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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The effect of rhBMP-2 and PRP delivery by biodegradable β-tricalcium phosphate scaffolds on new bone formation in a non-through rabbit cranial defect model</title>
<author><name sortKey="Lim, Hyun Pil" sort="Lim, Hyun Pil" uniqKey="Lim H" first="Hyun-Pil" last="Lim">Hyun-Pil Lim</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mercado Pagan, Angel E" sort="Mercado Pagan, Angel E" uniqKey="Mercado Pagan A" first="Angel E." last="Mercado-Pagan">Angel E. Mercado-Pagan</name>
<affiliation><nlm:aff id="A2">Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yun, Kwi Dug" sort="Yun, Kwi Dug" uniqKey="Yun K" first="Kwi-Dug" last="Yun">Kwi-Dug Yun</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kang, Seong Soo" sort="Kang, Seong Soo" uniqKey="Kang S" first="Seong-Soo" last="Kang">Seong-Soo Kang</name>
<affiliation><nlm:aff id="A3">College of Veterinary Medicine, Chonnam National University, Gwangju, Korea</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Choi, Taek Hue" sort="Choi, Taek Hue" uniqKey="Choi T" first="Taek-Hue" last="Choi">Taek-Hue Choi</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bishop, Julius" sort="Bishop, Julius" uniqKey="Bishop J" first="Julius" last="Bishop">Julius Bishop</name>
<affiliation><nlm:aff id="A2">Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Koh, Jeong Tae" sort="Koh, Jeong Tae" uniqKey="Koh J" first="Jeong-Tae" last="Koh">Jeong-Tae Koh</name>
<affiliation><nlm:aff id="A4">Department of Pharmacology and Dental Therapeutics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University, Gwangju</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Maloney, William" sort="Maloney, William" uniqKey="Maloney W" first="William" last="Maloney">William Maloney</name>
<affiliation><nlm:aff id="A2">Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lee, Kwang Min" sort="Lee, Kwang Min" uniqKey="Lee K" first="Kwang-Min" last="Lee">Kwang-Min Lee</name>
<affiliation><nlm:aff id="A5">Department of Materials Science and Engineering, Research Institute for Functional Surface Engineering, Chonnam National University, Gwangju, Korea</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yang, Yunzhi" sort="Yang, Yunzhi" uniqKey="Yang Y" first="Yunzhi" last="Yang">Yunzhi Yang</name>
<affiliation><nlm:aff id="A2">Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A6">Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang-Won" last="Park">Sang-Won Park</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23779152</idno>
<idno type="pmc">4012921</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012921</idno>
<idno type="RBID">PMC:4012921</idno>
<idno type="doi">10.1007/s10856-013-4939-9</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000421</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The effect of rhBMP-2 and PRP delivery by biodegradable β-tricalcium phosphate scaffolds on new bone formation in a non-through rabbit cranial defect model</title>
<author><name sortKey="Lim, Hyun Pil" sort="Lim, Hyun Pil" uniqKey="Lim H" first="Hyun-Pil" last="Lim">Hyun-Pil Lim</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mercado Pagan, Angel E" sort="Mercado Pagan, Angel E" uniqKey="Mercado Pagan A" first="Angel E." last="Mercado-Pagan">Angel E. Mercado-Pagan</name>
<affiliation><nlm:aff id="A2">Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yun, Kwi Dug" sort="Yun, Kwi Dug" uniqKey="Yun K" first="Kwi-Dug" last="Yun">Kwi-Dug Yun</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kang, Seong Soo" sort="Kang, Seong Soo" uniqKey="Kang S" first="Seong-Soo" last="Kang">Seong-Soo Kang</name>
<affiliation><nlm:aff id="A3">College of Veterinary Medicine, Chonnam National University, Gwangju, Korea</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Choi, Taek Hue" sort="Choi, Taek Hue" uniqKey="Choi T" first="Taek-Hue" last="Choi">Taek-Hue Choi</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bishop, Julius" sort="Bishop, Julius" uniqKey="Bishop J" first="Julius" last="Bishop">Julius Bishop</name>
<affiliation><nlm:aff id="A2">Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Koh, Jeong Tae" sort="Koh, Jeong Tae" uniqKey="Koh J" first="Jeong-Tae" last="Koh">Jeong-Tae Koh</name>
<affiliation><nlm:aff id="A4">Department of Pharmacology and Dental Therapeutics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University, Gwangju</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Maloney, William" sort="Maloney, William" uniqKey="Maloney W" first="William" last="Maloney">William Maloney</name>
<affiliation><nlm:aff id="A2">Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lee, Kwang Min" sort="Lee, Kwang Min" uniqKey="Lee K" first="Kwang-Min" last="Lee">Kwang-Min Lee</name>
<affiliation><nlm:aff id="A5">Department of Materials Science and Engineering, Research Institute for Functional Surface Engineering, Chonnam National University, Gwangju, Korea</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yang, Yunzhi" sort="Yang, Yunzhi" uniqKey="Yang Y" first="Yunzhi" last="Yang">Yunzhi Yang</name>
<affiliation><nlm:aff id="A2">Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A6">Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang-Won" last="Park">Sang-Won Park</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of materials science. Materials in medicine</title>
<idno type="ISSN">0957-4530</idno>
<idno type="eISSN">1573-4838</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">This study evaluated whether the combination of biodegradable β-tricalcium phosphate (β-TCP) scaffolds with recombinant human bone morphogenetic protein-2 (rhBMP-2) or platelet-rich plasma (PRP) could accelerate bone formation and increase bone height using a rabbit non-through cranial bone defect model. Four non-through cylindrical bone defects with a diameter of 8-mm were surgically created on the cranium of rabbits. β-TCP scaffolds in the presence and absence of impregnated rhBMP-2 or PRP were placed into the defects. At 8 and 16 weeks after implantation, samples were dissected and fixed for analysis by microcomputed tomography and histology. Only defects with rhBMP-2 impregnated β-TCP scaffolds showed significantly enhanced bone formation compared to non-impregnated β-TCP scaffolds (<italic>p</italic>
<0.05). Although new bone was higher than adjacent bone at 8 weeks after implantation, vertical bone augmentation was not observed at 16 weeks after implantation, probably due to scaffold resorption occurring concurrently with new bone formation.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9013087</journal-id>
<journal-id journal-id-type="pubmed-jr-id">22799</journal-id>
<journal-id journal-id-type="nlm-ta">J Mater Sci Mater Med</journal-id>
<journal-id journal-id-type="iso-abbrev">J Mater Sci Mater Med</journal-id>
<journal-title-group><journal-title>Journal of materials science. Materials in medicine</journal-title>
</journal-title-group>
<issn pub-type="ppub">0957-4530</issn>
<issn pub-type="epub">1573-4838</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23779152</article-id>
<article-id pub-id-type="pmc">4012921</article-id>
<article-id pub-id-type="doi">10.1007/s10856-013-4939-9</article-id>
<article-id pub-id-type="manuscript">NIHMS495780</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>The effect of rhBMP-2 and PRP delivery by biodegradable β-tricalcium phosphate scaffolds on new bone formation in a non-through rabbit cranial defect model</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Lim</surname>
<given-names>Hyun-Pil</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mercado-Pagan</surname>
<given-names>Angel E.</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yun</surname>
<given-names>Kwi-Dug</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kang</surname>
<given-names>Seong-Soo</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Choi</surname>
<given-names>Taek-Hue</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bishop</surname>
<given-names>Julius</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Koh</surname>
<given-names>Jeong-Tae</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Maloney</surname>
<given-names>William</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Kwang-Min</given-names>
</name>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yang</surname>
<given-names>Yunzhi</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Park</surname>
<given-names>Sang-Won</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</aff>
<aff id="A2"><label>2</label>
Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</aff>
<aff id="A3"><label>3</label>
College of Veterinary Medicine, Chonnam National University, Gwangju, Korea</aff>
<aff id="A4"><label>4</label>
Department of Pharmacology and Dental Therapeutics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University, Gwangju</aff>
<aff id="A5"><label>5</label>
Department of Materials Science and Engineering, Research Institute for Functional Surface Engineering, Chonnam National University, Gwangju, Korea</aff>
<aff id="A6"><label>6</label>
Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA</aff>
<author-notes><corresp id="FN1">Corresponding authors: Sang-Won Park, Ph.D., D.D.S., Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University, 33 Yongbong-ro, Buk-gu, Gwangju 500-757, KOREA, Tel.: +82 62 530 5842, Fax: +82 62 530 5639, <email>psw320@chonnam.ac.kr</email>
. Yunzhi Peter Yang, Ph.D., Department of Orthopedic Surgery, Stanford University, 300 Pasteur Drive, Edwards, R155, Stanford, CA 94305, Mail code: 5341, T: 650-723-0772 (Office), 650-725-8698 (Lab), F: 650-721-5404, <email>ypyang@stanford.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>17</day>
<month>7</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>19</day>
<month>6</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="ppub"><month>8</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>8</month>
<year>2014</year>
</pub-date>
<volume>24</volume>
<issue>8</issue>
<fpage>1895</fpage>
<lpage>1903</lpage>
<pmc-comment>elocation-id from pubmed: 10.1007/s10856-013-4939-9</pmc-comment>
<abstract><p id="P1">This study evaluated whether the combination of biodegradable β-tricalcium phosphate (β-TCP) scaffolds with recombinant human bone morphogenetic protein-2 (rhBMP-2) or platelet-rich plasma (PRP) could accelerate bone formation and increase bone height using a rabbit non-through cranial bone defect model. Four non-through cylindrical bone defects with a diameter of 8-mm were surgically created on the cranium of rabbits. β-TCP scaffolds in the presence and absence of impregnated rhBMP-2 or PRP were placed into the defects. At 8 and 16 weeks after implantation, samples were dissected and fixed for analysis by microcomputed tomography and histology. Only defects with rhBMP-2 impregnated β-TCP scaffolds showed significantly enhanced bone formation compared to non-impregnated β-TCP scaffolds (<italic>p</italic>
<0.05). Although new bone was higher than adjacent bone at 8 weeks after implantation, vertical bone augmentation was not observed at 16 weeks after implantation, probably due to scaffold resorption occurring concurrently with new bone formation.</p>
</abstract>
<kwd-group><kwd>rhBMP-2</kwd>
<kwd>PRP</kwd>
<kwd>calvarial defect</kwd>
<kwd>porous scaffolds</kwd>
<kwd>ceramic scaffolds</kwd>
<kwd>vertical augmentation</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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