Regenerative nanomedicine: current perspectives and future directions
Identifieur interne : 000816 ( Pmc/Curation ); précédent : 000815; suivant : 000817Regenerative nanomedicine: current perspectives and future directions
Auteurs : Koel Chaudhury [Inde] ; Vishu Kumar [Inde] ; Jayaprakash Kandasamy [Inde] ; Sourav Roychoudhury [Inde]Source :
- International Journal of Nanomedicine [ 1176-9114 ] ; 2014.
Abstract
Nanotechnology has considerably accelerated the growth of regenerative medicine in recent years. Application of nanotechnology in regenerative medicine has revolutionized the designing of grafts and scaffolds which has resulted in new grafts/scaffold systems having significantly enhanced cellular and tissue regenerative properties. Since the cell–cell and cell-matrix interaction in biological systems takes place at the nanoscale level, the application of nanotechnology gives an edge in modifying the cellular function and/or matrix function in a more desired way to mimic the native tissue/organ. In this review, we focus on the nanotechnology-based recent advances and trends in regenerative medicine and discussed under individual organ systems including bone, cartilage, nerve, skin, teeth, myocardium, liver and eye. Recent studies that are related to the design of various types of nanostructured scaffolds and incorporation of nanomaterials into the matrices are reported. We have also documented reports where these materials and matrices have been compared for their better biocompatibility and efficacy in supporting the damaged tissue. In addition to the recent developments, future directions and possible challenges in translating the findings from bench to bedside are outlined.
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DOI: 10.2147/IJN.S45332
PubMed: 25214780
PubMed Central: 4159316
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Regenerative nanomedicine: current perspectives and future directions</title><author><name sortKey="Chaudhury, Koel" sort="Chaudhury, Koel" uniqKey="Chaudhury K" first="Koel" last="Chaudhury">Koel Chaudhury</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-9-4153">School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal</wicri:regionArea></affiliation></author><author><name sortKey="Kumar, Vishu" sort="Kumar, Vishu" uniqKey="Kumar V" first="Vishu" last="Kumar">Vishu Kumar</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-9-4153">School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal</wicri:regionArea></affiliation></author><author><name sortKey="Kandasamy, Jayaprakash" sort="Kandasamy, Jayaprakash" uniqKey="Kandasamy J" first="Jayaprakash" last="Kandasamy">Jayaprakash Kandasamy</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-9-4153">School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal</wicri:regionArea></affiliation></author><author><name sortKey="Roychoudhury, Sourav" sort="Roychoudhury, Sourav" uniqKey="Roychoudhury S" first="Sourav" last="Roychoudhury">Sourav Roychoudhury</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-9-4153">School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25214780</idno><idno type="pmc">4159316</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159316</idno><idno type="RBID">PMC:4159316</idno><idno type="doi">10.2147/IJN.S45332</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000816</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000816</idno><idno type="wicri:Area/Pmc/Curation">000816</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000816</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Regenerative nanomedicine: current perspectives and future directions</title><author><name sortKey="Chaudhury, Koel" sort="Chaudhury, Koel" uniqKey="Chaudhury K" first="Koel" last="Chaudhury">Koel Chaudhury</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-9-4153">School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal</wicri:regionArea></affiliation></author><author><name sortKey="Kumar, Vishu" sort="Kumar, Vishu" uniqKey="Kumar V" first="Vishu" last="Kumar">Vishu Kumar</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-9-4153">School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal</wicri:regionArea></affiliation></author><author><name sortKey="Kandasamy, Jayaprakash" sort="Kandasamy, Jayaprakash" uniqKey="Kandasamy J" first="Jayaprakash" last="Kandasamy">Jayaprakash Kandasamy</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-9-4153">School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal</wicri:regionArea></affiliation></author><author><name sortKey="Roychoudhury, Sourav" sort="Roychoudhury, Sourav" uniqKey="Roychoudhury S" first="Sourav" last="Roychoudhury">Sourav Roychoudhury</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-9-4153">School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal</wicri:regionArea></affiliation></author></analytic><series><title level="j">International Journal of Nanomedicine</title><idno type="ISSN">1176-9114</idno><idno type="eISSN">1178-2013</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Nanotechnology has considerably accelerated the growth of regenerative medicine in recent years. Application of nanotechnology in regenerative medicine has revolutionized the designing of grafts and scaffolds which has resulted in new grafts/scaffold systems having significantly enhanced cellular and tissue regenerative properties. Since the cell–cell and cell-matrix interaction in biological systems takes place at the nanoscale level, the application of nanotechnology gives an edge in modifying the cellular function and/or matrix function in a more desired way to mimic the native tissue/organ. In this review, we focus on the nanotechnology-based recent advances and trends in regenerative medicine and discussed under individual organ systems including bone, cartilage, nerve, skin, teeth, myocardium, liver and eye. Recent studies that are related to the design of various types of nanostructured scaffolds and incorporation of nanomaterials into the matrices are reported. We have also documented reports where these materials and matrices have been compared for their better biocompatibility and efficacy in supporting the damaged tissue. In addition to the recent developments, future directions and possible challenges in translating the findings from bench to bedside are outlined.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Chiapasco, M" uniqKey="Chiapasco M">M Chiapasco</name></author><author><name sortKey="Giammattei, M" uniqKey="Giammattei M">M Giammattei</name></author><author><name sortKey="Carmagnola, D" uniqKey="Carmagnola D">D Carmagnola</name></author><author><name sortKey="Autelitano, L" uniqKey="Autelitano L">L Autelitano</name></author><author><name sortKey="Rabbiosi, D" uniqKey="Rabbiosi D">D Rabbiosi</name></author><author><name sortKey="Dellavia, C" uniqKey="Dellavia C">C Dellavia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Depalma, Af" uniqKey="Depalma A">AF DePalma</name></author><author><name sortKey="Rothman, Rh" uniqKey="Rothman R">RH Rothman</name></author><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Nanomedicine</journal-id><journal-id journal-id-type="iso-abbrev">Int J Nanomedicine</journal-id><journal-id journal-id-type="publisher-id">International Journal of Nanomedicine</journal-id><journal-title-group><journal-title>International Journal of Nanomedicine</journal-title></journal-title-group><issn pub-type="ppub">1176-9114</issn><issn pub-type="epub">1178-2013</issn><publisher><publisher-name>Dove Medical Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25214780</article-id><article-id pub-id-type="pmc">4159316</article-id><article-id pub-id-type="doi">10.2147/IJN.S45332</article-id><article-id pub-id-type="publisher-id">ijn-9-4153</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Regenerative nanomedicine: current perspectives and future directions</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chaudhury</surname><given-names>Koel</given-names></name><xref ref-type="aff" rid="af1-ijn-9-4153"></xref><xref ref-type="corresp" rid="c1-ijn-9-4153"></xref></contrib><contrib contrib-type="author"><name><surname>Kumar</surname><given-names>Vishu</given-names></name><xref ref-type="aff" rid="af1-ijn-9-4153"></xref></contrib><contrib contrib-type="author"><name><surname>Kandasamy</surname><given-names>Jayaprakash</given-names></name><xref ref-type="aff" rid="af1-ijn-9-4153"></xref></contrib><contrib contrib-type="author"><name><surname>RoyChoudhury</surname><given-names>Sourav</given-names></name><xref ref-type="aff" rid="af1-ijn-9-4153"></xref></contrib><aff id="af1-ijn-9-4153">School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India</aff></contrib-group><author-notes><corresp id="c1-ijn-9-4153">Correspondence: Koel Chaudhury, School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, PIN 721302, India, Tel +91 3222 283 572, Fax +91 3222 282 221, Email <email>koel@smst.iitkgp.ernet.in</email></corresp></author-notes><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>01</day><month>9</month><year>2014</year></pub-date><volume>9</volume><fpage>4153</fpage><lpage>4167</lpage><permissions><copyright-statement>© 2014 Chaudhury et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License</copyright-statement><copyright-year>2014</copyright-year><license><license-p>The full terms of the License are available at <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.</license-p></license></permissions><abstract><p>Nanotechnology has considerably accelerated the growth of regenerative medicine in recent years. Application of nanotechnology in regenerative medicine has revolutionized the designing of grafts and scaffolds which has resulted in new grafts/scaffold systems having significantly enhanced cellular and tissue regenerative properties. Since the cell–cell and cell-matrix interaction in biological systems takes place at the nanoscale level, the application of nanotechnology gives an edge in modifying the cellular function and/or matrix function in a more desired way to mimic the native tissue/organ. In this review, we focus on the nanotechnology-based recent advances and trends in regenerative medicine and discussed under individual organ systems including bone, cartilage, nerve, skin, teeth, myocardium, liver and eye. Recent studies that are related to the design of various types of nanostructured scaffolds and incorporation of nanomaterials into the matrices are reported. We have also documented reports where these materials and matrices have been compared for their better biocompatibility and efficacy in supporting the damaged tissue. In addition to the recent developments, future directions and possible challenges in translating the findings from bench to bedside are outlined.</p></abstract><kwd-group><title>Keywords</title><kwd>regenerative medicine</kwd><kwd>nanomedicine</kwd><kwd>nanotechnology</kwd></kwd-group></article-meta></front><floats-group><fig id="f1-ijn-9-4153" position="float"><label>Figure 1</label><caption><p>Various nanotechnology approaches in regenerative medicine.</p></caption><graphic xlink:href="ijn-9-4153Fig1"></graphic></fig><fig id="f2-ijn-9-4153" position="float"><label>Figure 2</label><caption><p>Schematic representation of bone regeneration using nanotechnology.</p><p><bold>Notes:</bold> Improved bone healing using (<bold>A</bold>) nanofibrous scaffold and (<bold>B</bold>) culturing MSCs on nano matrices.</p><p><bold>Abbreviation:</bold> MSCs, mesenchymal stem cells.</p></caption><graphic xlink:href="ijn-9-4153Fig2"></graphic></fig><fig id="f3-ijn-9-4153" position="float"><label>Figure 3</label><caption><p>Various nanotechnology-based methods for skin regeneration.</p></caption><graphic xlink:href="ijn-9-4153Fig3"></graphic></fig><fig id="f4-ijn-9-4153" position="float"><label>Figure 4</label><caption><p>Surface modification showing improved performance and longevity of dental implants.</p><p><bold>Abbreviation:</bold> HA, hydroxyapatite.</p></caption><graphic xlink:href="ijn-9-4153Fig4"></graphic></fig><table-wrap id="t1-ijn-9-4153" position="float"><label>Table 1</label><caption><p>Recent advances in nanomaterials used in regenerative medicine</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" valign="top" rowspan="1" colspan="1">Organ</th><th align="left" valign="top" rowspan="1" colspan="1">Nanomaterials</th><th align="left" valign="top" rowspan="1" colspan="1">Outcome (type of study)</th><th align="left" valign="top" rowspan="1" colspan="1">References</th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="8" colspan="1">Bone</td><td align="left" valign="top" rowspan="2" colspan="1">Poly(epsilon caprolactone)</td><td align="left" valign="top" rowspan="1" colspan="1">Improved cell attachment, proliferation, differentiation, and mineralization of osteoblasts (in vitro)</td><td align="left" valign="top" rowspan="1" colspan="1">Wang J et al<xref rid="b13-ijn-9-4153" ref-type="bibr">13</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Lineage restriction of progenitor cells by topographical cues (in vitro)</td><td align="left" valign="top" rowspan="1" colspan="1">Cassidy JW et al<xref rid="b113-ijn-9-4153" ref-type="bibr">113</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Nanoscaled calcium phosphate</td><td align="left" valign="top" rowspan="1" colspan="1">Large-sized blood vessel infiltration leads to bone formation (in vivo; canines)</td><td align="left" valign="top" rowspan="1" colspan="1">Appleford MR et al<xref rid="b15-ijn-9-4153" ref-type="bibr">15</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">HA-coated titanium</td><td align="left" valign="top" rowspan="1" colspan="1">Enhanced and accelerated osseoimplant integration (in vivo; rats)</td><td align="left" valign="top" rowspan="1" colspan="1">Yamada M et al<xref rid="b17-ijn-9-4153" ref-type="bibr">17</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Nanostructured beta tricalcium phosphate-coated over poly(lactic acid)</td><td align="left" valign="top" rowspan="1" colspan="1">Enhanced osteoconductivity of scaffold (in vitro) and heterotrophic bone formation (in vivo; rabbits)</td><td align="left" valign="top" rowspan="1" colspan="1">Cao L et al<xref rid="b20-ijn-9-4153" ref-type="bibr">20</xref></td></tr><tr><td align="left" valign="top" rowspan="2" colspan="1">Carbon nanotubes</td><td align="left" valign="top" rowspan="1" colspan="1">ECM calcification (in vitro); lamellar bone regeneration (in vivo; mice)</td><td align="left" valign="top" rowspan="1" colspan="1">Lobo AO et al<xref rid="b26-ijn-9-4153" ref-type="bibr">26</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Porous bone formation in bone defect (in vivo; rats)</td><td align="left" valign="top" rowspan="1" colspan="1">Hirata E et al<xref rid="b27-ijn-9-4153" ref-type="bibr">27</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Silica nanofibers</td><td align="left" valign="top" rowspan="1" colspan="1">Proliferation and maturation of MG63 cells (in vitro)</td><td align="left" valign="top" rowspan="1" colspan="1">Ravichandran R et al<xref rid="b29-ijn-9-4153" ref-type="bibr">29</xref></td></tr><tr><td align="left" valign="top" rowspan="4" colspan="1">Cartilage</td><td align="left" valign="top" rowspan="1" colspan="1">Pentosan poly sulfate in poly (ethylene glycol) HA</td><td align="left" valign="top" rowspan="1" colspan="1">Formation of cartilage like tissues by mesenchymal progenitor cells (in vitro)</td><td align="left" valign="top" rowspan="1" colspan="1">Frith JE et al<xref rid="b56-ijn-9-4153" ref-type="bibr">56</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">PVA/PCL</td><td align="left" valign="top" rowspan="1" colspan="1">Proliferation and chondrogenic differentiation of MSCs (in vitro); improved healing of cartilage defects (in vivo; rabbits)</td><td align="left" valign="top" rowspan="1" colspan="1">Shafiee A et al<xref rid="b57-ijn-9-4153" ref-type="bibr">57</xref></td></tr><tr><td align="left" valign="top" rowspan="2" colspan="1">POSS–PCU</td><td align="left" valign="top" rowspan="1" colspan="1">Enhanced survival, proliferation, and chondrogenic differentiation of adipose tissue derived stem cells (in vitro)</td><td align="left" valign="top" rowspan="1" colspan="1">Guasti L et al<xref rid="b114-ijn-9-4153" ref-type="bibr">114</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Enhanced growth and proliferation of nasoseptal chondrocytes (in vitro)</td><td align="left" valign="top" rowspan="1" colspan="1">Oseni AO et al<xref rid="b115-ijn-9-4153" ref-type="bibr">115</xref></td></tr><tr><td align="left" valign="top" rowspan="2" colspan="1">Peripheral nervous system</td><td align="left" valign="top" rowspan="1" colspan="1">Electrospun collagen/poly (lactic-co-glycolic acid)</td><td align="left" valign="top" rowspan="1" colspan="1">Axon regeneration, myelination, and action potential propagation (in vivo; rats)</td><td align="left" valign="top" rowspan="1" colspan="1">Ouyang Y et al<xref rid="b63-ijn-9-4153" ref-type="bibr">63</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">POSS–PCU–MWCNT</td><td align="left" valign="top" rowspan="1" colspan="1">Novel biomaterial capable of electronic interfacing with tissue holds potential to promote nerve regeneration</td><td align="left" valign="top" rowspan="1" colspan="1">Antoniadou EV et al<xref rid="b64-ijn-9-4153" ref-type="bibr">64</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Central nervous system</td><td align="left" valign="top" rowspan="1" colspan="1">Si-RNA chitosan nanoparticles</td><td align="left" valign="top" rowspan="1" colspan="1">Increased delivery of drugs by crossing BBB (in vivo; rats)</td><td align="left" valign="top" rowspan="1" colspan="1">Malmo J et al<xref rid="b71-ijn-9-4153" ref-type="bibr">71</xref></td></tr><tr><td align="left" valign="top" rowspan="4" colspan="1">Myocardial tissue</td><td align="left" valign="top" rowspan="1" colspan="1">IGF-1 with poly(lactic-co-glycolic acid)</td><td align="left" valign="top" rowspan="1" colspan="1">Increased Akt phosphorylation and reduced infarct size (in vivo; mice)</td><td align="left" valign="top" rowspan="1" colspan="1">Chang MY et al<xref rid="b74-ijn-9-4153" ref-type="bibr">74</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Electrospun (hb/gel/fib)</td><td align="left" valign="top" rowspan="1" colspan="1">Cardiomyogenic differentiation of MSCs (in vitro)</td><td align="left" valign="top" rowspan="1" colspan="1">Ravichandran R et al<xref rid="b75-ijn-9-4153" ref-type="bibr">75</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">PGS</td><td align="left" valign="top" rowspan="1" colspan="1">Increased transplant cell retention and survival (in vitro)</td><td align="left" valign="top" rowspan="1" colspan="1">Ravichandran R et al<xref rid="b77-ijn-9-4153" ref-type="bibr">77</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Gold nanoparticles-loaded hybrid nanofibers</td><td align="left" valign="top" rowspan="1" colspan="1">Cardiomyogenic differentiation of MSCs; superior biological and functional properties (in vitro)</td><td align="left" valign="top" rowspan="1" colspan="1">Ravichandran R et al<xref rid="b116-ijn-9-4153" ref-type="bibr">116</xref></td></tr><tr><td align="left" valign="top" rowspan="3" colspan="1">Skin</td><td align="left" valign="top" rowspan="1" colspan="1">Silver nanoparticles</td><td align="left" valign="top" rowspan="1" colspan="1">Reduced inflammation and promotion of wound healing (in vitro)</td><td align="left" valign="top" rowspan="1" colspan="1">Wu J et al<xref rid="b48-ijn-9-4153" ref-type="bibr">48</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Plasma-treated electrospun poly(lactic-acid) co-poly(epsilon caprolactone), and gelatin</td><td align="left" valign="top" rowspan="1" colspan="1">Increased fibroblast proliferation and collagen secretion (in vitro)</td><td align="left" valign="top" rowspan="1" colspan="1">Chandrasekaran AR et al<xref rid="b43-ijn-9-4153" ref-type="bibr">43</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Rosette nanotubes with PHEMA</td><td align="left" valign="top" rowspan="1" colspan="1">Increased keratinocyte and fibroblast proliferation (in vitro)</td><td align="left" valign="top" rowspan="1" colspan="1">Sun L et al<xref rid="b50-ijn-9-4153" ref-type="bibr">50</xref></td></tr><tr><td align="left" valign="top" rowspan="2" colspan="1">Eye</td><td align="left" valign="top" rowspan="1" colspan="1">Polydimethylsiloxane</td><td align="left" valign="top" rowspan="1" colspan="1">Topographical cue for formation of functioning corneal endothelium (in vitro)</td><td align="left" valign="top" rowspan="1" colspan="1">Teo BK et al<xref rid="b100-ijn-9-4153" ref-type="bibr">100</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Super paramagnetic nanoparticles</td><td align="left" valign="top" rowspan="1" colspan="1">Increased gene expression and neurite growth, subcellular organelle localization, and nano therapeutics delivery (in vitro)</td><td align="left" valign="top" rowspan="1" colspan="1">Steketee MB et al<xref rid="b101-ijn-9-4153" ref-type="bibr">101</xref></td></tr><tr><td align="left" valign="top" rowspan="2" colspan="1">Lung</td><td align="left" valign="top" rowspan="1" colspan="1">Deferoxamine</td><td align="left" valign="top" rowspan="1" colspan="1">Regeneration of microvascular anastomosis in airways (in vivo; mice)</td><td align="left" valign="top" rowspan="1" colspan="1">Jiang X et al<xref rid="b117-ijn-9-4153" ref-type="bibr">117</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"><italic>101F6</italic> (tumor suppressor gene) nanoparticles</td><td align="left" valign="top" rowspan="1" colspan="1">Increased tumor cell lysis (in vitro and in vivo; mice)</td><td align="left" valign="top" rowspan="1" colspan="1">Ohtani S et al<xref rid="b118-ijn-9-4153" ref-type="bibr">118</xref></td></tr></tbody></table><table-wrap-foot><fn id="tfn1-ijn-9-4153"><p><bold>Abbreviations:</bold> HA, hydroxyapatite; ECM, extracellular matrix; Akt, protein kinase B; PVA/PCL, poly(vinyl alcohol) poly(caprolactone); POSS-PCU, polyhedral oligomeric silsesquioxane with polycarbonate polyurethane; MWCNT, multiwalled carbon nanotube; poly(hb/gel/fib), poly(hemoglobin/gelatin/fibrinogen); PGS, poly(glycerol sebacate); PHEMA, poly(2-hydroxyethyl methacrylate); BBB, blood–brain barrier; MSCs, mesenchymal stem cells; MI, myocardial infarction; Si-RNA, small interfering ribonucleic acid; IGF-1, insulin-like growth factor-1.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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