Socket preservation using demineralized freezed dried bone allograft with and without plasma rich in growth factor: A canine study
Identifieur interne : 000091 ( Pmc/Checkpoint ); précédent : 000090; suivant : 000092Socket preservation using demineralized freezed dried bone allograft with and without plasma rich in growth factor: A canine study
Auteurs : Ahmad Mogharehabed [Iran] ; Reza Birang [Iran] ; Nakisa Torabinia [Iran] ; Saman Nasiri [Iran] ; Parichehr Behfarnia [Iran]Source :
- Dental Research Journal [ 1735-3327 ] ; 2014.
Abstract
The accelerating effect of plasma rich in growth factors (PRGFs) in the healing of extraction sockets has been demonstrated by some studies. The aim of the present study was to histologically and histomorphometrically evaluate whether bone formation would increase by the combined use of PRGF and demineralized freeze-dried bone allograft (DFDBA).
In four female dogs, the distal root of the second, third and fourth lower premolars were extracted bilaterally and the mesial roots were preserved. The extraction sockets were randomly divided into DFDBA + PRGF, DFDBA + saline or control groups. Two dogs were sacrificed after 2 weeks and two dogs were sacrificed after 6 weeks. The extraction sockets were evaluated from both histological and histomorphometrical aspects. The data were analyzed by Mann-Whitney followed by Kruskal-Wallis tests using the Statistical Package for the Social Sciences version 20 (SPSS Inc., Chicago, IL, USA). Significant levels were set at 0.05.
The least decrease in socket height was observed in the DFDBA + PRGF group (0.73 ± 0.42 mm). The least decrease in the coronal portion was observed in the DFDBA + PRGF group (1.38 ± 1.35 mm²). The least decrease in the middle surface was observed in the DFDBA group (0.61 ± 0.80 mm²). The least decrease in the apical portion was observed in the DFDBA group (0.34 ± 0.39 mm²).
The present study showed better socket preservation subsequent to the application of DFDBA and PRGF combination in comparison with the two other groups. However, the difference was not statistically significant.
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PubMed: 25225559
PubMed Central: 4163824
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Socket preservation using demineralized freezed dried bone allograft with and without plasma rich in growth factor: A canine study</title><author><name sortKey="Mogharehabed, Ahmad" sort="Mogharehabed, Ahmad" uniqKey="Mogharehabed A" first="Ahmad" last="Mogharehabed">Ahmad Mogharehabed</name><affiliation wicri:level="1"><nlm:aff id="aff1">Dental Implants Research Center and Department of Periodontics, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Dental Implants Research Center and Department of Periodontics, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea><wicri:noRegion>Isfahan</wicri:noRegion></affiliation></author><author><name sortKey="Birang, Reza" sort="Birang, Reza" uniqKey="Birang R" first="Reza" last="Birang">Reza Birang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Torabinejad Research Center and Department of Periodontics, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Torabinejad Research Center and Department of Periodontics, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea><wicri:noRegion>Isfahan</wicri:noRegion></affiliation></author><author><name sortKey="Torabinia, Nakisa" sort="Torabinia, Nakisa" uniqKey="Torabinia N" first="Nakisa" last="Torabinia">Nakisa Torabinia</name><affiliation wicri:level="1"><nlm:aff id="aff3">Dental Materials Research Center and Department of Oral Pathology, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Dental Materials Research Center and Department of Oral Pathology, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea><wicri:noRegion>Isfahan</wicri:noRegion></affiliation></author><author><name sortKey="Nasiri, Saman" sort="Nasiri, Saman" uniqKey="Nasiri S" first="Saman" last="Nasiri">Saman Nasiri</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Periodontics, School of Dentistry, Lorestan University of Medical Sciences, Lorestan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Periodontics, School of Dentistry, Lorestan University of Medical Sciences, Lorestan</wicri:regionArea><wicri:noRegion>Lorestan</wicri:noRegion></affiliation></author><author><name sortKey="Behfarnia, Parichehr" sort="Behfarnia, Parichehr" uniqKey="Behfarnia P" first="Parichehr" last="Behfarnia">Parichehr Behfarnia</name><affiliation wicri:level="1"><nlm:aff id="aff5">Dental Implants Research Center and Department of Periodontics, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Dental Implants Research Center and Department of Periodontics, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea><wicri:noRegion>Isfahan</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25225559</idno><idno type="pmc">4163824</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163824</idno><idno type="RBID">PMC:4163824</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000529</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000529</idno><idno type="wicri:Area/Pmc/Curation">000529</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000529</idno><idno type="wicri:Area/Pmc/Checkpoint">000091</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000091</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Socket preservation using demineralized freezed dried bone allograft with and without plasma rich in growth factor: A canine study</title><author><name sortKey="Mogharehabed, Ahmad" sort="Mogharehabed, Ahmad" uniqKey="Mogharehabed A" first="Ahmad" last="Mogharehabed">Ahmad Mogharehabed</name><affiliation wicri:level="1"><nlm:aff id="aff1">Dental Implants Research Center and Department of Periodontics, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Dental Implants Research Center and Department of Periodontics, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea><wicri:noRegion>Isfahan</wicri:noRegion></affiliation></author><author><name sortKey="Birang, Reza" sort="Birang, Reza" uniqKey="Birang R" first="Reza" last="Birang">Reza Birang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Torabinejad Research Center and Department of Periodontics, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Torabinejad Research Center and Department of Periodontics, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea><wicri:noRegion>Isfahan</wicri:noRegion></affiliation></author><author><name sortKey="Torabinia, Nakisa" sort="Torabinia, Nakisa" uniqKey="Torabinia N" first="Nakisa" last="Torabinia">Nakisa Torabinia</name><affiliation wicri:level="1"><nlm:aff id="aff3">Dental Materials Research Center and Department of Oral Pathology, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Dental Materials Research Center and Department of Oral Pathology, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea><wicri:noRegion>Isfahan</wicri:noRegion></affiliation></author><author><name sortKey="Nasiri, Saman" sort="Nasiri, Saman" uniqKey="Nasiri S" first="Saman" last="Nasiri">Saman Nasiri</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Periodontics, School of Dentistry, Lorestan University of Medical Sciences, Lorestan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Periodontics, School of Dentistry, Lorestan University of Medical Sciences, Lorestan</wicri:regionArea><wicri:noRegion>Lorestan</wicri:noRegion></affiliation></author><author><name sortKey="Behfarnia, Parichehr" sort="Behfarnia, Parichehr" uniqKey="Behfarnia P" first="Parichehr" last="Behfarnia">Parichehr Behfarnia</name><affiliation wicri:level="1"><nlm:aff id="aff5">Dental Implants Research Center and Department of Periodontics, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Dental Implants Research Center and Department of Periodontics, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea><wicri:noRegion>Isfahan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Dental Research Journal</title><idno type="ISSN">1735-3327</idno><idno type="eISSN">2008-0255</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title><p>The accelerating effect of plasma rich in growth factors (PRGFs) in the healing of extraction sockets has been demonstrated by some studies. The aim of the present study was to histologically and histomorphometrically evaluate whether bone formation would increase by the combined use of PRGF and demineralized freeze-dried bone allograft (DFDBA).</p></sec><sec id="st2"><title>Materials and Methods:</title><p>In four female dogs, the distal root of the second, third and fourth lower premolars were extracted bilaterally and the mesial roots were preserved. The extraction sockets were randomly divided into DFDBA + PRGF, DFDBA + saline or control groups. Two dogs were sacrificed after 2 weeks and two dogs were sacrificed after 6 weeks. The extraction sockets were evaluated from both histological and histomorphometrical aspects. The data were analyzed by Mann-Whitney followed by Kruskal-Wallis tests using the Statistical Package for the Social Sciences version 20 (SPSS Inc., Chicago, IL, USA). Significant levels were set at 0.05.</p></sec><sec id="st3"><title>Results:</title><p>The least decrease in socket height was observed in the DFDBA + PRGF group (0.73 ± 0.42 mm). The least decrease in the coronal portion was observed in the DFDBA + PRGF group (1.38 ± 1.35 mm²). The least decrease in the middle surface was observed in the DFDBA group (0.61 ± 0.80 mm²). The least decrease in the apical portion was observed in the DFDBA group (0.34 ± 0.39 mm²).</p></sec><sec id="st4"><title>Conclusion:</title><p>The present study showed better socket preservation subsequent to the application of DFDBA and PRGF combination in comparison with the two other groups. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Dent Res J (Isfahan)</journal-id><journal-id journal-id-type="iso-abbrev">Dent Res J (Isfahan)</journal-id><journal-id journal-id-type="publisher-id">DRJ</journal-id><journal-title-group><journal-title>Dental Research Journal</journal-title></journal-title-group><issn pub-type="ppub">1735-3327</issn><issn pub-type="epub">2008-0255</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25225559</article-id><article-id pub-id-type="pmc">4163824</article-id><article-id pub-id-type="publisher-id">DRJ-11-460</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Socket preservation using demineralized freezed dried bone allograft with and without plasma rich in growth factor: A canine study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mogharehabed</surname><given-names>Ahmad</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Birang</surname><given-names>Reza</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Torabinia</surname><given-names>Nakisa</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Nasiri</surname><given-names>Saman</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Behfarnia</surname><given-names>Parichehr</given-names></name><xref ref-type="aff" rid="aff5">5</xref><xref ref-type="corresp" rid="cor1"></xref></contrib></contrib-group><aff id="aff1"><label>1</label>Dental Implants Research Center and Department of Periodontics, Isfahan University of Medical Sciences, Isfahan, Iran</aff><aff id="aff2"><label>2</label>Torabinejad Research Center and Department of Periodontics, Isfahan University of Medical Sciences, Isfahan, Iran</aff><aff id="aff3"><label>3</label>Dental Materials Research Center and Department of Oral Pathology, Isfahan University of Medical Sciences, Isfahan, Iran</aff><aff id="aff4"><label>4</label>Department of Periodontics, School of Dentistry, Lorestan University of Medical Sciences, Lorestan, Iran</aff><aff id="aff5"><label>5</label>Dental Implants Research Center and Department of Periodontics, Isfahan University of Medical Sciences, Isfahan, Iran</aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Dr. Parichehr Behfarnia, Dental Implants Research Center and Department of Periodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran. E-mail: <email xlink:href="behfarnia@dnt.mui.ac.ir">behfarnia@dnt.mui.ac.ir</email></corresp></author-notes><pub-date pub-type="ppub"><season>Jul-Aug</season><year>2014</year></pub-date><volume>11</volume><issue>4</issue><fpage>460</fpage><lpage>468</lpage><history><date date-type="received"><month>6</month><year>2013</year></date><date date-type="accepted"><month>8</month><year>2013</year></date></history><permissions><copyright-statement>Copyright: © Dental Research Journal</copyright-statement><copyright-year>2014</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec id="st1"><title>Background:</title><p>The accelerating effect of plasma rich in growth factors (PRGFs) in the healing of extraction sockets has been demonstrated by some studies. The aim of the present study was to histologically and histomorphometrically evaluate whether bone formation would increase by the combined use of PRGF and demineralized freeze-dried bone allograft (DFDBA).</p></sec><sec id="st2"><title>Materials and Methods:</title><p>In four female dogs, the distal root of the second, third and fourth lower premolars were extracted bilaterally and the mesial roots were preserved. The extraction sockets were randomly divided into DFDBA + PRGF, DFDBA + saline or control groups. Two dogs were sacrificed after 2 weeks and two dogs were sacrificed after 6 weeks. The extraction sockets were evaluated from both histological and histomorphometrical aspects. The data were analyzed by Mann-Whitney followed by Kruskal-Wallis tests using the Statistical Package for the Social Sciences version 20 (SPSS Inc., Chicago, IL, USA). Significant levels were set at 0.05.</p></sec><sec id="st3"><title>Results:</title><p>The least decrease in socket height was observed in the DFDBA + PRGF group (0.73 ± 0.42 mm). The least decrease in the coronal portion was observed in the DFDBA + PRGF group (1.38 ± 1.35 mm²). The least decrease in the middle surface was observed in the DFDBA group (0.61 ± 0.80 mm²). The least decrease in the apical portion was observed in the DFDBA group (0.34 ± 0.39 mm²).</p></sec><sec id="st4"><title>Conclusion:</title><p>The present study showed better socket preservation subsequent to the application of DFDBA and PRGF combination in comparison with the two other groups. However, the difference was not statistically significant.</p></sec></abstract><kwd-group><kwd>Allograft</kwd><kwd>growth factor</kwd><kwd>guided bone regeneration</kwd><kwd>plasma rich</kwd><kwd>socket graft</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Iran</li></country></list><tree><country name="Iran"><noRegion><name sortKey="Mogharehabed, Ahmad" sort="Mogharehabed, Ahmad" uniqKey="Mogharehabed A" first="Ahmad" last="Mogharehabed">Ahmad Mogharehabed</name></noRegion><name sortKey="Behfarnia, Parichehr" sort="Behfarnia, Parichehr" uniqKey="Behfarnia P" first="Parichehr" last="Behfarnia">Parichehr Behfarnia</name><name sortKey="Birang, Reza" sort="Birang, Reza" uniqKey="Birang R" first="Reza" last="Birang">Reza Birang</name><name sortKey="Nasiri, Saman" sort="Nasiri, Saman" uniqKey="Nasiri S" first="Saman" last="Nasiri">Saman Nasiri</name><name sortKey="Torabinia, Nakisa" sort="Torabinia, Nakisa" uniqKey="Torabinia N" first="Nakisa" last="Torabinia">Nakisa Torabinia</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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