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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bisphenol A and Related Compounds in Dental Materials</title><author><name sortKey="Fleisch, Abby F" sort="Fleisch, Abby F" uniqKey="Fleisch A" first="Abby F." last="Fleisch">Abby F. Fleisch</name><affiliation><nlm:aff id="A1">Department of Medicine, Children’s Hospital Boston, Harvard Medical School, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Sheffield, Perry E" sort="Sheffield, Perry E" uniqKey="Sheffield P" first="Perry E." last="Sheffield">Perry E. Sheffield</name><affiliation><nlm:aff id="A2">Departments of Pediatrics and Preventive Medicine, Mount Sinai School of Medicine, New York, New York</nlm:aff></affiliation></author><author><name sortKey="Chinn, Courtney" sort="Chinn, Courtney" uniqKey="Chinn C" first="Courtney" last="Chinn">Courtney Chinn</name><affiliation><nlm:aff id="A3">Section of Social and Behavioral Sciences, Division of Community Health, Columbia University College of Dental Medicine, New York, New York</nlm:aff></affiliation></author><author><name sortKey="Edelstein, Burton L" sort="Edelstein, Burton L" uniqKey="Edelstein B" first="Burton L." last="Edelstein">Burton L. Edelstein</name><affiliation><nlm:aff id="A3">Section of Social and Behavioral Sciences, Division of Community Health, Columbia University College of Dental Medicine, New York, New York</nlm:aff></affiliation></author><author><name sortKey="Landrigan, Philip J" sort="Landrigan, Philip J" uniqKey="Landrigan P" first="Philip J." last="Landrigan">Philip J. Landrigan</name><affiliation><nlm:aff id="A2">Departments of Pediatrics and Preventive Medicine, Mount Sinai School of Medicine, New York, New York</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20819896</idno><idno type="pmc">4139922</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139922</idno><idno type="RBID">PMC:4139922</idno><idno type="doi">10.1542/peds.2009-2693</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000383</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000383</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bisphenol A and Related Compounds in Dental Materials</title><author><name sortKey="Fleisch, Abby F" sort="Fleisch, Abby F" uniqKey="Fleisch A" first="Abby F." last="Fleisch">Abby F. Fleisch</name><affiliation><nlm:aff id="A1">Department of Medicine, Children’s Hospital Boston, Harvard Medical School, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Sheffield, Perry E" sort="Sheffield, Perry E" uniqKey="Sheffield P" first="Perry E." last="Sheffield">Perry E. Sheffield</name><affiliation><nlm:aff id="A2">Departments of Pediatrics and Preventive Medicine, Mount Sinai School of Medicine, New York, New York</nlm:aff></affiliation></author><author><name sortKey="Chinn, Courtney" sort="Chinn, Courtney" uniqKey="Chinn C" first="Courtney" last="Chinn">Courtney Chinn</name><affiliation><nlm:aff id="A3">Section of Social and Behavioral Sciences, Division of Community Health, Columbia University College of Dental Medicine, New York, New York</nlm:aff></affiliation></author><author><name sortKey="Edelstein, Burton L" sort="Edelstein, Burton L" uniqKey="Edelstein B" first="Burton L." last="Edelstein">Burton L. Edelstein</name><affiliation><nlm:aff id="A3">Section of Social and Behavioral Sciences, Division of Community Health, Columbia University College of Dental Medicine, New York, New York</nlm:aff></affiliation></author><author><name sortKey="Landrigan, Philip J" sort="Landrigan, Philip J" uniqKey="Landrigan P" first="Philip J." last="Landrigan">Philip J. Landrigan</name><affiliation><nlm:aff id="A2">Departments of Pediatrics and Preventive Medicine, Mount Sinai School of Medicine, New York, New York</nlm:aff></affiliation></author></analytic><series><title level="j">Pediatrics</title><idno type="ISSN">0031-4005</idno><idno type="eISSN">1098-4275</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>CONTEXT</title><p id="P1">Dental sealants and composite filling materials containing bisphenol A (BPA) derivatives are increasingly used in childhood dentistry. Evidence is accumulating that BPA and some BPA derivatives can pose health risks attributable to their endocrine-disrupting, estrogenic properties.</p></sec><sec id="S2"><title>OBJECTIVES</title><p id="P2">To systematically compile and critically evaluate the literature characterizing BPA content of dental materials; to assess BPA exposures from dental materials and potential health risks; and to develop evidence-based guidance for reducing BPA exposures while promoting oral health.</p></sec><sec id="S3"><title>METHODS</title><p id="P3">The extant toxicological literature and material safety data sheets were used as data sources.</p></sec><sec id="S4"><title>RESULTS</title><p id="P4">BPA is released from dental resins through salivary enzymatic hydrolysis of BPA derivatives, and BPA is detectable in saliva for up to 3 hours after resin placement. The quantity and duration of systemic BPA absorption is not clear from the available data. Dental products containing the bisphenol A derivative glycidyl dimethacrylate (bis-GMA) are less likely to be hydrolyzed to BPA and have less estrogenicity than those containing bisphenol A dimethacrylate (bis-DMA). Most other BPA derivatives used in dental materials have not been evaluated for estrogenicity. BPA exposure can be reduced by cleaning and rinsing surfaces of sealants and composites immediately after placement.</p></sec><sec id="S5"><title>CONCLUSIONS</title><p id="P5">On the basis of the proven benefits of resin-based dental materials and the brevity of BPA exposure, we recommend continued use with strict adherence to precautionary application techniques. Use of these materials should be minimized during pregnancy whenever possible. Manufacturers should be required to report complete information on the chemical composition of dental products and encouraged to develop materials with less estrogenic potential.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0376422</journal-id><journal-id journal-id-type="pubmed-jr-id">6405</journal-id><journal-id journal-id-type="nlm-ta">Pediatrics</journal-id><journal-id journal-id-type="iso-abbrev">Pediatrics</journal-id><journal-title-group><journal-title>Pediatrics</journal-title></journal-title-group><issn pub-type="ppub">0031-4005</issn><issn pub-type="epub">1098-4275</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20819896</article-id><article-id pub-id-type="pmc">4139922</article-id><article-id pub-id-type="doi">10.1542/peds.2009-2693</article-id><article-id pub-id-type="manuscript">NIHMS614240</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Bisphenol A and Related Compounds in Dental Materials</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Fleisch</surname><given-names>Abby F.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Sheffield</surname><given-names>Perry E.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Chinn</surname><given-names>Courtney</given-names></name><degrees>DDS, MPH</degrees><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Edelstein</surname><given-names>Burton L.</given-names></name><degrees>DDS, MPH</degrees><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Landrigan</surname><given-names>Philip J.</given-names></name><degrees>MD, MSc</degrees><xref ref-type="aff" rid="A2">b</xref></contrib></contrib-group><aff id="A1"><label>a</label>Department of Medicine, Children’s Hospital Boston, Harvard Medical School, Boston, Massachusetts</aff><aff id="A2"><label>b</label>Departments of Pediatrics and Preventive Medicine, Mount Sinai School of Medicine, New York, New York</aff><aff id="A3"><label>c</label>Section of Social and Behavioral Sciences, Division of Community Health, Columbia University College of Dental Medicine, New York, New York</aff><author-notes><corresp id="FN1">Address correspondence to Abby F. Fleisch, MD, Children’s Hospital Boston, 300 Longwood Ave, Boston, MA 02115. <email>abby.fleisch@childrens.harvard.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>18</day><month>7</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>06</day><month>9</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>21</day><month>8</month><year>2014</year></pub-date><volume>126</volume><issue>4</issue><fpage>760</fpage><lpage>768</lpage><pmc-comment>elocation-id from pubmed: 10.1542/peds.2009-2693</pmc-comment>
<permissions><copyright-statement>Copyright © 2010 by the American Academy of Pediatrics</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><sec id="S1"><title>CONTEXT</title><p id="P1">Dental sealants and composite filling materials containing bisphenol A (BPA) derivatives are increasingly used in childhood dentistry. Evidence is accumulating that BPA and some BPA derivatives can pose health risks attributable to their endocrine-disrupting, estrogenic properties.</p></sec><sec id="S2"><title>OBJECTIVES</title><p id="P2">To systematically compile and critically evaluate the literature characterizing BPA content of dental materials; to assess BPA exposures from dental materials and potential health risks; and to develop evidence-based guidance for reducing BPA exposures while promoting oral health.</p></sec><sec id="S3"><title>METHODS</title><p id="P3">The extant toxicological literature and material safety data sheets were used as data sources.</p></sec><sec id="S4"><title>RESULTS</title><p id="P4">BPA is released from dental resins through salivary enzymatic hydrolysis of BPA derivatives, and BPA is detectable in saliva for up to 3 hours after resin placement. The quantity and duration of systemic BPA absorption is not clear from the available data. Dental products containing the bisphenol A derivative glycidyl dimethacrylate (bis-GMA) are less likely to be hydrolyzed to BPA and have less estrogenicity than those containing bisphenol A dimethacrylate (bis-DMA). Most other BPA derivatives used in dental materials have not been evaluated for estrogenicity. BPA exposure can be reduced by cleaning and rinsing surfaces of sealants and composites immediately after placement.</p></sec><sec id="S5"><title>CONCLUSIONS</title><p id="P5">On the basis of the proven benefits of resin-based dental materials and the brevity of BPA exposure, we recommend continued use with strict adherence to precautionary application techniques. Use of these materials should be minimized during pregnancy whenever possible. Manufacturers should be required to report complete information on the chemical composition of dental products and encouraged to develop materials with less estrogenic potential.</p></sec></abstract><kwd-group><kwd>pit and fissure sealants</kwd><kwd>dental sealants</kwd><kwd>dental composites</kwd><kwd>bisphenol A</kwd><kwd>endocrine disruptors</kwd><kwd>oral health</kwd><kwd>pediatric dentistry</kwd><kwd>children’s environmental health</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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