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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cost-effectiveness landscape analysis of treatments addressing xerostomia in patients receiving head and neck radiation therapy</title><author><name sortKey="Sasportas, Laura S" sort="Sasportas, Laura S" uniqKey="Sasportas L" first="Laura S." last="Sasportas">Laura S. Sasportas</name><affiliation><nlm:aff id="A1">Department of Bioengineering, Biodesign Innovation Program, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Hosford, Andrew T" sort="Hosford, Andrew T" uniqKey="Hosford A" first="Andrew T." last="Hosford">Andrew T. Hosford</name><affiliation><nlm:aff id="A1">Department of Bioengineering, Biodesign Innovation Program, Stanford University, Stanford, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Mechanical Engineering, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Sodini, Maria A" sort="Sodini, Maria A" uniqKey="Sodini M" first="Maria A." last="Sodini">Maria A. Sodini</name><affiliation><nlm:aff id="A1">Department of Bioengineering, Biodesign Innovation Program, Stanford University, Stanford, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Stanford Graduate School of Business, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Waters, Dale J" sort="Waters, Dale J" uniqKey="Waters D" first="Dale J." last="Waters">Dale J. Waters</name><affiliation><nlm:aff id="A1">Department of Bioengineering, Biodesign Innovation Program, Stanford University, Stanford, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Chemical Engineering, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Zambricki, Elizabeth A" sort="Zambricki, Elizabeth A" uniqKey="Zambricki E" first="Elizabeth A." last="Zambricki">Elizabeth A. Zambricki</name><affiliation><nlm:aff id="A1">Department of Bioengineering, Biodesign Innovation Program, Stanford University, Stanford, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Stanford Graduate School of Business, Stanford University, Stanford, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Barral, Joelle K" sort="Barral, Joelle K" uniqKey="Barral J" first="Joëlle K." last="Barral">Joëlle K. Barral</name><affiliation><nlm:aff id="A1">Department of Bioengineering, Biodesign Innovation Program, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Graves, Edward E" sort="Graves, Edward E" uniqKey="Graves E" first="Edward E." last="Graves">Edward E. Graves</name><affiliation><nlm:aff id="A6">Department of Radiation Oncology, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Brinton, Todd J" sort="Brinton, Todd J" uniqKey="Brinton T" first="Todd J." last="Brinton">Todd J. Brinton</name><affiliation><nlm:aff id="A1">Department of Bioengineering, Biodesign Innovation Program, Stanford University, Stanford, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Stanford Graduate School of Business, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Yock, Paul G" sort="Yock, Paul G" uniqKey="Yock P" first="Paul G." last="Yock">Paul G. Yock</name><affiliation><nlm:aff id="A1">Department of Bioengineering, Biodesign Innovation Program, Stanford University, Stanford, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Stanford Graduate School of Business, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Le, Quynh Thu" sort="Le, Quynh Thu" uniqKey="Le Q" first="Quynh-Thu" last="Le">Quynh-Thu Le</name><affiliation><nlm:aff id="A6">Department of Radiation Oncology, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Sirjani, Davud" sort="Sirjani, Davud" uniqKey="Sirjani D" first="Davud" last="Sirjani">Davud Sirjani</name><affiliation><nlm:aff id="A5">Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23643579</idno><idno type="pmc">4018820</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018820</idno><idno type="RBID">PMC:4018820</idno><idno type="doi">10.1016/j.oooo.2013.02.017</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000404</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000404</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cost-effectiveness landscape analysis of treatments addressing xerostomia in patients receiving head and neck radiation therapy</title><author><name sortKey="Sasportas, Laura S" sort="Sasportas, Laura S" uniqKey="Sasportas L" first="Laura S." last="Sasportas">Laura S. Sasportas</name><affiliation><nlm:aff id="A1">Department of Bioengineering, Biodesign Innovation Program, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Hosford, Andrew T" sort="Hosford, Andrew T" uniqKey="Hosford A" first="Andrew T." last="Hosford">Andrew T. Hosford</name><affiliation><nlm:aff id="A1">Department of Bioengineering, Biodesign Innovation Program, Stanford University, Stanford, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Mechanical Engineering, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Sodini, Maria A" sort="Sodini, Maria A" uniqKey="Sodini M" first="Maria A." last="Sodini">Maria A. Sodini</name><affiliation><nlm:aff id="A1">Department of Bioengineering, Biodesign Innovation Program, Stanford University, Stanford, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Stanford Graduate School of Business, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Waters, Dale J" sort="Waters, Dale J" uniqKey="Waters D" first="Dale J." last="Waters">Dale J. Waters</name><affiliation><nlm:aff id="A1">Department of Bioengineering, Biodesign Innovation Program, Stanford University, Stanford, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Chemical Engineering, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Zambricki, Elizabeth A" sort="Zambricki, Elizabeth A" uniqKey="Zambricki E" first="Elizabeth A." last="Zambricki">Elizabeth A. Zambricki</name><affiliation><nlm:aff id="A1">Department of Bioengineering, Biodesign Innovation Program, Stanford University, Stanford, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Stanford Graduate School of Business, Stanford University, Stanford, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Barral, Joelle K" sort="Barral, Joelle K" uniqKey="Barral J" first="Joëlle K." last="Barral">Joëlle K. Barral</name><affiliation><nlm:aff id="A1">Department of Bioengineering, Biodesign Innovation Program, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Graves, Edward E" sort="Graves, Edward E" uniqKey="Graves E" first="Edward E." last="Graves">Edward E. Graves</name><affiliation><nlm:aff id="A6">Department of Radiation Oncology, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Brinton, Todd J" sort="Brinton, Todd J" uniqKey="Brinton T" first="Todd J." last="Brinton">Todd J. Brinton</name><affiliation><nlm:aff id="A1">Department of Bioengineering, Biodesign Innovation Program, Stanford University, Stanford, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Stanford Graduate School of Business, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Yock, Paul G" sort="Yock, Paul G" uniqKey="Yock P" first="Paul G." last="Yock">Paul G. Yock</name><affiliation><nlm:aff id="A1">Department of Bioengineering, Biodesign Innovation Program, Stanford University, Stanford, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Stanford Graduate School of Business, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Le, Quynh Thu" sort="Le, Quynh Thu" uniqKey="Le Q" first="Quynh-Thu" last="Le">Quynh-Thu Le</name><affiliation><nlm:aff id="A6">Department of Radiation Oncology, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Sirjani, Davud" sort="Sirjani, Davud" uniqKey="Sirjani D" first="Davud" last="Sirjani">Davud Sirjani</name><affiliation><nlm:aff id="A5">Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Oral surgery, oral medicine, oral pathology and oral radiology</title><idno type="ISSN">2212-4403</idno><idno type="eISSN">2212-4411</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Head and neck (H&N) radiation therapy (RT) can induce irreversible damage to the salivary glands thereby causing long-term xerostomia or dry mouth in 68%–85% of the patients. Not only does xerostomia significantly impair patients’ quality-of-life (QOL) but it also has important medical sequelae, incurring high medical and dental costs. In this article, we review various measures to assess xerostomia and evaluate current and emerging solutions to address this condition in H&N cancer patients. These solutions typically seek to accomplish 1 of the 4 objectives: (1) to protect the salivary glands during RT, (2) to stimulate the remaining gland function, (3) to treat the symptoms of xerostomia, or (4) to regenerate the salivary glands. For each treatment, we assess its mechanisms of action, efficacy, safety, clinical utilization, and cost. We conclude that intensity-modulated radiation therapy is both the most widely used prevention approach and the most cost-effective existing solution and we highlight novel and promising techniques on the cost-effectiveness landscape.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101576782</journal-id><journal-id journal-id-type="pubmed-jr-id">39863</journal-id><journal-id journal-id-type="nlm-ta">Oral Surg Oral Med Oral Pathol Oral Radiol</journal-id><journal-id journal-id-type="iso-abbrev">Oral Surg Oral Med Oral Pathol Oral Radiol</journal-id><journal-title-group><journal-title>Oral surgery, oral medicine, oral pathology and oral radiology</journal-title></journal-title-group><issn pub-type="ppub">2212-4403</issn><issn pub-type="epub">2212-4411</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23643579</article-id><article-id pub-id-type="pmc">4018820</article-id><article-id pub-id-type="doi">10.1016/j.oooo.2013.02.017</article-id><article-id pub-id-type="manuscript">NIHMS578022</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Cost-effectiveness landscape analysis of treatments addressing xerostomia in patients receiving head and neck radiation therapy</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Sasportas</surname><given-names>Laura S.</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Hosford</surname><given-names>Andrew T.</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Sodini</surname><given-names>Maria A.</given-names></name><degrees>MBA</degrees><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Waters</surname><given-names>Dale J.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Zambricki</surname><given-names>Elizabeth A.</given-names></name><degrees>MD, MBA</degrees><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A3">c</xref><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Barral</surname><given-names>Joëlle K.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Graves</surname><given-names>Edward E.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Brinton</surname><given-names>Todd J.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Yock</surname><given-names>Paul G.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Le</surname><given-names>Quynh-Thu</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Sirjani</surname><given-names>Davud</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A5">e</xref></contrib></contrib-group><aff id="A1"><label>a</label>Department of Bioengineering, Biodesign Innovation Program, Stanford University, Stanford, CA, USA</aff><aff id="A2"><label>b</label>Department of Mechanical Engineering, Stanford University, Stanford, CA, USA</aff><aff id="A3"><label>c</label>Stanford Graduate School of Business, Stanford University, Stanford, CA, USA</aff><aff id="A4"><label>d</label>Department of Chemical Engineering, Stanford University, Stanford, CA, USA</aff><aff id="A5"><label>e</label>Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, USA</aff><aff id="A6"><label>f</label>Department of Radiation Oncology, Stanford University, Stanford, CA, USA</aff><pub-date pub-type="nihms-submitted"><day>1</day><month>5</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>03</day><month>5</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>13</day><month>5</month><year>2014</year></pub-date><volume>116</volume><issue>1</issue><fpage>e37</fpage><lpage>e51</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.oooo.2013.02.017</pmc-comment>
<permissions><copyright-statement>© 2013 Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2013</copyright-year></permissions><abstract><p id="P1">Head and neck (H&N) radiation therapy (RT) can induce irreversible damage to the salivary glands thereby causing long-term xerostomia or dry mouth in 68%–85% of the patients. Not only does xerostomia significantly impair patients’ quality-of-life (QOL) but it also has important medical sequelae, incurring high medical and dental costs. In this article, we review various measures to assess xerostomia and evaluate current and emerging solutions to address this condition in H&N cancer patients. These solutions typically seek to accomplish 1 of the 4 objectives: (1) to protect the salivary glands during RT, (2) to stimulate the remaining gland function, (3) to treat the symptoms of xerostomia, or (4) to regenerate the salivary glands. For each treatment, we assess its mechanisms of action, efficacy, safety, clinical utilization, and cost. We conclude that intensity-modulated radiation therapy is both the most widely used prevention approach and the most cost-effective existing solution and we highlight novel and promising techniques on the cost-effectiveness landscape.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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