Determination of the Dynamics of Healing at the Tissue-Implant Interface by Means of Microcomputed Tomography and Functional Apparent Moduli
Identifieur interne : 000420 ( Pmc/Curation ); précédent : 000419; suivant : 000421Determination of the Dynamics of Healing at the Tissue-Implant Interface by Means of Microcomputed Tomography and Functional Apparent Moduli
Auteurs : Po-Chun Chang [Singapour] ; Yang-Jo Seol [Corée du Sud] ; Steven A. Goldstein [États-Unis] ; William V. Giannobile [États-Unis]Source :
- The International journal of oral & maxillofacial implants [ 0882-2786 ] ; 2013.
Abstract
It is currently a challenge to determine the biomechanical properties of the hard tissue–dental implant interface. Recent advances in intraoral imaging and tomographic methods, such as microcomputed tomography (micro-CT), provide three-dimensional details, offering significant potential to evaluate the bone-implant interface, but yield limited information regarding osseointegration because of physical scattering effects emanating from metallic implant surfaces. In the present study, it was hypothesized that functional apparent moduli (FAM), generated from functional incorporation of the peri-implant structure, would eliminate the radiographic artifact–affected layer and serve as a feasible means to evaluate the biomechanical dynamics of tissue-implant integration in vivo.
Cylindric titanium mini-implants were placed in osteotomies and osteotomies with defects in rodent maxillae. The layers affected by radiographic artifacts were identified, and the pattern of tissue-implant integration was evaluated from histology and micro-CT images over a 21-day observation period. Analyses of structural information, FAM, and the relationship between FAM and interfacial stiffness (IS) were done before and after eliminating artifacts.
Physical artifacts were present within a zone of about 100 to 150 μm around the implant in both experimental defect situations (osteotomy alone and osteotomy + defect). All correlations were evaluated before and after eliminating the artifact-affected layers, most notably during the maturation period of osseointegration. A strong correlation existed between functional bone apparent modulus and IS within 300 μm at the osteotomy defects (r > 0.9) and functional composite tissue apparent modulus in the osteotomy defects (r > 0.75).
Micro-CT imaging and FAM were of value in measuring the temporal process of tissue-implant integration in vivo. This approach will be useful to complement imaging technologies for longitudinal monitoring of osseointegration.
Url:
PubMed: 23377049
PubMed Central: 4111564
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<author><name sortKey="Chang, Po Chun" sort="Chang, Po Chun" uniqKey="Chang P" first="Po-Chun" last="Chang">Po-Chun Chang</name>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title>
<p id="P1">It is currently a challenge to determine the biomechanical properties of the hard tissue–dental implant interface. Recent advances in intraoral imaging and tomographic methods, such as microcomputed tomography (micro-CT), provide three-dimensional details, offering significant potential to evaluate the bone-implant interface, but yield limited information regarding osseointegration because of physical scattering effects emanating from metallic implant surfaces. In the present study, it was hypothesized that functional apparent moduli (FAM), generated from functional incorporation of the peri-implant structure, would eliminate the radiographic artifact–affected layer and serve as a feasible means to evaluate the biomechanical dynamics of tissue-implant integration in vivo.</p>
</sec>
<sec id="S2"><title>Materials and Methods</title>
<p id="P2">Cylindric titanium mini-implants were placed in osteotomies and osteotomies with defects in rodent maxillae. The layers affected by radiographic artifacts were identified, and the pattern of tissue-implant integration was evaluated from histology and micro-CT images over a 21-day observation period. Analyses of structural information, FAM, and the relationship between FAM and interfacial stiffness (IS) were done before and after eliminating artifacts.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Physical artifacts were present within a zone of about 100 to 150 μm around the implant in both experimental defect situations (osteotomy alone and osteotomy + defect). All correlations were evaluated before and after eliminating the artifact-affected layers, most notably during the maturation period of osseointegration. A strong correlation existed between functional bone apparent modulus and IS within 300 μm at the osteotomy defects (r > 0.9) and functional composite tissue apparent modulus in the osteotomy defects (r > 0.75).</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">Micro-CT imaging and FAM were of value in measuring the temporal process of tissue-implant integration in vivo. This approach will be useful to complement imaging technologies for longitudinal monitoring of osseointegration.</p>
</sec>
</div>
</front>
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<journal-id journal-id-type="nlm-ta">Int J Oral Maxillofac Implants</journal-id>
<journal-id journal-id-type="iso-abbrev">Int J Oral Maxillofac Implants</journal-id>
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<title-group><article-title>Determination of the Dynamics of Healing at the Tissue-Implant Interface by Means of Microcomputed Tomography and Functional Apparent Moduli</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Chang</surname>
<given-names>Po-Chun</given-names>
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<degrees>DDS, PhD</degrees>
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<contrib contrib-type="author"><name><surname>Seol</surname>
<given-names>Yang-Jo</given-names>
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<contrib contrib-type="author"><name><surname>Goldstein</surname>
<given-names>Steven A.</given-names>
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<degrees>PhD</degrees>
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<contrib contrib-type="author"><name><surname>Giannobile</surname>
<given-names>William V.</given-names>
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<aff id="A1"><label>1</label>
Researcher, Department of Periodontics and Oral Medicine, School of Dentistry; Researcher, Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, Michigan, USA; Current Position, Assistant Professor, Discipline of Periodontics, Faculty of Dentistry, National University of Singapore, Singapore</aff>
<aff id="A2"><label>2</label>
Researcher, Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA; Current Position, Associate Professor, Department of Periodontology, School of Dentistry, Seoul National University, Seoul, Korea</aff>
<aff id="A3"><label>3</label>
Professor, Department of Biomedical Engineering, College of Engineering; Professor, Department of Orthopedic Surgery, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA</aff>
<aff id="A4"><label>4</label>
Professor, Department of Periodontics and Oral Medicine, School of Dentistry; Professor, Department of Biomedical Engineering, College of Engineering; Director, Michigan Center for Oral Health Research, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA</aff>
<author-notes><corresp id="FN1">Correspondence to: Dr Po-Chun Chang, National University of Singapore, Faculty of Dentistry, 11 Lower Kent Ridge Road, Singapore 119083, Singapore. Fax: +65-6773-2602. <email>dencpc@nus.edu.sg</email>
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<pub-date pub-type="nihms-submitted"><day>13</day>
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<year>2014</year>
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<year>2013</year>
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<pub-date pub-type="pmc-release"><day>25</day>
<month>7</month>
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<permissions><copyright-statement>©2013 by Quintessence Publishing Co Inc.</copyright-statement>
<copyright-year>2013</copyright-year>
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<abstract><sec id="S1"><title>Purpose</title>
<p id="P1">It is currently a challenge to determine the biomechanical properties of the hard tissue–dental implant interface. Recent advances in intraoral imaging and tomographic methods, such as microcomputed tomography (micro-CT), provide three-dimensional details, offering significant potential to evaluate the bone-implant interface, but yield limited information regarding osseointegration because of physical scattering effects emanating from metallic implant surfaces. In the present study, it was hypothesized that functional apparent moduli (FAM), generated from functional incorporation of the peri-implant structure, would eliminate the radiographic artifact–affected layer and serve as a feasible means to evaluate the biomechanical dynamics of tissue-implant integration in vivo.</p>
</sec>
<sec id="S2"><title>Materials and Methods</title>
<p id="P2">Cylindric titanium mini-implants were placed in osteotomies and osteotomies with defects in rodent maxillae. The layers affected by radiographic artifacts were identified, and the pattern of tissue-implant integration was evaluated from histology and micro-CT images over a 21-day observation period. Analyses of structural information, FAM, and the relationship between FAM and interfacial stiffness (IS) were done before and after eliminating artifacts.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Physical artifacts were present within a zone of about 100 to 150 μm around the implant in both experimental defect situations (osteotomy alone and osteotomy + defect). All correlations were evaluated before and after eliminating the artifact-affected layers, most notably during the maturation period of osseointegration. A strong correlation existed between functional bone apparent modulus and IS within 300 μm at the osteotomy defects (r > 0.9) and functional composite tissue apparent modulus in the osteotomy defects (r > 0.75).</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">Micro-CT imaging and FAM were of value in measuring the temporal process of tissue-implant integration in vivo. This approach will be useful to complement imaging technologies for longitudinal monitoring of osseointegration.</p>
</sec>
</abstract>
<kwd-group><kwd>biomechanics</kwd>
<kwd>dental implants</kwd>
<kwd>finite element analysis</kwd>
<kwd>microcomputed tomography</kwd>
</kwd-group>
</article-meta>
</front>
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