Vitamin D Supplementation Enhances the Fixation of Titanium Implants in Chronic Kidney Disease Mice
Identifieur interne : 000750 ( Pmc/Curation ); précédent : 000749; suivant : 000751Vitamin D Supplementation Enhances the Fixation of Titanium Implants in Chronic Kidney Disease Mice
Auteurs : Weiqing Liu [République populaire de Chine] ; Shiwen Zhang [République populaire de Chine] ; Dan Zhao [République populaire de Chine] ; Huawei Zou [République populaire de Chine] ; Ningyuan Sun [République populaire de Chine] ; Xing Liang [République populaire de Chine] ; Michel Dard [États-Unis] ; Beate Lanske [États-Unis] ; Quan Yuan [République populaire de Chine]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
Vitamin D (Vit D) deficiency is a common condition in chronic kidney disease (CKD) patients that negatively affects bone regeneration and fracture healing. Previous study has shown that timely healing of titanium implants is impaired in CKD. This study aimed to investigate the effect of Vit D supplementation on implant osseointegration in CKD mice. Uremia was induced by 5/6 nephrectomy in C57BL mice. Eight weeks after the second renal surgery, animals were given 1,25(OH)2D3 three times a week intraperitoneally for four weeks. Experimental titanium implants were inserted into the distal end of femurs two weeks later. Serum measurements confirmed decreased 1,25(OH)2D levels in CKD mice, which could be successfully corrected by Vit D injections. Moreover, the hyperparathyroidism observed in CKD mice was also corrected. X-ray examination and histological sections showed successful osseointegration in these mice. Histomorphometrical analysis revealed that the bone-implant contact (BIC) ratio and bone volume (BV/TV) around the implant were significantly increased in the Vit D-supplementation group. In addition, resistance of the implant, as measured by a push-in method, was significantly improved compared to that in the vehicle group. These results demonstrate that Vit D supplementation is an effective approach to improve the fixation of titanium implants in CKD.
Url:
DOI: 10.1371/journal.pone.0095689
PubMed: 24752599
PubMed Central: 3994107
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wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Shiwen" sort="Zhang, Shiwen" uniqKey="Zhang S" first="Shiwen" last="Zhang">Shiwen Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Dan" sort="Zhao, Dan" uniqKey="Zhao D" first="Dan" last="Zhao">Dan Zhao</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu</wicri:regionArea></affiliation></author><author><name sortKey="Zou, Huawei" sort="Zou, Huawei" uniqKey="Zou H" first="Huawei" last="Zou">Huawei Zou</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Ningyuan" sort="Sun, Ningyuan" uniqKey="Sun N" first="Ningyuan" last="Sun">Ningyuan Sun</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu</wicri:regionArea></affiliation></author><author><name sortKey="Liang, Xing" sort="Liang, Xing" uniqKey="Liang X" first="Xing" last="Liang">Xing Liang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu</wicri:regionArea></affiliation></author><author><name sortKey="Dard, Michel" sort="Dard, Michel" uniqKey="Dard M" first="Michel" last="Dard">Michel Dard</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York</wicri:regionArea></affiliation></author><author><name sortKey="Lanske, Beate" sort="Lanske, Beate" uniqKey="Lanske B" first="Beate" last="Lanske">Beate Lanske</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental medicine, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Yuan, Quan" sort="Yuan, Quan" uniqKey="Yuan Q" first="Quan" last="Yuan">Quan Yuan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu</wicri:regionArea></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Vitamin D (Vit D) deficiency is a common condition in chronic kidney disease (CKD) patients that negatively affects bone regeneration and fracture healing. Previous study has shown that timely healing of titanium implants is impaired in CKD. This study aimed to investigate the effect of Vit D supplementation on implant osseointegration in CKD mice. Uremia was induced by 5/6 nephrectomy in C57BL mice. Eight weeks after the second renal surgery, animals were given 1,25(OH)<sub>2</sub>D<sub>3</sub> three times a week intraperitoneally for four weeks. Experimental titanium implants were inserted into the distal end of femurs two weeks later. Serum measurements confirmed decreased 1,25(OH)<sub>2</sub>D levels in CKD mice, which could be successfully corrected by Vit D injections. Moreover, the hyperparathyroidism observed in CKD mice was also corrected. X-ray examination and histological sections showed successful osseointegration in these mice. Histomorphometrical analysis revealed that the bone-implant contact (BIC) ratio and bone volume (BV/TV) around the implant were significantly increased in the Vit D-supplementation group. In addition, resistance of the implant, as measured by a push-in method, was significantly improved compared to that in the vehicle group. These results demonstrate that Vit D supplementation is an effective approach to improve the fixation of titanium implants in CKD.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Moe, S" uniqKey="Moe S">S Moe</name></author><author><name sortKey="Drueke, T" uniqKey="Drueke T">T Drueke</name></author><author><name sortKey="Cunningham, J" uniqKey="Cunningham J">J Cunningham</name></author><author><name sortKey="Goodman, W" uniqKey="Goodman W">W Goodman</name></author><author><name sortKey="Martin, K" uniqKey="Martin K">K Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="National Kidney, F" uniqKey="National Kidney F">F National Kidney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levey, As" uniqKey="Levey A">AS Levey</name></author><author><name sortKey="Atkins, R" uniqKey="Atkins R">R Atkins</name></author><author><name sortKey="Coresh, J" 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24752599</article-id><article-id pub-id-type="pmc">3994107</article-id><article-id pub-id-type="publisher-id">PONE-D-13-44576</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0095689</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biology and Life Sciences</subject><subj-group><subject>Anatomy</subject><subj-group><subject>Biological Tissue</subject><subj-group><subject>Connective Tissue</subject><subj-group><subject>Bone</subject></subj-group></subj-group></subj-group><subj-group><subject>Musculoskeletal System</subject></subj-group></subj-group><subj-group><subject>Biochemistry</subject><subj-group><subject>Metabolism</subject><subj-group><subject>Bone and Mineral Metabolism</subject></subj-group></subj-group></subj-group><subj-group><subject>Nutrition</subject><subj-group><subject>Nutrients</subject><subj-group><subject>Vitamins</subject></subj-group></subj-group><subj-group><subject>Nutritional Deficiencies</subject><subj-group><subject>Micronutrient Deficiencies</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine and Health Sciences</subject><subj-group><subject>Nephrology</subject><subj-group><subject>Chronic Kidney Disease</subject><subject>Mineral Metabolism and the Kidney</subject></subj-group></subj-group><subj-group><subject>Oral Medicine</subject><subj-group><subject>Dentistry</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Research and Analysis Methods</subject><subj-group><subject>Model Organisms</subject><subj-group><subject>Animal Models</subject><subj-group><subject>Mouse Models</subject></subj-group></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Vitamin D Supplementation Enhances the Fixation of Titanium Implants in Chronic Kidney Disease Mice</article-title><alt-title alt-title-type="running-head">Vit D Enhances Implant Fixation in CKD</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Weiqing</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Shiwen</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Dan</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zou</surname><given-names>Huawei</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sun</surname><given-names>Ningyuan</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Liang</surname><given-names>Xing</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dard</surname><given-names>Michel</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lanske</surname><given-names>Beate</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yuan</surname><given-names>Quan</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York, United States of America</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental medicine, Boston, Massachusetts, United States of America</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Burdmann</surname><given-names>Emmanuel A.</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>University of Sao Paulo Medical School, Brazil</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>yuanquan@scu.edu.cn</email></corresp><fn fn-type="conflict"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: QY BL MD. Performed the experiments: WL SZ DZ HZ NS. Analyzed the data: WL XL QY. Contributed reagents/materials/analysis tools: MD BL. Wrote the paper: WL BL QY.</p></fn></author-notes><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>21</day><month>4</month><year>2014</year></pub-date><pub-date pub-type="ecorrected"><day>21</day><month>5</month><year>2014</year></pub-date><volume>9</volume><issue>4</issue><elocation-id>e95689</elocation-id><history><date date-type="received"><day>31</day><month>10</month><year>2013</year></date><date date-type="accepted"><day>30</day><month>3</month><year>2014</year></date></history><permissions><copyright-year>2014</copyright-year><copyright-holder>Liu et al</copyright-holder><license><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><p>Vitamin D (Vit D) deficiency is a common condition in chronic kidney disease (CKD) patients that negatively affects bone regeneration and fracture healing. Previous study has shown that timely healing of titanium implants is impaired in CKD. This study aimed to investigate the effect of Vit D supplementation on implant osseointegration in CKD mice. Uremia was induced by 5/6 nephrectomy in C57BL mice. Eight weeks after the second renal surgery, animals were given 1,25(OH)<sub>2</sub>D<sub>3</sub> three times a week intraperitoneally for four weeks. Experimental titanium implants were inserted into the distal end of femurs two weeks later. Serum measurements confirmed decreased 1,25(OH)<sub>2</sub>D levels in CKD mice, which could be successfully corrected by Vit D injections. Moreover, the hyperparathyroidism observed in CKD mice was also corrected. X-ray examination and histological sections showed successful osseointegration in these mice. Histomorphometrical analysis revealed that the bone-implant contact (BIC) ratio and bone volume (BV/TV) around the implant were significantly increased in the Vit D-supplementation group. In addition, resistance of the implant, as measured by a push-in method, was significantly improved compared to that in the vehicle group. These results demonstrate that Vit D supplementation is an effective approach to improve the fixation of titanium implants in CKD.</p></abstract><funding-group><funding-statement>This work was supported by grants from the National Natural Science Foundation of China (NSFC 81371173), New Century Excellent Talents in University (NCET-12-0379) and International Team of Implantology (ITI 717_2010) to Q.Y., and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, R01-073944) to B.L. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="6"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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