillogenesis and ECM organization as well as the inflammatory/immune responses involving the alternative activated pathway are observed in implant adherent cells at early (3-7 days) after implantation. These gene expression events may indicate a pivotal role of collagen fibrillogenesis as well as immunomodulation in altering bone accrual and biomechanical physical properties of the implant-bone interface.</AbstractText><CopyrightInformation>© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Thalji</LastName><ForeName>Ghadeer N</ForeName><Initials>GN</Initials><AffiliationInfo><Affiliation>Department of Prosthodontics, University of Iowa, Iowa City, IA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nares</LastName><ForeName>Salvador</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Cooper</LastName><ForeName>Lyndon F</ForeName><Initials>LF</Initials></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>GENBANK</DataBankName><AccessionNumberList><AccessionNumber>GSE41446</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>09</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>Denmark</Country><MedlineTA>Clin Oral Implants Res</MedlineTA><NlmUniqueID>9105713</NlmUniqueID><ISSNLinking>0905-7161</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D026921">Amino Acid Transport Systems, Neutral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018951">Antigens, CD20</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C111792">CCL18 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019742">Chemokines, 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Immunologic</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051117">Scavenger Receptors, Class A</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-34-5</RegistryNumber><NameOfSubstance UI="D003094">Collagen</NameOfSubstance></Chemical><Chemical><RegistryNumber>D1JT611TNE</RegistryNumber><NameOfSubstance UI="D014025">Titanium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D026921" MajorTopicYN="N">Amino Acid Transport Systems, Neutral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018951" MajorTopicYN="N">Antigens, CD20</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000069343" MajorTopicYN="N">Bone-Implant Interface</DescriptorName><QualifierName UI="Q000033" MajorTopicYN="Y">anatomy & histology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019742" MajorTopicYN="N">Chemokines, CC</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003094" MajorTopicYN="N">Collagen</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015921" MajorTopicYN="Y">Dental Implants</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003764" MajorTopicYN="N">Dental Materials</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017267" MajorTopicYN="N">Dental Prosthesis Design</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005109" MajorTopicYN="N">Extracellular Matrix</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020869" MajorTopicYN="N">Gene Expression Profiling</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008262" MajorTopicYN="N">Macrophage Activation</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008565" MajorTopicYN="N">Membrane Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018919" MajorTopicYN="N">Neovascularization, Physiologic</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009419" MajorTopicYN="N">Nerve Tissue Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016348" MajorTopicYN="N">Osseointegration</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011971" MajorTopicYN="N">Receptors, Immunologic</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051117" MajorTopicYN="N">Scavenger Receptors, Class A</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013499" MajorTopicYN="N">Surface Properties</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014025" MajorTopicYN="N">Titanium</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014158" MajorTopicYN="N">Transcription, Genetic</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">biomaterials</Keyword><Keyword MajorTopicYN="N">bone implant interactions</Keyword><Keyword MajorTopicYN="N">wound healing</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>08</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>10</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>10</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>9</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24118318</ArticleId><ArticleId IdType="doi">10.1111/clr.12266</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Iowa</li></region><settlement><li>Iowa City</li></settlement><orgName><li>Université de l'Iowa</li></orgName></list><tree><noCountry><name sortKey="Cooper, Lyndon F" sort="Cooper, Lyndon F" uniqKey="Cooper L" first="Lyndon F" last="Cooper">Lyndon F. Cooper</name><name sortKey="Nares, Salvador" sort="Nares, Salvador" uniqKey="Nares S" first="Salvador" last="Nares">Salvador Nares</name></noCountry><country name="États-Unis"><region name="Iowa"><name sortKey="Thalji, Ghadeer N" sort="Thalji, Ghadeer N" uniqKey="Thalji G" first="Ghadeer N" last="Thalji">Ghadeer N. Thalji</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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