The efficacy of BMP-2 preloaded on bone substitute or hydrogel for bone regeneration at peri-implant defects in dogs.
Identifieur interne : 000041 ( PubMed/Checkpoint ); précédent : 000040; suivant : 000042The efficacy of BMP-2 preloaded on bone substitute or hydrogel for bone regeneration at peri-implant defects in dogs.
Auteurs : Ui-Won Jung [Corée du Sud] ; In-Kyeong Lee [Corée du Sud] ; Jin-Young Park [Corée du Sud] ; Daniel S. Thoma [Suisse] ; Christoph H F. H Mmerle [Suisse] ; Ronald E. Jung [Suisse]Source :
- Clinical oral implants research [ 1600-0501 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Chiens, Implants dentaires, Lâchage de suture (imagerie diagnostique), Lâchage de suture (traitement médicamenteux), Mandibule (), Mandibule (imagerie diagnostique), Microtomographie aux rayons X, Mâle, Polyéthylène glycols (pharmacologie), Pose d'implant dentaire endo-osseux (), Protéine morphogénétique osseuse de type 2 (pharmacologie), Régénération osseuse (), Substituts osseux (pharmacologie).
- MESH :
- imagerie diagnostique : Lâchage de suture, Mandibule.
- pharmacologie : Polyéthylène glycols, Protéine morphogénétique osseuse de type 2, Substituts osseux.
- traitement médicamenteux : Lâchage de suture.
- Animaux, Chiens, Implants dentaires, Mandibule, Microtomographie aux rayons X, Mâle, Pose d'implant dentaire endo-osseux, Régénération osseuse.
English descriptors
- KwdEn :
- Animals, Bone Morphogenetic Protein 2 (pharmacology), Bone Regeneration (drug effects), Bone Substitutes (pharmacology), Dental Implantation, Endosseous (methods), Dental Implants, Dogs, Hydrogel, Polyethylene Glycol Dimethacrylate (pharmacology), Male, Mandible (diagnostic imaging), Mandible (surgery), Polyethylene Glycols (pharmacology), Surgical Wound Dehiscence (diagnostic imaging), Surgical Wound Dehiscence (drug therapy), X-Ray Microtomography.
- MESH :
- chemical , pharmacology : Bone Morphogenetic Protein 2, Bone Substitutes, Hydrogel, Polyethylene Glycol Dimethacrylate, Polyethylene Glycols.
- diagnostic imaging : Mandible, Surgical Wound Dehiscence.
- drug effects : Bone Regeneration.
- drug therapy : Surgical Wound Dehiscence.
- methods : Dental Implantation, Endosseous.
- surgery : Mandible.
- Animals, Dental Implants, Dogs, Male, X-Ray Microtomography.
Abstract
The objective of this experiment was to test whether or not a synthetic bone substitute (SBS) was more effective than a polyethylene glycol hydrogel as a carrier material for bone morphogenetic protein-2 (BMP-2) when attempting to regenerate bone.
DOI: 10.1111/clr.12491
PubMed: 25263966
Affiliations:
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pubmed:25263966Le document en format XML
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Thoma</name><affiliation wicri:level="4"><nlm:affiliation>Department of Fixed and Removable Prosthodontics and Dental Material Science, Dental School, University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Fixed and Removable Prosthodontics and Dental Material Science, Dental School, University of Zurich, Zurich</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="H Mmerle, Christoph H F" sort="H Mmerle, Christoph H F" uniqKey="H Mmerle C" first="Christoph H F" last="H Mmerle">Christoph H F. H Mmerle</name><affiliation wicri:level="4"><nlm:affiliation>Department of Fixed and Removable Prosthodontics and Dental Material Science, Dental School, University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Fixed and Removable Prosthodontics and Dental Material Science, Dental School, University of Zurich, Zurich</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Jung, Ronald E" sort="Jung, Ronald E" uniqKey="Jung R" first="Ronald E" last="Jung">Ronald E. Jung</name><affiliation wicri:level="4"><nlm:affiliation>Department of Fixed and Removable Prosthodontics and Dental Material Science, Dental School, University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Fixed and Removable Prosthodontics and Dental Material Science, Dental School, University of Zurich, Zurich</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author></analytic><series><title level="j">Clinical oral implants research</title><idno type="eISSN">1600-0501</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bone Morphogenetic Protein 2 (pharmacology)</term><term>Bone Regeneration (drug effects)</term><term>Bone Substitutes (pharmacology)</term><term>Dental Implantation, Endosseous (methods)</term><term>Dental Implants</term><term>Dogs</term><term>Hydrogel, Polyethylene Glycol Dimethacrylate (pharmacology)</term><term>Male</term><term>Mandible (diagnostic imaging)</term><term>Mandible (surgery)</term><term>Polyethylene Glycols (pharmacology)</term><term>Surgical Wound Dehiscence (diagnostic imaging)</term><term>Surgical Wound Dehiscence (drug therapy)</term><term>X-Ray Microtomography</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chiens</term><term>Implants dentaires</term><term>Lâchage de suture (imagerie diagnostique)</term><term>Lâchage de suture (traitement médicamenteux)</term><term>Mandibule ()</term><term>Mandibule (imagerie diagnostique)</term><term>Microtomographie aux rayons X</term><term>Mâle</term><term>Polyéthylène glycols (pharmacologie)</term><term>Pose d'implant dentaire endo-osseux ()</term><term>Protéine morphogénétique osseuse de type 2 (pharmacologie)</term><term>Régénération osseuse ()</term><term>Substituts osseux (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Bone Morphogenetic Protein 2</term><term>Bone Substitutes</term><term>Hydrogel, Polyethylene Glycol Dimethacrylate</term><term>Polyethylene Glycols</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Mandible</term><term>Surgical Wound Dehiscence</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Bone Regeneration</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Surgical Wound Dehiscence</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Lâchage de suture</term><term>Mandibule</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Dental Implantation, Endosseous</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Polyéthylène glycols</term><term>Protéine morphogénétique osseuse de type 2</term><term>Substituts osseux</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Mandible</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Lâchage de suture</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dental Implants</term><term>Dogs</term><term>Male</term><term>X-Ray Microtomography</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Chiens</term><term>Implants dentaires</term><term>Mandibule</term><term>Microtomographie aux rayons X</term><term>Mâle</term><term>Pose d'implant dentaire endo-osseux</term><term>Régénération osseuse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this experiment was to test whether or not a synthetic bone substitute (SBS) was more effective than a polyethylene glycol hydrogel as a carrier material for bone morphogenetic protein-2 (BMP-2) when attempting to regenerate bone.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25263966</PMID><DateCompleted><Year>2017</Year><Month>05</Month><Day>15</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-0501</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>12</Issue><PubDate><Year>2015</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Clinical oral implants research</Title><ISOAbbreviation>Clin Oral Implants Res</ISOAbbreviation></Journal><ArticleTitle>The efficacy of BMP-2 preloaded on bone substitute or hydrogel for bone regeneration at peri-implant defects in dogs.</ArticleTitle><Pagination><MedlinePgn>1456-65</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/clr.12491</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The objective of this experiment was to test whether or not a synthetic bone substitute (SBS) was more effective than a polyethylene glycol hydrogel as a carrier material for bone morphogenetic protein-2 (BMP-2) when attempting to regenerate bone.</AbstractText><AbstractText Label="MATERIAL AND METHODS" NlmCategory="METHODS">Two identical, box-type dehiscence defects (4 × 4 mm buccolingually and apicocoronally, and 8 mm mesiodistally) were surgically prepared on buccal sides of the left and right edentulous ridge in five beagle dogs. Following implant placement, the defects either received (i) no graft, (ii) SBS+hydrogel, (iii) SBS+BMP-2 loaded hydrogel, and (iv) BMP-2-loaded SBS+hydrogel. The animals were euthanized at 8 weeks postsurgery. Radiographic and histomorphometric analyses were performed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The hydrogel alone was not able to stabilize the grafted bone particles at 8 weeks, and SBS+hydrogel group did not significantly differ from the control group in all volumetric measurements. On the other hand, extensively regenerated new bone was connected with most of the remaining SBS particles in the BMP-2 groups. The BMP-2 groups exhibited significantly greater new bone formation (10.65 mm(3) and 1.47 mm(2) in the SBS+BMP-2-loaded hydrogel group; 14.17 mm(3) and 0.93 mm(2) in the BMP-2-loaded SBS+hydrogel) than non-BMP-2 groups (1.27 mm(3) and 0.00 mm(2) in the control group; 2.01 mm(3) and 0.19 mm(2) in the SBS+hydrogel group) in volumetric and histomorphometric analyses (P < 0.001). However, there were no significant differences between both BMP-2 groups.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">BMP-2 could yield enhanced bone regeneration in the critical-size peri-implant defects regardless of whether SBS or hydrogel is used for preloading, although the outcomes seem to be more reproducible with BMP-2 preloaded on SBS.</AbstractText><CopyrightInformation>© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jung</LastName><ForeName>Ui-Won</ForeName><Initials>UW</Initials><AffiliationInfo><Affiliation>Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>In-Kyeong</ForeName><Initials>IK</Initials><AffiliationInfo><Affiliation>Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Jin-Young</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thoma</LastName><ForeName>Daniel S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Department of Fixed and Removable Prosthodontics and Dental Material Science, Dental School, University of Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hämmerle</LastName><ForeName>Christoph H F</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Department of Fixed and Removable Prosthodontics and Dental Material Science, Dental School, University of Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jung</LastName><ForeName>Ronald E</ForeName><Initials>RE</Initials><AffiliationInfo><Affiliation>Department of Fixed and Removable Prosthodontics and Dental Material Science, Dental School, University of Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>09</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>Denmark</Country><MedlineTA>Clin Oral Implants Res</MedlineTA><NlmUniqueID>9105713</NlmUniqueID><ISSNLinking>0905-7161</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C525718">BMP2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D055396">Bone Morphogenetic Protein 2</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018786">Bone Substitutes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015921">Dental Implants</NameOfSubstance></Chemical><Chemical><RegistryNumber>25852-47-5</RegistryNumber><NameOfSubstance UI="D020136">Hydrogel, Polyethylene Glycol Dimethacrylate</NameOfSubstance></Chemical><Chemical><RegistryNumber>30IQX730WE</RegistryNumber><NameOfSubstance UI="D011092">Polyethylene Glycols</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055396" MajorTopicYN="N">Bone Morphogenetic Protein 2</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001861" MajorTopicYN="N">Bone Regeneration</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018786" MajorTopicYN="N">Bone Substitutes</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003758" MajorTopicYN="N">Dental Implantation, Endosseous</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015921" MajorTopicYN="Y">Dental Implants</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004285" MajorTopicYN="N">Dogs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020136" MajorTopicYN="N">Hydrogel, Polyethylene Glycol Dimethacrylate</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008334" MajorTopicYN="N">Mandible</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011092" MajorTopicYN="N">Polyethylene Glycols</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013529" MajorTopicYN="N">Surgical Wound Dehiscence</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055114" MajorTopicYN="N">X-Ray Microtomography</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Bone morphogenetic protein-2</Keyword><Keyword MajorTopicYN="N">bone substitutes</Keyword><Keyword MajorTopicYN="N">dental implants</Keyword><Keyword MajorTopicYN="N">drug delivery system</Keyword><Keyword MajorTopicYN="N">hydrogel</Keyword><Keyword MajorTopicYN="N">polyethylene glycol</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>08</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>9</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>9</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>5</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25263966</ArticleId><ArticleId IdType="doi">10.1111/clr.12491</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li><li>Suisse</li></country><region><li>Canton de Zurich</li><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li><li>Zurich</li></settlement><orgName><li>Université de Zurich</li></orgName></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Jung, Ui Won" sort="Jung, Ui Won" uniqKey="Jung U" first="Ui-Won" last="Jung">Ui-Won Jung</name></region><name sortKey="Lee, In Kyeong" sort="Lee, In Kyeong" uniqKey="Lee I" first="In-Kyeong" last="Lee">In-Kyeong Lee</name><name sortKey="Park, Jin Young" sort="Park, Jin Young" uniqKey="Park J" first="Jin-Young" last="Park">Jin-Young Park</name></country><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Thoma, Daniel S" sort="Thoma, Daniel S" uniqKey="Thoma D" first="Daniel S" last="Thoma">Daniel S. Thoma</name></region><name sortKey="H Mmerle, Christoph H F" sort="H Mmerle, Christoph H F" uniqKey="H Mmerle C" first="Christoph H F" last="H Mmerle">Christoph H F. H Mmerle</name><name sortKey="Jung, Ronald E" sort="Jung, Ronald E" uniqKey="Jung R" first="Ronald E" last="Jung">Ronald E. Jung</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:25263966" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV1
| This area was generated with Dilib version V0.6.33. |  |