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Effect of umbilical cord mesenchymal stem cell in peri-implant bone defect after immediate implant: an experiment study in beagle dogs

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Effect of umbilical cord mesenchymal stem cell in peri-implant bone defect after immediate implant: an experiment study in beagle dogs

Auteurs : Peng-Jie Hao [République populaire de Chine] ; Zhi-Guo Wang [République populaire de Chine] ; Quan-Chen Xu [République populaire de Chine] ; Sheng Xu [République populaire de Chine] ; Zhuo-Ri Li [République populaire de Chine] ; Pi-Shan Yang [République populaire de Chine] ; Zhong-Hao Liu [République populaire de Chine]

Source :

International Journal of Clinical and Experimental Pathology [ 1936-2625 ] ; 2014.

RBID : PMC:4270625

Abstract

Background: For the sake of reducing post extraction resorption, getting optimal positioning of the implant and shortening treatment time, immediate implant placement following tooth extraction has been proposed as a treatment option. However, the large bone defect peri-implant has a negative influence on the process of bone healing. In this study, umbilical cord mesenchymal stem cells (UCMSCs) were transplanted into the bone defect peri-implant inbeagle dogs and the effect of UCMSCs on bone regeneration in peri-implant were assessed. Methods: The mandibular second, third and fourth premolars of 8 beagle dogs were extracted bilaterally. The defects in one side were filled with platelet-rich fibrin (PRF) and then UCMSCs were injected into the defect area, while the defects in the other side were filled with PRF only as control group. The titanium implant was placed into the distal root socket of each extracted tooth. The animals were sacrificed at week 2, 4 and 8 post operative. The bone defects adjacent to the implant which are 4 mm in height, 4 mm in the mesio-distal direction and 3.5 mm in the bucco-lingual direction were made after immediate implant. Histomorphometric analysis was performed using methylene blue-fuchsin acid staining and hematoxylin and eosin (HE) staining to evaluate bone regeneration. Results: The direct bone-to-implant contact (BIC) in the experiment after 4 and 8 weeks was 56.47±1.18% and 76.23±2.08%; and in the control group was40.79±0.65% and 61.17±2.79%, respectively. The percentage of newly formed bone after 2, 4 and 8 weeks was 17.60±1.5%, 49.82±4.02% and 67.16±2.1% in experiment group; and in control group 14.30±1.25%, 37.04±2.29% and 58.83±3.36%, respectively. These results represented significant differences statistically. Conclusion: Intra-bone marrow injection of UCMSCs can promote new bone formation. UCMSCs can be used to as excellent seed cells to repair the large defect peri-implant after immediate implant.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270625

PubMed: 25550885
PubMed Central: 4270625

Affiliations:

République populaire de Chine

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<author><name sortKey="Hao, Peng Jie" sort="Hao, Peng Jie" uniqKey="Hao P" first="Peng-Jie" last="Hao">Peng-Jie Hao</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effect of umbilical cord mesenchymal stem cell in peri-implant bone defect after immediate implant: an experiment study in beagle dogs</title>
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<series><title level="j">International Journal of Clinical and Experimental Pathology</title>
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<front><div type="abstract" xml:lang="en"><p>Background: For the sake of reducing post extraction resorption, getting optimal positioning of the implant and shortening treatment time, immediate implant placement following tooth extraction has been proposed as a treatment option. However, the large bone defect peri-implant has a negative influence on the process of bone healing. In this study, umbilical cord mesenchymal stem cells (UCMSCs) were transplanted into the bone defect peri-implant inbeagle dogs and the effect of UCMSCs on bone regeneration in peri-implant were assessed. Methods: The mandibular second, third and fourth premolars of 8 beagle dogs were extracted bilaterally. The defects in one side were filled with platelet-rich fibrin (PRF) and then UCMSCs were injected into the defect area, while the defects in the other side were filled with PRF only as control group. The titanium implant was placed into the distal root socket of each extracted tooth. The animals were sacrificed at week 2, 4 and 8 post operative. The bone defects adjacent to the implant which are 4 mm in height, 4 mm in the mesio-distal direction and 3.5 mm in the bucco-lingual direction were made after immediate implant. Histomorphometric analysis was performed using methylene blue-fuchsin acid staining and hematoxylin and eosin (HE) staining to evaluate bone regeneration. Results: The direct bone-to-implant contact (BIC) in the experiment after 4 and 8 weeks was 56.47±1.18% and 76.23±2.08%; and in the control group was40.79±0.65% and 61.17±2.79%, respectively. The percentage of newly formed bone after 2, 4 and 8 weeks was 17.60±1.5%, 49.82±4.02% and 67.16±2.1% in experiment group; and in control group 14.30±1.25%, 37.04±2.29% and 58.83±3.36%, respectively. These results represented significant differences statistically. Conclusion: Intra-bone marrow injection of UCMSCs can promote new bone formation. UCMSCs can be used to as excellent seed cells to repair the large defect peri-implant after immediate implant.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Clin Exp Pathol</journal-id>
<journal-id journal-id-type="iso-abbrev">Int J Clin Exp Pathol</journal-id>
<journal-id journal-id-type="publisher-id">ijcep</journal-id>
<journal-title-group><journal-title>International Journal of Clinical and Experimental Pathology</journal-title>
</journal-title-group>
<issn pub-type="epub">1936-2625</issn>
<publisher><publisher-name>e-Century Publishing Corporation</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25550885</article-id>
<article-id pub-id-type="pmc">4270625</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Effect of umbilical cord mesenchymal stem cell in peri-implant bone defect after immediate implant: an experiment study in beagle dogs</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Hao</surname>
<given-names>Peng-Jie</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
<xref ref-type="aff" rid="au2">2</xref>
<xref ref-type="author-notes" rid="fn1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Zhi-Guo</given-names>
</name>
<xref ref-type="aff" rid="au3">3</xref>
<xref ref-type="author-notes" rid="fn1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Xu</surname>
<given-names>Quan-Chen</given-names>
</name>
<xref ref-type="aff" rid="au3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Xu</surname>
<given-names>Sheng</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Zhuo-Ri</given-names>
</name>
<xref ref-type="aff" rid="au4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yang</surname>
<given-names>Pi-Shan</given-names>
</name>
<xref ref-type="aff" rid="au2">2</xref>
<xref ref-type="aff" rid="au5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Liu</surname>
<given-names>Zhong-Hao</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
</contrib>
<aff id="au1"><label>1</label>
<institution>Yantai Stomatological Hospital</institution>
<addr-line>Yantai, China</addr-line>
</aff>
<aff id="au2"><label>2</label>
<institution>Department of Periodontology, School of Dentistry, Shandong University</institution>
<addr-line>Jinan, China</addr-line>
</aff>
<aff id="au3"><label>3</label>
<institution>The Affliated Hospital of Qingdao University Medical College</institution>
<addr-line>Qingdao, China</addr-line>
</aff>
<aff id="au4"><label>4</label>
<institution>Weihai Municipal Hospital</institution>
<addr-line>Weihai, China</addr-line>
</aff>
<aff id="au5"><label>5</label>
<institution>Department of Endodontics, School of Dentistry, Shandong University</institution>
<addr-line>Jinan, China</addr-line>
</aff>
</contrib-group>
<author-notes><corresp><bold>Address correspondence to:</bold>
 Dr. Pi-Shan Yang, Department of Periodontology, School of Dentistry, Shandong University, 44-1 West Wen Hua Road, Jinan 250012, Shandong, P. R. of China. Tel: +86-531-88382368; Fax: +86-531-829-50194; E-mail: <email>yangps@sdu.edu.cn</email>
; Dr. Zhong-Hao Liu, Yantai Stomatological Hospital, 142 Notrh StreetYantai, 264001, Shandong, China. Tel: +86-535-6228080; Fax: +86-535-6228045; E-mail: <email>dentlzh@163.com</email>
</corresp>
<fn id="fn1"><label>*</label>
<p>Equal contributors.</p>
</fn>
</author-notes>
<pub-date pub-type="collection"><year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>15</day>
<month>10</month>
<year>2014</year>
</pub-date>
<volume>7</volume>
<issue>11</issue>
<fpage>8271</fpage>
<lpage>8278</lpage>
<history><date date-type="received"><day>11</day>
<month>9</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>31</day>
<month>10</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>IJCEP Copyright © 2014</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract><p>Background: For the sake of reducing post extraction resorption, getting optimal positioning of the implant and shortening treatment time, immediate implant placement following tooth extraction has been proposed as a treatment option. However, the large bone defect peri-implant has a negative influence on the process of bone healing. In this study, umbilical cord mesenchymal stem cells (UCMSCs) were transplanted into the bone defect peri-implant inbeagle dogs and the effect of UCMSCs on bone regeneration in peri-implant were assessed. Methods: The mandibular second, third and fourth premolars of 8 beagle dogs were extracted bilaterally. The defects in one side were filled with platelet-rich fibrin (PRF) and then UCMSCs were injected into the defect area, while the defects in the other side were filled with PRF only as control group. The titanium implant was placed into the distal root socket of each extracted tooth. The animals were sacrificed at week 2, 4 and 8 post operative. The bone defects adjacent to the implant which are 4 mm in height, 4 mm in the mesio-distal direction and 3.5 mm in the bucco-lingual direction were made after immediate implant. Histomorphometric analysis was performed using methylene blue-fuchsin acid staining and hematoxylin and eosin (HE) staining to evaluate bone regeneration. Results: The direct bone-to-implant contact (BIC) in the experiment after 4 and 8 weeks was 56.47±1.18% and 76.23±2.08%; and in the control group was40.79±0.65% and 61.17±2.79%, respectively. The percentage of newly formed bone after 2, 4 and 8 weeks was 17.60±1.5%, 49.82±4.02% and 67.16±2.1% in experiment group; and in control group 14.30±1.25%, 37.04±2.29% and 58.83±3.36%, respectively. These results represented significant differences statistically. Conclusion: Intra-bone marrow injection of UCMSCs can promote new bone formation. UCMSCs can be used to as excellent seed cells to repair the large defect peri-implant after immediate implant.</p>
</abstract>
<kwd-group><kwd>Umbilical cord mesenchymal stem cells</kwd>
<kwd>dental implant</kwd>
<kwd>peri-implant bone defect</kwd>
<kwd>immediate implant</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Hao, Peng Jie" sort="Hao, Peng Jie" uniqKey="Hao P" first="Peng-Jie" last="Hao">Peng-Jie Hao</name>
</noRegion>
<name sortKey="Hao, Peng Jie" sort="Hao, Peng Jie" uniqKey="Hao P" first="Peng-Jie" last="Hao">Peng-Jie Hao</name>
<name sortKey="Li, Zhuo Ri" sort="Li, Zhuo Ri" uniqKey="Li Z" first="Zhuo-Ri" last="Li">Zhuo-Ri Li</name>
<name sortKey="Liu, Zhong Hao" sort="Liu, Zhong Hao" uniqKey="Liu Z" first="Zhong-Hao" last="Liu">Zhong-Hao Liu</name>
<name sortKey="Wang, Zhi Guo" sort="Wang, Zhi Guo" uniqKey="Wang Z" first="Zhi-Guo" last="Wang">Zhi-Guo Wang</name>
<name sortKey="Xu, Quan Chen" sort="Xu, Quan Chen" uniqKey="Xu Q" first="Quan-Chen" last="Xu">Quan-Chen Xu</name>
<name sortKey="Xu, Sheng" sort="Xu, Sheng" uniqKey="Xu S" first="Sheng" last="Xu">Sheng Xu</name>
<name sortKey="Yang, Pi Shan" sort="Yang, Pi Shan" uniqKey="Yang P" first="Pi-Shan" last="Yang">Pi-Shan Yang</name>
<name sortKey="Yang, Pi Shan" sort="Yang, Pi Shan" uniqKey="Yang P" first="Pi-Shan" last="Yang">Pi-Shan Yang</name>
</country>
</tree>
</affiliations>
</record>

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Effect of umbilical cord mesenchymal stem cell in peri-implant bone defect after immediate implant: an experiment study in beagle dogs

Effect of umbilical cord mesenchymal stem cell in peri-implant bone defect after immediate implant: an experiment study in beagle dogs

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