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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dental implant survival in diabetic patients; review and recommendations</title><author><name sortKey="Dubey, Rajendra Kumar" sort="Dubey, Rajendra Kumar" uniqKey="Dubey R" first="Rajendra Kumar" last="Dubey">Rajendra Kumar Dubey</name><affiliation><nlm:aff id="aff1">Department of Prosthodontics, Government Dental College, Raipur, Chhattisgarh, India</nlm:aff></affiliation></author><author><name sortKey="Gupta, Deepesh Kumar" sort="Gupta, Deepesh Kumar" uniqKey="Gupta D" first="Deepesh Kumar" last="Gupta">Deepesh Kumar Gupta</name><affiliation><nlm:aff id="aff1">Department of Prosthodontics, Government Dental College, Raipur, Chhattisgarh, India</nlm:aff></affiliation></author><author><name sortKey="Singh, Amit Kumar" sort="Singh, Amit Kumar" uniqKey="Singh A" first="Amit Kumar" last="Singh">Amit Kumar Singh</name><affiliation><nlm:aff id="aff2">Department of Prosthodontics, PIDS, Gorakhpur, Uttar Pradesh, India</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24665167</idno><idno type="pmc">3961886</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961886</idno><idno type="RBID">PMC:3961886</idno><idno type="doi">10.4103/0975-5950.127642</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000848</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000848</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Dental implant survival in diabetic patients; review and recommendations</title><author><name sortKey="Dubey, Rajendra Kumar" sort="Dubey, Rajendra Kumar" uniqKey="Dubey R" first="Rajendra Kumar" last="Dubey">Rajendra Kumar Dubey</name><affiliation><nlm:aff id="aff1">Department of Prosthodontics, Government Dental College, Raipur, Chhattisgarh, India</nlm:aff></affiliation></author><author><name sortKey="Gupta, Deepesh Kumar" sort="Gupta, Deepesh Kumar" uniqKey="Gupta D" first="Deepesh Kumar" last="Gupta">Deepesh Kumar Gupta</name><affiliation><nlm:aff id="aff1">Department of Prosthodontics, Government Dental College, Raipur, Chhattisgarh, India</nlm:aff></affiliation></author><author><name sortKey="Singh, Amit Kumar" sort="Singh, Amit Kumar" uniqKey="Singh A" first="Amit Kumar" last="Singh">Amit Kumar Singh</name><affiliation><nlm:aff id="aff2">Department of Prosthodontics, PIDS, Gorakhpur, Uttar Pradesh, India</nlm:aff></affiliation></author></analytic><series><title level="j">National Journal of Maxillofacial Surgery</title><idno type="ISSN">0975-5950</idno><idno type="eISSN">2229-3418</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Rising population of diabetic individuals across the world has become a big concern to the society. The persistent hyperglycemia may affect each and every tissue and consequently results in morbidity and eventually mortality in diabetic patients. A direct negative response of diabetes has been observed on oral tissues with few contradictions however, little are known about effect of diabetes on dental implant treatment and the consequent results. Many studies concerned with osteointegration and prognosis of dental implant in diabetic patients have been conducted and published since 1994. These studies have been critically reviewed to understand the impact of diabetes on the success of dental implant and the factors to improve osseointegration and consequently survival of dental implant in diabetic patients. Theoretical literatures and studies in diabetic animals substantiate high failure rate of implants but most of clinical studies indicated statistically insignificant failure of dental implants even in moderately uncontrolled diabetic patients. Success of dental implant in well and fairly controlled diabetic patients with proper treatment planning, prophylactic remedies and adequate postsurgical maintenance appears as good as normal individuals.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Yang, W" uniqKey="Yang W">W Yang</name></author><author><name sortKey="Lu, J" uniqKey="Lu J">J Lu</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Jia, W" uniqKey="Jia W">W Jia</name></author><author><name sortKey="Ji, L" uniqKey="Ji L">L Ji</name></author><author><name sortKey="Xiao, J" uniqKey="Xiao J">J Xiao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vaz, Nc" uniqKey="Vaz N">NC Vaz</name></author><author><name sortKey="Ferreira, Am" uniqKey="Ferreira A">AM Ferreira</name></author><author><name sortKey="Kulkarni, Ms" uniqKey="Kulkarni M">MS Kulkarni</name></author><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Natl J Maxillofac Surg</journal-id><journal-id journal-id-type="iso-abbrev">Natl J Maxillofac Surg</journal-id><journal-id journal-id-type="publisher-id">NJMS</journal-id><journal-title-group><journal-title>National Journal of Maxillofacial Surgery</journal-title></journal-title-group><issn pub-type="ppub">0975-5950</issn><issn pub-type="epub">2229-3418</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24665167</article-id><article-id pub-id-type="pmc">3961886</article-id><article-id pub-id-type="publisher-id">NJMS-4-142</article-id><article-id pub-id-type="doi">10.4103/0975-5950.127642</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title>Dental implant survival in diabetic patients; review and recommendations</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Dubey</surname><given-names>Rajendra Kumar</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Gupta</surname><given-names>Deepesh Kumar</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Singh</surname><given-names>Amit Kumar</given-names></name><xref ref-type="aff" rid="aff2">1</xref></contrib></contrib-group><aff id="aff1">Department of Prosthodontics, Government Dental College, Raipur, Chhattisgarh, India</aff><aff id="aff2"><label>1</label>Department of Prosthodontics, PIDS, Gorakhpur, Uttar Pradesh, India</aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Dr. Rajendra Kumar Dubey, Department of Prosthodontics, Government Dental College, Raipur, Chhattisgarh, India. E-mail: <email xlink:href="rkdubey2005@yahoo.co.in">rkdubey2005@yahoo.co.in</email></corresp></author-notes><pub-date pub-type="ppub"><season>Jul-Dec</season><year>2013</year></pub-date><volume>4</volume><issue>2</issue><fpage>142</fpage><lpage>150</lpage><permissions><copyright-statement>Copyright: © National Journal of Maxillofacial Surgery</copyright-statement><copyright-year>2013</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Rising population of diabetic individuals across the world has become a big concern to the society. The persistent hyperglycemia may affect each and every tissue and consequently results in morbidity and eventually mortality in diabetic patients. A direct negative response of diabetes has been observed on oral tissues with few contradictions however, little are known about effect of diabetes on dental implant treatment and the consequent results. Many studies concerned with osteointegration and prognosis of dental implant in diabetic patients have been conducted and published since 1994. These studies have been critically reviewed to understand the impact of diabetes on the success of dental implant and the factors to improve osseointegration and consequently survival of dental implant in diabetic patients. Theoretical literatures and studies in diabetic animals substantiate high failure rate of implants but most of clinical studies indicated statistically insignificant failure of dental implants even in moderately uncontrolled diabetic patients. Success of dental implant in well and fairly controlled diabetic patients with proper treatment planning, prophylactic remedies and adequate postsurgical maintenance appears as good as normal individuals.</p></abstract><kwd-group><kwd>Dental implant</kwd><kwd>hyperglycemia</kwd><kwd>osteointegration</kwd></kwd-group></article-meta></front><body><sec id="sec1-1"><title>I<sc>NTRODUCTION</sc></title><p>The recent studies in China[<xref rid="ref1" ref-type="bibr">1</xref>] and India[<xref rid="ref2" ref-type="bibr">2</xref>] has shown that the number of diabetic individuals has surpassed the estimate of IDF-2009[<xref rid="ref3" ref-type="bibr">3</xref>] i.e., approximately 285 million people worldwide will have diabetes in 2010 and by 2030, 438 million people of adult population is expected to have diabetes with majority of effected population from China, India and USA.</p><p>The comforts like natural dentition, conservative treatment compared to teeth supported FPDs and long term success for the edentulous patients, as well as partially edentulous patients have made dental implants supported prosthetic treatment as an attractive substitute to traditional removable or fixed dental prosthesis besides being costly and lengthy procedures with surgical intervention.[<xref rid="ref4" ref-type="bibr">4</xref><xref rid="ref5" ref-type="bibr">5</xref><xref rid="ref6" ref-type="bibr">6</xref>] The growing economy of developing nations like china and India has also been playing a key role in popularizing the implant dental treatment. In light of above facts, the dental fraternity may encounter with more number of diabetic patients for dental implant treatments.</p><p>Diabetes mellitus is a chronic disorder of carbohydrate metabolism characterized by hyperglycemia, reflecting distortion in physiological equilibrium in utilization of glucose by tissue, liberation of glucose by liver and production-liberation of pancreatic anterior pituitary and adrenocortical hormone. The debilitating characteristic of diabetes mellitus was known as early as in second century AD, when Areteous named it as diabetes means “a siphon” as he perceived that the condition was characterized by melting down of flesh and limb into urine.[<xref rid="ref7" ref-type="bibr">7</xref>] Various modern research and discoveries have shown that diabetes mellitus, more or less, affects every tissues of body directly or indirectly through late complications [<xref ref-type="table" rid="T1">Table 1</xref>].[<xref rid="ref8" ref-type="bibr">8</xref>] Concerning the effect on oral tissues, Loe.[<xref rid="ref9" ref-type="bibr">9</xref>] recognized the periodontal disease as sixth major complication of diabetes. Number of studies has proved the adverse effect of chronic hyperglycemia on oral mucosa and with some controversies on alveolar bone.</p><table-wrap id="T1" position="float"><label>Table 1</label><caption><p>Late-onset complications of diabetes</p></caption><graphic xlink:href="NJMS-4-142-g001"></graphic></table-wrap><p>This review caters actual scenario to practicing dentists regarding success and failure of dental implant treatment in diabetic individuals observed by various studies. The experience based suggestions and experimental studies about increasing osteointegration and consequently improving success rate of dental implant treatment in diabetic patients have also been discussed.</p><sec id="sec2-1"><title>Effect of diabetes on bone and osteointegration</title><p>The persistent hyperglycemia in diabetic individuals, inhibit osteoblastic activity and alters the response of parathyroid hormone that regulates metabolism of Ca and P,[<xref rid="ref10" ref-type="bibr">10</xref>] decreases collagen formation during callus formation,[<xref rid="ref11" ref-type="bibr">11</xref>] induces apoptosis in lining cells of bone[<xref rid="ref12" ref-type="bibr">12</xref>] and increases osteoclastic activity[<xref rid="ref13" ref-type="bibr">13</xref><xref rid="ref14" ref-type="bibr">14</xref>] due to persistent inflammatory response. It also induces deleterious effect on bone matrix and diminishes growth and accumulation of extracellular matrix.[<xref rid="ref15" ref-type="bibr">15</xref>] The consequent result is diminished bone formation during healing, which is observed in number of experimental animal studies.[<xref rid="ref16" ref-type="bibr">16</xref><xref rid="ref17" ref-type="bibr">17</xref><xref rid="ref18" ref-type="bibr">18</xref><xref rid="ref19" ref-type="bibr">19</xref>]</p><p>Type -1 diabetes causes decreased bone mineral density, as well as reduced bone formation and higher bone resorption[<xref rid="ref20" ref-type="bibr">20</xref>] whereas Type -2 diabetes produces normal or greater bone mineral density in some patients.[<xref rid="ref21" ref-type="bibr">21</xref>] It has been observed that insulin not only reduces the deleterious effect of hyperglycemia by controlling it but also stimulates osteoblastic activity. Hence, bone matrix formation in insulin treated experimental models is similar to control ones.[<xref rid="ref22" ref-type="bibr">22</xref>]</p><p>Most of the studies have been performed in streptozotocin/alloxan induced diabetic experimental models (rat/rabbit) to observe osseointegration of implants. Histo-chemical/histomorphic/planimetric/biomechanical torque/manometric analysis showed that bone volume formed in diabetic animals was similar to non-diabetic animals[<xref rid="ref23" ref-type="bibr">23</xref>] however, bone implant contact (BIC) in diabetic animals was lesser compared to non-diabetics.[<xref rid="ref24" ref-type="bibr">24</xref>] The rate of mineral apposition in newly formed bone and bone density around implant was significantly less in uncontrolled diabetic animals.[<xref rid="ref25" ref-type="bibr">25</xref>] The bone volume and bone density around implant in insulin controlled diabetic animals was observed similar or greater to non-diabetic but BIC was found significantly less[<xref rid="ref22" ref-type="bibr">22</xref><xref rid="ref26" ref-type="bibr">26</xref><xref rid="ref27" ref-type="bibr">27</xref><xref rid="ref28" ref-type="bibr">28</xref><xref rid="ref29" ref-type="bibr">29</xref><xref rid="ref30" ref-type="bibr">30</xref>](Even in insulin controlled diabetic animals).</p><p>Only few case studies for histological observation of dental implant osseointegration in human being have been reported. In one report,[<xref rid="ref31" ref-type="bibr">31</xref>] an implant was placed and intended to support an overdenture in 65-year-old diabetic women was retrieved after 2 months due to prosthetically unfavorable condition. In histological analysis, no symptoms of implant failure recognized with 80% bone implant contact ratio. A case of diabetes mellitus type-2 having implant failure within 6 months, was reported by Park JB[<xref rid="ref32" ref-type="bibr">32</xref>] with conclusion that osseointegration was not affected by diabetes mellitus as there was no sign and symptoms of failure before loading.</p></sec><sec id="sec2-2"><title>Success/failure of dental implants in diabetic patients</title><p>Most of the studies[<xref rid="ref43" ref-type="bibr">43</xref><xref rid="ref44" ref-type="bibr">44</xref><xref rid="ref46" ref-type="bibr">46</xref><xref rid="ref48" ref-type="bibr">48</xref>] observed slightly high percentage of early failure of implants in diabetics compared to late failure. Some reports[<xref rid="ref45" ref-type="bibr">45</xref><xref rid="ref46" ref-type="bibr">46</xref><xref rid="ref50" ref-type="bibr">50</xref>] indicated increased failure rate within first year of placement of implant. The published retrospective and prospective studies data, retrieved through various sources from 1994 to 2011 [<xref ref-type="table" rid="T2">Table 2</xref>], indicated that the success rate of dental implants in diabetic patients were in range of 85.5-100% and were comparable to the non-diabetic patients. Most of the studies were of opinion that success rate in well/fairly controlled diabetics was either equal or insignificantly lower than normal individuals. Two studies[<xref rid="ref36" ref-type="bibr">36</xref><xref rid="ref39" ref-type="bibr">39</xref>], has taken chance to involve uncontrolled diabetic patients for dental implantation and observed encouraging results as early implant success was similar to non-diabetics. However, it is noteworthy that number of patients and implants placed (4 implants in 3 patients) in uncontrolled diabetics was quite low and all the patients selected were free of micro and macro-vascular complications. Only two studies[<xref rid="ref36" ref-type="bibr">36</xref><xref rid="ref41" ref-type="bibr">41</xref>] reported significantly high failure of implant in diabetic patients even when glucose level was adequately under control. One of these studies retrospectively included early, as well as late failures of implants over the period of 10 years but did not specify the glycemic control over that period. While other study, prospective in nature, observed significantly high early failures with probable reason that placement of multiple adjoining implants in diabetic patients increased the failure rates due to large wound, delayed healing and greater force posed over implants. Inadequate time (study period 90 days only) provided for osseointegration and regaining stability to implant in the study seems to be the cause of observing very high failure in diabetic patients.</p><table-wrap id="T2" position="float"><label>Table 2</label><caption><p>Outcome of studies showing survival/success of dental implant in diabetic patients</p></caption><graphic xlink:href="NJMS-4-142-g002"></graphic></table-wrap><p>Most of the studies[<xref rid="ref43" ref-type="bibr">43</xref><xref rid="ref44" ref-type="bibr">44</xref><xref rid="ref46" ref-type="bibr">46</xref><xref rid="ref48" ref-type="bibr">48</xref>] observed slightly high percentage of early failure of implants in diabetics compared to late failure. Some reports[<xref rid="ref45" ref-type="bibr">45</xref><xref rid="ref46" ref-type="bibr">46</xref><xref rid="ref50" ref-type="bibr">50</xref>] indicated increased failure rate within first year of loading suggesting the risk of implant failure is associated with uncovering of implants and early phase of implant loading. T W Oates observation[<xref rid="ref35" ref-type="bibr">35</xref>] also supports high early failure in diabetic patients as such patients experienced low implant stability quotient (ISQ) in period of 2-12 weeks and lower the level of glycemic control, higher the amount of ISQ reduction and longer the duration of recovery in ISQ at base level was required. However, most of implants attained base level of stability within 4 months even in uncontrolled diabetic patients, if the patients were refrained with micro- and macro-vascular complications.</p><p>Duration of diabetes significantly affected the success of dental implant, observed in one study[<xref rid="ref48" ref-type="bibr">48</xref>] while another did not demonstrate significantly higher late implant failures in diabetic patients even with longer duration. Overall lower success of implant in patients with diabetes of longer duration may be due to higher chance of micro-vascular complications which consequently lead to delayed healing around implants and hence higher early failure.</p><p>Few studies,[<xref rid="ref40" ref-type="bibr">40</xref>] demonstrated significantly higher failure of implant in type-1 diabetic patients than patients with type-2 diabetes (in one study, only one implant placed in a person with diabetes type-1 and it failed i.e., failure rate = 100%, an extremely unlikely true estimate of risk). While one study[<xref rid="ref34" ref-type="bibr">34</xref>] did not find any significant difference in late failure of dental implant in type-1 and type-2 diabetic patients. Higher failure rate in diabetic type-1 may be due to depletion of insulin in tissues whereas presence of insulin in tissues of type-2 diabetic individuals may reduce deleterious effect of hyperglycemia. There is no study exclusively reported the survival/success of implant in type-1 diabetes however, very few retrospective studies had subject with type-1 and type-2 diabetes but little number of type-1 diabetic subjects.</p><p>Immediate loading did not significantly affect the survival of dental implant in diabetic patients provided their plasma glucose level were under normal range.[<xref rid="ref37" ref-type="bibr">37</xref><xref rid="ref39" ref-type="bibr">39</xref><xref rid="ref44" ref-type="bibr">44</xref><xref rid="ref45" ref-type="bibr">45</xref>] Balshi SF[<xref rid="ref39" ref-type="bibr">39</xref>] reported 100% survival of 18 implants after 2.5 years after placement followed by immediate loading with screwed retained fixed prosthesis in a 71-year-old diabetic patient. The study suggests that controlled mechanical stimuli over implant can be beneficial for osseointegration and implant survival.</p><p>The studies[<xref rid="ref37" ref-type="bibr">37</xref><xref rid="ref45" ref-type="bibr">45</xref>] observed lower survival of implant in diabetic patients of very old age group but difference was not statically significant. Although, none of the studies had compared success of implant in diabetic females and males but number of studies reported survival as good as in females compared to males in general population. The experience of surgeons and advance surgical process did not significantly affect success of dental implant in diabetics as observed in studies.[<xref rid="ref38" ref-type="bibr">38</xref><xref rid="ref46" ref-type="bibr">46</xref>]</p></sec><sec id="sec2-3"><title>Measures for improving success of dental implant in diabetics</title><p>Good glycemic control, preoperative and post-operative, is required to achieve improved osseointegration in diabetics.[<xref rid="ref51" ref-type="bibr">51</xref>] Prophylactic antibiotics [<xref ref-type="table" rid="T3">Table 3</xref>] have shown to be effective for success of dental implants in diabetic patients and use of 0. 12% chlorhexidine further improves the success rate.[<xref rid="ref45" ref-type="bibr">45</xref><xref rid="ref48" ref-type="bibr">48</xref><xref rid="ref49" ref-type="bibr">49</xref><xref rid="ref50" ref-type="bibr">50</xref><xref rid="ref51" ref-type="bibr">51</xref><xref rid="ref52" ref-type="bibr">52</xref>] Certain factors like implant surface characteristics (implant coated with bioactive material) and higher implant length and width has been shown to improve success rate of implant in diabetic patients. Some researcher has found positive results in experimental studies to improve osseointegration and results are yet to be verified in human being. In few studies,[<xref rid="ref53" ref-type="bibr">53</xref><xref rid="ref54" ref-type="bibr">54</xref>] it was observed that systemic administration of aminoguanidine reduced the deleterious effect of diabetes on osseointregration. Satana <italic>et al.</italic>[<xref rid="ref55" ref-type="bibr">55</xref>] used rhFGF2 (recombinant human fibroblast growth factor-2) encapsulated with poly glycosylated poly lactide (PGLA) membrane in calvarial defect of diabetic rat and formation of normal bone level was observed in histomorphic analysis. Wang <italic>et al.</italic>,[<xref rid="ref56" ref-type="bibr">56</xref>] in a study based on similar concept, used rrIGF-1(Recombinant rat insulin like growth factor) encapsulated with PGLA around Ti implant inserted in calvaria of diabetic rat. It was found in histomorphic analysis that diabetic rat with rrIGF-1 had higher BIC around the implant compare to rat without rrIGF-1 after 4-8 weeks of surgical placement. A recent hypothesis was made by Bai <italic>et al.</italic>[<xref rid="ref57" ref-type="bibr">57</xref>] that adiponectin, an insulin sensitive adipokine may improve osseointregration in diabetic patients by infusing it systemically or using locally as it has shown potent anti-inflammatory properties and increased bone density by enhancing osteoblast and inhibiting osteoclast formation.</p><table-wrap id="T3" position="float"><label>Table 3</label><caption><p>Prophylactic antibiotics and their doses</p></caption><graphic xlink:href="NJMS-4-142-g003"></graphic></table-wrap></sec></sec><sec sec-type="discussion" id="sec1-2"><title>D<sc>ISCUSSION</sc></title><p>Most of the experimental studies have been indicated that the bone matrix formation and bone mineralization was almost equal in controlled diabetic and non-diabetic animals but BIC was lower even in controlled diabetic subjects. Number of studies has proposed and explained mechanism of deleterious effect of diabetes over wound healing and true association (osseointegration) of bone to implant surface [Figures <xref ref-type="fig" rid="F1">1</xref> and <xref ref-type="fig" rid="F2">2</xref>]. However studies,[<xref rid="ref31" ref-type="bibr">31</xref><xref rid="ref32" ref-type="bibr">32</xref>] performed in humans specifically with diabetes type-2, observed insignificant effect over BIC and consequently good osseointegration of dental implant in controlled diabetic patients. As most of the experimental studies conducted in rats and rabbits, the architectural and compositional difference in bone, higher metabolic rate, very permissive bone healing, faster skeletal changes and bone turnover[<xref rid="ref58" ref-type="bibr">58</xref><xref rid="ref59" ref-type="bibr">59</xref>] may be the reason for the difference in results of experimental animals and humans. The difference in developing diabetes (alloxan or streptozotocin destruct beta cells of Langerhans consequently induces diabetes) in experimental animals and human being (type-2 diabetes develop due to glucose resistance at cellular level and higher level of glucose in tissue consequently suppress the function of beta cells of Langerhans in long duration) maybe one reason for the difference in BIC. The result of an experimental study in obese diabetic rat strengthens the above explanation, as no difference in BIC was observed in obese diabetic rat than normal one.[<xref rid="ref60" ref-type="bibr">60</xref>]</p><fig id="F1" position="float"><label>Figure 1</label><caption><p>Mechanism of development of diabetic complication</p></caption><graphic xlink:href="NJMS-4-142-g004"></graphic></fig><fig id="F2" position="float"><label>Figure 2</label><caption><p>Possible effects of diabetes over mechanism of osteointegration</p></caption><graphic xlink:href="NJMS-4-142-g005"></graphic></fig><p>Most of clinical studies reported success of dental implant in diabetic individual as good as normal peoples. The reason may appear to be the inclusion of controlled diabetics in the almost all studies. The persistent hyperglycemia is responsible for development of micro-vascular complication and consequently the early or late implant failure. Hence the uncontrolled level of diabetes, reflected through measurement of glycated hemoglobin HbAc1 (indicate average glucose level over preceding 2-3 months period,[<xref rid="ref61" ref-type="bibr">61</xref>] level 6 to 8 shows well controlled, 8.1 to 10 moderately controlled and more than 10 shows poorly controlled diabetes), persistent for longer duration with sign of micro-vascular complication may affect the success of dental implant significantly. However, none of the study included such uncontrolled patients or in other word it can be concluded that none of the surgeon had taken risk to insert dental implant in such human beings.</p><p>Even the fairly or moderately controlled diabetes persisting for very longer duration (more than 10 years) may produce complications and diminish the health of tissues. The compromised condition along with some unfavorable restorative factors may bargain the success of dental implants. Therefore, numerous factors associated with rehabilitation and diabetes itself, more or less, affect the survival of dental implant in diabetic subjects[<xref rid="ref62" ref-type="bibr">62</xref>] [<xref ref-type="table" rid="T4">Table 4</xref>]. Cautious consideration of the mentioned factors during rehabilitation improves the success and hence the survival of dental implants in diabetic individuals.</p><table-wrap id="T4" position="float"><label>Table 4</label><caption><p>Probable factors affecting survival of dental implants</p></caption><graphic xlink:href="NJMS-4-142-g006"></graphic></table-wrap></sec><sec sec-type="conclusions" id="sec1-3"><title>C<sc>ONCLUSION</sc></title><p>The survival of dental implant in well/fairly controlled diabetic patients appears as good as in general population. Use of prophylactic antibiotic, longer duration of post surgical antibiotic course, chlorhexidine mouth rinse, bioactive material coated implants and implant with higher width and length seems to further improve the survival of implant in diabetic individuals. Systemic administration of some insulin sensitive adipokine and use of local growth factors have been found to improve osseointegration in diabetic experimental animals but yet to be verified in human beings. However, it is advisable to delay the placement of implant in poorly controlled diabetics till the control of diabetes. Longer duration prospective clinical studies with greater number of diabetic individuals and non-diabetic controls are still required to develop better understanding of impact of diabetes over dental implant success.</p></sec></body><back><fn-group><fn fn-type="supported-by"><p><bold>Source of Support:</bold> Nil.</p></fn><fn fn-type="conflict"><p><bold>Conflict of Interest:</bold> None declared.</p></fn></fn-group><ref-list><title>R<sc>EFERENCES</sc></title><ref id="ref1"><label>1</label><element-citation publication-type="journal"><person-group 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