Alveolar bone regeneration using absorbable poly(L-lactide-co-ε-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth
Identifieur interne : 000323 ( PascalFrancis/Curation ); précédent : 000322; suivant : 000324Alveolar bone regeneration using absorbable poly(L-lactide-co-ε-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth
Auteurs : Y. Kinoshita [Japon] ; M. Matsuo [Japon] ; K. Todoki [Japon] ; S. Ozono [Japon] ; S. Fukuoka [Japon] ; H. Tsuzuki [Japon] ; M. Nakamura [Japon] ; K. Tomihata [Japon] ; T. Shimamoto [Japon] ; Y. Ikada [Japon]Source :
- International journal of oral and maxillofacial surgery [ 0901-5027 ] ; 2008.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
Abstract
The aim of this study was to evaluate the effects of combining a porous poly(L-lactide-co-e-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblastic growth factor (bFGF) on bone regeneration in mandibular ridges. Four full-thickness saddle-type defects (10 mm long x 5 mm deep) were symmetrically created in both edentulous mandibular alveolar ridges of 6 beagles. The dome-shaped membrane was secured to each defect site, and a gelatin sponge containing 200 μg bFGF was implanted on the left side of each defect (experimental group). Only the membranes (control group) were secured to the defect sites on the right. Three and 6 months later, 3 animals were killed. Bone regeneration was analyzed by soft X-ray photographs, micro-computed tomography (CT) images, and peripheral quantitative CT (pQCT), and then examined histologically. Soft X-ray examination revealed an increase in new bone volume in the experimental group 6 months postoperatively. pQCT showed that immature bone density was higher in the experimental group. Micro-CT images revealed well formed new bone along the original contour of the dome-shaped membrane in the experimental group. Histologically, inflammatory infiltration of tissue surrounding the membranes was slight. These results suggest that combining the poly(L-lactide-co-e-caprolactone)/(β-tricalcium phosphate membrane and bFGF-gelatin sponge is promising for alveolar ridge reconstruction.
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<series><title level="j" type="main">International journal of oral and maxillofacial surgery</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Absorbable</term>
<term>Alveolar bone</term>
<term>Basic fibroblast growth factor</term>
<term>Fibroblast</term>
<term>Gelatin</term>
<term>Growth</term>
<term>Guidance</term>
<term>Lactic acid polymer</term>
<term>Phosphates</term>
<term>Regeneration</term>
<term>Sponge</term>
<term>Stomatology</term>
<term>Surgery</term>
<term>Treatment</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Chirurgie</term>
<term>Os alvéolaire</term>
<term>Régénération</term>
<term>Résorbable</term>
<term>Lactique acide polymère</term>
<term>Phosphate</term>
<term>Gélatine</term>
<term>Eponge</term>
<term>Fibroblaste</term>
<term>Croissance</term>
<term>Guidage</term>
<term>Facteur croissance fibroblaste basique</term>
<term>Stomatologie</term>
<term>Traitement</term>
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<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Chirurgie</term>
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<front><div type="abstract" xml:lang="en">The aim of this study was to evaluate the effects of combining a porous poly(L-lactide-co-e-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblastic growth factor (bFGF) on bone regeneration in mandibular ridges. Four full-thickness saddle-type defects (10 mm long x 5 mm deep) were symmetrically created in both edentulous mandibular alveolar ridges of 6 beagles. The dome-shaped membrane was secured to each defect site, and a gelatin sponge containing 200 μg bFGF was implanted on the left side of each defect (experimental group). Only the membranes (control group) were secured to the defect sites on the right. Three and 6 months later, 3 animals were killed. Bone regeneration was analyzed by soft X-ray photographs, micro-computed tomography (CT) images, and peripheral quantitative CT (pQCT), and then examined histologically. Soft X-ray examination revealed an increase in new bone volume in the experimental group 6 months postoperatively. pQCT showed that immature bone density was higher in the experimental group. Micro-CT images revealed well formed new bone along the original contour of the dome-shaped membrane in the experimental group. Histologically, inflammatory infiltration of tissue surrounding the membranes was slight. These results suggest that combining the poly(L-lactide-co-e-caprolactone)/(β-tricalcium phosphate membrane and bFGF-gelatin sponge is promising for alveolar ridge reconstruction.</div>
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<fA66 i1="01"><s0>NLD</s0>
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<fC01 i1="01" l="ENG"><s0>The aim of this study was to evaluate the effects of combining a porous poly(L-lactide-co-e-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblastic growth factor (bFGF) on bone regeneration in mandibular ridges. Four full-thickness saddle-type defects (10 mm long x 5 mm deep) were symmetrically created in both edentulous mandibular alveolar ridges of 6 beagles. The dome-shaped membrane was secured to each defect site, and a gelatin sponge containing 200 μg bFGF was implanted on the left side of each defect (experimental group). Only the membranes (control group) were secured to the defect sites on the right. Three and 6 months later, 3 animals were killed. Bone regeneration was analyzed by soft X-ray photographs, micro-computed tomography (CT) images, and peripheral quantitative CT (pQCT), and then examined histologically. Soft X-ray examination revealed an increase in new bone volume in the experimental group 6 months postoperatively. pQCT showed that immature bone density was higher in the experimental group. Micro-CT images revealed well formed new bone along the original contour of the dome-shaped membrane in the experimental group. Histologically, inflammatory infiltration of tissue surrounding the membranes was slight. These results suggest that combining the poly(L-lactide-co-e-caprolactone)/(β-tricalcium phosphate membrane and bFGF-gelatin sponge is promising for alveolar ridge reconstruction.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B10</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Chirurgie</s0>
<s5>04</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Surgery</s0>
<s5>04</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Cirugía</s0>
<s5>04</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Os alvéolaire</s0>
<s5>07</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Alveolar bone</s0>
<s5>07</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Hueso alveolar</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Régénération</s0>
<s5>08</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Regeneration</s0>
<s5>08</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Regeneración</s0>
<s5>08</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Résorbable</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Absorbable</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Reabsorbible</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Lactique acide polymère</s0>
<s2>NK</s2>
<s5>13</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Lactic acid polymer</s0>
<s2>NK</s2>
<s5>13</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Láctico ácido polímero</s0>
<s2>NK</s2>
<s5>13</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Phosphate</s0>
<s2>NA</s2>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Phosphates</s0>
<s2>NA</s2>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Fosfato</s0>
<s2>NA</s2>
<s5>14</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Gélatine</s0>
<s5>15</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Gelatin</s0>
<s5>15</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Gelatina</s0>
<s5>15</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Eponge</s0>
<s5>16</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Sponge</s0>
<s5>16</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Esponja</s0>
<s5>16</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Fibroblaste</s0>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Fibroblast</s0>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Fibroblasto</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Croissance</s0>
<s5>18</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Growth</s0>
<s5>18</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Crecimiento</s0>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Guidage</s0>
<s5>19</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Guidance</s0>
<s5>19</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Guiado</s0>
<s5>19</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Facteur croissance fibroblaste basique</s0>
<s5>20</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Basic fibroblast growth factor</s0>
<s5>20</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Factor crecimiento fibroblasto básico</s0>
<s5>20</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Stomatologie</s0>
<s5>21</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Stomatology</s0>
<s5>21</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Estomatología</s0>
<s5>21</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Traitement</s0>
<s5>30</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Treatment</s0>
<s5>30</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Tratamiento</s0>
<s5>30</s5>
</fC03>
<fN21><s1>112</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>
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