Wnt signaling during tooth replacement in zebrafish (Danio rerio): pitfalls and perspectives
Identifieur interne : 000548 ( Pmc/Curation ); précédent : 000547; suivant : 000549Wnt signaling during tooth replacement in zebrafish (Danio rerio): pitfalls and perspectives
Auteurs : Ann Huysseune ; Mieke Soenens ; Fien ElderweirdtSource :
- Frontiers in Physiology [ 1664-042X ] ; 2014.
Abstract
The canonical (β-catenin dependent) Wnt signaling pathway has emerged as a likely candidate for regulating tooth replacement in continuously renewing dentitions. So far, the involvement of canonical Wnt signaling has been experimentally demonstrated predominantly in amniotes. These studies tend to show stimulation of tooth formation by activation of the Wnt pathway, and inhibition of tooth formation when blocking the pathway. Here, we report a strong and dynamic expression of the soluble Wnt inhibitor
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DOI: 10.3389/fphys.2014.00386
PubMed: 25339911
PubMed Central: 4186270
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Wnt signaling during tooth replacement in zebrafish (<italic>Danio rerio</italic>): pitfalls and perspectives</title><author><name sortKey="Huysseune, Ann" sort="Huysseune, Ann" uniqKey="Huysseune A" first="Ann" last="Huysseune">Ann Huysseune</name></author><author><name sortKey="Soenens, Mieke" sort="Soenens, Mieke" uniqKey="Soenens M" first="Mieke" last="Soenens">Mieke Soenens</name></author><author><name sortKey="Elderweirdt, Fien" sort="Elderweirdt, Fien" uniqKey="Elderweirdt F" first="Fien" last="Elderweirdt">Fien Elderweirdt</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25339911</idno><idno type="pmc">4186270</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186270</idno><idno type="RBID">PMC:4186270</idno><idno type="doi">10.3389/fphys.2014.00386</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000548</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000548</idno><idno type="wicri:Area/Pmc/Curation">000548</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000548</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Wnt signaling during tooth replacement in zebrafish (<italic>Danio rerio</italic>): pitfalls and perspectives</title><author><name sortKey="Huysseune, Ann" sort="Huysseune, Ann" uniqKey="Huysseune A" first="Ann" last="Huysseune">Ann Huysseune</name></author><author><name sortKey="Soenens, Mieke" sort="Soenens, Mieke" uniqKey="Soenens M" first="Mieke" last="Soenens">Mieke Soenens</name></author><author><name sortKey="Elderweirdt, Fien" sort="Elderweirdt, Fien" uniqKey="Elderweirdt F" first="Fien" last="Elderweirdt">Fien Elderweirdt</name></author></analytic><series><title level="j">Frontiers in Physiology</title><idno type="eISSN">1664-042X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The canonical (β-catenin dependent) Wnt signaling pathway has emerged as a likely candidate for regulating tooth replacement in continuously renewing dentitions. So far, the involvement of canonical Wnt signaling has been experimentally demonstrated predominantly in amniotes. These studies tend to show stimulation of tooth formation by activation of the Wnt pathway, and inhibition of tooth formation when blocking the pathway. Here, we report a strong and dynamic expression of the soluble Wnt inhibitor <italic>dickkopf1</italic> (<italic>dkk1</italic>) in developing zebrafish (<italic>Danio rerio</italic>) tooth germs, suggesting an active repression of Wnt signaling during morphogenesis and cytodifferentiation of a tooth, and derepression of Wnt signaling during start of replacement tooth formation. To further analyse the role of Wnt signaling, we used different gain-of-function approaches. These yielded disjunct results, yet none of them indicating enhanced tooth replacement. Thus, masterblind (<italic>mbl</italic>) mutants, defective in <italic>axin1</italic>, mimic overexpression of Wnt, but display a normally patterned dentition in which teeth are replaced at the appropriate times and positions. Activating the pathway with LiCl had variable outcomes, either resulting in the absence, or the delayed formation, of first-generation teeth, or yielding a regular dentition with normal replacement, but no supernumerary teeth or accelerated tooth replacement. The failure so far to influence tooth replacement in the zebrafish by perturbing Wnt signaling is discussed in the light of (i) potential technical pitfalls related to dose- or time-dependency, (ii) the complexity of the canonical Wnt pathway, and (iii) species-specific differences in the nature and activity of pathway components. Finally, we emphasize the importance of in-depth knowledge of the wild-type pattern for reliable interpretations. It is hoped that our analysis can be inspiring to critically assess and elucidate the role of Wnt signaling in tooth development in polyphyodonts.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ahn, Y" uniqKey="Ahn Y">Y. Ahn</name></author><author><name sortKey="Sanderson, B W" uniqKey="Sanderson B">B. W. Sanderson</name></author><author><name sortKey="Klein, O D" uniqKey="Klein O">O. D. Klein</name></author><author><name sortKey="Krumlauf, R" uniqKey="Krumlauf R">R. Krumlauf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andl, T" uniqKey="Andl T">T. Andl</name></author><author><name sortKey="Reddy, S T" uniqKey="Reddy S">S. T. Reddy</name></author><author><name sortKey="Gaddapara, T" uniqKey="Gaddapara T">T. Gaddapara</name></author><author><name sortKey="Millar, S E" uniqKey="Millar S">S. E. Millar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baarsma, H A" uniqKey="Baarsma H">H. A. Baarsma</name></author><author><name sortKey="Konigshoff, M" uniqKey="Konigshoff M">M. Königshoff</name></author><author><name sortKey="Gosens, R" uniqKey="Gosens R">R. Gosens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bao, J" uniqKey="Bao J">J. Bao</name></author><author><name sortKey="Zheng, J J" uniqKey="Zheng J">J. J. Zheng</name></author><author><name sortKey="Wu, D" uniqKey="Wu D">D. Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Borday Birraux, V" uniqKey="Borday Birraux V">V. Borday-Birraux</name></author><author><name sortKey="Van Der Heyden, C" uniqKey="Van Der Heyden C">C. Van der heyden</name></author><author><name sortKey="Debiais Thibaud, M" uniqKey="Debiais Thibaud M">M. Debiais-Thibaud</name></author><author><name sortKey="Verreijdt, L" uniqKey="Verreijdt L">L. Verreijdt</name></author><author><name sortKey="Stock, D W" uniqKey="Stock D">D. W. Stock</name></author><author><name sortKey="Huysseune, A" uniqKey="Huysseune A">A. Huysseune</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brembeck, F H" uniqKey="Brembeck F">F. H. Brembeck</name></author><author><name sortKey="Rosario, M" uniqKey="Rosario M">M. Rosario</name></author><author><name sortKey="Birchmeier, W" uniqKey="Birchmeier W">W. Birchmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bruhn, L" uniqKey="Bruhn L">L. Bruhn</name></author><author><name sortKey="Munnerlyn, A" uniqKey="Munnerlyn A">A. Munnerlyn</name></author><author><name sortKey="Grosschedl, R" uniqKey="Grosschedl R">R. Grosschedl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name></author><author><name sortKey="Lan, Y" uniqKey="Lan Y">Y. Lan</name></author><author><name sortKey="Baek, J A" uniqKey="Baek J">J.-A. Baek</name></author><author><name sortKey="Gao, Y" uniqKey="Gao Y">Y. Gao</name></author><author><name sortKey="Jiang, R" uniqKey="Jiang R">R. Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clevers, H" uniqKey="Clevers H">H. Clevers</name></author><author><name sortKey="Nusse, R" uniqKey="Nusse R">R. Nusse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, P" uniqKey="Cohen P">P. Cohen</name></author><author><name sortKey="Goedert, M" uniqKey="Goedert M">M. Goedert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Denayer, T" uniqKey="Denayer T">T. Denayer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Esteve, P" uniqKey="Esteve P">P. Esteve</name></author><author><name sortKey="Sandonis, A" uniqKey="Sandonis A">A. Sandonìs</name></author><author><name sortKey="Iba Ez, C" uniqKey="Iba Ez C">C. Ibañez</name></author><author><name sortKey="Shimono, A" uniqKey="Shimono A">A. Shimono</name></author><author><name sortKey="Guerrero, I" uniqKey="Guerrero I">I. Guerrero</name></author><author><name sortKey="Bovolenta, P" uniqKey="Bovolenta P">P. Bovolenta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fagotto, F" uniqKey="Fagotto F">F. Fagotto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fjeld, K" uniqKey="Fjeld K">K. Fjeld</name></author><author><name sortKey="Kettunen, P" uniqKey="Kettunen P">P. Kettunen</name></author><author><name sortKey="Furmanek, T" uniqKey="Furmanek T">T. Furmanek</name></author><author><name sortKey="Kvinnsland, I H" uniqKey="Kvinnsland I">I. H. Kvinnsland</name></author><author><name sortKey="Luukko, K" uniqKey="Luukko K">K. Luukko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fraser, G J" uniqKey="Fraser G">G. J. Fraser</name></author><author><name sortKey="Bloomquist, R F" uniqKey="Bloomquist R">R. F. Bloomquist</name></author><author><name sortKey="Streelman, J T" uniqKey="Streelman J">J. T. Streelman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gaete, M" uniqKey="Gaete M">M. Gaete</name></author><author><name sortKey="Tucker, A S" uniqKey="Tucker A">A. S. Tucker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, C" uniqKey="Gao C">C. Gao</name></author><author><name sortKey="Xiao, G" uniqKey="Xiao G">G. Xiao</name></author><author><name sortKey="Hu, J" uniqKey="Hu J">J. Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glinka, A" uniqKey="Glinka A">A. Glinka</name></author><author><name sortKey="Wu, W" uniqKey="Wu W">W. Wu</name></author><author><name sortKey="Delius, H" uniqKey="Delius H">H. Delius</name></author><author><name sortKey="Monaghan, A P" uniqKey="Monaghan A">A. P. Monaghan</name></author><author><name sortKey="Blumenstock, C" uniqKey="Blumenstock C">C. Blumenstock</name></author><author><name sortKey="Niehrs, C" uniqKey="Niehrs C">C. Niehrs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Handrigan, G R" uniqKey="Handrigan G">G. R. Handrigan</name></author><author><name sortKey="Leung, K J" uniqKey="Leung K">K. J. Leung</name></author><author><name sortKey="Richman, J M" uniqKey="Richman J">J. M. Richman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Handrigan, G R" uniqKey="Handrigan G">G. R. Handrigan</name></author><author><name sortKey="Richman, J M" uniqKey="Richman J">J. M. Richman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haramis, A P" uniqKey="Haramis A">A. P. Haramis</name></author><author><name sortKey="Hurlstone, A" uniqKey="Hurlstone A">A. Hurlstone</name></author><author><name sortKey="Van Der Velden, Y" uniqKey="Van Der Velden Y">Y. van der Velden</name></author><author><name sortKey="Begthel, H" uniqKey="Begthel H">H. Begthel</name></author><author><name sortKey="Van Den Born, M" uniqKey="Van Den Born M">M. van den Born</name></author><author><name sortKey="Offerhaus, G J" uniqKey="Offerhaus G">G. J. Offerhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hashimoto, H" uniqKey="Hashimoto H">H. Hashimoto</name></author><author><name sortKey="Itoh, M" uniqKey="Itoh M">M. Itoh</name></author><author><name sortKey="Yamanaka, Y" uniqKey="Yamanaka Y">Y. Yamanaka</name></author><author><name sortKey="Yamashita, S" uniqKey="Yamashita S">S. Yamashita</name></author><author><name sortKey="Shimizu, T" uniqKey="Shimizu T">T. Shimizu</name></author><author><name sortKey="Solnica Krezel, L" uniqKey="Solnica Krezel L">L. Solnica-Krezel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heisenberg, C P" uniqKey="Heisenberg C">C.-P. Heisenberg</name></author><author><name sortKey="Houart, C" uniqKey="Houart C">C. Houart</name></author><author><name sortKey="Takeuchi, M" uniqKey="Takeuchi M">M. Takeuchi</name></author><author><name sortKey="Rauch, G J" uniqKey="Rauch G">G.-J. Rauch</name></author><author><name sortKey="Young, N" uniqKey="Young N">N. Young</name></author><author><name sortKey="Coutinho, P" uniqKey="Coutinho P">P. Coutinho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huelsken, J" uniqKey="Huelsken J">J. Huelsken</name></author><author><name sortKey="Vogel, R" uniqKey="Vogel R">R. Vogel</name></author><author><name sortKey="Erdmann, B" uniqKey="Erdmann B">B. Erdmann</name></author><author><name sortKey="Cotsarelis, G" uniqKey="Cotsarelis G">G. Cotsarelis</name></author><author><name sortKey="Birchmeier, W" uniqKey="Birchmeier W">W. Birchmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hurlstone, A F L" uniqKey="Hurlstone A">A. F. L. Hurlstone</name></author><author><name sortKey="Haramis, A P G" uniqKey="Haramis A">A.-P. G. Haramis</name></author><author><name sortKey="Wienholds, E" uniqKey="Wienholds E">E. Wienholds</name></author><author><name sortKey="Begthel, H" uniqKey="Begthel H">H. Begthel</name></author><author><name sortKey="Korving, J" uniqKey="Korving J">J. Korving</name></author><author><name sortKey="Van Eeden, F" uniqKey="Van Eeden F">F. van Eeden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huysseune, A" uniqKey="Huysseune A">A. Huysseune</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huysseune, A" uniqKey="Huysseune A">A. Huysseune</name></author><author><name sortKey="Delgado, S" uniqKey="Delgado S">S. Delgado</name></author><author><name sortKey="Witten, P E" uniqKey="Witten P">P. E. Witten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huysseune, A" uniqKey="Huysseune A">A. Huysseune</name></author><author><name sortKey="Sire, J Y" uniqKey="Sire J">J.-Y. Sire</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huysseune, A" uniqKey="Huysseune A">A. Huysseune</name></author><author><name sortKey="Sire, J Y" uniqKey="Sire J">J.-Y. Sire</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huysseune, A" uniqKey="Huysseune A">A. Huysseune</name></author><author><name sortKey="Thesleff, I" uniqKey="Thesleff I">I. Thesleff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ishitani, T" uniqKey="Ishitani T">T. Ishitani</name></author><author><name sortKey="Ninomiya Tsuji, J" uniqKey="Ninomiya Tsuji J">J. Ninomiya-Tsuji</name></author><author><name sortKey="Matsumoto, K" uniqKey="Matsumoto K">K. Matsumoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jackman, W R" uniqKey="Jackman W">W. R. Jackman</name></author><author><name sortKey="Davies, S H" uniqKey="Davies S">S. H. Davies</name></author><author><name sortKey="Lyons, D B" uniqKey="Lyons D">D. B. Lyons</name></author><author><name sortKey="Stauder, C K" uniqKey="Stauder C">C. K. Stauder</name></author><author><name sortKey="Denton Schneider, B R" uniqKey="Denton Schneider B">B. R. Denton-Schneider</name></author><author><name sortKey="Jowdry, A" uniqKey="Jowdry A">A. Jowdry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jackman, W R" uniqKey="Jackman W">W. R. Jackman</name></author><author><name sortKey="Draper, B W" uniqKey="Draper B">B. W. Draper</name></author><author><name sortKey="Stock, D W" uniqKey="Stock D">D. W. Stock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="J Rvinen, E" uniqKey="J Rvinen E">E. Järvinen</name></author><author><name sortKey="Salazar Ciudad, I" uniqKey="Salazar Ciudad I">I. Salazar-Ciudad</name></author><author><name sortKey="Birchmeier, W" uniqKey="Birchmeier W">W. Birchmeier</name></author><author><name sortKey="Taketo, M M" uniqKey="Taketo M">M. M. Taketo</name></author><author><name sortKey="Jernvall, J" uniqKey="Jernvall J">J. Jernvall</name></author><author><name sortKey="Thesleff, I" uniqKey="Thesleff I">I. Thesleff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jernvall, J" uniqKey="Jernvall J">J. Jernvall</name></author><author><name sortKey="Thesleff, I" uniqKey="Thesleff I">I. Thesleff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jho, E H" uniqKey="Jho E">E. H. Jho</name></author><author><name sortKey="Zhang, T" uniqKey="Zhang T">T. Zhang</name></author><author><name sortKey="Domon, C" uniqKey="Domon C">C. Domon</name></author><author><name sortKey="Joo, C K" uniqKey="Joo C">C. K. Joo</name></author><author><name sortKey="Freund, J N" uniqKey="Freund J">J. N. Freund</name></author><author><name sortKey="Costantini, F" uniqKey="Costantini F">F. Costantini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Joly, J S" uniqKey="Joly J">J.-S. Joly</name></author><author><name sortKey="Joly, C" uniqKey="Joly C">C. Joly</name></author><author><name sortKey="Schulte Merker, S" uniqKey="Schulte Merker S">S. Schulte-Merker</name></author><author><name sortKey="Boulekbache, H" uniqKey="Boulekbache H">H. Boulekbache</name></author><author><name sortKey="Condamine, H" uniqKey="Condamine H">H. Condamine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kapsimali, M" uniqKey="Kapsimali M">M. Kapsimali</name></author><author><name sortKey="Kaushik, A L" uniqKey="Kaushik A">A.-L. Kaushik</name></author><author><name sortKey="Gibon, G" uniqKey="Gibon G">G. Gibon</name></author><author><name sortKey="Dirian, L" uniqKey="Dirian L">L. Dirian</name></author><author><name sortKey="Ernest, S" uniqKey="Ernest S">S. Ernest</name></author><author><name sortKey="Rosa, F M" uniqKey="Rosa F">F. M. Rosa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawano, Y" uniqKey="Kawano Y">Y. Kawano</name></author><author><name sortKey="Kypta, R" uniqKey="Kypta R">R. Kypta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kestler, H A" uniqKey="Kestler H">H. A. Kestler</name></author><author><name sortKey="Kuhl, M" uniqKey="Kuhl M">M. Kühl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lammi, L" uniqKey="Lammi L">L. Lammi</name></author><author><name sortKey="Arte, S" uniqKey="Arte S">S. Arte</name></author><author><name sortKey="Somer, M" uniqKey="Somer M">M. Somer</name></author><author><name sortKey="J Rvinen, H" uniqKey="J Rvinen H">H. Järvinen</name></author><author><name sortKey="Lahermo, P" uniqKey="Lahermo P">P. Lahermo</name></author><author><name sortKey="Thesleff, I" uniqKey="Thesleff I">I. Thesleff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lan, Y" uniqKey="Lan Y">Y. Lan</name></author><author><name sortKey="Jia, S" uniqKey="Jia S">S. Jia</name></author><author><name sortKey="Jiang, R" uniqKey="Jiang R">R. Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laurenti, P" uniqKey="Laurenti P">P. Laurenti</name></author><author><name sortKey="Thaeron, C" uniqKey="Thaeron C">C. Thaëron</name></author><author><name sortKey="Allizard, F" uniqKey="Allizard F">F. Allizard</name></author><author><name sortKey="Huysseune, A" uniqKey="Huysseune A">A. Huysseune</name></author><author><name sortKey="Sire, J Y" uniqKey="Sire J">J.-Y. Sire</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, F" uniqKey="Liu F">F. Liu</name></author><author><name sortKey="Chu, E Y" uniqKey="Chu E">E. Y. Chu</name></author><author><name sortKey="Watt, B" uniqKey="Watt B">B. Watt</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Gallant, N M" uniqKey="Gallant N">N. M. Gallant</name></author><author><name sortKey="Andl, T" uniqKey="Andl T">T. Andl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Logan, C Y" uniqKey="Logan C">C. Y. Logan</name></author><author><name sortKey="Nusse, R" uniqKey="Nusse R">R. Nusse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcgraw, H F" uniqKey="Mcgraw H">H. F. McGraw</name></author><author><name sortKey="Drerup, C M" uniqKey="Drerup C">C. M. Drerup</name></author><author><name sortKey="Culbertson, M D" uniqKey="Culbertson M">M. D. Culbertson</name></author><author><name sortKey="Linbo, T" uniqKey="Linbo T">T. Linbo</name></author><author><name sortKey="Raible, D W" uniqKey="Raible D">D. W. Raible</name></author><author><name sortKey="Nechiporuk, A V" uniqKey="Nechiporuk A">A. V. Nechiporuk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monaghan, A P" uniqKey="Monaghan A">A. P. Monaghan</name></author><author><name sortKey="Kioschis, P" uniqKey="Kioschis P">P. Kioschis</name></author><author><name sortKey="Wu, W" uniqKey="Wu W">W. Wu</name></author><author><name sortKey="Zuniga, A" uniqKey="Zuniga A">A. Zuniga</name></author><author><name sortKey="Bock, D" uniqKey="Bock D">D. Bock</name></author><author><name sortKey="Poustka, A" uniqKey="Poustka A">A. Poustka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moriguchi, M" uniqKey="Moriguchi M">M. Moriguchi</name></author><author><name sortKey="Kosika, M" uniqKey="Kosika M">M. Kosika</name></author><author><name sortKey="Miake, Y" uniqKey="Miake Y">Y. Miake</name></author><author><name sortKey="Yamaguchi, Y" uniqKey="Yamaguchi Y">Y. Yamaguchi</name></author><author><name sortKey="Yamazaki, T" uniqKey="Yamazaki T">T. Yamazaki</name></author><author><name sortKey="Yamamoto, H" uniqKey="Yamamoto H">H. Yamamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Munne, P M" uniqKey="Munne P">P. M. Munne</name></author><author><name sortKey="Tummers, M" uniqKey="Tummers M">M. Tummers</name></author><author><name sortKey="J Rvinen, E" uniqKey="J Rvinen E">E. Järvinen</name></author><author><name sortKey="Thesleff, I" uniqKey="Thesleff I">I. Thesleff</name></author><author><name sortKey="Jernvall, J" uniqKey="Jernvall J">J. Jernvall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Niehrs, C" uniqKey="Niehrs C">C. Niehrs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Niida, A" uniqKey="Niida A">A. Niida</name></author><author><name sortKey="Hiroko, T" uniqKey="Hiroko T">T. Hiroko</name></author><author><name sortKey="Kasai, M" uniqKey="Kasai M">M. Kasai</name></author><author><name sortKey="Furukawa, Y" uniqKey="Furukawa Y">Y. Furukawa</name></author><author><name sortKey="Nakamura, Y" uniqKey="Nakamura Y">Y. Nakamura</name></author><author><name sortKey="Suzuki, Y" uniqKey="Suzuki Y">Y. Suzuki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parsons, K J" uniqKey="Parsons K">K. J. Parsons</name></author><author><name sortKey="Taylor, A T" uniqKey="Taylor A">A. T. Taylor</name></author><author><name sortKey="Powder, K E" uniqKey="Powder K">K. E. Powder</name></author><author><name sortKey="Albertson, R C" uniqKey="Albertson R">R. C. Albertson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Porntaveetus, T" uniqKey="Porntaveetus T">T. Porntaveetus</name></author><author><name sortKey="Ohazama, A" uniqKey="Ohazama A">A. Ohazama</name></author><author><name sortKey="Choi, H Y" uniqKey="Choi H">H. Y. Choi</name></author><author><name sortKey="Herz, J" uniqKey="Herz J">J. Herz</name></author><author><name sortKey="Sharpe, P T" uniqKey="Sharpe P">P. T. Sharpe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richman, J M" uniqKey="Richman J">J. M. Richman</name></author><author><name sortKey="Handrigan, G R" uniqKey="Handrigan G">G. R. Handrigan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, D M" uniqKey="Roberts D">D. M. Roberts</name></author><author><name sortKey="Pronobis, M I" uniqKey="Pronobis M">M. I. Pronobis</name></author><author><name sortKey="Poulton, J S" uniqKey="Poulton J">J. S. Poulton</name></author><author><name sortKey="Waldmann, J D" uniqKey="Waldmann J">J. D. Waldmann</name></author><author><name sortKey="Stephenson, E M" uniqKey="Stephenson E">E. M. Stephenson</name></author><author><name sortKey="Hanna, S" uniqKey="Hanna S">S. Hanna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Robertson, J K" uniqKey="Robertson J">J. K. Robertson</name></author><author><name sortKey="Danzmann, K" uniqKey="Danzmann K">K. Danzmann</name></author><author><name sortKey="Charles, S" uniqKey="Charles S">S. Charles</name></author><author><name sortKey="Blake, K" uniqKey="Blake K">K. Blake</name></author><author><name sortKey="Olivares, A" uniqKey="Olivares A">A. Olivares</name></author><author><name sortKey="Bamikole, S" uniqKey="Bamikole S">S. Bamikole</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sarkar, L" uniqKey="Sarkar L">L. Sarkar</name></author><author><name sortKey="Sharpe, P T" uniqKey="Sharpe P">P. T. Sharpe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sick, S" uniqKey="Sick S">S. Sick</name></author><author><name sortKey="Reinker, S" uniqKey="Reinker S">S. Reinker</name></author><author><name sortKey="Timmer, J" uniqKey="Timmer J">J. Timmer</name></author><author><name sortKey="Schlake, T" uniqKey="Schlake T">T. Schlake</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, X" uniqKey="Song X">X. Song</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S. Wang</name></author><author><name sortKey="Li, L" uniqKey="Li L">L. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Staal, F J T" uniqKey="Staal F">F. J. T. Staal</name></author><author><name sortKey="Van Noort, M" uniqKey="Van Noort M">M. van Noort</name></author><author><name sortKey="Strous, G J" uniqKey="Strous G">G. J. Strous</name></author><author><name sortKey="Clevers, H C" uniqKey="Clevers H">H. C. Clevers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stoick Cooper, C L" uniqKey="Stoick Cooper C">C. L. Stoick-Cooper</name></author><author><name sortKey="Weidinger, G" uniqKey="Weidinger G">G. Weidinger</name></author><author><name sortKey="Riehle, K J" uniqKey="Riehle K">K. J. Riehle</name></author><author><name sortKey="Hubbert, C" uniqKey="Hubbert C">C. Hubbert</name></author><author><name sortKey="Major, M B" uniqKey="Major M">M. B. Major</name></author><author><name sortKey="Fausto, N" uniqKey="Fausto N">N. Fausto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thakker, N" uniqKey="Thakker N">N. Thakker</name></author><author><name sortKey="Davies, R" uniqKey="Davies R">R. Davies</name></author><author><name sortKey="Homer, K" uniqKey="Homer K">K. Homer</name></author><author><name sortKey="Armstrong, J" uniqKey="Armstrong J">J. Armstrong</name></author><author><name sortKey="Clancy, T" uniqKey="Clancy T">T. Clancy</name></author><author><name sortKey="Guy, S" uniqKey="Guy S">S. Guy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thorpe, C J" uniqKey="Thorpe C">C. J. Thorpe</name></author><author><name sortKey="Moon, R T" uniqKey="Moon R">R. T. Moon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tucker, A S" uniqKey="Tucker A">A. S. Tucker</name></author><author><name sortKey="Fraser, G J" uniqKey="Fraser G">G. J. Fraser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Untergasser, G" uniqKey="Untergasser G">G. Untergasser</name></author><author><name sortKey="Martowicz, A" uniqKey="Martowicz A">A. Martowicz</name></author><author><name sortKey="Hermann, M" uniqKey="Hermann M">M. Hermann</name></author><author><name sortKey="Tochterle, S" uniqKey="Tochterle S">S. Töchterle</name></author><author><name sortKey="Meyer, D" uniqKey="Meyer D">D. Meyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Amerongen, R" uniqKey="Van Amerongen R">R. van Amerongen</name></author><author><name sortKey="Nawijn, M" uniqKey="Nawijn M">M. Nawijn</name></author><author><name sortKey="Franca Koh, J" uniqKey="Franca Koh J">J. Franca-Koh</name></author><author><name sortKey="Zevenhoven, J" uniqKey="Zevenhoven J">J. Zevenhoven</name></author><author><name sortKey="Van Der Gulden, H" uniqKey="Van Der Gulden H">H. van der Gulden</name></author><author><name sortKey="Jonkers, J" uniqKey="Jonkers J">J. Jonkers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Heyden, C" uniqKey="Van Der Heyden C">C. Van der heyden</name></author><author><name sortKey="Allizard, F" uniqKey="Allizard F">F. Allizard</name></author><author><name sortKey="Sire, J Y" uniqKey="Sire J">J.-Y. Sire</name></author><author><name sortKey="Huysseune, A" uniqKey="Huysseune A">A. Huysseune</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Heyden, C" uniqKey="Van Der Heyden C">C. Van der heyden</name></author><author><name sortKey="Huysseune, A" uniqKey="Huysseune A">A. Huysseune</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van De Water, S" uniqKey="Van De Water S">S. van de Water</name></author><author><name sortKey="Van De Wetering, M" uniqKey="Van De Wetering M">M. van de Wetering</name></author><author><name sortKey="Joore, J" uniqKey="Joore J">J. Joore</name></author><author><name sortKey="Esseling, J" uniqKey="Esseling J">J. Esseling</name></author><author><name sortKey="Bink, R" uniqKey="Bink R">R. Bink</name></author><author><name sortKey="Clevers, H" uniqKey="Clevers H">H. Clevers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verstraeten, B" uniqKey="Verstraeten B">B. Verstraeten</name></author><author><name sortKey="Sanders, E" uniqKey="Sanders E">E. Sanders</name></author><author><name sortKey="Huysseune, A" uniqKey="Huysseune A">A. Huysseune</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wada, H" uniqKey="Wada H">H. Wada</name></author><author><name sortKey="Ghysen, A" uniqKey="Ghysen A">A. Ghysen</name></author><author><name sortKey="Asakawa, K" uniqKey="Asakawa K">K. Asakawa</name></author><author><name sortKey="Abe, G" uniqKey="Abe G">G. Abe</name></author><author><name sortKey="Ishitani, T" uniqKey="Ishitani T">T. Ishitani</name></author><author><name sortKey="Kawakami, K" uniqKey="Kawakami K">K. Kawakami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, X P" uniqKey="Wang X">X.-P. Wang</name></author><author><name sortKey="Fan, J" uniqKey="Fan J">J. Fan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, X P" uniqKey="Wang X">X.-P. Wang</name></author><author><name sortKey="O Connell, D J" uniqKey="O Connell D">D. J. O'Connell</name></author><author><name sortKey="Lund, J J" uniqKey="Lund J">J. J. Lund</name></author><author><name sortKey="Saadi, I" uniqKey="Saadi I">I. Saadi</name></author><author><name sortKey="Kuraguchi, M" uniqKey="Kuraguchi M">M. Kuraguchi</name></author><author><name sortKey="Turbe Doan, A" uniqKey="Turbe Doan A">A. Turbe-Doan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wautier, K" uniqKey="Wautier K">K. Wautier</name></author><author><name sortKey="Van Der Heyden, C" uniqKey="Van Der Heyden C">C. Van der heyden</name></author><author><name sortKey="Huysseune, A" uniqKey="Huysseune A">A. Huysseune</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weeks, O" uniqKey="Weeks O">O. Weeks</name></author><author><name sortKey="Bhullar, B A S" uniqKey="Bhullar B">B.-A. S. Bhullar</name></author><author><name sortKey="Abzhanov, A" uniqKey="Abzhanov A">A. Abzhanov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, P" uniqKey="Wu P">P. Wu</name></author><author><name sortKey="Wu, X" uniqKey="Wu X">X. Wu</name></author><author><name sortKey="Jiang, T X" uniqKey="Jiang T">T.-X. Jiang</name></author><author><name sortKey="Elsey, R M" uniqKey="Elsey R">R. M. Elsey</name></author><author><name sortKey="Temple, B L" uniqKey="Temple B">B. L. Temple</name></author><author><name sortKey="Divers, S J" uniqKey="Divers S">S. J. Divers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yost, C" uniqKey="Yost C">C. Yost</name></author><author><name sortKey="Farr, G H" uniqKey="Farr G">G. H. Farr</name></author><author><name sortKey="Pierce, S B" uniqKey="Pierce S">S. B. Pierce</name></author><author><name sortKey="Ferkey, D M" uniqKey="Ferkey D">D. M. Ferkey</name></author><author><name sortKey="Chen, M M" uniqKey="Chen M">M. M. Chen</name></author><author><name sortKey="Kimelman, D" uniqKey="Kimelman D">D. Kimelman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zarnescu, O" uniqKey="Zarnescu O">O. Zarnescu</name></author><author><name sortKey="Stavri, S" uniqKey="Stavri S">S. Stavri</name></author><author><name sortKey="Moldovan, L" uniqKey="Moldovan L">L. Moldovan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeng, L" uniqKey="Zeng L">L. Zeng</name></author><author><name sortKey="Fagotto, F" uniqKey="Fagotto F">F. Fagotto</name></author><author><name sortKey="Zhang, T" uniqKey="Zhang T">T. Zhang</name></author><author><name sortKey="Hsu, W" uniqKey="Hsu W">W. Hsu</name></author><author><name sortKey="Vasicek, T J" uniqKey="Vasicek T">T. J. Vasicek</name></author><author><name sortKey="Perry, W L" uniqKey="Perry W">W. L. Perry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, X J" uniqKey="Zhu X">X. J. Zhu</name></author><author><name sortKey="Zhao, P" uniqKey="Zhao P">P. Zhao</name></author><author><name sortKey="Liu, Y D" uniqKey="Liu Y">Y. D. Liu</name></author><author><name sortKey="Zhang, X Y" uniqKey="Zhang X">X. Y. Zhang</name></author><author><name sortKey="Fu, J" uniqKey="Fu J">J. Fu</name></author><author><name sortKey="Yu, H M I" uniqKey="Yu H">H.-M. I. Yu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Physiol</journal-id><journal-id journal-id-type="iso-abbrev">Front Physiol</journal-id><journal-id journal-id-type="publisher-id">Front. Physiol.</journal-id><journal-title-group><journal-title>Frontiers in Physiology</journal-title></journal-title-group><issn pub-type="epub">1664-042X</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25339911</article-id><article-id pub-id-type="pmc">4186270</article-id><article-id pub-id-type="doi">10.3389/fphys.2014.00386</article-id><article-categories><subj-group subj-group-type="heading"><subject>Physiology</subject><subj-group><subject>Original Research Article</subject></subj-group></subj-group></article-categories><title-group><article-title>Wnt signaling during tooth replacement in zebrafish (<italic>Danio rerio</italic>): pitfalls and perspectives</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Huysseune</surname><given-names>Ann</given-names></name><xref ref-type="author-notes" rid="fn001"><sup>*</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/18053"></uri></contrib><contrib contrib-type="author"><name><surname>Soenens</surname><given-names>Mieke</given-names></name><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/182689"></uri></contrib><contrib contrib-type="author"><name><surname>Elderweirdt</surname><given-names>Fien</given-names></name><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/172286"></uri></contrib></contrib-group><aff><institution>Evolutionary Developmental Biology Research Group, Biology Department, Ghent University</institution><country>Ghent, Belgium</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Cyril Charles, Ecole Normale Supérieure de Lyon, France</p></fn><fn fn-type="edited-by"><p>Reviewed by: Eumorphia Remboutsika, Biomedical Sciences Research Center “Alexander Fleming”, Greece; David W. Stock, University of Colorado, USA; Claudio Cantù, University of Zurich, Switzerland</p></fn><corresp id="fn001">*Correspondence: Ann Huysseune, Evolutionary Developmental Biology, Biology Department, Ghent University, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium e-mail: <email xlink:type="simple">ann.huysseune@ugent.be</email></corresp><fn fn-type="other" id="fn002"><p>This article was submitted to Craniofacial Biology, a section of the journal Frontiers in Physiology.</p></fn></author-notes><pub-date pub-type="epub"><day>06</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="collection"><year>2014</year></pub-date><volume>5</volume><elocation-id>386</elocation-id><history><date date-type="received"><day>05</day><month>7</month><year>2014</year></date><date date-type="accepted"><day>18</day><month>9</month><year>2014</year></date></history><permissions><copyright-statement>Copyright © 2014 Huysseune, Soenens and Elderweirdt.</copyright-statement><copyright-year>2014</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>The canonical (β-catenin dependent) Wnt signaling pathway has emerged as a likely candidate for regulating tooth replacement in continuously renewing dentitions. So far, the involvement of canonical Wnt signaling has been experimentally demonstrated predominantly in amniotes. These studies tend to show stimulation of tooth formation by activation of the Wnt pathway, and inhibition of tooth formation when blocking the pathway. Here, we report a strong and dynamic expression of the soluble Wnt inhibitor <italic>dickkopf1</italic> (<italic>dkk1</italic>) in developing zebrafish (<italic>Danio rerio</italic>) tooth germs, suggesting an active repression of Wnt signaling during morphogenesis and cytodifferentiation of a tooth, and derepression of Wnt signaling during start of replacement tooth formation. To further analyse the role of Wnt signaling, we used different gain-of-function approaches. These yielded disjunct results, yet none of them indicating enhanced tooth replacement. Thus, masterblind (<italic>mbl</italic>) mutants, defective in <italic>axin1</italic>, mimic overexpression of Wnt, but display a normally patterned dentition in which teeth are replaced at the appropriate times and positions. Activating the pathway with LiCl had variable outcomes, either resulting in the absence, or the delayed formation, of first-generation teeth, or yielding a regular dentition with normal replacement, but no supernumerary teeth or accelerated tooth replacement. The failure so far to influence tooth replacement in the zebrafish by perturbing Wnt signaling is discussed in the light of (i) potential technical pitfalls related to dose- or time-dependency, (ii) the complexity of the canonical Wnt pathway, and (iii) species-specific differences in the nature and activity of pathway components. Finally, we emphasize the importance of in-depth knowledge of the wild-type pattern for reliable interpretations. It is hoped that our analysis can be inspiring to critically assess and elucidate the role of Wnt signaling in tooth development in polyphyodonts.</p></abstract><kwd-group><kwd>Wnt</kwd><kwd>tooth replacement</kwd><kwd>zebrafish</kwd><kwd>dickkopf</kwd><kwd>polyphyodont</kwd><kwd>axin</kwd><kwd>APC</kwd><kwd>LiCl</kwd></kwd-group><counts><fig-count count="5"></fig-count><table-count count="1"></table-count><equation-count count="0"></equation-count><ref-count count="80"></ref-count><page-count count="11"></page-count><word-count count="8667"></word-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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