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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Narrow-diameter implants: Are they a predictable
treatment option? A literature review</title><author><name sortKey="Sierra Sanchez, Jose L" sort="Sierra Sanchez, Jose L" uniqKey="Sierra Sanchez J" first="José L." last="Sierra-Sánchez">José L. Sierra-Sánchez</name><affiliation><nlm:aff id="A1">Master in Advanced Oral Implantology Professor, Universidad Europea de Valencia</nlm:aff></affiliation></author><author><name sortKey="Martinez Gonzalez, Amparo" sort="Martinez Gonzalez, Amparo" uniqKey="Martinez Gonzalez A" first="Amparo" last="Martínez-González">Amparo Martínez-González</name><affiliation><nlm:aff id="A1">Master in Advanced Oral Implantology Professor, Universidad Europea de Valencia</nlm:aff></affiliation></author><author><name sortKey="Garcia Sala Bonmati, Fernando" sort="Garcia Sala Bonmati, Fernando" uniqKey="Garcia Sala Bonmati F" first="Fernando" last="García-Sala Bonmatí">Fernando García-Sala Bonmatí</name><affiliation><nlm:aff id="A1">Master in Advanced Oral Implantology Professor, Universidad Europea de Valencia</nlm:aff></affiliation></author><author><name sortKey="Ma Es Ferrer, Jose F" sort="Ma Es Ferrer, Jose F" uniqKey="Ma Es Ferrer J" first="José F." last="Ma Es-Ferrer">José F. Ma Es-Ferrer</name><affiliation><nlm:aff id="A1">Master in Advanced Oral Implantology Professor, Universidad Europea de Valencia</nlm:aff></affiliation></author><author><name sortKey="Brotons Oliver, Alejandro" sort="Brotons Oliver, Alejandro" uniqKey="Brotons Oliver A" first="Alejandro" last="Brotons-Oliver">Alejandro Brotons-Oliver</name><affiliation><nlm:aff id="A2">Master in Advanced Oral Implantology Director, Universidad Europea de Valencia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24316701</idno><idno type="pmc">3909436</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909436</idno><idno type="RBID">PMC:3909436</idno><idno type="doi">10.4317/medoral.19306</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000842</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000842</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Narrow-diameter implants: Are they a predictable
treatment option? A literature review</title><author><name sortKey="Sierra Sanchez, Jose L" sort="Sierra Sanchez, Jose L" uniqKey="Sierra Sanchez J" first="José L." last="Sierra-Sánchez">José L. Sierra-Sánchez</name><affiliation><nlm:aff id="A1">Master in Advanced Oral Implantology Professor, Universidad Europea de Valencia</nlm:aff></affiliation></author><author><name sortKey="Martinez Gonzalez, Amparo" sort="Martinez Gonzalez, Amparo" uniqKey="Martinez Gonzalez A" first="Amparo" last="Martínez-González">Amparo Martínez-González</name><affiliation><nlm:aff id="A1">Master in Advanced Oral Implantology Professor, Universidad Europea de Valencia</nlm:aff></affiliation></author><author><name sortKey="Garcia Sala Bonmati, Fernando" sort="Garcia Sala Bonmati, Fernando" uniqKey="Garcia Sala Bonmati F" first="Fernando" last="García-Sala Bonmatí">Fernando García-Sala Bonmatí</name><affiliation><nlm:aff id="A1">Master in Advanced Oral Implantology Professor, Universidad Europea de Valencia</nlm:aff></affiliation></author><author><name sortKey="Ma Es Ferrer, Jose F" sort="Ma Es Ferrer, Jose F" uniqKey="Ma Es Ferrer J" first="José F." last="Ma Es-Ferrer">José F. Ma Es-Ferrer</name><affiliation><nlm:aff id="A1">Master in Advanced Oral Implantology Professor, Universidad Europea de Valencia</nlm:aff></affiliation></author><author><name sortKey="Brotons Oliver, Alejandro" sort="Brotons Oliver, Alejandro" uniqKey="Brotons Oliver A" first="Alejandro" last="Brotons-Oliver">Alejandro Brotons-Oliver</name><affiliation><nlm:aff id="A2">Master in Advanced Oral Implantology Director, Universidad Europea de Valencia</nlm:aff></affiliation></author></analytic><series><title level="j">Medicina Oral, Patología Oral y Cirugía Bucal</title><idno type="ISSN">1698-4447</idno><idno type="eISSN">1698-6946</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Objective: To evaluate the predictability of narrow-diameter implants as a treatment option in routine clinical practice. A literature review was performed of studies reporting clinical results obtained with these implants. Survival rates, peri-implant bone loss and related complications were evaluated. The working hypothesis was that narrow-diameter implants offer clinical results similar to those obtained with implants of greater diameter.
Material and Methods: A Medline-PubMed search covering the period between 2002 and 2012 was carried out. Studies published in English and with a follow-up period of at least 12 months were considered for inclusion. A manual search was also conducted in different journals with an important impact factor.
Results: Twenty-one studies meeting the screening criteria were included in the literature review. A total of 2980 narrow-diameter implants placed in 1607 patients were analyzed.
Conclusions: The results obtained from the literature indicate that narrow-diameter implants are a predictable treatment option, since they afford clinical results comparable to those obtained with implants of greater diameter.
</p><p><bold> Key words:</bold>Narrow implant, survival rate, peri-implant bone loss, related complications.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Summers, Rb" uniqKey="Summers R">RB Summers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hammerle, Ch" uniqKey="Hammerle C">CH Hammerle</name></author><author><name sortKey="Jung, Re" uniqKey="Jung R">RE Jung</name></author><author><name sortKey="Feloutzis, A" uniqKey="Feloutzis A">A Feloutzis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcallister, Bs" uniqKey="Mcallister B">BS McAllister</name></author><author><name sortKey="Haghighat, K" uniqKey="Haghighat K">K Haghighat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scipioni, A" uniqKey="Scipioni A">A Scipioni</name></author><author><name sortKey="Bruschi, G" uniqKey="Bruschi G">G 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Med Oral Patol Oral Cir Bucal</journal-id><journal-id journal-id-type="iso-abbrev">Med Oral Patol Oral Cir Bucal</journal-id><journal-id journal-id-type="publisher-id">Medicina Oral S.L.</journal-id><journal-title-group><journal-title>Medicina Oral, Patología Oral y Cirugía Bucal</journal-title></journal-title-group><issn pub-type="ppub">1698-4447</issn><issn pub-type="epub">1698-6946</issn><publisher><publisher-name>Medicina Oral S.L.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24316701</article-id><article-id pub-id-type="pmc">3909436</article-id><article-id pub-id-type="publisher-id">19306</article-id><article-id pub-id-type="doi">10.4317/medoral.19306</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject><subj-group><subject>Implantology</subject></subj-group></subj-group></article-categories><title-group><article-title>Narrow-diameter implants: Are they a predictable
treatment option? A literature review</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Sierra-Sánchez</surname><given-names>José L.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Martínez-González</surname><given-names>Amparo</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>García-Sala Bonmatí</surname><given-names>Fernando</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Mañes-Ferrer</surname><given-names>José F.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Brotons-Oliver</surname><given-names>Alejandro</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Master in Advanced Oral Implantology Professor, Universidad Europea de Valencia</aff><aff id="A2"><label>2</label>Master in Advanced Oral Implantology Director, Universidad Europea de Valencia</aff><author-notes><corresp> Clínica Universitaria Odontológica de la Universidad Europea de Valencia
C/ Alfambra, 4 – bajo
46009 – Valencia, Spain
, E-mail: <email>joseluis.sierra@uem.es</email></corresp></author-notes><pub-date pub-type="ppub"><month>1</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>7</day><month>12</month><year>2013</year></pub-date><volume>19</volume><issue>1</issue><fpage>e74</fpage><lpage>e81</lpage><history><date date-type="accepted"><day>28</day><month>8</month><year>2013</year></date><date date-type="received"><day>7</day><month>5</month><year>2013</year></date></history><permissions><copyright-statement>Copyright: © 2014 Medicina Oral S.L.</copyright-statement><copyright-year>2014</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.5/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Objective: To evaluate the predictability of narrow-diameter implants as a treatment option in routine clinical practice. A literature review was performed of studies reporting clinical results obtained with these implants. Survival rates, peri-implant bone loss and related complications were evaluated. The working hypothesis was that narrow-diameter implants offer clinical results similar to those obtained with implants of greater diameter.
Material and Methods: A Medline-PubMed search covering the period between 2002 and 2012 was carried out. Studies published in English and with a follow-up period of at least 12 months were considered for inclusion. A manual search was also conducted in different journals with an important impact factor.
Results: Twenty-one studies meeting the screening criteria were included in the literature review. A total of 2980 narrow-diameter implants placed in 1607 patients were analyzed.
Conclusions: The results obtained from the literature indicate that narrow-diameter implants are a predictable treatment option, since they afford clinical results comparable to those obtained with implants of greater diameter.
</p><p><bold> Key words:</bold>Narrow implant, survival rate, peri-implant bone loss, related complications.</p></abstract></article-meta></front><body><sec><title>Introduction</title><p>Treatment with dental implants offers a predictable solution for most situations seen in routine clinical practice. However, bone availability is often a limiting factor in planning our treatments.</p><p>A number of surgical techniques allow us to increase the available bone width, such as for example expansion with osteotomes (<xref rid="B1" ref-type="bibr">1</xref>), guided bone regeneration (<xref rid="B2" ref-type="bibr">2</xref>), autologous bone grafts (<xref rid="B3" ref-type="bibr">3</xref>), crestal expansion techniques (<xref rid="B4" ref-type="bibr">4</xref>), and osteogenic distraction (<xref rid="B5" ref-type="bibr">5</xref>,<xref rid="B6" ref-type="bibr">6</xref>).</p><p>Although these procedures offer good results in implantology, they are not without complications (<xref rid="B7" ref-type="bibr">7</xref>,<xref rid="B8" ref-type="bibr">8</xref>). The associated inconven-iences are increased morbidity, longer healing times, and infection secondary to wound dehiscence or membrane exposure (<xref rid="B9" ref-type="bibr">9</xref>,<xref rid="B10" ref-type="bibr">10</xref>). In patients with deficient crest width, the utilization of narrow-diameter implants therefore constitutes a technically more simple treatment alternative.</p><p>The definition of a narrow-diameter implant is subject to controversy. Although no universally accepted classification of implant diameters has been established to date, a narrow-diameter implant is generally taken to have a diameter of ? 3.0 mm and ? 3.5 mm. Some recent studies with narrow-diameter implants have reported implant success and survival rates similar to those obtained with greater diameter implants (<xref rid="B11" ref-type="bibr">11</xref>,<xref rid="B12" ref-type="bibr">12</xref>). However, few studies with prolonged periods of follow-up evaluating the predictability of these implants have been published.</p><p>The objective of the present literature review is to evaluate the predictability of narrow-diameter implants as an alternative to other technically more complex procedures, based on the survival rates, changes in peri-implant bone height and related complications.</p></sec><sec sec-type="materials|methods"><title>Material and Methods</title><p>- Search strategy</p><p>A Medline-PubMed search was conducted of studies published in English between January 2002 and June 2012 (both included), using the following MESH terms: “narrow implant”, “survival rate”, “peri-implant bone loss”, “related complications”. In order to minimize search bias, we also conducted a manual search of relevant articles published in four major implant journals with an important impact factor (International Journal of Oral & Maxillofacial Implants, Clinical Oral Implants Research, Journal of Periodontology, and Clinical Implant Dentistry and Related Research). The electronic and manual searches yielded fifty-one potentially relevant studies, based on the review of the corresponding abstracts. Following the full-text evaluation of these publications, only twenty-one studies were found to meet the inclusion criteria and were finally included in the review.</p><p>- Selection of studies and inclusion criteria</p><p>A single reviewer carried out the search. The variables of interest were implant survival, changes in peri-implant bone height, and related complications. Implant survival was defined as implant persistence in the mouth at the time of evaluation.</p><p>The studies included in the review were required to meet the following criteria:</p><p>o Full-text articles published in English in indexed journals between January 2002 and June 2012 (both included).</p><p>o Presentation of clinical results with implants of diameter ? 3.5 mm and ? of 3.0 mm.</p><p>o Systematic reviews, randomized clinical trials, and prospective or retrospective human cohort studies.</p><p>o A duration of follow-up of at least 12 months.</p><p>- Data extraction</p><p>All of the included studies were independently reviewed and analyzed. We collected data referred to the design of the studies (type of study, duration of follow-up, number of patients, number of implants, and type of edentulism) and the characteristics of treatment (type of implant, surgical technique employed, location of the implants, and type of prosthetic restoration). We also analyzed the variables reflecting the results of treatment (survival rate, peri-implant bone loss, associated complications [biological, prosthetic and aesthetic] and the results obtained with immediate loading).</p></sec><sec sec-type="results"><title>Results</title><p>- Variables associated to the study design (<xref ref-type="table" rid="T1"> Table 1</xref>)</p><p><table-wrap id="T1" orientation="portrait" position="float"><label>Table 1</label><caption><title> Variables associated to the study design ( ) Mean follow-up, TE: totally edentulous, PE: partially edentulous, P-TE: partially & totally edentuolous, ST: single-tooth. </title></caption><graphic xlink:href="medoral-19-e74-t001"></graphic></table-wrap></p><p>The review included four randomized clinical trials (<xref rid="B13" ref-type="bibr">13</xref>-<xref rid="B16" ref-type="bibr">16</xref>), ten prospective studies (<xref rid="B17" ref-type="bibr">17</xref>-<xref rid="B26" ref-type="bibr">26</xref>) and seven retrospective studies (<xref rid="B12" ref-type="bibr">12</xref>,<xref rid="B27" ref-type="bibr">27</xref>-<xref rid="B32" ref-type="bibr">32</xref>). The follow-up periods ranged from 12 months to 12 years.</p><p>The twenty-one reviewed studies included a total of 1607 patients. Five studies involved over 100 patients (<xref rid="B12" ref-type="bibr">12</xref>,<xref rid="B19" ref-type="bibr">19</xref>,<xref rid="B27" ref-type="bibr">27</xref>,<xref rid="B28" ref-type="bibr">28</xref>,<xref rid="B30" ref-type="bibr">30</xref>). The patient age ranged from 13 to 87 years. Medically compromised subjects were excluded in all the studies. A total of 2980 implants were included in the review.</p><p>Regarding the type of edentulism, three studies included only totally edentulous individuals (<xref rid="B16" ref-type="bibr">16</xref>,<xref rid="B21" ref-type="bibr">21</xref>,<xref rid="B24" ref-type="bibr">24</xref>), five studies included both partially and totally edentulous patients (<xref rid="B13" ref-type="bibr">13</xref>,<xref rid="B19" ref-type="bibr">19</xref>,<xref rid="B22" ref-type="bibr">22</xref>,<xref rid="B30" ref-type="bibr">30</xref>,<xref rid="B31" ref-type="bibr">31</xref>), seven studies included partially edentulous cases (<xref rid="B12" ref-type="bibr">12</xref>,<xref rid="B18" ref-type="bibr">18</xref>,<xref rid="B20" ref-type="bibr">20</xref>,<xref rid="B26" ref-type="bibr">26</xref>-<xref rid="B29" ref-type="bibr">29</xref>), and six studies included only patients with a single missing tooth (<xref rid="B13" ref-type="bibr">13</xref>-<xref rid="B15" ref-type="bibr">15</xref>,<xref rid="B23" ref-type="bibr">23</xref>,<xref rid="B25" ref-type="bibr">25</xref>,<xref rid="B32" ref-type="bibr">32</xref>).</p><p>- Variables associated to the characteristics of treatment (<xref ref-type="table" rid="T2"> Table 2</xref>)</p><p><table-wrap id="T2" orientation="portrait" position="float"><label>Table 2</label><caption><title> Variables associated to the characteristics of the treatment. OD: overdenture FPP: fixed partial prostheses ANT & POST: anterior & posterior FTF: full-thickness flap. </title></caption><graphic xlink:href="medoral-19-e74-t002"></graphic></table-wrap></p><p>Use was made of implants with different designs and surface treatments. The diameter of the implants ranged between 3.0 and 3.5 mm, and the length between 8 and 18 mm. Apart from the study published by Comfort et al. (<xref rid="B17" ref-type="bibr">17</xref>), in which machined screw-shaped narrow implants (Bränemark System) were used, twenty studies described results corresponding to implants with different surface treatments (<xref rid="B12" ref-type="bibr">12</xref>-<xref rid="B16" ref-type="bibr">16</xref>,<xref rid="B18" ref-type="bibr">18</xref>-<xref rid="B32" ref-type="bibr">32</xref>). Two of these twenty studies used both machined implants and implants with surface treatments (<xref rid="B27" ref-type="bibr">27</xref>,<xref rid="B28" ref-type="bibr">28</xref>).</p><p>Regarding the location of the implants, nine studies presented results with implants placed only in the anterior zone (<xref rid="B13" ref-type="bibr">13</xref>-<xref rid="B16" ref-type="bibr">16</xref>,<xref rid="B21" ref-type="bibr">21</xref>,<xref rid="B23" ref-type="bibr">23</xref>,<xref rid="B25" ref-type="bibr">25</xref>,<xref rid="B29" ref-type="bibr">29</xref>,<xref rid="B32" ref-type="bibr">32</xref>), two studies reported results with implants positioned only in the posterior zone (<xref rid="B20" ref-type="bibr">20</xref>,<xref rid="B27" ref-type="bibr">27</xref>), and ten studies presented results corresponding to both the anterior and posterior zones (<xref rid="B12" ref-type="bibr">12</xref>,<xref rid="B17" ref-type="bibr">17</xref>-<xref rid="B19" ref-type="bibr">19</xref>,<xref rid="B22" ref-type="bibr">22</xref>,<xref rid="B24" ref-type="bibr">24</xref>,<xref rid="B26" ref-type="bibr">26</xref>,<xref rid="B28" ref-type="bibr">28</xref>,<xref rid="B30" ref-type="bibr">30</xref>,<xref rid="B31" ref-type="bibr">31</xref>).</p><p>Three studies presented results corresponding to implants positioned only in the mandible (<xref rid="B16" ref-type="bibr">16</xref>,<xref rid="B21" ref-type="bibr">21</xref>,<xref rid="B32" ref-type="bibr">32</xref>), another three studies included implants only in the upper maxilla (<xref rid="B14" ref-type="bibr">14</xref>,<xref rid="B24" ref-type="bibr">24</xref>,<xref rid="B25" ref-type="bibr">25</xref>), and fifteen studies included implants in both the upper maxilla and mandible (<xref rid="B12" ref-type="bibr">12</xref>-<xref rid="B14" ref-type="bibr">14</xref>,<xref rid="B17" ref-type="bibr">17</xref>-<xref rid="B20" ref-type="bibr">20</xref>,<xref rid="B22" ref-type="bibr">22</xref>,<xref rid="B23" ref-type="bibr">23</xref>,<xref rid="B26" ref-type="bibr">26</xref>-<xref rid="B31" ref-type="bibr">31</xref>).</p><p>Regarding the surgical technique employed, a full-thickness flap was raised for implant placement in all the studies (<xref rid="B12" ref-type="bibr">12</xref>-<xref rid="B32" ref-type="bibr">32</xref>). Nine studies used a single-step surgical protocol (<xref rid="B12" ref-type="bibr">12</xref>-<xref rid="B15" ref-type="bibr">15</xref>,<xref rid="B20" ref-type="bibr">20</xref>-<xref rid="B22" ref-type="bibr">22</xref>,<xref rid="B26" ref-type="bibr">26</xref>,<xref rid="B27" ref-type="bibr">27</xref>), five studies used a two-step protocol (<xref rid="B17" ref-type="bibr">17</xref>,<xref rid="B19" ref-type="bibr">19</xref>,<xref rid="B24" ref-type="bibr">24</xref>,<xref rid="B25" ref-type="bibr">25</xref>,<xref rid="B31" ref-type="bibr">31</xref>), two studies included both single and two-step surgical protocols (<xref rid="B18" ref-type="bibr">18</xref>,<xref rid="B30" ref-type="bibr">30</xref>), and three studies performed surgery involving the raising of a full-thickness flap without offering further details (<xref rid="B16" ref-type="bibr">16</xref>,<xref rid="B28" ref-type="bibr">28</xref>,<xref rid="B29" ref-type="bibr">29</xref>). Only three studies presented results comparing implants placed with a flapless technique versus the raising of a full-thickness flap (<xref rid="B15" ref-type="bibr">15</xref>,<xref rid="B23" ref-type="bibr">23</xref>,<xref rid="B29" ref-type="bibr">29</xref>).</p><p>Six of the reviewed studies included only single-tooth cases (<xref rid="B13" ref-type="bibr">13</xref>,<xref rid="B14" ref-type="bibr">14</xref>,<xref rid="B15" ref-type="bibr">15</xref>,<xref rid="B23" ref-type="bibr">23</xref>,<xref rid="B25" ref-type="bibr">25</xref>,<xref rid="B26" ref-type="bibr">26</xref>). Regarding the rest of the studies, three of them included only fixed partial prostheses (<xref rid="B12" ref-type="bibr">12</xref>,<xref rid="B18" ref-type="bibr">18</xref>,<xref rid="B20" ref-type="bibr">20</xref>), two studies presented only results corresponding to mandibular overdentures (<xref rid="B16" ref-type="bibr">16</xref>,<xref rid="B21" ref-type="bibr">21</xref>), and one study included only cases of full arch fixed rehabilitations (<xref rid="B24" ref-type="bibr">24</xref>). On the other hand, six studies presented results corresponding to both single-tooth cases and fixed partial prostheses (<xref rid="B26" ref-type="bibr">26</xref>,<xref rid="B27" ref-type="bibr">27</xref>,<xref rid="B28" ref-type="bibr">28</xref>,<xref rid="B29" ref-type="bibr">29</xref>-<xref rid="B31" ref-type="bibr">31</xref>), two studies presented results corresponding to single-tooth cases, fixed partial prostheses and overdentures (<xref rid="B19" ref-type="bibr">19</xref>,<xref rid="B22" ref-type="bibr">22</xref>), and one study presented results corresponding to both full arch fixed rehabilitations and fixed partial prostheses (<xref rid="B17" ref-type="bibr">17</xref>).</p><p>- Variables associated to the results of treatment (<xref ref-type="table" rid="T3"> Table 3</xref>)</p><p><table-wrap id="T3" orientation="portrait" position="float"><label>Table 3</label><caption><title> Variables associated to the results of the treatment * 1 year ** 2 years *** 3 years ? 5 years # 10 years N.P = NOT PUBLISHED. </title></caption><graphic xlink:href="medoral-19-e74-t003"></graphic></table-wrap></p><p>The recorded implant survival rates were above 90% in all the studies. Six studies published a survival rate of 100% at the end of the follow-up period (<xref rid="B14" ref-type="bibr">14</xref>,<xref rid="B20" ref-type="bibr">20</xref>,<xref rid="B22" ref-type="bibr">22</xref>,<xref rid="B24" ref-type="bibr">24</xref>,<xref rid="B29" ref-type="bibr">29</xref>,<xref rid="B32" ref-type="bibr">32</xref>). The lowest survival rate (90.9%) corresponded to the study published by Barter et al. (<xref rid="B18" ref-type="bibr">18</xref>).</p><p>58 failures (implant loss) were recorded out of a total of 2980 implants. Only five studies (<xref rid="B12" ref-type="bibr">12</xref>,<xref rid="B27" ref-type="bibr">27</xref>,<xref rid="B28" ref-type="bibr">28</xref>,<xref rid="B30" ref-type="bibr">30</xref>,<xref rid="B31" ref-type="bibr">31</xref>) offered information on the length of the failed implants (43 implants). A larger number of failures were recorded with implants measuring ? 13 mm in length, compared with implants > 13 mm in length. The authors did not examine whether these data were statistically significant or not.</p><p>Nineteen studies measured changes in peri-implant bone height after implant loading (<xref rid="B12" ref-type="bibr">12</xref>-<xref rid="B18" ref-type="bibr">18</xref>,<xref rid="B20" ref-type="bibr">20</xref>-<xref rid="B30" ref-type="bibr">30</xref>,<xref rid="B32" ref-type="bibr">32</xref>). The values ranged be-tween 0.065 mm the first year according to Galindo-Moreno et al. (<xref rid="B13" ref-type="bibr">13</xref>) and 1.74 mm after a follow-up period of 10 years in the study published by Malo and de Araújo (<xref rid="B27" ref-type="bibr">27</xref>).</p><p>In relation to the recorded complications, eleven studies (<xref rid="B13" ref-type="bibr">13</xref>,<xref rid="B15" ref-type="bibr">15</xref>-<xref rid="B17" ref-type="bibr">17</xref>,<xref rid="B19" ref-type="bibr">19</xref>,<xref rid="B21" ref-type="bibr">21</xref>,<xref rid="B23" ref-type="bibr">23</xref>,<xref rid="B26" ref-type="bibr">26</xref>,<xref rid="B28" ref-type="bibr">28</xref>,<xref rid="B30" ref-type="bibr">30</xref>,<xref rid="B31" ref-type="bibr">31</xref>) registered biological complications. The latter were mainly related to a lack of implant osseointegration and infectious problems.</p><p>Prosthetic complications were registered in eight studies (<xref rid="B13" ref-type="bibr">13</xref>-<xref rid="B15" ref-type="bibr">15</xref>,<xref rid="B19" ref-type="bibr">19</xref>,<xref rid="B20" ref-type="bibr">20</xref>,<xref rid="B26" ref-type="bibr">26</xref>,<xref rid="B28" ref-type="bibr">28</xref>,<xref rid="B30" ref-type="bibr">30</xref>). Only the study published by Zinsli et al. (<xref rid="B19" ref-type="bibr">19</xref>) reported implant fractures. Specifically, the authors recorded two fractures after an observation period of less than two years in one case and more than six years in the other.</p><p>Other prosthetic complications of lesser importance associated to the use of narrow-diameter implants were also documented, such as screw loosening, prostheses decementation, screw fracture or prostheses fracture.</p><p>Five studies presented results referred to aesthetic complications (<xref rid="B15" ref-type="bibr">15</xref>,<xref rid="B23" ref-type="bibr">23</xref>,<xref rid="B25" ref-type="bibr">25</xref>,<xref rid="B30" ref-type="bibr">30</xref>,<xref rid="B32" ref-type="bibr">32</xref>). These problems mainly involved a poor aesthetic outcome of the definitive restoration or insufficient filling of the interproximal papilla.</p><p>Lastly, as regards of the results obtained with immediate loading, only five studies (<xref rid="B12" ref-type="bibr">12</xref>,<xref rid="B14" ref-type="bibr">14</xref>,<xref rid="B15" ref-type="bibr">15</xref>,<xref rid="B20" ref-type="bibr">20</xref>,<xref rid="B27" ref-type="bibr">27</xref>) offered information compar-ing an immediate loading protocol and a delayed loading protocol. In 2008, Malo and de Araujo (<xref rid="B27" ref-type="bibr">27</xref>) published a retrospective study on 3.3 mm implants placed in posterior areas and rehabilitated following an immediate loading protocol. The recorded implant survival rate was 95.5% after 9 years of follow-up. That same year, Degidi et al. (<xref rid="B12" ref-type="bibr">12</xref>) published a study comparing delayed and immediate loading in narrow-diameter implants placed in both anterior and posterior zones. The reported survival rate was 99.4% after a mean follow-up of 20 months. In 2009, the same authors (<xref rid="B20" ref-type="bibr">20</xref>) reported a 100% survival rate with 3.0 mm implants. In this study the authors treated patients with partially edentulous posterior areas rehabilitated with an immediate loading protocol followed-up on for 48 months. Likewise in 2009, Degidi et al. (<xref rid="B14" ref-type="bibr">14</xref>) published another study comparing peri-implant bone loss and probing depth between the two protocols. In this study, involving a follow-up period of 36 months, the differences were not statistically significant. In 2011, Zembic et al. (<xref rid="B15" ref-type="bibr">15</xref>) reported a survival rate of 98% for single 3.0 mm implants subjected to immediate loading and followed-up on for one year.</p></sec><sec sec-type="discussion"><title>Discussion</title><p>Some studies have found the survival of narrow-diameter implants (3.0 - 3.5 mm range) to be comparable to those obtained with standard-diameter implants (<xref rid="B12" ref-type="bibr">12</xref>,<xref rid="B19" ref-type="bibr">19</xref>). This review only included four randomized clinical trials supporting such performance (<xref rid="B13" ref-type="bibr">13</xref>-<xref rid="B16" ref-type="bibr">16</xref>).</p><p>Thirteen of the twenty-one studies included in the review presented a mean follow-up period of at least 24 months (<xref rid="B14" ref-type="bibr">14</xref>,<xref rid="B17" ref-type="bibr">17</xref>-<xref rid="B22" ref-type="bibr">22</xref>,<xref rid="B25" ref-type="bibr">25</xref>-<xref rid="B28" ref-type="bibr">28</xref>,<xref rid="B30" ref-type="bibr">30</xref>,<xref rid="B31" ref-type="bibr">31</xref>). The patient sample was quite large and included both totally and partially edentulous individuals. Due to the great variety of implants analyzed and the high survival rates recorded, it is difficult to establish a relationship between the characteristics of the different surfaces and implant survival. Regarding length, the failure rate tended to increase when using implants measuring ? 13 mm in length, compared with longer implants. The statistical significance of these results could not be analyzed.</p><p>In 2006, Cardaropoli et al. (<xref rid="B33" ref-type="bibr">33</xref>) reported a mean interproximal bone loss of 1.5 mm during the first year for standard-diameter implants. Other authors, based on finite elements analysis, found that an increase in implant diameter exerts a greater effect in terms of the reduction of stress transmission than an increase in implant length (<xref rid="B34" ref-type="bibr">34</xref>).</p><p>The possibility is therefore raised that smaller-diameter implants are associated to greater bone loss after functional loading. The results obtained in this review contradict this idea, since thirteen of the reviewed studies recorded a mean bone loss of ? 1 mm (<xref rid="B12" ref-type="bibr">12</xref>-<xref rid="B14" ref-type="bibr">14</xref>,<xref rid="B16" ref-type="bibr">16</xref>-<xref rid="B18" ref-type="bibr">18</xref>,<xref rid="B21" ref-type="bibr">21</xref>-<xref rid="B24" ref-type="bibr">24</xref>,<xref rid="B28" ref-type="bibr">28</xref>,<xref rid="B29" ref-type="bibr">29</xref>,<xref rid="B32" ref-type="bibr">32</xref>). The greatest peri-implant bone loss value was 1.74 mm, reported in a study published by Malo and de Araujo, with a follow-up period of 10 years (<xref rid="B27" ref-type="bibr">27</xref>).</p><p>Independently of the surgical technique used, good results were obtained with narrow-diameter implants placed in both the anterior and the posterior areas of both jaws.</p><p>Favorable results were also obtained with narrow-diameter implants supporting different types of prosthetic restorations, some of which implied increased biomechanical demands upon the implants.</p><p>Although some authors have related the use of narrow-diameter implants with an increased risk of implant fracture (<xref rid="B35" ref-type="bibr">35</xref>,<xref rid="B36" ref-type="bibr">36</xref>), no such association was observed in this review. Indeed, only two fractures were recorded out of a total of 2980 implants. In any case, these results are probably conditioned by the study designs involved.</p><p>Since the need for bone grafts or regeneration techniques was obviated, the incidence of biological complications was relatively low. The recorded prosthetic complications were generally few and easy to resolve. Very little information was obtained on the aesthetic complications associated to the use of narrow-diameter implants.</p><p>Only five of the twenty-one studies included in the review contributed information on the results obtained with narrow-diameter implants subjected to immediate loading (<xref rid="B12" ref-type="bibr">12</xref>,<xref rid="B14" ref-type="bibr">14</xref>,<xref rid="B15" ref-type="bibr">15</xref>,<xref rid="B20" ref-type="bibr">20</xref>,<xref rid="B27" ref-type="bibr">27</xref>). The follow-up periods in these studies were 12 months, 20 months (mean follow-up), 36 months, 48 months and 9 years. Good results (with implant survival rates of over 95%) were observed in all of them. However, since the publications were so few, further studies involving longer periods of follow-up are needed in order to confirm these results.</p><p>Different factors may have influenced the results obtained. Firstly, most of the studies excluded smokers, patients with bruxism and medically compromised subjects from the analysis of results. Secondly, bone quality - which conditions primary implant stability - and the experience of the clinician, may have exerted a decisive influence.</p></sec><sec sec-type="conclusions"><title>Conclusion</title><p>Despite the limitations inherent to reviews of this kind, the results obtained appear to confirm the idea that treatment with narrow-diameter implants offers clinical results in terms of implant survival, peri-implant bone loss and associated complications similar to those of treatment with implants of greater diameter. 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