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Alveolar bone regeneration using absorbable poly(L-lactide-co-ε-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth

Identifieur interne : 000323 ( PascalFrancis/Curation ); précédent : 000322; suivant : 000324

Alveolar bone regeneration using absorbable poly(L-lactide-co-ε-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth

Auteurs : Y. Kinoshita [Japon] ; M. Matsuo [Japon] ; K. Todoki [Japon] ; S. Ozono [Japon] ; S. Fukuoka [Japon] ; H. Tsuzuki [Japon] ; M. Nakamura [Japon] ; K. Tomihata [Japon] ; T. Shimamoto [Japon] ; Y. Ikada [Japon]

Source :

RBID : Pascal:08-0183378

Descripteurs français

English descriptors

Abstract

The aim of this study was to evaluate the effects of combining a porous poly(L-lactide-co-e-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblastic growth factor (bFGF) on bone regeneration in mandibular ridges. Four full-thickness saddle-type defects (10 mm long x 5 mm deep) were symmetrically created in both edentulous mandibular alveolar ridges of 6 beagles. The dome-shaped membrane was secured to each defect site, and a gelatin sponge containing 200 μg bFGF was implanted on the left side of each defect (experimental group). Only the membranes (control group) were secured to the defect sites on the right. Three and 6 months later, 3 animals were killed. Bone regeneration was analyzed by soft X-ray photographs, micro-computed tomography (CT) images, and peripheral quantitative CT (pQCT), and then examined histologically. Soft X-ray examination revealed an increase in new bone volume in the experimental group 6 months postoperatively. pQCT showed that immature bone density was higher in the experimental group. Micro-CT images revealed well formed new bone along the original contour of the dome-shaped membrane in the experimental group. Histologically, inflammatory infiltration of tissue surrounding the membranes was slight. These results suggest that combining the poly(L-lactide-co-e-caprolactone)/(β-tricalcium phosphate membrane and bFGF-gelatin sponge is promising for alveolar ridge reconstruction.
pA  
A01 01  1    @0 0901-5027
A02 01      @0 IJOSE9
A03   1    @0 Int. j. oral maxillofac. surg.
A05       @2 37
A06       @2 3
A08 01  1  ENG  @1 Alveolar bone regeneration using absorbable poly(L-lactide-co-ε-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth
A11 01  1    @1 KINOSHITA (Y.)
A11 02  1    @1 MATSUO (M.)
A11 03  1    @1 TODOKI (K.)
A11 04  1    @1 OZONO (S.)
A11 05  1    @1 FUKUOKA (S.)
A11 06  1    @1 TSUZUKI (H.)
A11 07  1    @1 NAKAMURA (M.)
A11 08  1    @1 TOMIHATA (K.)
A11 09  1    @1 SHIMAMOTO (T.)
A11 10  1    @1 IKADA (Y.)
A14 01      @1 Institute for Frontier Oral Science, Kanagawa Dental College @2 Yokosuka, Kanagawa @3 JPN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 10 aut.
A14 02      @1 Medical Material Center, Research & Development Center, Gunze Ltd @3 JPN @Z 8 aut. @Z 9 aut.
A14 03      @1 Nara Medical University @2 Nara @3 JPN @Z 10 aut.
A20       @1 275-281
A21       @1 2008
A23 01      @0 ENG
A43 01      @1 INIST @2 16201 @5 354000173681930120
A44       @0 0000 @1 © 2008 INIST-CNRS. All rights reserved.
A45       @0 23 ref.
A47 01  1    @0 08-0183378
A60       @1 P
A61       @0 A
A64 01  1    @0 International journal of oral and maxillofacial surgery
A66 01      @0 NLD
C01 01    ENG  @0 The aim of this study was to evaluate the effects of combining a porous poly(L-lactide-co-e-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblastic growth factor (bFGF) on bone regeneration in mandibular ridges. Four full-thickness saddle-type defects (10 mm long x 5 mm deep) were symmetrically created in both edentulous mandibular alveolar ridges of 6 beagles. The dome-shaped membrane was secured to each defect site, and a gelatin sponge containing 200 μg bFGF was implanted on the left side of each defect (experimental group). Only the membranes (control group) were secured to the defect sites on the right. Three and 6 months later, 3 animals were killed. Bone regeneration was analyzed by soft X-ray photographs, micro-computed tomography (CT) images, and peripheral quantitative CT (pQCT), and then examined histologically. Soft X-ray examination revealed an increase in new bone volume in the experimental group 6 months postoperatively. pQCT showed that immature bone density was higher in the experimental group. Micro-CT images revealed well formed new bone along the original contour of the dome-shaped membrane in the experimental group. Histologically, inflammatory infiltration of tissue surrounding the membranes was slight. These results suggest that combining the poly(L-lactide-co-e-caprolactone)/(β-tricalcium phosphate membrane and bFGF-gelatin sponge is promising for alveolar ridge reconstruction.
C02 01  X    @0 002B10
C03 01  X  FRE  @0 Chirurgie @5 04
C03 01  X  ENG  @0 Surgery @5 04
C03 01  X  SPA  @0 Cirugía @5 04
C03 02  X  FRE  @0 Os alvéolaire @5 07
C03 02  X  ENG  @0 Alveolar bone @5 07
C03 02  X  SPA  @0 Hueso alveolar @5 07
C03 03  X  FRE  @0 Régénération @5 08
C03 03  X  ENG  @0 Regeneration @5 08
C03 03  X  SPA  @0 Regeneración @5 08
C03 04  X  FRE  @0 Résorbable @5 09
C03 04  X  ENG  @0 Absorbable @5 09
C03 04  X  SPA  @0 Reabsorbible @5 09
C03 05  X  FRE  @0 Lactique acide polymère @2 NK @5 13
C03 05  X  ENG  @0 Lactic acid polymer @2 NK @5 13
C03 05  X  SPA  @0 Láctico ácido polímero @2 NK @5 13
C03 06  X  FRE  @0 Phosphate @2 NA @5 14
C03 06  X  ENG  @0 Phosphates @2 NA @5 14
C03 06  X  SPA  @0 Fosfato @2 NA @5 14
C03 07  X  FRE  @0 Gélatine @5 15
C03 07  X  ENG  @0 Gelatin @5 15
C03 07  X  SPA  @0 Gelatina @5 15
C03 08  X  FRE  @0 Eponge @5 16
C03 08  X  ENG  @0 Sponge @5 16
C03 08  X  SPA  @0 Esponja @5 16
C03 09  X  FRE  @0 Fibroblaste @5 17
C03 09  X  ENG  @0 Fibroblast @5 17
C03 09  X  SPA  @0 Fibroblasto @5 17
C03 10  X  FRE  @0 Croissance @5 18
C03 10  X  ENG  @0 Growth @5 18
C03 10  X  SPA  @0 Crecimiento @5 18
C03 11  X  FRE  @0 Guidage @5 19
C03 11  X  ENG  @0 Guidance @5 19
C03 11  X  SPA  @0 Guiado @5 19
C03 12  X  FRE  @0 Facteur croissance fibroblaste basique @5 20
C03 12  X  ENG  @0 Basic fibroblast growth factor @5 20
C03 12  X  SPA  @0 Factor crecimiento fibroblasto básico @5 20
C03 13  X  FRE  @0 Stomatologie @5 21
C03 13  X  ENG  @0 Stomatology @5 21
C03 13  X  SPA  @0 Estomatología @5 21
C03 14  X  FRE  @0 Traitement @5 30
C03 14  X  ENG  @0 Treatment @5 30
C03 14  X  SPA  @0 Tratamiento @5 30
N21       @1 112
N44 01      @1 OTO
N82       @1 OTO

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Pascal:08-0183378

Le document en format XML

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<keywords scheme="KwdEn" xml:lang="en">
<term>Absorbable</term>
<term>Alveolar bone</term>
<term>Basic fibroblast growth factor</term>
<term>Fibroblast</term>
<term>Gelatin</term>
<term>Growth</term>
<term>Guidance</term>
<term>Lactic acid polymer</term>
<term>Phosphates</term>
<term>Regeneration</term>
<term>Sponge</term>
<term>Stomatology</term>
<term>Surgery</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Chirurgie</term>
<term>Os alvéolaire</term>
<term>Régénération</term>
<term>Résorbable</term>
<term>Lactique acide polymère</term>
<term>Phosphate</term>
<term>Gélatine</term>
<term>Eponge</term>
<term>Fibroblaste</term>
<term>Croissance</term>
<term>Guidage</term>
<term>Facteur croissance fibroblaste basique</term>
<term>Stomatologie</term>
<term>Traitement</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr">
<term>Chirurgie</term>
<term>Phosphate</term>
<term>Gélatine</term>
</keywords>
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<front>
<div type="abstract" xml:lang="en">The aim of this study was to evaluate the effects of combining a porous poly(L-lactide-co-e-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblastic growth factor (bFGF) on bone regeneration in mandibular ridges. Four full-thickness saddle-type defects (10 mm long x 5 mm deep) were symmetrically created in both edentulous mandibular alveolar ridges of 6 beagles. The dome-shaped membrane was secured to each defect site, and a gelatin sponge containing 200 μg bFGF was implanted on the left side of each defect (experimental group). Only the membranes (control group) were secured to the defect sites on the right. Three and 6 months later, 3 animals were killed. Bone regeneration was analyzed by soft X-ray photographs, micro-computed tomography (CT) images, and peripheral quantitative CT (pQCT), and then examined histologically. Soft X-ray examination revealed an increase in new bone volume in the experimental group 6 months postoperatively. pQCT showed that immature bone density was higher in the experimental group. Micro-CT images revealed well formed new bone along the original contour of the dome-shaped membrane in the experimental group. Histologically, inflammatory infiltration of tissue surrounding the membranes was slight. These results suggest that combining the poly(L-lactide-co-e-caprolactone)/(β-tricalcium phosphate membrane and bFGF-gelatin sponge is promising for alveolar ridge reconstruction.</div>
</front>
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<s0>IJOSE9</s0>
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<s0>Int. j. oral maxillofac. surg.</s0>
</fA03>
<fA05>
<s2>37</s2>
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<s2>3</s2>
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<s1>Alveolar bone regeneration using absorbable poly(L-lactide-co-ε-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth</s1>
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<s1>IKADA (Y.)</s1>
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<s1>Institute for Frontier Oral Science, Kanagawa Dental College</s1>
<s2>Yokosuka, Kanagawa</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
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<s1>Medical Material Center, Research & Development Center, Gunze Ltd</s1>
<s3>JPN</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="03">
<s1>Nara Medical University</s1>
<s2>Nara</s2>
<s3>JPN</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA20>
<s1>275-281</s1>
</fA20>
<fA21>
<s1>2008</s1>
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<s1>© 2008 INIST-CNRS. All rights reserved.</s1>
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<s0>23 ref.</s0>
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<s0>08-0183378</s0>
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<s1>P</s1>
</fA60>
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<s0>A</s0>
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<fA64 i1="01" i2="1">
<s0>International journal of oral and maxillofacial surgery</s0>
</fA64>
<fA66 i1="01">
<s0>NLD</s0>
</fA66>
<fC01 i1="01" l="ENG">
<s0>The aim of this study was to evaluate the effects of combining a porous poly(L-lactide-co-e-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblastic growth factor (bFGF) on bone regeneration in mandibular ridges. Four full-thickness saddle-type defects (10 mm long x 5 mm deep) were symmetrically created in both edentulous mandibular alveolar ridges of 6 beagles. The dome-shaped membrane was secured to each defect site, and a gelatin sponge containing 200 μg bFGF was implanted on the left side of each defect (experimental group). Only the membranes (control group) were secured to the defect sites on the right. Three and 6 months later, 3 animals were killed. Bone regeneration was analyzed by soft X-ray photographs, micro-computed tomography (CT) images, and peripheral quantitative CT (pQCT), and then examined histologically. Soft X-ray examination revealed an increase in new bone volume in the experimental group 6 months postoperatively. pQCT showed that immature bone density was higher in the experimental group. Micro-CT images revealed well formed new bone along the original contour of the dome-shaped membrane in the experimental group. Histologically, inflammatory infiltration of tissue surrounding the membranes was slight. These results suggest that combining the poly(L-lactide-co-e-caprolactone)/(β-tricalcium phosphate membrane and bFGF-gelatin sponge is promising for alveolar ridge reconstruction.</s0>
</fC01>
<fC02 i1="01" i2="X">
<s0>002B10</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE">
<s0>Chirurgie</s0>
<s5>04</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG">
<s0>Surgery</s0>
<s5>04</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA">
<s0>Cirugía</s0>
<s5>04</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE">
<s0>Os alvéolaire</s0>
<s5>07</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG">
<s0>Alveolar bone</s0>
<s5>07</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA">
<s0>Hueso alveolar</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE">
<s0>Régénération</s0>
<s5>08</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Regeneration</s0>
<s5>08</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Regeneración</s0>
<s5>08</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE">
<s0>Résorbable</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG">
<s0>Absorbable</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>Reabsorbible</s0>
<s5>09</s5>
</fC03>
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<s0>Lactique acide polymère</s0>
<s2>NK</s2>
<s5>13</s5>
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<fC03 i1="05" i2="X" l="ENG">
<s0>Lactic acid polymer</s0>
<s2>NK</s2>
<s5>13</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA">
<s0>Láctico ácido polímero</s0>
<s2>NK</s2>
<s5>13</s5>
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<fC03 i1="06" i2="X" l="FRE">
<s0>Phosphate</s0>
<s2>NA</s2>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG">
<s0>Phosphates</s0>
<s2>NA</s2>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA">
<s0>Fosfato</s0>
<s2>NA</s2>
<s5>14</s5>
</fC03>
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<s0>Gélatine</s0>
<s5>15</s5>
</fC03>
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<s0>Gelatin</s0>
<s5>15</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA">
<s0>Gelatina</s0>
<s5>15</s5>
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<fC03 i1="08" i2="X" l="FRE">
<s0>Eponge</s0>
<s5>16</s5>
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<fC03 i1="08" i2="X" l="ENG">
<s0>Sponge</s0>
<s5>16</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA">
<s0>Esponja</s0>
<s5>16</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE">
<s0>Fibroblaste</s0>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG">
<s0>Fibroblast</s0>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA">
<s0>Fibroblasto</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE">
<s0>Croissance</s0>
<s5>18</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG">
<s0>Growth</s0>
<s5>18</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA">
<s0>Crecimiento</s0>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE">
<s0>Guidage</s0>
<s5>19</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG">
<s0>Guidance</s0>
<s5>19</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA">
<s0>Guiado</s0>
<s5>19</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE">
<s0>Facteur croissance fibroblaste basique</s0>
<s5>20</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG">
<s0>Basic fibroblast growth factor</s0>
<s5>20</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA">
<s0>Factor crecimiento fibroblasto básico</s0>
<s5>20</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE">
<s0>Stomatologie</s0>
<s5>21</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG">
<s0>Stomatology</s0>
<s5>21</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA">
<s0>Estomatología</s0>
<s5>21</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE">
<s0>Traitement</s0>
<s5>30</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG">
<s0>Treatment</s0>
<s5>30</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA">
<s0>Tratamiento</s0>
<s5>30</s5>
</fC03>
<fN21>
<s1>112</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
</fN44>
<fN82>
<s1>OTO</s1>
</fN82>
</pA>
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