Nothing to smile about
Identifieur interne : 000720 ( Pmc/Corpus ); précédent : 000719; suivant : 000721Nothing to smile about
Auteurs : Maria Luca ; Antonina Luca ; Carmelo Maria Augusto Vittorio Grasso ; Carmela CalandraSource :
- Neuropsychiatric Disease and Treatment [ 1176-6328 ] ; 2014.
Abstract
Several studies have demonstrated the high incidence of periodontal disorders among patients suffering from mental illnesses, probably because of self-care impairment, the difficult financial conditions, and the lack of motivation. The primary aim of this study was to evaluate the impact of depression and alexithymia on periodontal status. Due to the influence of personality traits on behavior in general, the secondary aim of our study was to investigate the possible impact of personality disorders on dental status.
Patients with major depression (DP) referred to our psychiatry unit and healthy individuals (controls) were consecutively enrolled during the period April 2012–September 2012. All the participants to the study underwent a psychiatric evaluation (through questionnaires investigating the presence of depression, anxiety, personality disorders, and alexithymia) and a dental examination through the following indexes: plaque index, gingival index, simplified oral hygiene index, periodontal index.
Fifty DP (aged 56.7±15.2 years) and 40 controls (aged 56.1±15.9 years) were enrolled in the study. DP showed a worse oral hygiene status. In particular, statistically significant differences were found when comparing DP and controls in terms of plaque index, simplified oral hygiene index, gingival index, periodontal index, and oral health impact profile. In addition, periodontal health was found to be negatively related to the severity of depression and the presence of alexithymia. The strength of association between depression and dental indexes was reduced after adjusting for the other psychiatric variables (alexithymia and personality disorders) and was confirmed only for oral health impact profile.
Psychiatric variables seem to affect the patients’ periodontal status; due to the high frequency of dental problems, patients suffering from mental illnesses should be referred to the oral health services for evaluation.
Url:
DOI: 10.2147/NDT.S70127
PubMed: 25364254
PubMed Central: 4211900
Links to Exploration step
PMC:4211900Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nothing to smile about</title><author><name sortKey="Luca, Maria" sort="Luca, Maria" uniqKey="Luca M" first="Maria" last="Luca">Maria Luca</name><affiliation><nlm:aff id="af1-ndt-10-1999">Department of Medical and Surgery Specialties, Psychiatry Unit, University Hospital “Policlinico-Vittorio Emanuele” of Catania, Sicily, Italy</nlm:aff></affiliation></author><author><name sortKey="Luca, Antonina" sort="Luca, Antonina" uniqKey="Luca A" first="Antonina" last="Luca">Antonina Luca</name><affiliation><nlm:aff id="af2-ndt-10-1999">Department “GF Ingrassia”, Section of Neuroscience, University Hospital “Policlinico-Vittorio Emanuele” of Catania, Sicily, Italy</nlm:aff></affiliation></author><author><name sortKey="Grasso, Carmelo Maria Augusto Vittorio" sort="Grasso, Carmelo Maria Augusto Vittorio" uniqKey="Grasso C" first="Carmelo Maria Augusto Vittorio" last="Grasso">Carmelo Maria Augusto Vittorio Grasso</name><affiliation><nlm:aff id="af3-ndt-10-1999">Department of Medical and Surgery Specialties, Dental Unit, University Hospital “Policlinico-Vittorio Emanuele” of Catania, Sicily, Italy</nlm:aff></affiliation></author><author><name sortKey="Calandra, Carmela" sort="Calandra, Carmela" uniqKey="Calandra C" first="Carmela" last="Calandra">Carmela Calandra</name><affiliation><nlm:aff id="af1-ndt-10-1999">Department of Medical and Surgery Specialties, Psychiatry Unit, University Hospital “Policlinico-Vittorio Emanuele” of Catania, Sicily, Italy</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25364254</idno><idno type="pmc">4211900</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211900</idno><idno type="RBID">PMC:4211900</idno><idno type="doi">10.2147/NDT.S70127</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000720</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000720</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Nothing to smile about</title><author><name sortKey="Luca, Maria" sort="Luca, Maria" uniqKey="Luca M" first="Maria" last="Luca">Maria Luca</name><affiliation><nlm:aff id="af1-ndt-10-1999">Department of Medical and Surgery Specialties, Psychiatry Unit, University Hospital “Policlinico-Vittorio Emanuele” of Catania, Sicily, Italy</nlm:aff></affiliation></author><author><name sortKey="Luca, Antonina" sort="Luca, Antonina" uniqKey="Luca A" first="Antonina" last="Luca">Antonina Luca</name><affiliation><nlm:aff id="af2-ndt-10-1999">Department “GF Ingrassia”, Section of Neuroscience, University Hospital “Policlinico-Vittorio Emanuele” of Catania, Sicily, Italy</nlm:aff></affiliation></author><author><name sortKey="Grasso, Carmelo Maria Augusto Vittorio" sort="Grasso, Carmelo Maria Augusto Vittorio" uniqKey="Grasso C" first="Carmelo Maria Augusto Vittorio" last="Grasso">Carmelo Maria Augusto Vittorio Grasso</name><affiliation><nlm:aff id="af3-ndt-10-1999">Department of Medical and Surgery Specialties, Dental Unit, University Hospital “Policlinico-Vittorio Emanuele” of Catania, Sicily, Italy</nlm:aff></affiliation></author><author><name sortKey="Calandra, Carmela" sort="Calandra, Carmela" uniqKey="Calandra C" first="Carmela" last="Calandra">Carmela Calandra</name><affiliation><nlm:aff id="af1-ndt-10-1999">Department of Medical and Surgery Specialties, Psychiatry Unit, University Hospital “Policlinico-Vittorio Emanuele” of Catania, Sicily, Italy</nlm:aff></affiliation></author></analytic><series><title level="j">Neuropsychiatric Disease and Treatment</title><idno type="ISSN">1176-6328</idno><idno type="eISSN">1178-2021</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Several studies have demonstrated the high incidence of periodontal disorders among patients suffering from mental illnesses, probably because of self-care impairment, the difficult financial conditions, and the lack of motivation. The primary aim of this study was to evaluate the impact of depression and alexithymia on periodontal status. Due to the influence of personality traits on behavior in general, the secondary aim of our study was to investigate the possible impact of personality disorders on dental status.</p></sec><sec><title>Methods</title><p>Patients with major depression (DP) referred to our psychiatry unit and healthy individuals (controls) were consecutively enrolled during the period April 2012–September 2012. All the participants to the study underwent a psychiatric evaluation (through questionnaires investigating the presence of depression, anxiety, personality disorders, and alexithymia) and a dental examination through the following indexes: plaque index, gingival index, simplified oral hygiene index, periodontal index.</p></sec><sec><title>Results</title><p>Fifty DP (aged 56.7±15.2 years) and 40 controls (aged 56.1±15.9 years) were enrolled in the study. DP showed a worse oral hygiene status. In particular, statistically significant differences were found when comparing DP and controls in terms of plaque index, simplified oral hygiene index, gingival index, periodontal index, and oral health impact profile. In addition, periodontal health was found to be negatively related to the severity of depression and the presence of alexithymia. The strength of association between depression and dental indexes was reduced after adjusting for the other psychiatric variables (alexithymia and personality disorders) and was confirmed only for oral health impact profile.</p></sec><sec><title>Conclusion</title><p>Psychiatric variables seem to affect the patients’ periodontal status; due to the high frequency of dental problems, patients suffering from mental illnesses should be referred to the oral health services for evaluation.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Petersen, Pe" uniqKey="Petersen P">PE Petersen</name></author><author><name sortKey="Bourgeois, D" uniqKey="Bourgeois D">D Bourgeois</name></author><author><name sortKey="Ogawa, H" uniqKey="Ogawa H">H Ogawa</name></author><author><name sortKey="Estupinan Day, S" uniqKey="Estupinan Day S">S Estupinan-Day</name></author><author><name sortKey="Ndiaye, C" uniqKey="Ndiaye C">C 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Stamp</name></author><author><name sortKey="Khalilova, I" uniqKey="Khalilova I">I Khalilova</name></author><author><name sortKey="Tarr, Jm" uniqKey="Tarr J">JM Tarr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assumpcao, Cr" uniqKey="Assumpcao C">CR Assumpção</name></author><author><name sortKey="Brunini, Tmc" uniqKey="Brunini T">TMC Brunini</name></author><author><name sortKey="Matsuura, C" uniqKey="Matsuura C">C Matsuura</name></author><author><name sortKey="Resende, Ac" uniqKey="Resende A">AC Resende</name></author><author><name sortKey="Mendes Ribeiro, Ac" uniqKey="Mendes Ribeiro A">AC Mendes-Ribeiro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reissmann, Dr" uniqKey="Reissmann D">DR Reissmann</name></author><author><name sortKey="John, Mt" uniqKey="John M">MT John</name></author><author><name sortKey="Schierz, O" uniqKey="Schierz O">O Schierz</name></author><author><name sortKey="Kriston, L" 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Neuropsychiatr Dis Treat</journal-id><journal-id journal-id-type="iso-abbrev">Neuropsychiatr Dis Treat</journal-id><journal-id journal-id-type="publisher-id">Neuropsychiatric Disease and Treatment</journal-id><journal-title-group><journal-title>Neuropsychiatric Disease and Treatment</journal-title></journal-title-group><issn pub-type="ppub">1176-6328</issn><issn pub-type="epub">1178-2021</issn><publisher><publisher-name>Dove Medical Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25364254</article-id><article-id pub-id-type="pmc">4211900</article-id><article-id pub-id-type="doi">10.2147/NDT.S70127</article-id><article-id pub-id-type="publisher-id">ndt-10-1999</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject></subj-group></article-categories><title-group><article-title>Nothing to smile about</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Luca</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="af1-ndt-10-1999">1</xref></contrib><contrib contrib-type="author"><name><surname>Luca</surname><given-names>Antonina</given-names></name><xref ref-type="aff" rid="af2-ndt-10-1999">2</xref></contrib><contrib contrib-type="author"><name><surname>Grasso</surname><given-names>Carmelo Maria Augusto Vittorio</given-names></name><xref ref-type="aff" rid="af3-ndt-10-1999">3</xref></contrib><contrib contrib-type="author"><name><surname>Calandra</surname><given-names>Carmela</given-names></name><xref ref-type="aff" rid="af1-ndt-10-1999">1</xref><xref ref-type="corresp" rid="c1-ndt-10-1999"></xref></contrib></contrib-group><aff id="af1-ndt-10-1999"><label>1</label>Department of Medical and Surgery Specialties, Psychiatry Unit, University Hospital “Policlinico-Vittorio Emanuele” of Catania, Sicily, Italy</aff><aff id="af2-ndt-10-1999"><label>2</label>Department “GF Ingrassia”, Section of Neuroscience, University Hospital “Policlinico-Vittorio Emanuele” of Catania, Sicily, Italy</aff><aff id="af3-ndt-10-1999"><label>3</label>Department of Medical and Surgery Specialties, Dental Unit, University Hospital “Policlinico-Vittorio Emanuele” of Catania, Sicily, Italy</aff><author-notes><corresp id="c1-ndt-10-1999">Correspondence: Carmela Calandra, Department of Medical and Surgery Specialties, Psychiatry Unit, University Hospital “Policlinico-Vittorio Emanuele” of Catania, Via Santa Sofia 78, 95100 Catania, Sicily, Italy, Tel/Fax +39 095 378 2636, Email <email>c.calandra@unict.it</email></corresp></author-notes><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>23</day><month>10</month><year>2014</year></pub-date><volume>10</volume><fpage>1999</fpage><lpage>2008</lpage><permissions><copyright-statement>© 2014 Luca et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License</copyright-statement><copyright-year>2014</copyright-year><license><license-p>The full terms of the License are available at <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.</license-p></license></permissions><abstract><sec><title>Background</title><p>Several studies have demonstrated the high incidence of periodontal disorders among patients suffering from mental illnesses, probably because of self-care impairment, the difficult financial conditions, and the lack of motivation. The primary aim of this study was to evaluate the impact of depression and alexithymia on periodontal status. Due to the influence of personality traits on behavior in general, the secondary aim of our study was to investigate the possible impact of personality disorders on dental status.</p></sec><sec><title>Methods</title><p>Patients with major depression (DP) referred to our psychiatry unit and healthy individuals (controls) were consecutively enrolled during the period April 2012–September 2012. All the participants to the study underwent a psychiatric evaluation (through questionnaires investigating the presence of depression, anxiety, personality disorders, and alexithymia) and a dental examination through the following indexes: plaque index, gingival index, simplified oral hygiene index, periodontal index.</p></sec><sec><title>Results</title><p>Fifty DP (aged 56.7±15.2 years) and 40 controls (aged 56.1±15.9 years) were enrolled in the study. DP showed a worse oral hygiene status. In particular, statistically significant differences were found when comparing DP and controls in terms of plaque index, simplified oral hygiene index, gingival index, periodontal index, and oral health impact profile. In addition, periodontal health was found to be negatively related to the severity of depression and the presence of alexithymia. The strength of association between depression and dental indexes was reduced after adjusting for the other psychiatric variables (alexithymia and personality disorders) and was confirmed only for oral health impact profile.</p></sec><sec><title>Conclusion</title><p>Psychiatric variables seem to affect the patients’ periodontal status; due to the high frequency of dental problems, patients suffering from mental illnesses should be referred to the oral health services for evaluation.</p></sec></abstract><kwd-group><title>Keywords</title><kwd>depression</kwd><kwd>alexithymia</kwd><kwd>oral health</kwd><kwd>dental health</kwd><kwd>oral health-related quality of life</kwd><kwd>dental indexes</kwd></kwd-group></article-meta></front><body><sec><title>Background</title><p>Poor oral health is a major public problem all over the world. The impact of oral disturbances on individuals and communities are notable, particularly if the consequences on oral function and quality of life, as well as the societal costs, are taken into consideration.<xref rid="b1-ndt-10-1999" ref-type="bibr">1</xref> Oral diseases affect systemic health and social functioning of the patients; the pain, the negative esthetic impact, and the discomfort has important repercussions on public and private relationships.<xref rid="b2-ndt-10-1999" ref-type="bibr">2</xref>,<xref rid="b3-ndt-10-1999" ref-type="bibr">3</xref> Furthermore, recent studies have suggested that periodontitis could be considered as a risk factor for cognitive decline.<xref rid="b4-ndt-10-1999" ref-type="bibr">4</xref> Several factors, such as nutritional habits, hygiene, tobacco and alcohol use, stress, and traumatic events exert a role in the occurrence of oral health problems.<xref rid="b5-ndt-10-1999" ref-type="bibr">5</xref> In light of the risk factors, the high incidence of oral disorders all over the world, particularly among disadvantaged populations, needs no explanation.<xref rid="b6-ndt-10-1999" ref-type="bibr">6</xref> Oral health should be interpreted as an issue pertaining general health and its promotion should not be limited to the dentistry field. In everyday medical practice, while performing the general examination, proper attention must be given also to oral health; this could facilitate the achievement of the ambitious goal proposed by the World Health Organization: the improvement of oral health status in the world.<xref rid="b7-ndt-10-1999" ref-type="bibr">7</xref> In addition, special attention should be dedicated to the most vulnerable patients, who tend to adopt bad habits and would benefit from simple oral hygiene advice. Among the at-risk categories, patients suffering from mental illnesses are certainly in need of consideration. Several studies have demonstrated the high incidence of periodontal problems among psychotic patients, probably because of self-care impairment, the side effects of many psychotropic medications, the difficult financial conditions, and the lack of motivation.<xref rid="b8-ndt-10-1999" ref-type="bibr">8</xref>,<xref rid="b9-ndt-10-1999" ref-type="bibr">9</xref></p><p>The care of these patients should not be limited to the psychopathological aspects; their unhealthy habits cannot be passively accepted as a natural consequence of their psychiatric illness. Moreover, the problem of poor oral hygiene is not limited to the patients suffering from severe mental disorders and presenting limited management skills, but pertains also to patients affected by mild psychiatric disturbances. Although to date there are no systematic studies on the prevalence of depression in dental patients, an association between stress, depression, and chronic forms of periodontal disease has been documented.<xref rid="b10-ndt-10-1999" ref-type="bibr">10</xref> Major depression in the general population has a lifetime prevalence ranging from 10% to 15%<xref rid="b11-ndt-10-1999" ref-type="bibr">11</xref> with an increased rate in females.<xref rid="b12-ndt-10-1999" ref-type="bibr">12</xref></p><p>Patients with major depression (DP) are notoriously poorly dedicated to their oral hygiene and tend to follow a self-destructive lifestyle in terms of nutrition and voluptuary habits.<xref rid="b13-ndt-10-1999" ref-type="bibr">13</xref> This self-destructive behavior exposes DP to the occurrence of oral health problems that worsen their quality of life through the occurrence of psychological disturbances; in fact, oral clefts, missing teeth, severe malocclusion, and severe caries are associated with feelings of embarrassment, withdrawal, anxiety, and insomnia<xref rid="b3-ndt-10-1999" ref-type="bibr">3</xref>,<xref rid="b14-ndt-10-1999" ref-type="bibr">14</xref> Moreover, depression is frequently accompanied by alexithymia, a personality trait involving difficulties in emotional regulation (difficulties in identifying feelings, difficulties in describing feelings, and externally oriented thinking).<xref rid="b15-ndt-10-1999" ref-type="bibr">15</xref>,<xref rid="b16-ndt-10-1999" ref-type="bibr">16</xref> Alexithymia has been found to be related to a poor oral health-related quality of life and dental fear;<xref rid="b17-ndt-10-1999" ref-type="bibr">17</xref>,<xref rid="b18-ndt-10-1999" ref-type="bibr">18</xref> the latter could lead to the avoidance of oral health services. The primary aim of our study was to evaluate the impact of depression and alexithymia on periodontal status. Due to the influence of personality traits on behavior in general, the secondary aim of our study was to investigate the possible impact of personality disorders (PDs) on dental status.</p></sec><sec sec-type="methods"><title>Methods</title><p>DP (outpatients) referred to our psychiatry unit for consultation were consecutively enrolled in the study. Healthy subjects (controls) with no neurological or psychiatric disorders were recruited from the general population (relatives of university students, hospital employees, acquaintances of the research team) during the period April 2012–September 2012. No form of compensation was given to the participants. Individuals suffering from cancer and acquired or congenital maxillofacial pathologies were excluded from the study. The study was approved by the local ethics committee of the University Hospital “Policlinico-Vittorio Emanuele” of Catania and each individual signed a written informed consent. All the enrolled subjects filled in a questionnaire pertaining to demographic data, voluptuary habits (tobacco smoking, coffee, alcohol, and drugs abuse), oral hygiene (frequency of teeth-brushing, type of toothbrush, use of mouthwash, use of flossing, etc), use of partial dentures or being edentulous. Smokers were divided into three groups according to the number of cigarettes smoked per day, according to previous studies: mild (less than 15 cigarettes/day), moderate (from 15 to 24 cigarettes/day), and heavy (25 or more cigarettes/day) smokers.<xref rid="b19-ndt-10-1999" ref-type="bibr">19</xref> Drinkers were divided into three groups according to the quantity of alcohol consumption: mild (from 1 to 14.9 g/day), moderate (from 15 to 29.9 g/day), and heavy drinkers (30 or more g/day).<xref rid="b20-ndt-10-1999" ref-type="bibr">20</xref> The presence of diabetes was recorded. As for DP, the presence of previous depressive episodes and suicidal ideation during the current episode were recorded.</p><p>All the participants underwent a psychiatric evaluation through the following questionnaires: 1) the Hamilton Rating Scale for Depression: it is a reliable tool consisting of 21 items for the assessment of depression. The severity of depression is evaluated as follows: ≥25 severe depression; 18–24 moderate depression; 8–17 mild depression; ≤7 absence of depression.<xref rid="b21-ndt-10-1999" ref-type="bibr">21</xref>,<xref rid="b22-ndt-10-1999" ref-type="bibr">22</xref> As to controls, the test was administered in order to exclude the presence of depressive symptoms. 2) The Hamilton Rating Scale for Anxiety: it is a validated and reliable tool consisting of 14 items for the assessment of anxiety. A total score ≥18 was considered pathological.<xref rid="b23-ndt-10-1999" ref-type="bibr">23</xref>,<xref rid="b24-ndt-10-1999" ref-type="bibr">24</xref> 3) The 20-item Toronto Alexithymia Scale: it is a reliable instrument consisting of three subscales assessing alexithymia: subscale I assessing the difficulty in identifying feelings; subscale II assessing the difficulty in describing feelings; subscale III assessing externally oriented thinking and the lack of introspective capacities. A total score of 61 and above indicates an alexithymic state. Scores between 51 and 60 indicate a condition of borderline alexithymia.<xref rid="b25-ndt-10-1999" ref-type="bibr">25</xref>,<xref rid="b26-ndt-10-1999" ref-type="bibr">26</xref> 4) The Structured Clinical Interview for DSM-IV Axis II Personality Disorders: it is a validated scale investigating the presence of PDs. It considers the eleven DSM-IV PDs (including PD not otherwise specified) and the appendix categories depressive PD and passive-aggressive PD.<xref rid="b27-ndt-10-1999" ref-type="bibr">27</xref>,<xref rid="b28-ndt-10-1999" ref-type="bibr">28</xref> 5) The oral health impact profile (OHIP-14): it is a validated scale <xref rid="b29-ndt-10-1999" ref-type="bibr">29</xref> assessing the burden of oral health status on the quality of life through 14 items. The total OHIP-14 score ranges from 0 to 56. The higher the OHIP-14 total score, the worse the oral health-related quality of life is.<xref rid="b30-ndt-10-1999" ref-type="bibr">30</xref>,<xref rid="b31-ndt-10-1999" ref-type="bibr">31</xref> Then, all the participants (except the fully edentulous ones) underwent a dental examination performed by a dentist evaluating six selected teeth (maxillary right first molar, maxillary right lateral incisor, maxillary left first bicuspid, mandibular left first molar, mandibular left lateral incisor, mandibular right first bicuspid). The following indexes have been calculated: 1) plaque index (PI): it is a validated index designed to estimate the presence of plaque.<xref rid="b32-ndt-10-1999" ref-type="bibr">32</xref> The total score for each tooth ranges from 0 to 3. The scores of each tooth are then added together and the value is divided by six in order to obtain the score of the patient. Four ratings have been assigned to each patient: 0 excellent; from 0.1 to 0.9 good; from 1.0 to 1.9 fair, from 2.0 to 3.0 poor.<xref rid="b33-ndt-10-1999" ref-type="bibr">33</xref> 2) Gingival index (GI): it is a validated and reliable index<xref rid="b34-ndt-10-1999" ref-type="bibr">34</xref> designed to estimate different degrees of inflammation in the marginal gingiva. The total score ranges from 0 to 3, according to the severity of the inflammation. The scores of each tooth are added together and the value is divided by six in order to obtain the score of the patient. Four ratings have been assigned to each patient: 0 excellent; from 0.1 to 1.0 good; from 1.1 to 2.0 fair; from 2.1 to 3.0 poor.<xref rid="b35-ndt-10-1999" ref-type="bibr">35</xref> 3) Simplified oral hygiene index (OHI-S): it is a good instrument that evaluates the level of oral hygiene. The total score ranges from 0 to 6. The total score is the sum of the debris index (that ranges from 0 to 3) and the calculus index (that ranges from 0 to 3). The following ratings have been assigned to each patient: from 0 to 1.2 good, from 1.3 to 3.0 fair, from 3.1 to 6.0 poor.<xref rid="b36-ndt-10-1999" ref-type="bibr">36</xref> 4) Periodontal index (PeI): it is a good index intended to estimate deeper periodontal disease by investigating the presence of gingival inflammation and its severity, the pocket formation, and masticatory function. The total score ranges from 0 to 8 as follows: from 0 to 0.2 normal (no inflammation), from 0.3 to 0.9 simple gingivitis (inflammation, not circumscribing the tooth), from 1.0 to 1.9 periodontal disease at early stage (inflammation circumscribing the tooth), from 2.0 to 4.9 mild periodontal disease (gingivitis with pocket formation), from 5.0 to 8.0 severe periodontal disease (tissue destruction with loss of function). Five ratings have been assigned to each patient: excellent (0–0.2), good (0.3–0.9), fair (1.0–1.9), poor (2.0–4.9), very poor (5.0–8.0).<xref rid="b37-ndt-10-1999" ref-type="bibr">37</xref></p><sec sec-type="methods"><title>Statistical analysis</title><p>All data analyses were generated using the Statistical Package for Social Sciences for Windows (version 13.0 for Windows; SPSS Inc., Chicago, IL, USA). Quantitative variables were described using mean and standard deviation. The difference between means and the difference between proportions was evaluated by the <italic>t</italic>-test and the chi-square test respectively. In case of not a normal distribution, appropriate nonparametric tests were performed. Only values of <italic>P</italic><0.05 were considered statistically significant.</p><p>A multivariate approach was then adopted in order to investigate the independent effect of a risk or protective factor after adjustment for the parameters significantly associated with the outcome at the univariate analysis. Unconditional logistic regression analysis was performed and we calculated odds ratio (OR), 95% confidence interval (CI), and <italic>P</italic>-value (two-tailed test, α=0.05) for each variable.</p></sec></sec><sec sec-type="results"><title>Results</title><sec sec-type="intro"><title>General characteristics of the sample</title><p>Fifty-three DP were eligible for the study. Three of them refused to participate. Then, 50 DP (15 men and 35 women; aged 56.7±15.2 years) and 40 controls (16 men and 24 women; aged 56.1±15.9 years) were enrolled in the study. No significant differences in age, sex, and years of schooling (9.8±3.6 years among DP versus 9.4±4.4 years among controls) were recorded when comparing DP and controls. No significant differences in terms of voluptuary habits and diabetes were found between the two groups. No heavy drinkers were found. Fourteen percent of the DP presented mild depression, 38% moderate depression, and 48% severe depression. Seventy-two percent of the DP presented anxiety versus 17.5% of the controls (OR 12.12, 95% CI 4.35–33.71; <italic>P</italic><0.001). In addition, 58% of the DP were alexithymic versus 7.5% of the controls (OR 35.04, 95% CI 8.4–145.44; <italic>P</italic><0.001). Twenty-six percent of DP presented a condition of borderline alexithymia versus 22.5% of the controls (OR 5.89, 95% CI 1.81–19.13; <italic>P</italic><0.001). Out of the 50 interviewed DP, 43 presented at least one PD at the Structured Clinical Interview for DSM-IV Axis II Personality Disorders, while only 14 controls were affected by at least one PD. The frequency of PDs among DP was as follows: absence of PD, seven (14%); borderline PD, seven (14%); histrionic PD, four (8%); narcissistic PD, one (2%); obsessive-compulsive PD, 12 (24%); paranoid PD, three (6%); avoidant PD, four (8%); depressive PD, two (4%); dependent PD, two (4%); passive-aggressive PD, zero (0%), not otherwise specified (intending more than one PD) PD, eight (16%). The frequency of PDs among controls was as follows: absence of PD, 26 (65%); borderline PD, zero (0%); histrionic PD, two (5%); narcissistic PD, two (5%); obsessive-compulsive PD, three (7.5%); paranoid PD, three (7.5%); avoidant PD, one (2.5%); depressive PD, zero (0%); dependent PD, zero (0%); passive-aggressive PD, one (2.5%); not otherwise specified PD, two (5%). The only PD that presented a statistically significant difference between DP and controls was the obsessive-compulsive PD, recorded in 12 (24%) DP and in three (7.5%) controls (OR 14.85, 95% CI 3.26–67.63, <italic>P</italic><0.001). For more details see <xref ref-type="table" rid="t1-ndt-10-1999">Table 1</xref>.</p></sec><sec><title>Periodontal status: DP versus controls</title><p>As to periodontal status, no significant differences in terms of frequency of teeth-brushing, type of toothbrush, use of mouthwash, flossing, use of partial dentures, being edentulous or not, were recorded when comparing DP and controls. On the contrary, significant differences were found when considering PI: 22% of DP versus 47.5% of controls presented a fair PI (OR 13.93, 95% CI 2.77–69.88, <italic>P</italic>=0.001); 38% of DP versus 5% of controls had a poor PI (OR 36.1, 95% CI 6.21–209.5, <italic>P</italic>=0.001). In addition, 44% of DP versus 12.5% of controls presented a poor OHI-S (OR 4.4, 95% CI 1.31–14.7, <italic>P</italic>=0.01). Thirty-four percent of DP presented a fair/poor GI versus 22.5% of controls (OR 3.1, 95% CI 1.01–9.33, <italic>P</italic>=0.04). Also, the PeI score was significantly different between the two groups: 42% of DP versus 20% of controls presented a fair/poor PeI (OR 4.43, 95% CI 1.42–13.75, <italic>P</italic>=0.009). As to the OHIP-14, the DP presented a mean score of 17.3±13.6 versus the 3.9±5.3 registered among the controls (OR 1.16, 95% CI 1.08–1.25, <italic>P</italic><0.001). For more details, see <xref ref-type="table" rid="t1-ndt-10-1999">Table 1</xref>.</p></sec><sec><title>Multivariate approach</title><p>A multivariate approach was adopted in order to investigate the independent effect of depression on periodontal status after adjustment for the parameters significantly associated with the outcome at the univariate analysis. Since few individuals were heavy smokers, a single category was created (moderate/heavy). The unconditional logistic regression performed for each dental index (OHIP-14, PI, GI, OHI-S, and PeI) adjusting for age, sex, smoking, alexithymia, anxiety, and PD confirmed only the strength of the association between depression and OHIP-14 found at the univariate analysis (adjusted OR 1.19, 95% CI 1.06–1.34, <italic>P</italic>=0.002).</p></sec><sec><title>Periodontal status and severity of depression</title><p>When considering the severity of depression, no significant differences in terms of OHIP-14 were found comparing the three levels (mild, moderate, and severe). On the contrary, there were significant differences pertaining to the frequency of excellent PI (57.1% in DP suffering from mild depression versus 0% in DP with moderate depression versus 4.2% in DP with severe depression; <italic>P</italic><0.05), excellent GI (85.7% in mild depression versus 21.1% in moderate depression versus 20.8% in severe depression; <italic>P</italic><0.05), good OHI-S (85.7% in mild depression versus 26% in moderate depression versus 16.7% in severe depression; <italic>P</italic><0.05) and excellent PeI (85.7% in mild depression versus 15.8% in moderate depression and 25% in severe depression; <italic>P</italic><0.05). For more details, see <xref ref-type="table" rid="t2-ndt-10-1999">Table 2</xref>.</p></sec><sec><title>Periodontal status and alexithymia</title><p>With regards to the correlations between periodontal status and alexithymia, 55.2% of DP with alexithymia presented a poor PI score versus 12.5% of DP without alexithymia and 15.4% of DP with borderline alexithymia (<italic>P</italic><0.05). A significant difference was also found when considering PeI: only 17.2% of DP with alexithymia presented an excellent PeI, versus 53.8% of DP with borderline alexithymia and 37.5% of DP without alexithymia (<italic>P</italic><0.05). No other significant differences were found when comparing the three groups (DP with/without alexithymia, DP with borderline alexithymia). For more details, see <xref ref-type="table" rid="t3-ndt-10-1999">Table 3</xref>. No correlations between status and the other variables evaluated in this study (eg, anxiety and personality) were found.</p></sec></sec><sec sec-type="discussion"><title>Discussion</title><p>Poor oral health is a silent epidemic with considerable consequences on the quality of life.<xref rid="b38-ndt-10-1999" ref-type="bibr">38</xref> Previous studies demonstrated poorer oral health in patients with mental disorders.<xref rid="b39-ndt-10-1999" ref-type="bibr">39</xref>,<xref rid="b40-ndt-10-1999" ref-type="bibr">40</xref> Our results support these literature data. In our study there were no significant differences in terms of age, voluptuary habits, and hygiene between DP and controls; however, when comparing the two groups, statistically significant differences pertaining to oral health were found. In particular, DP presented a statistically significant worse oral condition in terms of: OHIP-14, PI, GI, PeI, and OHI-S. Few studies have specifically examined the relationship between depression and oral health. Some studies reported that depression was significantly associated with periodontal disease, as measured by clinical attachment loss or alveolar bone loss and with toothless and, in general, with a nonuse of oral health services.<xref rid="b11-ndt-10-1999" ref-type="bibr">11</xref>,<xref rid="b41-ndt-10-1999" ref-type="bibr">41</xref>,<xref rid="b42-ndt-10-1999" ref-type="bibr">42</xref> Psychiatrists and dentists must strongly fight against this maladaptive habit. From an interdisciplinary point of view, patients should be referred to the centers for mental/dental health. The elevated frequency of periodontal problems among DP may be due, in part, to antidepressant therapy, apathy or, more generally, to the fact that people with mental illness are more likely to cancel or not attend appointments with dentists and/or oral hygienists.<xref rid="b43-ndt-10-1999" ref-type="bibr">43</xref> Moreover, it is well-known that psychopharmacological treatments reduce the salivary flow rate that could contribute to the development of periodontal diseases.<xref rid="b44-ndt-10-1999" ref-type="bibr">44</xref> In addition, the severe impairment in self-care described in depression and anxiety can lead to oral health problems;<xref rid="b13-ndt-10-1999" ref-type="bibr">13</xref> however, in our sample, other variables than behavioral issues seem to determine a worse periodontal status among DP, since the two examined groups (DP and controls) presented similar hygienic habits. Apart from hygiene, the association between depressive symptoms and higher lactobacillus counts or the association between depression and inflammation could offer an explanation of our findings.<xref rid="b45-ndt-10-1999" ref-type="bibr">45</xref>,<xref rid="b46-ndt-10-1999" ref-type="bibr">46</xref> Inflammation plays a crucial role in the development of oral pathology too, so that polymorphisms of the genes involved in the immune response can lead to a higher susceptibility to periodontitis.<xref rid="b47-ndt-10-1999" ref-type="bibr">47</xref> In particular, the cyclooxygenase, that converts arachidonic acid to prostaglandins, exerts a fundamental role in the inflammatory process involved in the tissue destruction occurring in periodontitis.<xref rid="b48-ndt-10-1999" ref-type="bibr">48</xref>–<xref rid="b50-ndt-10-1999" ref-type="bibr">50</xref> The same enzymatic way seems to be over-expressed in major depression. DP without other medical illnesses, in fact, present an increase of inflammatory markers both in serum and in the central nervous system.<xref rid="b51-ndt-10-1999" ref-type="bibr">51</xref> Hence, beyond the psychological explanation of the association between poor oral health and depression, there are biological factors that may contribute to the development of oral health problems among DP. The association between oral and mental health should not be underestimated, also considering that poor oral hygiene represents a risk factor for cardiovascular and kidney diseases, pulmonary infections, rheumatoid arthritis, and diabetes.<xref rid="b52-ndt-10-1999" ref-type="bibr">52</xref>–<xref rid="b56-ndt-10-1999" ref-type="bibr">56</xref> Generally speaking, the link between oral and general health is well-known in literature.<xref rid="b57-ndt-10-1999" ref-type="bibr">57</xref> Another interesting finding of this study pertains to the association between the severity of depression and periodontal health: DP with mild depression were more likely to present better dental index scores. More specifically, only few DP with severe depression presented an excellent PI, GI, PeI score, and a good OHI-S score. Compared to other studies, this paper highlights not only the link between affective symptoms and periodontal pathologies in general but also the importance of the severity of depression in terms of oral health outcomes. In addition, the analysis of our sample demonstrated a link between alexithymia and periodontal health: a considerable number of alexithymic patients presented, in fact, a poor PI and a fair PeI. Even in this case, inflammation could offer an explanation of the finding: the altered immune response found in depression has been demonstrated also in alexithymia. In particular, inflammatory markers such as high-sensitivity C reactive protein and interleukin-6 were found to be significantly higher among alexithymic patients than in non-alexithymic ones.<xref rid="b58-ndt-10-1999" ref-type="bibr">58</xref> Along with major depression, alexithymia and personality disturbances seem to exert a role on the patient’s periodontal health: in our sample, the strength of the association between depression and dental indexes was reduced by adjusting for these psychiatric variables. In fact, only the association between oral-health related quality of life (OHIP-14) and depression was confirmed and was not influenced by the presence of alexithymia and PDs. To the best of our knowledge, this is the first study examining the relationship between the severity of depression, alexithymia, and periodontal health. However, this study presents some limitations. Firstly, we did not use X-ray imaging, but a physical (dental) examination for the detection of oral health problems. Secondly, we did not consider the antidepressant therapy as a variable when evaluating the patient’s periodontal status. Furthermore, the present study cannot infer causality. The relationship between depression and poor periodontal health may, in fact, be bidirectional: depression may affect oral health, behaviors, and quality of life but, conversely, people with dental problems may have a lower self-esteem and self-confidence and these factors may lead to depression or worsen a current depressive episode.</p></sec><sec><title>Conclusion</title><p>Although the present study cannot ascertain causal association, it provides substantial evidence that oral and mental health are strictly linked. In particular, our study demonstrated a correlation between psychiatric variables and poor periodontal health. Longitudinal studies are necessary to clarify, in particular, the impact of depression and alexithymia on periodontal status. As a matter of fact, due to the high frequency of dental problems, patients suffering from mental illnesses should be referred to the oral health services for evaluation. 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<hr></hr></th><th colspan="2" align="left" valign="top" rowspan="1">Controls (n=40)
<hr></hr></th><th align="left" valign="top" rowspan="2" colspan="1">OR</th><th align="left" valign="top" rowspan="2" colspan="1">95% CI</th><th align="left" valign="top" rowspan="2" colspan="1"><italic>P</italic>-value</th></tr><tr><th align="left" valign="top" rowspan="1" colspan="1">N</th><th align="left" valign="top" rowspan="1" colspan="1">%</th><th align="left" valign="top" rowspan="1" colspan="1">N</th><th align="left" valign="top" rowspan="1" colspan="1">%</th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Age (mean ± SD)</td><td align="left" valign="top" rowspan="1" colspan="1">56.7±15.2</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">56.1±15.9</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">1</td><td align="left" valign="top" rowspan="1" colspan="1">0.98–1.03</td><td align="left" valign="top" rowspan="1" colspan="1">0.853</td></tr><tr><td colspan="8" align="left" valign="top" rowspan="1">Sex</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Women</td><td align="left" valign="top" rowspan="1" colspan="1">35</td><td align="left" valign="top" rowspan="1" colspan="1">70</td><td align="left" valign="top" rowspan="1" colspan="1">24</td><td align="left" valign="top" rowspan="1" colspan="1">60</td><td align="left" valign="top" rowspan="1" colspan="1">1</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Men</td><td align="left" valign="top" rowspan="1" colspan="1">15</td><td align="left" valign="top" rowspan="1" colspan="1">30</td><td align="left" valign="top" rowspan="1" colspan="1">16</td><td align="left" valign="top" rowspan="1" colspan="1">40</td><td align="left" valign="top" rowspan="1" colspan="1">0.64</td><td align="left" valign="top" rowspan="1" colspan="1">0.27–1.54</td><td align="left" valign="top" rowspan="1" colspan="1">0.322</td></tr><tr><td colspan="8" align="left" valign="top" rowspan="1">Depression</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Absent</td><td align="left" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">40</td><td align="left" valign="top" rowspan="1" colspan="1">100</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Mild depression</td><td align="left" valign="top" rowspan="1" colspan="1">7</td><td align="left" valign="top" rowspan="1" colspan="1">14</td><td align="left" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Moderate depression</td><td align="left" valign="top" rowspan="1" colspan="1">19</td><td align="left" valign="top" rowspan="1" colspan="1">38</td><td align="left" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Severe depression</td><td align="left" valign="top" rowspan="1" colspan="1">24</td><td align="left" valign="top" rowspan="1" colspan="1">48</td><td align="left" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td colspan="8" align="left" valign="top" rowspan="1">Marital status</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Married (reference)</td><td align="left" valign="top" rowspan="1" colspan="1">29</td><td align="left" valign="top" rowspan="1" colspan="1">58</td><td align="left" valign="top" rowspan="1" colspan="1">23</td><td align="left" valign="top" rowspan="1" colspan="1">46</td><td align="left" valign="top" rowspan="1" colspan="1">1</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Singles</td><td align="left" valign="top" rowspan="1" colspan="1">8</td><td align="left" valign="top" rowspan="1" colspan="1">16</td><td align="left" valign="top" rowspan="1" colspan="1">14</td><td align="left" valign="top" rowspan="1" colspan="1">28</td><td align="left" valign="top" rowspan="1" colspan="1">0.45</td><td align="left" valign="top" rowspan="1" colspan="1">0.16–1.26</td><td align="left" valign="top" rowspan="1" colspan="1">0.131</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Divorced/widowers</td><td align="left" valign="top" rowspan="1" colspan="1">13</td><td align="left" valign="top" rowspan="1" colspan="1">26</td><td align="left" valign="top" rowspan="1" colspan="1">3</td><td align="left" valign="top" rowspan="1" colspan="1">6</td><td align="left" valign="top" rowspan="1" colspan="1">3.43</td><td align="left" valign="top" rowspan="1" colspan="1">0.87–13.51</td><td align="left" valign="top" rowspan="1" colspan="1">0.07</td></tr><tr><td colspan="8" align="left" valign="top" rowspan="1">Tobacco</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Non smokers (reference)</td><td align="left" valign="top" rowspan="1" colspan="1">33</td><td align="left" valign="top" rowspan="1" colspan="1">66</td><td align="left" valign="top" rowspan="1" colspan="1">32</td><td align="left" valign="top" rowspan="1" colspan="1">80</td><td align="left" valign="top" rowspan="1" colspan="1">1</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Mild smokers</td><td align="left" valign="top" rowspan="1" colspan="1">8</td><td align="left" valign="top" rowspan="1" colspan="1">16</td><td align="left" valign="top" rowspan="1" colspan="1">6</td><td align="left" valign="top" rowspan="1" colspan="1">15</td><td align="left" valign="top" rowspan="1" colspan="1">1.29</td><td align="left" valign="top" rowspan="1" colspan="1">0.4–4.14</td><td align="left" valign="top" rowspan="1" colspan="1">0.665</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Moderate/heavy smokers</td><td align="left" valign="top" rowspan="1" colspan="1">9</td><td align="left" valign="top" rowspan="1" colspan="1">18</td><td align="left" valign="top" rowspan="1" colspan="1">2</td><td align="left" valign="top" rowspan="1" colspan="1">5</td><td align="left" valign="top" rowspan="1" colspan="1">4.36</td><td align="left" valign="top" rowspan="1" colspan="1">0.87–21.77</td><td align="left" valign="top" rowspan="1" colspan="1">0.07</td></tr><tr><td colspan="8" align="left" valign="top" rowspan="1">Coffee</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> No consumption</td><td align="left" valign="top" rowspan="1" colspan="1">16</td><td align="left" valign="top" rowspan="1" colspan="1">32</td><td align="left" valign="top" rowspan="1" colspan="1">7</td><td align="left" valign="top" rowspan="1" colspan="1">17.5</td><td align="left" valign="top" rowspan="1" colspan="1">1</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Consumption of <3 cups/day</td><td align="left" valign="top" rowspan="1" colspan="1">28</td><td align="left" valign="top" rowspan="1" colspan="1">56</td><td align="left" valign="top" rowspan="1" colspan="1">25</td><td align="left" valign="top" rowspan="1" colspan="1">62.5</td><td align="left" valign="top" rowspan="1" colspan="1">0.49</td><td align="left" valign="top" rowspan="1" colspan="1">0.17–1.38</td><td align="left" valign="top" rowspan="1" colspan="1">0.17</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Consumption of 3 or more cups/day</td><td align="left" valign="top" rowspan="1" colspan="1">6</td><td align="left" valign="top" rowspan="1" colspan="1">12</td><td align="left" valign="top" rowspan="1" colspan="1">8</td><td align="left" valign="top" rowspan="1" colspan="1">20</td><td align="left" valign="top" rowspan="1" colspan="1">0.32</td><td align="left" valign="top" rowspan="1" colspan="1">0.08–1.30</td><td align="left" valign="top" rowspan="1" colspan="1">0.11</td></tr><tr><td colspan="8" align="left" valign="top" rowspan="1">Alcohol</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> No consumption (reference)</td><td align="left" valign="top" rowspan="1" colspan="1">40</td><td align="left" valign="top" rowspan="1" colspan="1">80</td><td align="left" valign="top" rowspan="1" colspan="1">29</td><td align="left" valign="top" rowspan="1" colspan="1">72.5</td><td align="left" valign="top" rowspan="1" colspan="1">1</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Mild consumption</td><td align="left" valign="top" rowspan="1" colspan="1">5</td><td align="left" valign="top" rowspan="1" colspan="1">10</td><td align="left" valign="top" rowspan="1" colspan="1">9</td><td align="left" valign="top" rowspan="1" colspan="1">22.5</td><td align="left" valign="top" rowspan="1" colspan="1">0.4</td><td align="left" valign="top" rowspan="1" colspan="1">0.12–1.32</td><td align="left" valign="top" rowspan="1" colspan="1">0.13</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Moderate consumption</td><td align="left" valign="top" rowspan="1" colspan="1">5</td><td align="left" valign="top" rowspan="1" colspan="1">10</td><td align="left" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">1.81</td><td align="left" valign="top" rowspan="1" colspan="1">0.32–10</td><td align="left" valign="top" rowspan="1" colspan="1">0.49</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Diabetes</td><td align="left" valign="top" rowspan="1" colspan="1">13</td><td align="left" valign="top" rowspan="1" colspan="1">26</td><td align="left" valign="top" rowspan="1" colspan="1">5</td><td align="left" valign="top" rowspan="1" colspan="1">12.5</td><td align="left" valign="top" rowspan="1" colspan="1">2.45</td><td align="left" valign="top" rowspan="1" colspan="1">0.79–7.61</td><td align="left" valign="top" rowspan="1" colspan="1">0.11</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Cocaine</td><td align="left" valign="top" rowspan="1" colspan="1">3</td><td align="left" valign="top" rowspan="1" colspan="1">6</td><td align="left" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">5.97</td><td align="left" valign="top" rowspan="1" colspan="1">0.3–119</td><td align="left" valign="top" rowspan="1" colspan="1">0.42</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Anxiety</td><td align="left" valign="top" rowspan="1" colspan="1">36</td><td align="left" valign="top" rowspan="1" colspan="1">72</td><td align="left" valign="top" rowspan="1" colspan="1">7</td><td align="left" valign="top" rowspan="1" colspan="1">17.5</td><td align="left" valign="top" rowspan="1" colspan="1">12.12</td><td align="left" valign="top" rowspan="1" colspan="1">4.35–33.71</td><td align="left" valign="top" rowspan="1" colspan="1"><<bold>0.001</bold></td></tr><tr><td colspan="8" align="left" valign="top" rowspan="1">Alexithymia</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Absent (reference)</td><td align="left" valign="top" rowspan="1" colspan="1">8</td><td align="left" valign="top" rowspan="1" colspan="1">16</td><td align="left" valign="top" rowspan="1" colspan="1">28</td><td align="left" valign="top" rowspan="1" colspan="1">70</td><td align="left" valign="top" rowspan="1" colspan="1">1</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Borderline alexithymia</td><td align="left" valign="top" rowspan="1" colspan="1">13</td><td align="left" valign="top" rowspan="1" colspan="1">26</td><td align="left" valign="top" rowspan="1" colspan="1">9</td><td align="left" valign="top" rowspan="1" colspan="1">22.5</td><td align="left" valign="top" rowspan="1" colspan="1">5.89</td><td align="left" valign="top" rowspan="1" colspan="1">1.81–19.13</td><td align="left" valign="top" rowspan="1" colspan="1"><<bold>0.001</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Present</td><td align="left" valign="top" rowspan="1" colspan="1">29</td><td align="left" valign="top" rowspan="1" colspan="1">58</td><td align="left" valign="top" rowspan="1" colspan="1">3</td><td align="left" valign="top" rowspan="1" colspan="1">7.5</td><td align="left" valign="top" rowspan="1" colspan="1">35.04</td><td align="left" valign="top" rowspan="1" colspan="1">8.4–145.44</td><td align="left" valign="top" rowspan="1" colspan="1"><<bold>0.001</bold></td></tr><tr><td colspan="8" align="left" valign="top" rowspan="1">Personality disorders</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Absent (reference)</td><td align="left" valign="top" rowspan="1" colspan="1">7</td><td align="left" valign="top" rowspan="1" colspan="1">14</td><td align="left" valign="top" rowspan="1" colspan="1">26</td><td align="left" valign="top" rowspan="1" colspan="1">65</td><td align="left" valign="top" rowspan="1" colspan="1">1</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Obsessive-compulsive</td><td align="left" valign="top" rowspan="1" colspan="1">12</td><td align="left" valign="top" rowspan="1" colspan="1">24</td><td align="left" valign="top" rowspan="1" colspan="1">3</td><td align="left" valign="top" rowspan="1" colspan="1">7.5</td><td align="left" valign="top" rowspan="1" colspan="1">14.85</td><td align="left" valign="top" rowspan="1" colspan="1">3.26–67.63</td><td align="left" valign="top" rowspan="1" colspan="1"><<bold>0.001</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Others</td><td align="left" valign="top" rowspan="1" colspan="1">31</td><td align="left" valign="top" rowspan="1" colspan="1">62</td><td align="left" valign="top" rowspan="1" colspan="1">11</td><td align="left" valign="top" rowspan="1" colspan="1">27.5</td><td align="left" valign="top" rowspan="1" colspan="1">10.46</td><td align="left" valign="top" rowspan="1" colspan="1">3.54–30.57</td><td align="left" valign="top" rowspan="1" colspan="1"><<bold>0.001</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Suicidal ideation</td><td align="left" valign="top" rowspan="1" colspan="1">12</td><td align="left" valign="top" rowspan="1" colspan="1">24</td><td align="left" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">0.96</td><td align="left" valign="top" rowspan="1" colspan="1">0.41–2.24</td><td align="left" valign="top" rowspan="1" colspan="1">0.93</td></tr><tr><td colspan="8" align="left" valign="top" rowspan="1">Frequency of teeth-brushing</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> 2 times/day or less (reference)</td><td align="left" valign="top" rowspan="1" colspan="1">37</td><td align="left" valign="top" rowspan="1" colspan="1">74</td><td align="left" valign="top" rowspan="1" colspan="1">29</td><td align="left" valign="top" rowspan="1" colspan="1">72.5</td><td align="left" valign="top" rowspan="1" colspan="1">1</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> 3 or more times/day</td><td align="left" valign="top" rowspan="1" colspan="1">13</td><td align="left" valign="top" rowspan="1" colspan="1">26</td><td align="left" valign="top" rowspan="1" colspan="1">11</td><td align="left" valign="top" rowspan="1" colspan="1">27.5</td><td align="left" valign="top" rowspan="1" colspan="1">0.92</td><td align="left" valign="top" rowspan="1" colspan="1">0.36–2.36</td><td align="left" valign="top" rowspan="1" colspan="1">0.87</td></tr><tr><td colspan="8" align="left" valign="top" rowspan="1">Type of toothbrush</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Manual (reference)</td><td align="left" valign="top" rowspan="1" colspan="1">49</td><td align="left" valign="top" rowspan="1" colspan="1">98</td><td align="left" valign="top" rowspan="1" colspan="1">37</td><td align="left" valign="top" rowspan="1" colspan="1">92.5</td><td align="left" valign="top" rowspan="1" colspan="1">1</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Electric</td><td align="left" valign="top" rowspan="1" colspan="1">1</td><td align="left" valign="top" rowspan="1" colspan="1">2</td><td align="left" valign="top" rowspan="1" colspan="1">3</td><td align="left" valign="top" rowspan="1" colspan="1">7.5</td><td align="left" valign="top" rowspan="1" colspan="1">0.25</td><td align="left" valign="top" rowspan="1" colspan="1">0.02–2.51</td><td align="left" valign="top" rowspan="1" colspan="1">0.24</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Use of mouthwash</td><td align="left" valign="top" rowspan="1" colspan="1">8</td><td align="left" valign="top" rowspan="1" colspan="1">16</td><td align="left" valign="top" rowspan="1" colspan="1">11</td><td align="left" valign="top" rowspan="1" colspan="1">27.5</td><td align="left" valign="top" rowspan="1" colspan="1">0.5</td><td align="left" valign="top" rowspan="1" colspan="1">0.17–1.40</td><td align="left" valign="top" rowspan="1" colspan="1">0.18</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Flossing</td><td align="left" valign="top" rowspan="1" colspan="1">2</td><td align="left" valign="top" rowspan="1" colspan="1">4</td><td align="left" valign="top" rowspan="1" colspan="1">5</td><td align="left" valign="top" rowspan="1" colspan="1">12.5</td><td align="left" valign="top" rowspan="1" colspan="1">0.29</td><td align="left" valign="top" rowspan="1" colspan="1">0.05–1.59</td><td align="left" valign="top" rowspan="1" colspan="1">0.15</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Dentures</td><td align="left" valign="top" rowspan="1" colspan="1">20</td><td align="left" valign="top" rowspan="1" colspan="1">40</td><td align="left" valign="top" rowspan="1" colspan="1">9</td><td align="left" valign="top" rowspan="1" colspan="1">22.5</td><td align="left" valign="top" rowspan="1" colspan="1">2.29</td><td align="left" valign="top" rowspan="1" colspan="1">0.90–5.83</td><td align="left" valign="top" rowspan="1" colspan="1">0.08</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Edentulous</td><td align="left" valign="top" rowspan="1" colspan="1">3</td><td align="left" valign="top" rowspan="1" colspan="1">6</td><td align="left" valign="top" rowspan="1" colspan="1">2</td><td align="left" valign="top" rowspan="1" colspan="1">5</td><td align="left" valign="top" rowspan="1" colspan="1">1.21</td><td align="left" valign="top" rowspan="1" colspan="1">0.19–7.62</td><td align="left" valign="top" rowspan="1" colspan="1">0.83</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">OHIP-14 (mean ± SD)</td><td align="left" valign="top" rowspan="1" colspan="1">17.3±13.6</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">3.9±5.3</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">1.16</td><td align="left" valign="top" rowspan="1" colspan="1">1.08–1.25</td><td align="left" valign="top" rowspan="1" colspan="1"><<bold>0.001</bold></td></tr><tr><td colspan="8" align="left" valign="top" rowspan="1">PI</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Excellent (reference)</td><td align="left" valign="top" rowspan="1" colspan="1">5</td><td align="left" valign="top" rowspan="1" colspan="1">10</td><td align="left" valign="top" rowspan="1" colspan="1">19</td><td align="left" valign="top" rowspan="1" colspan="1">47.5</td><td align="left" valign="top" rowspan="1" colspan="1">1</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Good</td><td align="left" valign="top" rowspan="1" colspan="1">12</td><td align="left" valign="top" rowspan="1" colspan="1">24</td><td align="left" valign="top" rowspan="1" colspan="1">14</td><td align="left" valign="top" rowspan="1" colspan="1">35</td><td align="left" valign="top" rowspan="1" colspan="1">3.25</td><td align="left" valign="top" rowspan="1" colspan="1">0.93–11.39</td><td align="left" valign="top" rowspan="1" colspan="1">0.06</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Fair</td><td align="left" valign="top" rowspan="1" colspan="1">11</td><td align="left" valign="top" rowspan="1" colspan="1">22</td><td align="left" valign="top" rowspan="1" colspan="1">3</td><td align="left" valign="top" rowspan="1" colspan="1">7.5</td><td align="left" valign="top" rowspan="1" colspan="1">13.93</td><td align="left" valign="top" rowspan="1" colspan="1">2.77–69.88</td><td align="left" valign="top" rowspan="1" colspan="1"><bold>0.001</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Poor</td><td align="left" valign="top" rowspan="1" colspan="1">19</td><td align="left" valign="top" rowspan="1" colspan="1">38</td><td align="left" valign="top" rowspan="1" colspan="1">2</td><td align="left" valign="top" rowspan="1" colspan="1">5</td><td align="left" valign="top" rowspan="1" colspan="1">36.1</td><td align="left" valign="top" rowspan="1" colspan="1">6.21–209.5</td><td align="left" valign="top" rowspan="1" colspan="1"><bold>0.001</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Not applicable</td><td align="left" valign="top" rowspan="1" colspan="1">3</td><td align="left" valign="top" rowspan="1" colspan="1">6</td><td align="left" valign="top" rowspan="1" colspan="1">2</td><td align="left" valign="top" rowspan="1" colspan="1">5</td><td align="left" valign="top" rowspan="1" colspan="1">5.7</td><td align="left" valign="top" rowspan="1" colspan="1">0.73–43.94</td><td align="left" valign="top" rowspan="1" colspan="1">0.094</td></tr><tr><td colspan="8" align="left" valign="top" rowspan="1">OHI-S</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Good (reference)</td><td align="left" valign="top" rowspan="1" colspan="1">15</td><td align="left" valign="top" rowspan="1" colspan="1">30</td><td align="left" valign="top" rowspan="1" colspan="1">15</td><td align="left" valign="top" rowspan="1" colspan="1">37.5</td><td align="left" valign="top" rowspan="1" colspan="1">1</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Fair</td><td align="left" valign="top" rowspan="1" colspan="1">10</td><td align="left" valign="top" rowspan="1" colspan="1">20</td><td align="left" valign="top" rowspan="1" colspan="1">18</td><td align="left" valign="top" rowspan="1" colspan="1">45</td><td align="left" valign="top" rowspan="1" colspan="1">0.55</td><td align="left" valign="top" rowspan="1" colspan="1">0.19–1.59</td><td align="left" valign="top" rowspan="1" colspan="1">0.27</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Poor</td><td align="left" valign="top" rowspan="1" colspan="1">22</td><td align="left" valign="top" rowspan="1" colspan="1">44</td><td align="left" valign="top" rowspan="1" colspan="1">5</td><td align="left" valign="top" rowspan="1" colspan="1">12.5</td><td align="left" valign="top" rowspan="1" colspan="1">4.4</td><td align="left" valign="top" rowspan="1" colspan="1">1.31–14.7</td><td align="left" valign="top" rowspan="1" colspan="1"><bold>0.01</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Not applicable</td><td align="left" valign="top" rowspan="1" colspan="1">3</td><td align="left" valign="top" rowspan="1" colspan="1">6</td><td align="left" valign="top" rowspan="1" colspan="1">2</td><td align="left" valign="top" rowspan="1" colspan="1">5</td><td align="left" valign="top" rowspan="1" colspan="1">1.5</td><td align="left" valign="top" rowspan="1" colspan="1">0.21–10.30</td><td align="left" valign="top" rowspan="1" colspan="1">0.68</td></tr><tr><td colspan="8" align="left" valign="top" rowspan="1">GI</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Excellent (reference)</td><td align="left" valign="top" rowspan="1" colspan="1">15</td><td align="left" valign="top" rowspan="1" colspan="1">30</td><td align="left" valign="top" rowspan="1" colspan="1">19</td><td align="left" valign="top" rowspan="1" colspan="1">47.5</td><td align="left" valign="top" rowspan="1" colspan="1">1</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Good</td><td align="left" valign="top" rowspan="1" colspan="1">15</td><td align="left" valign="top" rowspan="1" colspan="1">30</td><td align="left" valign="top" rowspan="1" colspan="1">12</td><td align="left" valign="top" rowspan="1" colspan="1">30</td><td align="left" valign="top" rowspan="1" colspan="1">1.58</td><td align="left" valign="top" rowspan="1" colspan="1">0.57–4.37</td><td align="left" valign="top" rowspan="1" colspan="1">0.37</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Fair/Poor</td><td align="left" valign="top" rowspan="1" colspan="1">17</td><td align="left" valign="top" rowspan="1" colspan="1">34</td><td align="left" valign="top" rowspan="1" colspan="1">9</td><td align="left" valign="top" rowspan="1" colspan="1">22.5</td><td align="left" valign="top" rowspan="1" colspan="1">3.1</td><td align="left" valign="top" rowspan="1" colspan="1">1.01–9.33</td><td align="left" valign="top" rowspan="1" colspan="1"><bold>0.04</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Not applicable</td><td align="left" valign="top" rowspan="1" colspan="1">3</td><td align="left" valign="top" rowspan="1" colspan="1">6</td><td align="left" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">1.9</td><td align="left" valign="top" rowspan="1" colspan="1">0.28–12.86</td><td align="left" valign="top" rowspan="1" colspan="1">0.51</td></tr><tr><td colspan="8" align="left" valign="top" rowspan="1">PeI</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Excellent (reference)</td><td align="left" valign="top" rowspan="1" colspan="1">15</td><td align="left" valign="top" rowspan="1" colspan="1">30</td><td align="left" valign="top" rowspan="1" colspan="1">19</td><td align="left" valign="top" rowspan="1" colspan="1">47.5</td><td align="left" valign="top" rowspan="1" colspan="1">1</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Good</td><td align="left" valign="top" rowspan="1" colspan="1">11</td><td align="left" valign="top" rowspan="1" colspan="1">22</td><td align="left" valign="top" rowspan="1" colspan="1">13</td><td align="left" valign="top" rowspan="1" colspan="1">32.5</td><td align="left" valign="top" rowspan="1" colspan="1">1.07</td><td align="left" valign="top" rowspan="1" colspan="1">0.37–3.06</td><td align="left" valign="top" rowspan="1" colspan="1">0.89</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Fair/Poor</td><td align="left" valign="top" rowspan="1" colspan="1">21</td><td align="left" valign="top" rowspan="1" colspan="1">42</td><td align="left" valign="top" rowspan="1" colspan="1">8</td><td align="left" valign="top" rowspan="1" colspan="1">20</td><td align="left" valign="top" rowspan="1" colspan="1">4.43</td><td align="left" valign="top" rowspan="1" colspan="1">1.42–13.75</td><td align="left" valign="top" rowspan="1" colspan="1"><bold>0.009</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Not applicable</td><td align="left" valign="top" rowspan="1" colspan="1">3</td><td align="left" valign="top" rowspan="1" colspan="1">6</td><td align="left" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">1.9</td><td align="left" valign="top" rowspan="1" colspan="1">0.28–12.86</td><td align="left" valign="top" rowspan="1" colspan="1">0.51</td></tr></tbody></table><table-wrap-foot><fn id="tfn1-ndt-10-1999"><p><bold>Note:</bold> Bold <italic>P</italic>-values are statistically significant.</p></fn><fn id="tfn2-ndt-10-1999"><p><bold>Abbreviations:</bold> DP, patients with major depression; N, number; OR, odds ratio; CI, confidence interval; OHIP-14, oral health impact profile; PI, plaque index; GI, gingival index; OHI-S, simplified oral hygiene index; PeI, periodontal index; SD, standard deviation.</p></fn></table-wrap-foot></table-wrap><table-wrap id="t2-ndt-10-1999" position="float"><label>Table 2</label><caption><p>Oral hygiene habits and periodontal parameters according to depression severity</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" valign="top" rowspan="1" colspan="1"></th><th align="left" valign="top" rowspan="1" colspan="1">Mild depression (n=7)</th><th align="left" valign="top" rowspan="1" colspan="1">Moderate depression (n=19)</th><th align="left" valign="top" rowspan="1" colspan="1">Severe depression (n=24)</th><th align="left" valign="top" rowspan="1" colspan="1"><italic>P</italic>-value</th></tr></thead><tbody><tr><td colspan="5" align="left" valign="top" rowspan="1">Frequency of teeth-brushing (n, %)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> <2 times per day</td><td align="left" valign="top" rowspan="1" colspan="1">5 (71.4%)</td><td align="left" valign="top" rowspan="1" colspan="1">13 (68.4%)</td><td align="left" valign="top" rowspan="1" colspan="1">19 (79.2%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> 3 or more times per day</td><td align="left" valign="top" rowspan="1" colspan="1">2 (28.6%)</td><td align="left" valign="top" rowspan="1" colspan="1">6 (31.6%)</td><td align="left" valign="top" rowspan="1" colspan="1">5 (20.8%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td colspan="5" align="left" valign="top" rowspan="1">Type of toothbrush (n, %)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Manual toothbrush</td><td align="left" valign="top" rowspan="1" colspan="1">7 (100%)</td><td align="left" valign="top" rowspan="1" colspan="1">19 (100%)</td><td align="left" valign="top" rowspan="1" colspan="1">23 (95.8%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Electric toothbrush</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (4.2%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Use of mouthwash (n, %)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (14.3%)</td><td align="left" valign="top" rowspan="1" colspan="1">3 (15.8%)</td><td align="left" valign="top" rowspan="1" colspan="1">4 (16.7%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Flossing (n, %)</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">2 (8.3%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Dentures (n, %)</td><td align="left" valign="top" rowspan="1" colspan="1">2 (28.6%)</td><td align="left" valign="top" rowspan="1" colspan="1">6 (31.6%)</td><td align="left" valign="top" rowspan="1" colspan="1">12 (50%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Edentulous (n, %)</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">3 (12.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">OHIP-14 (mean ± SD)</td><td align="left" valign="top" rowspan="1" colspan="1">15.1±13.6</td><td align="left" valign="top" rowspan="1" colspan="1">15.6±14</td><td align="left" valign="top" rowspan="1" colspan="1">18.8±13.7</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td colspan="5" align="left" valign="top" rowspan="1">PI (n, %)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Excellent</td><td align="left" valign="top" rowspan="1" colspan="1">4 (57.1%)<xref ref-type="table-fn" rid="tfn3-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (4.2%)<xref ref-type="table-fn" rid="tfn3-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1"><<bold>0.05</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Good</td><td align="left" valign="top" rowspan="1" colspan="1">1 (14.3%)<xref ref-type="table-fn" rid="tfn3-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1">10 (52.6%)<xref ref-type="table-fn" rid="tfn3-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1">1 (4.2%)<xref ref-type="table-fn" rid="tfn3-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1"><<bold>0.05</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Fair</td><td align="left" valign="top" rowspan="1" colspan="1">1 (14.3%)</td><td align="left" valign="top" rowspan="1" colspan="1">3 (15.8%)</td><td align="left" valign="top" rowspan="1" colspan="1">7 (29.2%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Poor</td><td align="left" valign="top" rowspan="1" colspan="1">1 (14.3%)</td><td align="left" valign="top" rowspan="1" colspan="1">6 (31.6%)</td><td align="left" valign="top" rowspan="1" colspan="1">12 (50%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Not applicable</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">3 (12.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td colspan="5" align="left" valign="top" rowspan="1">GI (n, %)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Excellent</td><td align="left" valign="top" rowspan="1" colspan="1">6 (85.7%)<xref ref-type="table-fn" rid="tfn3-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1">4 (21.1%)<xref ref-type="table-fn" rid="tfn3-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1">5 (20.8%)<xref ref-type="table-fn" rid="tfn3-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1"><<bold>0.05</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Good</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">8 (42.1%)</td><td align="left" valign="top" rowspan="1" colspan="1">7 (29.2%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Fair</td><td align="left" valign="top" rowspan="1" colspan="1">1 (14.3%)</td><td align="left" valign="top" rowspan="1" colspan="1">5 (26.3%)</td><td align="left" valign="top" rowspan="1" colspan="1">6 (25%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Poor</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">2 (10.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">3 (12.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Not applicable</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">3 (12.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td colspan="5" align="left" valign="top" rowspan="1">OHI-S (n, %)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Good</td><td align="left" valign="top" rowspan="1" colspan="1">6 (85.7%)<xref ref-type="table-fn" rid="tfn3-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1">5 (26.3%)<xref ref-type="table-fn" rid="tfn3-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1">4 (16.7%)<xref ref-type="table-fn" rid="tfn3-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1"><<bold>0.05</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Fair</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">7 (36.8%)</td><td align="left" valign="top" rowspan="1" colspan="1">3 (12.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Poor</td><td align="left" valign="top" rowspan="1" colspan="1">1 (14.3%)</td><td align="left" valign="top" rowspan="1" colspan="1">7 (36.8%)</td><td align="left" valign="top" rowspan="1" colspan="1">14 (58.3%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Not applicable</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">3 (12.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td colspan="5" align="left" valign="top" rowspan="1">PeI (n, %)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Excellent</td><td align="left" valign="top" rowspan="1" colspan="1">6 (85.7%)<xref ref-type="table-fn" rid="tfn3-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1">3 (15.8%)<xref ref-type="table-fn" rid="tfn3-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1">6 (25%)<xref ref-type="table-fn" rid="tfn3-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1"><<bold>0.05</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Good</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">10 (52.6%)<xref ref-type="table-fn" rid="tfn3-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1">1 (4.2%)<xref ref-type="table-fn" rid="tfn3-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1"><<bold>0.05</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Fair</td><td align="left" valign="top" rowspan="1" colspan="1">1 (14.3%)</td><td align="left" valign="top" rowspan="1" colspan="1">4 (21.1%)</td><td align="left" valign="top" rowspan="1" colspan="1">12 (50%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Poor</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">2 (10.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">2 (8.3%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Very poor</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">–</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Not applicable</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">3 (12.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr></tbody></table><table-wrap-foot><fn><p><bold>Notes:</bold></p></fn><fn id="tfn3-ndt-10-1999"><label>*</label><p>Represents which variable is significant versus another with <italic>P</italic><0.05. Bold <italic>P</italic>-values are statistically significant.</p></fn><fn id="tfn4-ndt-10-1999"><p><bold>Abbreviations:</bold> OHIP-14, oral health impact profile; PI, plaque index; GI, gingival index; OHI-S, simplified oral hygiene index; PeI, periodontal index; ns, not significant; SD, standard deviation.</p></fn></table-wrap-foot></table-wrap><table-wrap id="t3-ndt-10-1999" position="float"><label>Table 3</label><caption><p>Oral hygiene habits, periodontal parameters, and alexithymia in DP</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" valign="top" rowspan="1" colspan="1"></th><th align="left" valign="top" rowspan="1" colspan="1">Absence of alexithymia (n=8)</th><th align="left" valign="top" rowspan="1" colspan="1">Borderline alexithymia (n=13)</th><th align="left" valign="top" rowspan="1" colspan="1">Presence of alexithymia (n=29)</th><th align="left" valign="top" rowspan="1" colspan="1"><italic>P</italic>-value</th></tr></thead><tbody><tr><td colspan="5" align="left" valign="top" rowspan="1">Frequency of teeth-brushing (n, %)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> <2 times per day</td><td align="left" valign="top" rowspan="1" colspan="1">6 (75%)</td><td align="left" valign="top" rowspan="1" colspan="1">12 (92.3%)</td><td align="left" valign="top" rowspan="1" colspan="1">19 (65.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> 3 or more times per day</td><td align="left" valign="top" rowspan="1" colspan="1">2 (25%)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (7.7%)</td><td align="left" valign="top" rowspan="1" colspan="1">10 (34.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td colspan="5" align="left" valign="top" rowspan="1">Type of toothbrush (n, %)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Manual toothbrush</td><td align="left" valign="top" rowspan="1" colspan="1">8 (100%)</td><td align="left" valign="top" rowspan="1" colspan="1">12 (92.3%)</td><td align="left" valign="top" rowspan="1" colspan="1">29 (100%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Electric toothbrush</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (7.7%)</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Use of mouthwash (n, %)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (12.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">2 (15.4%)</td><td align="left" valign="top" rowspan="1" colspan="1">5 (17.2%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Flossing (n, %)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (12.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">0 (100%)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (3.4%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Dentures (n, %)</td><td align="left" valign="top" rowspan="1" colspan="1">3 (37.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">5 (38.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">12 (41.4%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Edentulous (n, %)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (12.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (7.7%)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (3.4%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">OHIP-14 (mean ± SD)</td><td align="left" valign="top" rowspan="1" colspan="1">15.2±6.5</td><td align="left" valign="top" rowspan="1" colspan="1">15.5±11.3</td><td align="left" valign="top" rowspan="1" colspan="1">18.3±16</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td colspan="5" align="left" valign="top" rowspan="1">PI (n, %)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Excellent</td><td align="left" valign="top" rowspan="1" colspan="1">1 (12.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">3 (23.1%)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (3.4%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Good</td><td align="left" valign="top" rowspan="1" colspan="1">4 (50%)</td><td align="left" valign="top" rowspan="1" colspan="1">2 (15.4%)</td><td align="left" valign="top" rowspan="1" colspan="1">6 (20.7%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Fair</td><td align="left" valign="top" rowspan="1" colspan="1">1 (12.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">5 (38.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">5 (17.2%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Poor</td><td align="left" valign="top" rowspan="1" colspan="1">1 (12.5%)<xref ref-type="table-fn" rid="tfn5-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1">2 (15.4%)<xref ref-type="table-fn" rid="tfn5-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1">16 (55.2%)<xref ref-type="table-fn" rid="tfn5-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1"><<bold>0.05</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Not applicable</td><td align="left" valign="top" rowspan="1" colspan="1">1 (12.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (7.7%)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (3.4%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td colspan="5" align="left" valign="top" rowspan="1">GI (n, %)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Excellent</td><td align="left" valign="top" rowspan="1" colspan="1">4 (50%)</td><td align="left" valign="top" rowspan="1" colspan="1">6 (46.2%)</td><td align="left" valign="top" rowspan="1" colspan="1">5 (17.2%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Good</td><td align="left" valign="top" rowspan="1" colspan="1">3 (37.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">2 (15.4%)</td><td align="left" valign="top" rowspan="1" colspan="1">10 (34.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Fair</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">3 (23.1%)</td><td align="left" valign="top" rowspan="1" colspan="1">9 (31%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Poor</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (7.7%)</td><td align="left" valign="top" rowspan="1" colspan="1">4 (13.8%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Not applicable</td><td align="left" valign="top" rowspan="1" colspan="1">1 (12.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (7.7%)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (3.4%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td colspan="5" align="left" valign="top" rowspan="1">OHI-S (n, %)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Good</td><td align="left" valign="top" rowspan="1" colspan="1">4 (50%)</td><td align="left" valign="top" rowspan="1" colspan="1">6 (46.1%)</td><td align="left" valign="top" rowspan="1" colspan="1">5 (17.3%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Fair</td><td align="left" valign="top" rowspan="1" colspan="1">2 (25%)</td><td align="left" valign="top" rowspan="1" colspan="1">2 (15.4%)</td><td align="left" valign="top" rowspan="1" colspan="1">6 (20.7%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Poor</td><td align="left" valign="top" rowspan="1" colspan="1">1 (12.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">4 (30.8%)</td><td align="left" valign="top" rowspan="1" colspan="1">17 (58.6%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Not applicable</td><td align="left" valign="top" rowspan="1" colspan="1">1 (12.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (7.7%)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (3.4%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td colspan="5" align="left" valign="top" rowspan="1">PeI (n, %)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Excellent</td><td align="left" valign="top" rowspan="1" colspan="1">3 (37.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">7 (53.8%)<xref ref-type="table-fn" rid="tfn5-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1">5 (17.2%)<xref ref-type="table-fn" rid="tfn5-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1"><<bold>0.05</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Good</td><td align="left" valign="top" rowspan="1" colspan="1">3 (37.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">3 (23.1%)</td><td align="left" valign="top" rowspan="1" colspan="1">5 (17.2%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Fair</td><td align="left" valign="top" rowspan="1" colspan="1">1 (12.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (7.7%)<xref ref-type="table-fn" rid="tfn5-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1">15 (51.7%)<xref ref-type="table-fn" rid="tfn5-ndt-10-1999">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1"><<bold>0.05</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Poor</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (7.7%)</td><td align="left" valign="top" rowspan="1" colspan="1">3 (10.3%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Very poor (n, %)</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0%)</td><td align="left" valign="top" rowspan="1" colspan="1">–</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Not applicable</td><td align="left" valign="top" rowspan="1" colspan="1">1 (12.5%)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (7.7%)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (3.4%)</td><td align="left" valign="top" rowspan="1" colspan="1">ns</td></tr></tbody></table><table-wrap-foot><fn><p><bold>Notes:</bold></p></fn><fn id="tfn5-ndt-10-1999"><label>*</label><p>Represents which variable is significant versus another with <italic>P</italic><0.05. Bold <italic>P</italic>-values are statistically significant.</p></fn><fn id="tfn6-ndt-10-1999"><p><bold>Abbreviations:</bold> DP, patients with major depression; OHIP-14, oral health impact profile; PI, plaque index; GI, gingival index; OHI-S, simplified oral hygiene index; PeI, periodontal index; ns, not significant; SD, standard deviation.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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