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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Maxillary reconstruction: Current concepts and controversies</title><author><name sortKey="Iyer, Subramania" sort="Iyer, Subramania" uniqKey="Iyer S" first="Subramania" last="Iyer">Subramania Iyer</name><affiliation><nlm:aff id="aff1">Department of Plastic, Reconstructive and Head and Neck Surgery, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India</nlm:aff></affiliation></author><author><name sortKey="Thankappan, Krishnakumar" sort="Thankappan, Krishnakumar" uniqKey="Thankappan K" first="Krishnakumar" last="Thankappan">Krishnakumar Thankappan</name><affiliation><nlm:aff id="aff1">Department of Plastic, Reconstructive and Head and Neck Surgery, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24987199</idno><idno type="pmc">4075223</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075223</idno><idno type="RBID">PMC:4075223</idno><idno type="doi">10.4103/0970-0358.129618</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000254</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000254</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Maxillary reconstruction: Current concepts and controversies</title><author><name sortKey="Iyer, Subramania" sort="Iyer, Subramania" uniqKey="Iyer S" first="Subramania" last="Iyer">Subramania Iyer</name><affiliation><nlm:aff id="aff1">Department of Plastic, Reconstructive and Head and Neck Surgery, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India</nlm:aff></affiliation></author><author><name sortKey="Thankappan, Krishnakumar" sort="Thankappan, Krishnakumar" uniqKey="Thankappan K" first="Krishnakumar" last="Thankappan">Krishnakumar Thankappan</name><affiliation><nlm:aff id="aff1">Department of Plastic, Reconstructive and Head and Neck Surgery, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India</nlm:aff></affiliation></author></analytic><series><title level="j">Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India</title><idno type="ISSN">0970-0358</idno><idno type="eISSN">1998-376X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Maxillary reconstruction is still an evolving art when compared to the reconstruction of the mandible. The defects of maxilla apart from affecting the functions of the speech, swallowing and mastication also cause cosmetic disfigurement. Rehabilitation of the form and function in patients with maxillary defects is either by using an obturator prosthesis or by a surgical reconstruction. Literature is abundant with a variety of reconstructive methods. The classification systems are also varied, with no universal acceptance of any one of them. The oncologic safety of these procedures is still debated, and conclusive evidence in this regard has not emerged yet. Management of the orbit is also not yet addressed properly. Tissue engineering, that has been hyped to be one of the possible solutions for this vexing reconstructive problem, has not come out with reliable and reproducible results so far. This review article discusses the rationale and oncological safety of the reconstructing the maxillary defects, critically analyzes the classification systems, offers the different reconstructive methods and touches upon the controversies in this subject. The management of the retained and exenterated orbit associated with maxillectomy is reviewed. The surgical morbidity, complications and the recent advances in this field are also looked into. An algorithm, based on our experience, is presented.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Parr, Gr" uniqKey="Parr G">GR Parr</name></author><author><name sortKey="Tharp, Ge" uniqKey="Tharp G">GE Tharp</name></author><author><name sortKey="Rahn, Ao" uniqKey="Rahn A">AO Rahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eckert, Se" uniqKey="Eckert S">SE Eckert</name></author><author><name sortKey="Carr, Ab" uniqKey="Carr A">AB Carr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cordeiro, Pg" uniqKey="Cordeiro P">PG Cordeiro</name></author><author><name sortKey="Santamaria, E" uniqKey="Santamaria E">E Santamaria</name></author><author><name sortKey="Kraus, Dh" uniqKey="Kraus D">DH Kraus</name></author><author><name sortKey="Strong, Ew" uniqKey="Strong E">EW Strong</name></author><author><name sortKey="Shah, Jp" uniqKey="Shah J">JP 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Indian J Plast Surg</journal-id><journal-id journal-id-type="iso-abbrev">Indian J Plast Surg</journal-id><journal-id journal-id-type="publisher-id">IJPS</journal-id><journal-title-group><journal-title>Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India</journal-title></journal-title-group><issn pub-type="ppub">0970-0358</issn><issn pub-type="epub">1998-376X</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24987199</article-id><article-id pub-id-type="pmc">4075223</article-id><article-id pub-id-type="publisher-id">IJPS-47-8</article-id><article-id pub-id-type="doi">10.4103/0970-0358.129618</article-id><article-categories><subj-group subj-group-type="heading"><subject>Prof. Mira Sen (Banerjee) C.M.E. Article</subject></subj-group></article-categories><title-group><article-title>Maxillary reconstruction: Current concepts and controversies</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Iyer</surname><given-names>Subramania</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Thankappan</surname><given-names>Krishnakumar</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib></contrib-group><aff id="aff1">Department of Plastic, Reconstructive and Head and Neck Surgery, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India</aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Dr. Subramania Iyer, Professor and Head, Department of Plastic, Reconstructive and Head and Neck Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala, India. E-mail: <email xlink:href="subu.amrita@gmail.com">subu.amrita@gmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><season>Jan-Apr</season><year>2014</year></pub-date><volume>47</volume><issue>1</issue><fpage>8</fpage><lpage>19</lpage><permissions><copyright-statement>Copyright: © Indian Journal of Plastic Surgery</copyright-statement><copyright-year>2014</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Maxillary reconstruction is still an evolving art when compared to the reconstruction of the mandible. The defects of maxilla apart from affecting the functions of the speech, swallowing and mastication also cause cosmetic disfigurement. Rehabilitation of the form and function in patients with maxillary defects is either by using an obturator prosthesis or by a surgical reconstruction. Literature is abundant with a variety of reconstructive methods. The classification systems are also varied, with no universal acceptance of any one of them. The oncologic safety of these procedures is still debated, and conclusive evidence in this regard has not emerged yet. Management of the orbit is also not yet addressed properly. Tissue engineering, that has been hyped to be one of the possible solutions for this vexing reconstructive problem, has not come out with reliable and reproducible results so far. This review article discusses the rationale and oncological safety of the reconstructing the maxillary defects, critically analyzes the classification systems, offers the different reconstructive methods and touches upon the controversies in this subject. The management of the retained and exenterated orbit associated with maxillectomy is reviewed. The surgical morbidity, complications and the recent advances in this field are also looked into. An algorithm, based on our experience, is presented.</p></abstract><kwd-group><title>KEY WORDS</title><kwd>Free fibula</kwd><kwd>free flaps</kwd><kwd>head and neck cancer</kwd><kwd>head and neck reconstruction</kwd><kwd>maxillary</kwd><kwd>maxillectomy</kwd><kwd>reconstruction</kwd><kwd>orbital exenteration</kwd><kwd>orbital reconstruction</kwd></kwd-group></article-meta></front><body><sec sec-type="intro" id="sec1-1"><title>INTRODUCTION</title><p>The maxillary bone is important both for aesthesis of the face and function of the oral cavity. It separates the oral and orbital cavities and also provides skeletal support to the orbital contents. The defects of maxilla affect the speech, swallowing and mastication. Rehabilitation of the form and function in patients with maxillary defects is either by using an obturator prosthesis or by a surgical reconstruction. Traditionally, these defects were prosthetically rehabilitated, but, in the last two decades, several publications have demonstrated the advantages of surgically reconstructing these defects. A variety of regional and free flaps have been reported for this purpose. In order to facilitate logical thinking in maxillary reconstruction, various systems have been proposed for classifying these defects. These classifications, though have made the reporting of the results more comparable, still lack the uniformity and have differing levels of peer acceptance. In spite of the significant advances in the understanding of rehabilitating the maxillary defects, disagreement still exists in the methods suitable to address the associated orbital floor and exenteration defects. The oncologic safety of these procedures is still debated, and conclusive evidence in this regard has not emerged yet. Tissue engineering, that has been hyped to be one of the possible solutions for this vexing reconstructive problem, has not come out with reliable and reproducible results so far. Maxillary reconstruction is still an evolving art when compared to the reconstruction of the mandible. This review article will aim at looking at these various issues related to maxillary reconstruction.</p></sec><sec id="sec1-2"><title>RATIONALE AND ONCOLOGICAL SAFETY</title><p>Traditionally, post-maxillectomy defects were reconstructed using split-thickness skin grafts to line the post-resection cavity so as to facilitate a prosthetic obturator placement. Following healing of the cavity, an interim, and later on, a permanent obturator was provided. The retention was achieved by anchoring to the remaining teeth.[<xref rid="ref1" ref-type="bibr">1</xref>] To facilitate obturator placement in edentulous patients as well as cases of bilateral maxillectomy, osseous integrated implants have been used locating them in the adjacent bony structures like the zygoma.[<xref rid="ref2" ref-type="bibr">2</xref>] Obturation of the maxillary defects as a permanent definitive option is still practised widely due to its relative safety and least operative time. This method has an additional advantage of immediately restoring the dentition, whereas the flap reconstructions require further procedures or dentures. Above all, it has been believed that permanent sealing of the maxillary cavity would hinder its inspection during follow up for any recurrences. However, there are numerous disadvantages with the use of the obturator, which include inadequate sealing leading to poor oro-nasal separation and instability of the prosthesis due to the lack of buttressing areas. These become more evident when the resection defect is wider and posteriorly placed.[<xref rid="ref2" ref-type="bibr">2</xref><xref rid="ref3" ref-type="bibr">3</xref>] Few of the quality of life studies (QOL) showed low scores in patients using obturators when compared to the surgical reconstruction. Kornblith <italic>et al</italic>.[<xref rid="ref4" ref-type="bibr">4</xref>] observed that patients with more than a third of the soft palate and a fourth of the hard palate resected had poor speech scores and overall obturator function. Rogers <italic>et al</italic>.[<xref rid="ref5" ref-type="bibr">5</xref>] compared the QOL in a two similar small groups of patients having either prosthetic or surgical obturation of maxillectomy cavities. These patients completed a postoperative semi-structured interview with eight sets of questionnaires. No statistically significant differences were seen between the obturator and free flap groups. But, they reported borderline trends for obturator patients being more self-conscious, concerned about their appearance, to have more pain and soreness in their mouths, more and less satisfied with their upper dentures and function. The problems as noted by the authors not favourable to the use of obturator included larger soft or hard palatal resection defects, which included facial skin or orbital contents and presence of trismus. Okay <italic>et al</italic>. found that the stability of the prosthesis compromised as defect size increased, resulting in poor obturator function and QOL. They concluded that the defects that involved more than half the hard palate or included the premaxilla and both canines were poor candidates for prosthetic reconstruction.[<xref rid="ref6" ref-type="bibr">6</xref>] The influence of the horizontal extent of the palatal defect in determining the success of the use of obturators was stressed by Moreno and Hanasano in their comparative study of 73 cases with obturation and 40 cases with free flap reconstruction. They found a statistically significant reduction in the speech and swallowing outcome with the use of obturators where the horizontal defect was large.[<xref rid="ref7" ref-type="bibr">7</xref>] The superiority of free flaps in improving the quality of life even in small and medium defects of maxilla was reported by genden <italic>et al</italic>.[<xref rid="ref8" ref-type="bibr">8</xref>] The influence of post-operative radiotherapy that most of these patients have to undergo can be a cause for significant problems with obturator rehabilitation. The radiation could lead to trismus and resultant difficulty in insertion of the prosthesis, as well as dryness and soreness of the mucosa as reported by Chigurupati <italic>et al</italic>.[<xref rid="ref9" ref-type="bibr">9</xref>] Genden <italic>et al</italic>. noted that, in the group of patients who had undergone radiotherapy, there was pain and difficulty tolerating the prosthesis. They also needed frequent adjustment of the prosthesis.[<xref rid="ref10" ref-type="bibr">10</xref>] The importance of surveillance of the cavity for recurrences by keeping it open has been supported or negated by only very few studies. Moreno <italic>et al</italic>.[<xref rid="ref7" ref-type="bibr">7</xref>] compared the average time of presentation of recurrence in two groups of patients who had undergone maxillectomy; one group had reconstruction and the other had patients with obturator. Each group was matched for cancer stage and histology. No statistically significant differences between the two groups could be detected. Also, they found that the diagnosis of recurrence was more frequently made by physical examination in both groups than by imaging with CT or MRI scans. But, the number of cases included in this analysis was too small to reach into any reliable conclusion. But, the papers supporting reconstruction, without the support of any evidence, state that endoscopic examination and use of imaging modalities like CT and MRI scan can negate the necessity of keeping the cavity open.</p></sec><sec id="sec1-3"><title>CLASSIFICATION SYSTEMS</title><p>Various classification systems have tried to look at the defects either from their functional and/or aesthetic effects. Some of them have mainly looked at the reconstructive or rehabilitative considerations only. Brown <italic>et al</italic>.[<xref rid="ref11" ref-type="bibr">11</xref>] initially classified maxillectomy defects into four, based on the vertical and horizontal defect components. The vertical divisions (Class I-IV) denote the extent of unilateral involvement. The sub-classifications into a-c qualify the defect horizontally, denoting the amount of palate and alveolus removed. The loss of the vertical component causes more of an aesthetic problem, while the horizontal component loss results in greater functional deficits. The dental, masticatory and the articulatory aspects are given by the horizontal component, and the aesthetic and orbital aspects are highlighted by the vertical components. Recently, the authors modified the classification system[<xref rid="ref12" ref-type="bibr">12</xref>] to include a class V defect, the orbito-maxillary defect and class VI defect, the naso-maxillary defect. These two additions do not involve the ablation of the palate or the dental alveolus. They also included minimal changes in the horizontal classification into a-d.</p><p>Cordeirro <italic>et al</italic>. has suggested a four-part classification system.[<xref rid="ref13" ref-type="bibr">13</xref><xref rid="ref14" ref-type="bibr">14</xref><xref rid="ref15" ref-type="bibr">15</xref>] They could use this classification system to assess the surface area to volume requirement, the need for the palatal closure and the need for orbital reconstruction. Triana <italic>et al</italic>.[<xref rid="ref16" ref-type="bibr">16</xref>] classified the defects into (1) inferior partial maxillectomy, subdivided based on the extent of the palate lost and (2) Total maxillectomy, subdivided depending on whether the orbit was removed, and the amount of the malar bone and zygomatic arch lost. Okay <italic>et al</italic>.[<xref rid="ref6" ref-type="bibr">6</xref>] has described a scheme based on the defect in the horizontal planes. This classification system mainly takes into account the obturator stability and the retention.</p></sec><sec id="sec1-4"><title>CRITICAL REVIEW OF THE CLASSIFICATION SYSTEMS</title><p>A classification system should be valid, reliable, rationale and should grade the defects according to the reconstructive difficulty. It should describe the defect with increasing loss of the reconstructive components, and it should be the guide to an ideal reconstructive method. It should also be a means of documentation for the comparison of results and should identify the ability and deficits in achieving the reconstructive goals. While other system gives much importance on the restoration of the soft issue and the bony components, the classification proposed by Okay <italic>et al</italic>. stressed on importance to the dental and alveolar restoration and rehabilitation. The extent of the palatal defect itself or the stability for successful obturator retention was given prime consideration in their classification. Moreno <italic>et al</italic>.[<xref rid="ref7" ref-type="bibr">7</xref>] in their retrospective analysis pointed out that the success of denture obturator rehabilitation correlated very well when the defects were type 3 as per the Okay classification. They conclude that these defects are better covered with free flaps. Brown's classification[<xref rid="ref12" ref-type="bibr">12</xref>] also incorporates the horizontal extent of the defect grading them a-c depending on the extent of resection of the hard palate and alveolus. But, while considering the options in choosing the reconstructive choice of the flap, they stress on the vertical extent of the resection than on the horizontal extent. Cordeiro <italic>et al</italic>.,[<xref rid="ref17" ref-type="bibr">17</xref>] in their most recent modification, added two subgroups based on whether less or more than 50% of palate was resected, but failed substantiate this with any implications in the functional outcome.</p><p>The vertical extent of the defect as well as the components involved has been the mainstay of the well-publicized classification systems proposed by Cordeiro[<xref rid="ref3" ref-type="bibr">3</xref><xref rid="ref17" ref-type="bibr">17</xref>] and Brown. The four-part classification system proposed by Cordeiro and colleagues seems simple to follow and is based on the number of walls resected as well whether the orbital contents were included in the resection. They used this classification system to assess the surface area to volume requirement, the need for the palatal closure and the need for orbital reconstruction. They also tried to identify the best flap for a particular defect. But, since they relied mostly on soft tissue reconstruction only, especially with radial forearm, the guidance as to the ideal reconstructive choice based on their system of classification fails to serve in this purpose. Adding to the deficiencies of the system, this classification does not give much importance to the dental restoration. The Brown <italic>et al</italic>. classification is more sound in its principles both in terms of the description of the defects as well as the help rendered for planning the reconstruction and rehabilitation. This system does not quantify the amount of skin loss and skull base defect. Combining the Okay system palatal defect and the Browns classification as done in the series reported by Moreno <italic>et al</italic>.<sup>l</sup> seems most encompassing but may be difficult to follow in all future studies.</p></sec><sec id="sec1-5"><title>RECONSTRUCTIVE METHODS</title><p>The reconstructive options described for maxillectomy defects vary from regional soft tissue and bone containing flaps, free flaps with either soft tissue alone or with bone or combinations of soft tissue flaps and alloplastic implants. The regional soft tissue flaps used for reconstruction of these defects include temporalis myofacial flaps,[<xref rid="ref18" ref-type="bibr">18</xref>] Facial artery myomucosal flaps (FAMM),[<xref rid="ref19" ref-type="bibr">19</xref><xref rid="ref20" ref-type="bibr">20</xref>] buccal pad of fat[<xref rid="ref21" ref-type="bibr">21</xref><xref rid="ref22" ref-type="bibr">22</xref>] and reverse submental flaps.[<xref rid="ref23" ref-type="bibr">23</xref><xref rid="ref24" ref-type="bibr">24</xref>] Of these, the buccal pad of fat flaps and the FAMM [Figure <xref ref-type="fig" rid="F1">1a</xref>, <xref ref-type="fig" rid="F1">b</xref>] flaps are found to be useful in small and relatively lateral defects. The temporalis flap [Figure <xref ref-type="fig" rid="F2">2a</xref>–<xref ref-type="fig" rid="F2">d</xref>] which served as the workhorse in several initial publications[<xref rid="ref25" ref-type="bibr">25</xref>] on maxillary reconstructions is still useful and popular. But, the disadvantages of this flap include dehiscence in larger defects more than 4 cm and immediate or late trismus. The reverse submental artery flap based on the distal facial artery was reported to be successful in a series of 13 cases by Wang <italic>et al</italic>.[<xref rid="ref24" ref-type="bibr">24</xref>] The flaps were de-epithelialised and used to cover defects of inferior maxillary defects and allowed to epithelise similarly to the temporalis myofacial flaps. These flaps undergo a phase of inflammation, granulation tissue re-formation followed by epithelisation.[<xref rid="ref26" ref-type="bibr">26</xref>] But, all these flaps allowing epithelisation could lead to contraction and obliteration of the sulcus, making dental rehabilitation difficult.</p><fig id="F1" position="float"><label>Figure 1</label><caption><p>(a) Fascial Artery Myo-mucosal (FAMM) flap used for a lateral defect. The lesion and the flap marked (b) FAMM flap sutured to the defect</p></caption><graphic xlink:href="IJPS-47-8-g001"></graphic></fig><fig id="F2" position="float"><label>Figure 2</label><caption><p>(a) Tumour involving the posterior superior alveolar area (b) Temporalis flap sutured to the defect (c) Reconstructive outcome two years after surgery (d) Temporal deformity</p></caption><graphic xlink:href="IJPS-47-8-g002"></graphic></fig><p>The free soft tissue flaps described are radial forearm flaps,[<xref rid="ref27" ref-type="bibr">27</xref>] rectus abdominis,[<xref rid="ref28" ref-type="bibr">28</xref>] Anterolateral thigh flap[<xref rid="ref29" ref-type="bibr">29</xref><xref rid="ref30" ref-type="bibr">30</xref>] and DIEP flaps.[<xref rid="ref31" ref-type="bibr">31</xref>] The main objective of reconstruction using these flaps has been to seal the palatal defects. Hence, most of these flaps have been used in cases of maxillectomy, where orbital floor is preserved. <xref ref-type="fig" rid="F3">Figure 3</xref> shows an infrastructure maxillectomy defect reconstructed with free radial forearm flap. The advantage of these flaps includes their long pedicle that makes the vascular anastamosis in the neck easier.[<xref rid="ref32" ref-type="bibr">32</xref>] The drawback of these flaps is their inability to address the need of orbital support, the inability to prevent hollowing of cheek and unsuitability to place dental implants. Dental rehabilitation becomes difficult in these cases due to the insufficiency of the gingivo-buccal sulcus.</p><fig id="F3" position="float"><label>Figure 3</label><caption><p>Infrastructure maxillectomy defect reconstructed with free radial forearm flap</p></caption><graphic xlink:href="IJPS-47-8-g003"></graphic></fig><p>The disadvantages of lack of bony support to the orbit and the absence of skeletal support to the cheek, while using soft tissue flap alone, have been addressed in several reports by using implants or bone grafts along with them. Bianchi <italic>et al</italic>. reported successful use of iliac crest bone grafts along with both ALT[<xref rid="ref33" ref-type="bibr">33</xref>] and vertical rectus abdominis flaps.[<xref rid="ref34" ref-type="bibr">34</xref>] The number of cases reported was small, but they claimed the bone grafts withstanding post-operative radiation in some cases. Hashikawa <italic>et al</italic>.[<xref rid="ref35" ref-type="bibr">35</xref><xref rid="ref36" ref-type="bibr">36</xref>] used titanium mesh for reconstruction of floor of the orbit only, radial forearm free flap for covering of titanium mesh and lining of the cheek flap and obturator prosthesis for palatal and dental rehabilitation. Sun <italic>et al</italic>.[<xref rid="ref37" ref-type="bibr">37</xref>] also reported reconstruction of maxillary defects with titanium mesh and radial forearm free flap. Nakayama <italic>et al</italic>.[<xref rid="ref38" ref-type="bibr">38</xref>] reported using various soft tissue flaps like rectus abdominis muscle and ALT in combination with titanium mesh for maxillectomy defect reconstruction. The soft tissue flaps were put both in front and behind the mesh to prevent its exposure. Emil Dediol <italic>et al</italic>.[<xref rid="ref39" ref-type="bibr">39</xref>] in a recent report used a prefabricated titanium mesh, not only the orbital floor but also the infraorbital rim, the zygomatic prominence, the anterior wall of maxilla and the alveolus. The titanium mesh was bent intraoperatively on a 3D skeletal model. They used ALT flaps in majority of cases for palatal obturation. Part of the flap was de-epithelialised and used to cover the mesh from its anterior aspect, leaving it exposed in the sinus cavity.</p><p>Various bone flaps have been used in maxillary reconstructions. They provide a) support for the orbital contents, b) alveolar reconstruction and c) prominence to the cheek. Few regional bone containing flaps have been used for this purpose, but most of the reports are those using free bone flaps. The use of the coronoid process of the mandible based on the temporalis muscle for orbital support was reported by Curioni[<xref rid="ref40" ref-type="bibr">40</xref>] and Pryor <italic>et al</italic>.[<xref rid="ref41" ref-type="bibr">41</xref>] The coronoid process is harvested long enough into the ramus of the mandible, enabling it to reach the medial nasal wall, where it is attached with plate or wires. In the cases reported by Pryor <italic>et al</italic>., the maxillary cavity was covered with an obturator. Bilen <italic>et al</italic>.[<xref rid="ref42" ref-type="bibr">42</xref>] described a superficial temporal artery (STA) and vein based calvarial bone flaps using its outer table. Without disrupting the integrity of fascia and periosteum, the bone was separated into two segments. The two bone segments were transferred as one single flap, and one segment of the flap was used to reconstruct the orbital floor and the other for reconstruction of the anterior maxillary wall. Out of the five cases, in two, large skin defects were also covered with lateral frontal skin supplied by the STA. Yang <italic>et al</italic>.[<xref rid="ref43" ref-type="bibr">43</xref>] used the reverse submental de-epithelialised flap to carry the lower border of the mandible for reconstructing the upper alveolar defect. They even used immediate dental implants in these cases successfully. The mandibular donor site was filled with a MEDPOR Surgical Implant. The disadvantages of these pedicled flaps include difficulty in manoeuvring them as well as insufficient soft tissue cover. The behaviour of these to irradiation is also unpredictable.[<xref rid="ref44" ref-type="bibr">44</xref>]</p><p>The literature is abundant on the use of free bone flaps for maxillary reconstruction. In fact, the spurt in the number of maxillary reconstruction owes a lot to the use of different types of free bone flaps. The flaps that has been used include fibula osteocutaneous,[<xref rid="ref45" ref-type="bibr">45</xref><xref rid="ref46" ref-type="bibr">46</xref><xref rid="ref47" ref-type="bibr">47</xref><xref rid="ref48" ref-type="bibr">48</xref>] scapula,[<xref rid="ref49" ref-type="bibr">49</xref><xref rid="ref50" ref-type="bibr">50</xref><xref rid="ref51" ref-type="bibr">51</xref>] iliac crest,[<xref rid="ref52" ref-type="bibr">52</xref><xref rid="ref53" ref-type="bibr">53</xref><xref rid="ref54" ref-type="bibr">54</xref>] radial forearm,[<xref rid="ref55" ref-type="bibr">55</xref><xref rid="ref56" ref-type="bibr">56</xref>] Tensor facial lata — iliac crest,[<xref rid="ref57" ref-type="bibr">57</xref>] rectus abdominis with ribs[<xref rid="ref58" ref-type="bibr">58</xref>] and TFL — iliac crest with internal oblique[<xref rid="ref59" ref-type="bibr">59</xref>] medial femoral condyle flap.[<xref rid="ref60" ref-type="bibr">60</xref>] The need of the bone in maxillary reconstructions is a) to restore midface contour, b) to provide orbital floor support, c) to replace the missing alveolar bone and d) to act as a base for dental implants. The various bone flaps and the methods described utilising these flaps achieve these goals to widely variable extent. The radial forearm osteocutaneous flaps have the advantage of a long pedicle, large skin paddle for cheek or palatal lining, but with a small thin bony segment. Andredes <italic>et al</italic>.[<xref rid="ref56" ref-type="bibr">56</xref>] used these for zygomatic maxillary buttress with the skin paddle being used for covering the intraoral defect and the external skin defect. The orbital support was given by a mesh. Chepeha <italic>et al</italic>.[<xref rid="ref55" ref-type="bibr">55</xref>] used the radial bone for orbital floor support and obturator for the palatal defect. In general, their use is limited in maxillary reconstruction.</p><p>The advantages of the fibular flap are the sufficient bone length that allows multiple osteotomies to be made if needed. This becomes important when separate bone segments are needed for alveolus and the orbital floor support. The intervening segment of bone can be removed for this purpose [<xref ref-type="fig" rid="F4">Figure 4</xref>]. But, the greater advantage of fibula is the long pedicle length allowing a tension-free anastamosis in the neck. The skin paddle can be used for palatal obturation as well as skin cover if needed. The disadvantages of fibula include the lack of soft tissue to fill the maxillary cavity, especially if a mesh is used for orbital floor reconstruction and the inability to contour it to the needs of orbital floor support.</p><fig id="F4" position="float"><label>Figure 4</label><caption><p>Free fibula osteocutaneous flap with osteotomies and an intervening segment of bone removed to facilitate orbital and alveolar bone support</p></caption><graphic xlink:href="IJPS-47-8-g004"></graphic></fig><p>The deep circumflex iliac artery-based iliac crest flap was suggested as a better option by Brown <italic>et al</italic>.[<xref rid="ref61" ref-type="bibr">61</xref>] They oriented the iliac crest horizontally in their class 2 defects and vertically in the class 3 and 4 defects. The advantage of the iliac crest, when vertically placed for larger defects in restoration of the facial bone buttress, support to the nose and superior lip and reconstruction of the orbital rim were stressed by Futran[<xref rid="ref62" ref-type="bibr">62</xref>] and Bianchi.[<xref rid="ref54" ref-type="bibr">54</xref>] The drawbacks of the iliac crest flap have been the short pedicle length as well as the donor side morbidity. The solutions for the short pedicle length have been high dissection of the facial vessels in the cheek as the donor vessels or by extending the pedicle length by use of the ALT flap pedicle as an arterio-venous graft.[<xref rid="ref54" ref-type="bibr">54</xref>]</p><p>The scapula and parascapular flaps have been increasingly used in maxillary reconstruction.[<xref rid="ref63" ref-type="bibr">63</xref><xref rid="ref64" ref-type="bibr">64</xref>] The advantages of the scapula include long pedicle length, the two pedicle systems that can be used to vascularise the bone namely the subscapular vessels and the angular artery from thoracodorsal system, the availability of large amount of soft tissues with minimal donor site morbidity. The disadvantage of this flap includes the difficulty in harvesting the flap simultaneously, but Clark <italic>et al</italic>.[<xref rid="ref50" ref-type="bibr">50</xref>] refutes it by positioning the patient in such a way that they are able to harvest the flap without change of position, thereby reducing the time requires in the harvest. The thinness of the bone has been criticized as not to be suitable for implant placement.[<xref rid="ref65" ref-type="bibr">65</xref>]</p><p>Among the less commonly used free bone flaps, the medial femoral condyle based on the descending genicular vessels was reported to be useful in a case of small anterior or anterolateral alveolar defects by Kadameni <italic>et al</italic>.[<xref rid="ref66" ref-type="bibr">66</xref>] The periosteum provided the soft tissue surface to get mucosalised. In another single case report, Seikido <italic>et al</italic>.[<xref rid="ref58" ref-type="bibr">58</xref>] harvested a DIEP flap, dissected the vessels through the rectus abdominis and used the cranial part of the rectus muscle to vascularise the 9<sup>th</sup> and 10<sup>th</sup> ribs. They used these ribs for zygomatico maxillary buttress reconstruction. We have described the use of the iliac crest-tensor facia lata muscle with or without the overlying skin for maxillary reconstruction, where support of the globe was needed. Seven successful cases were reported where the bone used was nourished by the attachment of the TFL muscle.[<xref rid="ref67" ref-type="bibr">67</xref>] The authors reported further refinements on this technique, by combining it with the internal oblique muscle for orbital lining when orbital exenteration was carried out.[<xref rid="ref59" ref-type="bibr">59</xref>]</p></sec><sec id="sec1-6"><title>MANAGEMENT OF ORBITAL CAVITY IN MAXILLARY DEFECTS</title><p>Two types of defects may be encountered during maxillary reconstruction depending on whether the orbital contents are preserved or not. When the orbital contents are preserved, the need for the support of the globe becomes important. This need will depend upon the amount of maxillary walls resected. Minimal loss of the orbital floor in a standard maxillectomy may not result in loss of orbital support since the periorbita will support it. But, when the loss is more, either in the medio-lateral direction, especially when three lateral orbital walls are also resected or in the antero-posterior direction when entire floor of orbit is removed, support for the globe may be necessary. This situation also occurs when large area of the periorbita is excised for tumour clearance.</p><p>The use of soft tissue flaps alone in these situations may not be ideal as reported by Rao <italic>et al</italic>. The number of cases with enopthalmos and hypophthalmos was higher when compared to bony reconstruction of the floor in the series reported by them. Figure shows a patient in whom rectus abdominis flap was used. [Figure <xref ref-type="fig" rid="F5">5a</xref>–<xref ref-type="fig" rid="F5">d</xref>]. Provision for orbital floor support has been attempted by several methods[<xref rid="ref68" ref-type="bibr">68</xref>] including use of prolene mesh, facial or musculofacial slings,[<xref rid="ref69" ref-type="bibr">69</xref>] titanium mesh in combination with other flaps,[<xref rid="ref35" ref-type="bibr">35</xref><xref rid="ref38" ref-type="bibr">38</xref>] free bone grafts along with soft tissue flaps,[<xref rid="ref70" ref-type="bibr">70</xref>] pedicled calvarial[<xref rid="ref71" ref-type="bibr">71</xref>] and coronoid flaps[<xref rid="ref40" ref-type="bibr">40</xref><xref rid="ref41" ref-type="bibr">41</xref>] and free bone flaps. The free bone flaps suitable in these cases include fibula,[<xref rid="ref72" ref-type="bibr">72</xref>] Scapula,[<xref rid="ref50" ref-type="bibr">50</xref>] DCIA[<xref rid="ref52" ref-type="bibr">52</xref><xref rid="ref54" ref-type="bibr">54</xref>] and TFL-IC flap.[<xref rid="ref57" ref-type="bibr">57</xref>] The simplest solution for orbital support is the use of a titanium mesh that can be contoured to the defect very well [<xref ref-type="fig" rid="F6">Figure 6</xref>]. The problem with using the mesh is its high extrusion rate, especially with the post-operative radiation therapy. The importance of keeping the mesh posterior and not extending it to form the infraorbital rim in order to reduce the extrusion was stressed by Sarukawa <italic>et al</italic>.[<xref rid="ref73" ref-type="bibr">73</xref>] They also observed that, if a mesh is to be used, it needs to be straddled on all sides with a robust and vascular soft tissue. The use of other non-vascularised tissues is also debatable in view of the radiation therapy, even though few case reports support them. In a recent article from MD Anderson group,[<xref rid="ref74" ref-type="bibr">74</xref>] out of the 246 cases, 59 needed orbital floor reconstruction. The majority of the cases (30 patients) had non-vascularised tissue or alloplast-titanium mesh; bone grafts were used in 20 patients, porous polyethylene in four patients and a fascia lata graft in one patient. Four patients had bony free flaps. The implant exposure rate in their series of non-vascularised methods was very low. The implant got exposed in two cases of bone graft and in one case of titanium mesh. The authors’ preference[<xref rid="ref72" ref-type="bibr">72</xref>] is for a bone flap, either fibula or TFL-Iliac crest. Figure shows a patient with maxillectomy defect with orbital floor loss, reconstructed with free fibula osteo-cutaneous flap [Figure <xref ref-type="fig" rid="F7">7a</xref>–<xref ref-type="fig" rid="F7">f</xref>]. Titanium mesh was used in the cases where the bone flap failed to provide the support, either due to the architecture of the defect or poor pedicle length and in patients with risk for long surgery due to systemic problems. Figure shows a schematic representation of the three different options of reconstructing the orbital floor defects associated with maxillectomy with free flaps [Figure <xref ref-type="fig" rid="F8">8a</xref>–<xref ref-type="fig" rid="F8">c</xref>].</p><fig id="F5" position="float"><label>Figure 5</label><caption><p>(a) Palatal involvement by the tumour (b) Rectus abdominis free flap used to fill the maxillectomy cavity and the palatal defect (c) Reconstructive outcome one year after surgery and radiotherapy, frontal view. Note the sagging of the eye on the reconstructed side (d) Reconstructive outcome one year after surgery and radiotherapy, lateral view</p></caption><graphic xlink:href="IJPS-47-8-g005"></graphic></fig><fig id="F6" position="float"><label>Figure 6</label><caption><p>Titanium mesh for orbital support</p></caption><graphic xlink:href="IJPS-47-8-g006"></graphic></fig><fig id="F7" position="float"><label>Figure 7</label><caption><p>(a)Computed Tomogram of a patient with maxillary tumour with orbital floor involvement. Coronal view (b) Computed tomogram, Sagittal view (c) Total maxillectomy defect with orbital floor removed. Class III as per Brown's classification (d) Computed tomogram, three dimensional view showing free fibula flap used for reconstruction (e) Reconstructive outcome two years after surgery and radiotherapy. Frontal view (f) Reconstructive outcome, Lateral view</p></caption><graphic xlink:href="IJPS-47-8-g007"></graphic></fig><fig id="F8" position="float"><label>Figure 8</label><caption><p>(a) Line diagram showing the reconstruction with free fibula flap (b) Line diagram showing the reconstruction with free tensor fascia lata with iliac crest flap (c) Line diagram showing the reconstruction with a soft tissue flap, free rectus abdominis. The fascia of the flap (shown in pink) was used as a sling for the orbital contents</p></caption><graphic xlink:href="IJPS-47-8-g008"></graphic></fig></sec><sec id="sec1-7"><title>MANAGEMENT OF THE ORBITAL EXENTERATION DEFECTS ASSOCIATED WITH MAXILLECTOMY</title><p>When the orbital contents are exenterated along with a maxillectomy, the defect becomes complex with communication of the oral and nasal cavities with exterior and occasionally with the cranial cavity. Immediate goal in the reconstruction is achieved by using a soft tissue flap like rectus abdominis as advised by Hanasono <italic>et al</italic>.[<xref rid="ref75" ref-type="bibr">75</xref>] and Cordeiro <italic>et al</italic>.[<xref rid="ref27" ref-type="bibr">27</xref>] <xref ref-type="fig" rid="F9">Figure 9</xref> shows a patient with carcinoma of maxillary sinus with orbital content involvement who underwent orbital exenteration along with maxillectomy. Reconstruction was with free rectus abdominis flap [Figure <xref ref-type="fig" rid="F9">9a</xref>–<xref ref-type="fig" rid="F9">e</xref>]. The orbital rehabilitation becomes difficult in this method of reconstruction as only a spectacle borne external prosthesis could be used. Though attempts have been to fit an ocular prosthesis in the cavity formed by a muscle flap, the fibrosis that sets in pushes out the ocular prosthesis. Use of conventional bone flaps like The DCIA flap/fibula or scapula does not provide satisfactory reconstruction of the orbital cavity as the relative orientation of the bone, muscle and the skin paddle restricts this complex multi-axial reconstruction. A titanium mesh may be used for the orbital floor combined with a free soft tissue flap. But, technically, it is difficult to cover the mesh on the orbital cavity side, making this method not satisfactory. Using two flaps like DCIA or fibula for the suprastructure and a soft tissue flap like radial forearm flap for the palate may be considered. The authors described a new technique to address this issue by using a TFL- iliac crest- internal oblique flap (TFL-IC-IO) based on dual blood supply from the DCIA and TFL vessels[<xref rid="ref59" ref-type="bibr">59</xref>] [Figure <xref ref-type="fig" rid="F10">10a</xref>–<xref ref-type="fig" rid="F10">d</xref>].</p><fig id="F9" position="float"><label>Figure 9</label><caption><p>(a) Patient with squamous cell carcinoma of the maxilla, pre-operative frontal view (b) Intraoral view showing the palatal involvement (c) Maxillectomy defect with orbital exenteration, Brown's class IV (d) Reconstructed outcome with free rectus abdominis flap, two years after treatment (e) Maxillectomy with orbital exenteration defect</p></caption><graphic xlink:href="IJPS-47-8-g009"></graphic></fig><fig id="F10" position="float"><label>Figure 10</label><caption><p>(a) Reconstructed outcome - intraoral view (b) Line drawing showing the reconstruction with Tensor fascia lata-Iliac crest-Internal Oblique flap (TFL-IC-IO) with dual anastamosis (c) Outcome showing the reconstructed eye socket (d) Reconstructed outcome one year after treatment, frontal view</p></caption><graphic xlink:href="IJPS-47-8-g010"></graphic></fig></sec><sec id="sec1-8"><title>ALGORITHMIC APPROACH FOR MAXILLARY AND ORBITAL RECONSTRUCTION</title><p>Based on different classification systems available and personal experience, different authors have put up algorithmic approaches for maxillary reconstruction. Brown[<xref rid="ref76" ref-type="bibr">76</xref>] discusses the reconstructive options according to his earlier classification as well as its modification. He looked at the reconstructions reported till 2009, and after reclassifying them according to his method, found that, in class I, radial forearm flap dominated the method of reconstruction. In class II and III, more number of free bone flaps, especially fibula was used. Other bone flaps used included DCIA and scapular tip. In these defects, soft tissue flaps were also used; the radial forearm flap in class II and rectus abdominis in class III. In class IV, majority had either rectus abdominis or lattismus dorsi. When bone flaps were used, DCIA predominated. He suggested either obturation or regional flaps or radial forearm flap for class I defects. Bone flaps like for class II and III and soft tissue flaps for class IV defects. The bone flap preferred by him was DCIA or scapula or scapular tip based on thoracodorsal vessels. Cordeiro and associates,[<xref rid="ref27" ref-type="bibr">27</xref>] based on their 15 year experience in maxillary reconstruction and based on their classification system, proposed an algorithm for maxillary reconstruction. Their preference was for the use of radial forearm flaps as single, double paddles or along with the radius bone as a sandwich flap in majority of the cases. The rectus abdominis flap was used for defects requiring larger amounts of soft tissue. Okay[<xref rid="ref6" ref-type="bibr">6</xref>] and associates, after suggesting their classification guided by prosthodontic requirements, suggested an algorithm. They suggested options similar to the ones by Brown <italic>et al</italic>. They preferred obturation, regional flaps or soft tissue flaps for their type I defects, and all others were preferably reconstructed with bone flaps. Obturation could also be used in class II defects. They found bone flaps to be superior since they suggested implant placement for proper dental rehabilitation. They did not specify the type of bone flaps to be used. While reporting one of the largest series of free flap reconstructions in maxilla, Hanasono <italic>et al</italic>.[<xref rid="ref15" ref-type="bibr">15</xref>] from MD Anderson group looked at the defects more exhaustively using both Brown and Corderio classification. The number of subclasses in their algorithm was more in number, but essentially, the palato-alveolar, orbital floor and orbital exenteration defects were the main considerations for choosing the method of reconstruction. In general, they suggested bone flaps (free fibula osteo-cutaneous flap) for palate alveolar defects rather than soft tissue flaps since they felt that dental rehabilitation was difficult with the latter, mainly due to the sagging of the flaps. They opted for alloplastic implants or bone grafts in combination for the orbital floor defects and obliteration with soft tissue flaps for orbital exenteration defects. Others also have tried to suggest algorithms like the one suggested by Sarukawa <italic>et al</italic>.[<xref rid="ref73" ref-type="bibr">73</xref>] based on their treatment philosophies. They used the Cordeiro system and reconstructed only the class III and IV defects with soft tissue flaps. For large palatal defects, they adopted the Brown's classification[<xref rid="ref76" ref-type="bibr">76</xref>] and suggested bony reconstruction using fibula. Based on our experience of over 150 cases, we have evolved an algorithm as given in <xref ref-type="fig" rid="F11">Figure 11</xref>. We found the Brown's classification[<xref rid="ref11" ref-type="bibr">11</xref><xref rid="ref12" ref-type="bibr">12</xref>] to be more useful and reproducible. Our choice is regional or free soft tissue flaps or obturator for the type I defects. Free flaps, especially radial forearm flap, were preferred when the defect was larger transversely. In class II defects, our choice is fibula, mainly for its long pedicle length and good bone support. The fibular skin paddle gives a satisfactory oro-nasal separation. In class III defects requiring orbital support, especially when the periorbita is removed or when the bone defect is large, the choice is still debated. We still use fibula, but find it difficult to orient the orbital support segment properly in all cases. The other choice is TFL iliac crest flap, especially when the skin defect also needs to be covered. We have found the DCIA also to be useful. The only limiting factor is the short pedicle length. The use of mesh has been found to be unsatisfactory due to their extrusion in majority of the cases where we have used it with the post-operative radiation. In class IV defects, we would prefer to provide a bony orbital floor and hence prefer to use the TFL-iliac crest-Internal oblique flaps on the dual blood supply or double flaps with radial forearm providing the palatal cover and DCIA-internal oblique for the suprastructure defects.</p><fig id="F11" position="float"><label>Figure 11</label><caption><p>Amrita Algorithm for reconstructing the maxillectomy defects</p></caption><graphic xlink:href="IJPS-47-8-g011"></graphic></fig></sec><sec id="sec1-9"><title>SURGICAL MORBIDITY AND ASSOCIATED COMPLICATIONS</title><p>Maxillary reconstruction has been looked at with caution by many centres due to the perceived technical difficulties and the associated surgical morbidity. The pedicle length has been a worrying problem for the novice in selecting the flap and by experienced to limit their flap choices to soft tissue flaps with long pedicles in the majority of situations.[<xref rid="ref15" ref-type="bibr">15</xref>] The other alternative was to use superficial temporal vessels as a donor.[<xref rid="ref77" ref-type="bibr">77</xref>] The length of facial artery available in the neck can be increased by dissecting it into the cheek, with a vertical incision on the face, use of vein grafts and the use of composite ALT arteriovenous grafts.[<xref rid="ref78" ref-type="bibr">78</xref>] The flap loss in larger series has been between 3% and 7%. Hanasono <italic>et al</italic>.[<xref rid="ref15" ref-type="bibr">15</xref>] reported an overall complication rate of 37.8%, which included wound infection, dehiscence, fistulae and medical complications. Notable medical complication was pneumonia, which was reported in 6% cases.</p></sec><sec id="sec1-10"><title>OTHER METHODS AND DEVELOPMENTS IN TISSUE ENGINEERING IN MAXILLARY RECONSTRUCTION</title><p>Distraction osteogenesis has been used for maxilla and mandible in correcting bony deficiencies. This method was used by Xue-Gang Niu <italic>et al</italic>.[<xref rid="ref79" ref-type="bibr">79</xref>] in a case of maxillary ameloblastoma treated by maxillectomy. During the initial surgery, an internal curvilinear distraction device was put in the residual zygoma. After about a month, the wound was re-opened, and this distractor was replaced with another to achieve curvilinear distraction osteogenesis of the maxillary anterior alveolar process and straight distraction of the palate. After couple of months, these distractors were removed and small area of the defect was bridged with a bone graft. Though the final outcome was satisfactory, the authors concede that the procedure was lengthy as well as needed multiple procedures.</p><p>Tissue engineering has been considered as a possible solution to replace complex reconstructive methods. But, it has been hampered by the lack of adequate vascularisation of the engineered constructs and the lack of clinically usable methods of engineering the constructs. Good manufacturing practices in cell culture and seeding have been available and have been reported[<xref rid="ref80" ref-type="bibr">80</xref>] to be used successfully in reconstructing a segmental mandibular and maxillary defects. The autologous cells are handled and prepared without animal-derived material in good manufacturing practice (GMP) standard clean rooms; the cells can be considered safe for clinical cell therapy applications. Mesimäki <italic>et al</italic>.[<xref rid="ref81" ref-type="bibr">81</xref>] for the first time described a novel method of maxillary reconstruction using tissue engineering methods. In a case of maxillectomy for a keratocyst, they harvested abdominal and adipose tissue stem cells. These cells were then isolated and expanded under GMP facilities without contamination. After 17 days, a titanium cage was inserted, filling it with mixture of auto ASCs, beta-tricalcium phosphate and bone morphogenetic protein-into the rectus abdominis flap area. After 8 months of follow-up, the flap had developed mature bone structures and vasculature. This was then transplanted into the defect. After the flap was settled, dental implants were successfully placed into the reconstruction. This method combined the use of the tissue engineering methods and utilized the microsurgical carrier for revascularising the construct. The Helsinki group has performed 10 cases, so far, for maxillary reconstructions using this method with 3 failures (personal communication). They use of the computer-aided design for prefabricating the tray, which at present has been changed to biodegradable materials. The anterolateral thigh flap with the vastus lateralis is the preferred carrier for the construct now.</p></sec><sec id="sec1-11"><title>SUMMARY</title><p>Maxillary reconstruction is still in an evolving stage; considerable understanding has been obtained in various aspects of maxillary reconstruction. Level of evidence is not very high by which the role of obturation versus reconstruction can be defined, but general trend seems to be more towards accepting the superiority of reconstruction, especially in larger defects. An ideal classification for the defects is still not agreed upon, but Brown's classification seems to be gaining widespread acceptance. The algorithm for reconstruction is again far from being universally agreed up on, and still reports claiming superiority of one flap over the other will be in vogue for some time. Strictly comparable studies will be difficult to carry out. Hence, individual surgeons or institutions practice may still persist as the standard for them. 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