EdenteV1, PascalFrancis, Corpus, bibRecord, 000147

Simvastatin Application to Augment Facial Jaw Bone in a Dog Model: Pilot Study

Identifieur interne : 000147 ( PascalFrancis/Corpus ); précédent : 000146; suivant : 000148

Simvastatin Application to Augment Facial Jaw Bone in a Dog Model: Pilot Study

Auteurs : John Rutledge ; Matthew D. Schieber ; Judd M. Chamberlain ; Matthew Byarlay ; Amy C. Killeen ; Peter J. Giannini ; David B. Marx ; Richard A. Reinhardt

Source :

Journal of periodontology : (1970) [ 0022-3492 ] ; 2011.

RBID : Pascal:11-0211428

Descripteurs français

Pascal (Inist)
- Simvastatine, Histologie, Application, Face, Mâchoire, Os, Animal, Chien, Régénération, Ciblage, Plaie, Cicatrisation, Cicatrisant, Dentisterie, Hypolipémiant, Hypocholestérolémiant.

English descriptors

KwdEn :
- Animal, Antilipemic agent, Application, Bone, Cicatrization, Dentistry, Dog, Face, Healing agent, Histology, Hypocholesterolemic agent, Jaw, Regeneration, Simvastatin, Targeting, Wound.

Abstract

Background: Locally injected simvastatin (SIM) has been shown to induce bone growth in rat models. The purpose of this study is to evaluate the effects of locally injected simvastatin in several human-like clinical situations in a beagle dog model. Methods: Four beagle dogs completed the study and were used in a split-mouth design. Dehiscence defects of 5 x 3 mm were created bilaterally on the lateral aspect of the mandibular second premolar (PM2) mesial roots including removal of root cementum. At the same surgery, porous hydroxyapatite-collagen grafts with resorbable membranes with or without 10-mg SIM were placed buccal to the mandibular first molars (M1). One week later, three weekly local injections of 10-mg SIM in ethanol and contralateral ethanol alone were initiated at three sites through the buccal mucosa: 1) 6 mm apical to the cementoenamel junction (CEJ) of the maxillary fourth premolar (PM4; thin bone over root); 2) 6 mm apical to the CEJ of PM2 (dehiscence defect); and 3) 10 mm distoapical to the CEJ of the maxillary canine (edentulous ridge). Dogs were euthanized 2 months after the final injections. Block sections were harvested and specimens were decalcified and stained with hematoxylin and eosin. Histomorphometry was performed using digitized photographs and analyzed with distribution-free rank tests. Results: Regarding M1, the distance between CEJ and the alveolar crest was significantly more coronal in the SIM group (P= 0.038). Regarding the edentulous ridge, the width of new bone was significantly greater in SIM injection specimens (P= 0.0164). Regarding PM2, buccal bone in the dehiscence defects lacking periosteum was not augmented in the SIM group. Regarding PM4, the total width of bone 5 mm apical to the coronal height of contour (thin buccal bone covering the root) was significantly wider on the SIM side (SIM, 0.63 ± 0.53 mm; contralateral ethanol alone, 0.25 ± 0.19 mm; P= 0.0098). Conclusion: Locally injected SIM has the ability to induce modest amounts of new bone formation in closed injection sites over a periosteal surface.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`02`	`1`		`@1 SCHIEBER (Matthew D.)`
A11	`03`	`1`		`@1 CHAMBERLAIN (Judd M.)`
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A11	`05`	`1`		`@1 KILLEEN (Amy C.)`
A11	`06`	`1`		`@1 GIANNINI (Peter J.)`
A11	`07`	`1`		`@1 MARX (David B.)`
A11	`08`	`1`		`@1 REINHARDT (Richard A.)`
A14	`01`			`@1 Department of Surgical Specialties, College of Dentistry, University of Nebraska Medical Center @2 Lincoln, NE @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 8 aut.`
A14	`02`			`@1 Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center @3 USA @Z 6 aut.`
A14	`03`			`@1 Department of Statistics, University of Nebraska @2 Lincoln, NE @3 USA @Z 7 aut.`
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C01	`01`		`ENG`	@0 Background: Locally injected simvastatin (SIM) has been shown to induce bone growth in rat models. The purpose of this study is to evaluate the effects of locally injected simvastatin in several human-like clinical situations in a beagle dog model. Methods: Four beagle dogs completed the study and were used in a split-mouth design. Dehiscence defects of 5 x 3 mm were created bilaterally on the lateral aspect of the mandibular second premolar (PM2) mesial roots including removal of root cementum. At the same surgery, porous hydroxyapatite-collagen grafts with resorbable membranes with or without 10-mg SIM were placed buccal to the mandibular first molars (M1). One week later, three weekly local injections of 10-mg SIM in ethanol and contralateral ethanol alone were initiated at three sites through the buccal mucosa: 1) 6 mm apical to the cementoenamel junction (CEJ) of the maxillary fourth premolar (PM4; thin bone over root); 2) 6 mm apical to the CEJ of PM2 (dehiscence defect); and 3) 10 mm distoapical to the CEJ of the maxillary canine (edentulous ridge). Dogs were euthanized 2 months after the final injections. Block sections were harvested and specimens were decalcified and stained with hematoxylin and eosin. Histomorphometry was performed using digitized photographs and analyzed with distribution-free rank tests. Results: Regarding M1, the distance between CEJ and the alveolar crest was significantly more coronal in the SIM group (P= 0.038). Regarding the edentulous ridge, the width of new bone was significantly greater in SIM injection specimens (P= 0.0164). Regarding PM2, buccal bone in the dehiscence defects lacking periosteum was not augmented in the SIM group. Regarding PM4, the total width of bone 5 mm apical to the coronal height of contour (thin buccal bone covering the root) was significantly wider on the SIM side (SIM, 0.63 ± 0.53 mm; contralateral ethanol alone, 0.25 ± 0.19 mm; P= 0.0098). Conclusion: Locally injected SIM has the ability to induce modest amounts of new bone formation in closed injection sites over a periosteal surface.
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C03	`05`	`X`	`FRE`	`@0 Mâchoire @5 09`
C03	`05`	`X`	`ENG`	`@0 Jaw @5 09`
C03	`05`	`X`	`SPA`	`@0 Maxilar @5 09`
C03	`06`	`X`	`FRE`	`@0 Os @5 13`
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N21				`@1 143`
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Format Inist (serveur)

NO :	PASCAL 11-0211428 INIST
ET :	Simvastatin Application to Augment Facial Jaw Bone in a Dog Model: Pilot Study
AU :	RUTLEDGE (John); SCHIEBER (Matthew D.); CHAMBERLAIN (Judd M.); BYARLAY (Matthew); KILLEEN (Amy C.); GIANNINI (Peter J.); MARX (David B.); REINHARDT (Richard A.)
AF :	Department of Surgical Specialties, College of Dentistry, University of Nebraska Medical Center/Lincoln, NE/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 8 aut.); Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center/Etats-Unis (6 aut.); Department of Statistics, University of Nebraska/Lincoln, NE/Etats-Unis (7 aut.)
DT :	Publication en série; Niveau analytique
SO :	Journal of periodontology : (1970); ISSN 0022-3492; Etats-Unis; Da. 2011; Vol. 82; No. 4; Pp. 597-605; Bibl. 30 ref.
LA :	Anglais
EA :	Background: Locally injected simvastatin (SIM) has been shown to induce bone growth in rat models. The purpose of this study is to evaluate the effects of locally injected simvastatin in several human-like clinical situations in a beagle dog model. Methods: Four beagle dogs completed the study and were used in a split-mouth design. Dehiscence defects of 5 x 3 mm were created bilaterally on the lateral aspect of the mandibular second premolar (PM2) mesial roots including removal of root cementum. At the same surgery, porous hydroxyapatite-collagen grafts with resorbable membranes with or without 10-mg SIM were placed buccal to the mandibular first molars (M1). One week later, three weekly local injections of 10-mg SIM in ethanol and contralateral ethanol alone were initiated at three sites through the buccal mucosa: 1) 6 mm apical to the cementoenamel junction (CEJ) of the maxillary fourth premolar (PM4; thin bone over root); 2) 6 mm apical to the CEJ of PM2 (dehiscence defect); and 3) 10 mm distoapical to the CEJ of the maxillary canine (edentulous ridge). Dogs were euthanized 2 months after the final injections. Block sections were harvested and specimens were decalcified and stained with hematoxylin and eosin. Histomorphometry was performed using digitized photographs and analyzed with distribution-free rank tests. Results: Regarding M1, the distance between CEJ and the alveolar crest was significantly more coronal in the SIM group (P= 0.038). Regarding the edentulous ridge, the width of new bone was significantly greater in SIM injection specimens (P= 0.0164). Regarding PM2, buccal bone in the dehiscence defects lacking periosteum was not augmented in the SIM group. Regarding PM4, the total width of bone 5 mm apical to the coronal height of contour (thin buccal bone covering the root) was significantly wider on the SIM side (SIM, 0.63 ± 0.53 mm; contralateral ethanol alone, 0.25 ± 0.19 mm; P= 0.0098). Conclusion: Locally injected SIM has the ability to induce modest amounts of new bone formation in closed injection sites over a periosteal surface.
CC :	002B10
FD :	Simvastatine; Histologie; Application; Face; Mâchoire; Os; Animal; Chien; Régénération; Ciblage; Plaie; Cicatrisation; Cicatrisant; Dentisterie; Hypolipémiant; Hypocholestérolémiant
FG :	Fissipedia; Carnivora; Mammalia; Vertebrata; Hydroxymethylglutaryl-CoA reductase; Oxidoreductases; Enzyme; Inhibiteur enzyme; Dérivé de la statine; Inhibiteur de l'HMG-CoA reductase
ED :	Simvastatin; Histology; Application; Face; Jaw; Bone; Animal; Dog; Regeneration; Targeting; Wound; Cicatrization; Healing agent; Dentistry; Antilipemic agent; Hypocholesterolemic agent
EG :	Fissipedia; Carnivora; Mammalia; Vertebrata; Hydroxymethylglutaryl-CoA reductase; Oxidoreductases; Enzyme; Enzyme inhibitor; Statin derivative; HMG-CoA reductase inhibitor
SD :	Simvastatina; Histología; Aplicación; Cara; Maxilar; Hueso; Animal; Perro; Regeneración; Blancado; Herida; Cicatrización; Cicatrizante; Odontología; Hipolipemiante; Hipocolesterolemiante
LO :	INIST-874.354000191457630100
ID :	11-0211428

Links to Exploration step

Pascal:11-0211428

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Simvastatin Application to Augment Facial Jaw Bone in a Dog Model: Pilot Study</title>
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<author><name sortKey="Killeen, Amy C" sort="Killeen, Amy C" uniqKey="Killeen A" first="Amy C." last="Killeen">Amy C. Killeen</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Surgical Specialties, College of Dentistry, University of Nebraska Medical Center</s1>
<s2>Lincoln, NE</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Giannini, Peter J" sort="Giannini, Peter J" uniqKey="Giannini P" first="Peter J." last="Giannini">Peter J. Giannini</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center</s1>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Marx, David B" sort="Marx, David B" uniqKey="Marx D" first="David B." last="Marx">David B. Marx</name>
<affiliation><inist:fA14 i1="03"><s1>Department of Statistics, University of Nebraska</s1>
<s2>Lincoln, NE</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Reinhardt, Richard A" sort="Reinhardt, Richard A" uniqKey="Reinhardt R" first="Richard A." last="Reinhardt">Richard A. Reinhardt</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Surgical Specialties, College of Dentistry, University of Nebraska Medical Center</s1>
<s2>Lincoln, NE</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
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</author>
</analytic>
<series><title level="j" type="main">Journal of periodontology : (1970)</title>
<title level="j" type="abbreviated">J. periodontol. : (1970)</title>
<idno type="ISSN">0022-3492</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of periodontology : (1970)</title>
<title level="j" type="abbreviated">J. periodontol. : (1970)</title>
<idno type="ISSN">0022-3492</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Antilipemic agent</term>
<term>Application</term>
<term>Bone</term>
<term>Cicatrization</term>
<term>Dentistry</term>
<term>Dog</term>
<term>Face</term>
<term>Healing agent</term>
<term>Histology</term>
<term>Hypocholesterolemic agent</term>
<term>Jaw</term>
<term>Regeneration</term>
<term>Simvastatin</term>
<term>Targeting</term>
<term>Wound</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Simvastatine</term>
<term>Histologie</term>
<term>Application</term>
<term>Face</term>
<term>Mâchoire</term>
<term>Os</term>
<term>Animal</term>
<term>Chien</term>
<term>Régénération</term>
<term>Ciblage</term>
<term>Plaie</term>
<term>Cicatrisation</term>
<term>Cicatrisant</term>
<term>Dentisterie</term>
<term>Hypolipémiant</term>
<term>Hypocholestérolémiant</term>
</keywords>
</textClass>
</profileDesc>
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<front><div type="abstract" xml:lang="en">Background: Locally injected simvastatin (SIM) has been shown to induce bone growth in rat models. The purpose of this study is to evaluate the effects of locally injected simvastatin in several human-like clinical situations in a beagle dog model. Methods: Four beagle dogs completed the study and were used in a split-mouth design. Dehiscence defects of 5 x 3 mm were created bilaterally on the lateral aspect of the mandibular second premolar (PM2) mesial roots including removal of root cementum. At the same surgery, porous hydroxyapatite-collagen grafts with resorbable membranes with or without 10-mg SIM were placed buccal to the mandibular first molars (M1). One week later, three weekly local injections of 10-mg SIM in ethanol and contralateral ethanol alone were initiated at three sites through the buccal mucosa: 1) 6 mm apical to the cementoenamel junction (CEJ) of the maxillary fourth premolar (PM4; thin bone over root); 2) 6 mm apical to the CEJ of PM2 (dehiscence defect); and 3) 10 mm distoapical to the CEJ of the maxillary canine (edentulous ridge). Dogs were euthanized 2 months after the final injections. Block sections were harvested and specimens were decalcified and stained with hematoxylin and eosin. Histomorphometry was performed using digitized photographs and analyzed with distribution-free rank tests. Results: Regarding M1, the distance between CEJ and the alveolar crest was significantly more coronal in the SIM group (P= 0.038). Regarding the edentulous ridge, the width of new bone was significantly greater in SIM injection specimens (P= 0.0164). Regarding PM2, buccal bone in the dehiscence defects lacking periosteum was not augmented in the SIM group. Regarding PM4, the total width of bone 5 mm apical to the coronal height of contour (thin buccal bone covering the root) was significantly wider on the SIM side (SIM, 0.63 ± 0.53 mm; contralateral ethanol alone, 0.25 ± 0.19 mm; P= 0.0098). Conclusion: Locally injected SIM has the ability to induce modest amounts of new bone formation in closed injection sites over a periosteal surface.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-3492</s0>
</fA01>
<fA03 i2="1"><s0>J. periodontol. : (1970)</s0>
</fA03>
<fA05><s2>82</s2>
</fA05>
<fA06><s2>4</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Simvastatin Application to Augment Facial Jaw Bone in a Dog Model: Pilot Study</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>RUTLEDGE (John)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>SCHIEBER (Matthew D.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>CHAMBERLAIN (Judd M.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>BYARLAY (Matthew)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>KILLEEN (Amy C.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>GIANNINI (Peter J.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>MARX (David B.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>REINHARDT (Richard A.)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Surgical Specialties, College of Dentistry, University of Nebraska Medical Center</s1>
<s2>Lincoln, NE</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center</s1>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Statistics, University of Nebraska</s1>
<s2>Lincoln, NE</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA20><s1>597-605</s1>
</fA20>
<fA21><s1>2011</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>874</s2>
<s5>354000191457630100</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2011 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>30 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>11-0211428</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Journal of periodontology : (1970)</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background: Locally injected simvastatin (SIM) has been shown to induce bone growth in rat models. The purpose of this study is to evaluate the effects of locally injected simvastatin in several human-like clinical situations in a beagle dog model. Methods: Four beagle dogs completed the study and were used in a split-mouth design. Dehiscence defects of 5 x 3 mm were created bilaterally on the lateral aspect of the mandibular second premolar (PM2) mesial roots including removal of root cementum. At the same surgery, porous hydroxyapatite-collagen grafts with resorbable membranes with or without 10-mg SIM were placed buccal to the mandibular first molars (M1). One week later, three weekly local injections of 10-mg SIM in ethanol and contralateral ethanol alone were initiated at three sites through the buccal mucosa: 1) 6 mm apical to the cementoenamel junction (CEJ) of the maxillary fourth premolar (PM4; thin bone over root); 2) 6 mm apical to the CEJ of PM2 (dehiscence defect); and 3) 10 mm distoapical to the CEJ of the maxillary canine (edentulous ridge). Dogs were euthanized 2 months after the final injections. Block sections were harvested and specimens were decalcified and stained with hematoxylin and eosin. Histomorphometry was performed using digitized photographs and analyzed with distribution-free rank tests. Results: Regarding M1, the distance between CEJ and the alveolar crest was significantly more coronal in the SIM group (P= 0.038). Regarding the edentulous ridge, the width of new bone was significantly greater in SIM injection specimens (P= 0.0164). Regarding PM2, buccal bone in the dehiscence defects lacking periosteum was not augmented in the SIM group. Regarding PM4, the total width of bone 5 mm apical to the coronal height of contour (thin buccal bone covering the root) was significantly wider on the SIM side (SIM, 0.63 ± 0.53 mm; contralateral ethanol alone, 0.25 ± 0.19 mm; P= 0.0098). Conclusion: Locally injected SIM has the ability to induce modest amounts of new bone formation in closed injection sites over a periosteal surface.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B10</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Simvastatine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>04</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Simvastatin</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>04</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Simvastatina</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>04</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Histologie</s0>
<s5>05</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Histology</s0>
<s5>05</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Histología</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Application</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Application</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Aplicación</s0>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Face</s0>
<s5>08</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Face</s0>
<s5>08</s5>
</fC03>
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<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Mâchoire</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Jaw</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Maxilar</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Os</s0>
<s5>13</s5>
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<s5>13</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Hueso</s0>
<s5>13</s5>
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<fC03 i1="07" i2="X" l="FRE"><s0>Animal</s0>
<s5>14</s5>
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<fC03 i1="07" i2="X" l="ENG"><s0>Animal</s0>
<s5>14</s5>
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<fC03 i1="07" i2="X" l="SPA"><s0>Animal</s0>
<s5>14</s5>
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<s5>15</s5>
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<s5>15</s5>
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<s5>15</s5>
</fC03>
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<s5>16</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Regeneration</s0>
<s5>16</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Regeneración</s0>
<s5>16</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Ciblage</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Targeting</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Blancado</s0>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Plaie</s0>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Wound</s0>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Herida</s0>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Cicatrisation</s0>
<s5>19</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Cicatrization</s0>
<s5>19</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Cicatrización</s0>
<s5>19</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Cicatrisant</s0>
<s5>20</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Healing agent</s0>
<s5>20</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Cicatrizante</s0>
<s5>20</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Dentisterie</s0>
<s5>30</s5>
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<s5>30</s5>
</fC03>
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<s5>30</s5>
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<s5>31</s5>
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<s5>31</s5>
</fC03>
<fC03 i1="15" i2="X" l="SPA"><s0>Hipolipemiante</s0>
<s5>31</s5>
</fC03>
<fC03 i1="16" i2="X" l="FRE"><s0>Hypocholestérolémiant</s0>
<s5>32</s5>
</fC03>
<fC03 i1="16" i2="X" l="ENG"><s0>Hypocholesterolemic agent</s0>
<s5>32</s5>
</fC03>
<fC03 i1="16" i2="X" l="SPA"><s0>Hipocolesterolemiante</s0>
<s5>32</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Fissipedia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Fissipedia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Fissipedia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Carnivora</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Carnivora</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Carnivora</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
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<fC07 i1="03" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
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<fC07 i1="04" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
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<fC07 i1="04" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Hydroxymethylglutaryl-CoA reductase</s0>
<s2>FE</s2>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Hydroxymethylglutaryl-CoA reductase</s0>
<s2>FE</s2>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Hydroxymethylglutaryl-CoA reductase</s0>
<s2>FE</s2>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Oxidoreductases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Oxidoreductases</s0>
<s2>FE</s2>
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<fC07 i1="06" i2="X" l="SPA"><s0>Oxidoreductases</s0>
<s2>FE</s2>
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<fC07 i1="07" i2="X" l="FRE"><s0>Enzyme</s0>
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<fC07 i1="07" i2="X" l="ENG"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Enzima</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Inhibiteur enzyme</s0>
<s5>38</s5>
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<fC07 i1="08" i2="X" l="ENG"><s0>Enzyme inhibitor</s0>
<s5>38</s5>
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<fC07 i1="08" i2="X" l="SPA"><s0>Inhibidor enzima</s0>
<s5>38</s5>
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<fC07 i1="09" i2="X" l="FRE"><s0>Dérivé de la statine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>39</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Statin derivative</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>39</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Statina derivado</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>39</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Inhibiteur de l'HMG-CoA reductase</s0>
<s5>40</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>HMG-CoA reductase inhibitor</s0>
<s5>40</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Inhibidor HMG-CoA reductase</s0>
<s5>40</s5>
</fC07>
<fN21><s1>143</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 11-0211428 INIST</NO>
<ET>Simvastatin Application to Augment Facial Jaw Bone in a Dog Model: Pilot Study</ET>
<AU>RUTLEDGE (John); SCHIEBER (Matthew D.); CHAMBERLAIN (Judd M.); BYARLAY (Matthew); KILLEEN (Amy C.); GIANNINI (Peter J.); MARX (David B.); REINHARDT (Richard A.)</AU>
<AF>Department of Surgical Specialties, College of Dentistry, University of Nebraska Medical Center/Lincoln, NE/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 8 aut.); Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center/Etats-Unis (6 aut.); Department of Statistics, University of Nebraska/Lincoln, NE/Etats-Unis (7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of periodontology : (1970); ISSN 0022-3492; Etats-Unis; Da. 2011; Vol. 82; No. 4; Pp. 597-605; Bibl. 30 ref.</SO>
<LA>Anglais</LA>
<EA>Background: Locally injected simvastatin (SIM) has been shown to induce bone growth in rat models. The purpose of this study is to evaluate the effects of locally injected simvastatin in several human-like clinical situations in a beagle dog model. Methods: Four beagle dogs completed the study and were used in a split-mouth design. Dehiscence defects of 5 x 3 mm were created bilaterally on the lateral aspect of the mandibular second premolar (PM2) mesial roots including removal of root cementum. At the same surgery, porous hydroxyapatite-collagen grafts with resorbable membranes with or without 10-mg SIM were placed buccal to the mandibular first molars (M1). One week later, three weekly local injections of 10-mg SIM in ethanol and contralateral ethanol alone were initiated at three sites through the buccal mucosa: 1) 6 mm apical to the cementoenamel junction (CEJ) of the maxillary fourth premolar (PM4; thin bone over root); 2) 6 mm apical to the CEJ of PM2 (dehiscence defect); and 3) 10 mm distoapical to the CEJ of the maxillary canine (edentulous ridge). Dogs were euthanized 2 months after the final injections. Block sections were harvested and specimens were decalcified and stained with hematoxylin and eosin. Histomorphometry was performed using digitized photographs and analyzed with distribution-free rank tests. Results: Regarding M1, the distance between CEJ and the alveolar crest was significantly more coronal in the SIM group (P= 0.038). Regarding the edentulous ridge, the width of new bone was significantly greater in SIM injection specimens (P= 0.0164). Regarding PM2, buccal bone in the dehiscence defects lacking periosteum was not augmented in the SIM group. Regarding PM4, the total width of bone 5 mm apical to the coronal height of contour (thin buccal bone covering the root) was significantly wider on the SIM side (SIM, 0.63 ± 0.53 mm; contralateral ethanol alone, 0.25 ± 0.19 mm; P= 0.0098). Conclusion: Locally injected SIM has the ability to induce modest amounts of new bone formation in closed injection sites over a periosteal surface.</EA>
<CC>002B10</CC>
<FD>Simvastatine; Histologie; Application; Face; Mâchoire; Os; Animal; Chien; Régénération; Ciblage; Plaie; Cicatrisation; Cicatrisant; Dentisterie; Hypolipémiant; Hypocholestérolémiant</FD>
<FG>Fissipedia; Carnivora; Mammalia; Vertebrata; Hydroxymethylglutaryl-CoA reductase; Oxidoreductases; Enzyme; Inhibiteur enzyme; Dérivé de la statine; Inhibiteur de l'HMG-CoA reductase</FG>
<ED>Simvastatin; Histology; Application; Face; Jaw; Bone; Animal; Dog; Regeneration; Targeting; Wound; Cicatrization; Healing agent; Dentistry; Antilipemic agent; Hypocholesterolemic agent</ED>
<EG>Fissipedia; Carnivora; Mammalia; Vertebrata; Hydroxymethylglutaryl-CoA reductase; Oxidoreductases; Enzyme; Enzyme inhibitor; Statin derivative; HMG-CoA reductase inhibitor</EG>
<SD>Simvastatina; Histología; Aplicación; Cara; Maxilar; Hueso; Animal; Perro; Regeneración; Blancado; Herida; Cicatrización; Cicatrizante; Odontología; Hipolipemiante; Hipocolesterolemiante</SD>
<LO>INIST-874.354000191457630100</LO>
<ID>11-0211428</ID>
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Simvastatin Application to Augment Facial Jaw Bone in a Dog Model: Pilot Study

Simvastatin Application to Augment Facial Jaw Bone in a Dog Model: Pilot Study

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