Simvastatin prevents alveolar bone loss in an experimental rat model of periodontitis after ovariectomy
Identifieur interne : 001264 ( Ncbi/Merge ); précédent : 001263; suivant : 001265Simvastatin prevents alveolar bone loss in an experimental rat model of periodontitis after ovariectomy
Auteurs : Xin-Chen Xu [République populaire de Chine] ; Hui Chen [République populaire de Chine] ; Xi Zhang [République populaire de Chine] ; Zan-Jing Zhai [République populaire de Chine] ; Xu-Qiang Liu [République populaire de Chine] ; An Qin [République populaire de Chine] ; Er-Yi Lu [République populaire de Chine]Source :
- Journal of Translational Medicine [ 1479-5876 ] ; 2014.
Abstract
Periodontitis is an inflammatory disease characterized by the loss of connective tissue and alveolar bone. There is an increasing evidence that periodontitis is associated with a number of chronic disease, including osteoporosis. Periodontitis and osteoporosis are both bone destructive diseases and of high prevalence in adult population. Osteoporosis could increase some inflammatory factors that also participate in the progression of periodontitis, so as to facilitate the alveolar bone resorption. Simvastatin, specific inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme reductase, is of pleiotropic effects including anti-catabolic and anabolic effect on bone metabolism. This study aimed to explore the local and systemic effect of simvastatin on maxillary in rats with both osteoporosis and periodontitis.
Thirty-six 4-month-old female Sprague Dawley rats were randomly assigned to six groups: sham group, ligature group, ovariectomized (OVX) + ligature group, local simvastatin administration to OVX + ligature rats (local simvastatin group), oral simvastatin administration to OVX + ligature rats (oral simvastatin group), local and oral simvastatin administration to OVX + ligature rats (L&O simvastatin group). One month after OVX, ligatures were placed on the maxillary first (M1) and second molars (M2) for 4 weeks on all rats except those in the sham group, followed by simvastatin treatment for 2 months. The maxillae, serum, and femurs were collected for further examination including micro-computed (micro-CT) tomography, hematoxylin and eosin (H&E) staining, tartrate-resistant acid phosphatase (TRAP) staining, enzyme-linked immunosorbent assays (ELISA), and the three-point bending test.
Local simvastatin administration increased alveolar crest height and prevented local alveolar bone loss without alteration of systemic bone loss. Oral administration prevented local and systemic bone loss with no effect on alveolar crest height.
Our results indicate that simvastatin has the potential of promoting bone formation and reducing alveolar bone loss in maxillary following ovariectomy (OVX) and ligature placement in rats.
Url:
DOI: 10.1186/s12967-014-0284-0
PubMed: 25269614
PubMed Central: 4192445
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sortKey="Chen, Hui" sort="Chen, Hui" uniqKey="Chen H" first="Hui" last="Chen">Hui Chen</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai, 200011 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Xi" sort="Zhang, Xi" uniqKey="Zhang X" first="Xi" last="Zhang">Xi Zhang</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai, 200011 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Zhai, Zan Jing" sort="Zhai, Zan Jing" uniqKey="Zhai Z" first="Zan-Jing" last="Zhai">Zan-Jing Zhai</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Orthopaedic, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, 639 Zhizaoju Road, Shanghai, 200011 China</nlm:aff><country 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Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Qin, An" sort="Qin, An" uniqKey="Qin A" first="An" last="Qin">An Qin</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Orthopaedic, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, 639 Zhizaoju Road, Shanghai, 200011 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedic, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, 639 Zhizaoju Road, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Er Yi" sort="Lu, Er Yi" uniqKey="Lu E" first="Er-Yi" last="Lu">Er-Yi Lu</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai, 200011 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25269614</idno><idno type="pmc">4192445</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192445</idno><idno type="RBID">PMC:4192445</idno><idno type="doi">10.1186/s12967-014-0284-0</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000079</idno><idno type="wicri:explorRef" 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China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Hui" sort="Chen, Hui" uniqKey="Chen H" first="Hui" last="Chen">Hui Chen</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai, 200011 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Xi" sort="Zhang, Xi" uniqKey="Zhang X" first="Xi" last="Zhang">Xi Zhang</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai, 200011 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Zhai, Zan Jing" sort="Zhai, Zan Jing" uniqKey="Zhai Z" first="Zan-Jing" last="Zhai">Zan-Jing Zhai</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Orthopaedic, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, 639 Zhizaoju Road, Shanghai, 200011 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedic, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, 639 Zhizaoju Road, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Xu Qiang" sort="Liu, Xu Qiang" uniqKey="Liu X" first="Xu-Qiang" last="Liu">Xu-Qiang Liu</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Orthopaedic, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, 639 Zhizaoju Road, Shanghai, 200011 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedic, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, 639 Zhizaoju Road, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Qin, An" sort="Qin, An" uniqKey="Qin A" first="An" last="Qin">An Qin</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Orthopaedic, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, 639 Zhizaoju Road, Shanghai, 200011 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedic, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, 639 Zhizaoju Road, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Er Yi" sort="Lu, Er Yi" uniqKey="Lu E" first="Er-Yi" last="Lu">Er-Yi Lu</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai, 200011 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Translational Medicine</title><idno type="eISSN">1479-5876</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Periodontitis is an inflammatory disease characterized by the loss of connective tissue and alveolar bone. There is an increasing evidence that periodontitis is associated with a number of chronic disease, including osteoporosis. Periodontitis and osteoporosis are both bone destructive diseases and of high prevalence in adult population. Osteoporosis could increase some inflammatory factors that also participate in the progression of periodontitis, so as to facilitate the alveolar bone resorption. Simvastatin, specific inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme reductase, is of pleiotropic effects including anti-catabolic and anabolic effect on bone metabolism. This study aimed to explore the local and systemic effect of simvastatin on maxillary in rats with both osteoporosis and periodontitis.</p></sec><sec><title>Methods</title><p>Thirty-six 4-month-old female Sprague Dawley rats were randomly assigned to six groups: sham group, ligature group, ovariectomized (OVX) + ligature group, local simvastatin administration to OVX + ligature rats (local simvastatin group), oral simvastatin administration to OVX + ligature rats (oral simvastatin group), local and oral simvastatin administration to OVX + ligature rats (L&O simvastatin group). One month after OVX, ligatures were placed on the maxillary first (M1) and second molars (M2) for 4 weeks on all rats except those in the sham group, followed by simvastatin treatment for 2 months. The maxillae, serum, and femurs were collected for further examination including micro-computed (micro-CT) tomography, hematoxylin and eosin (H&E) staining, tartrate-resistant acid phosphatase (TRAP) staining, enzyme-linked immunosorbent assays (ELISA), and the three-point bending test.</p></sec><sec><title>Results</title><p>Local simvastatin administration increased alveolar crest height and prevented local alveolar bone loss without alteration of systemic bone loss. Oral administration prevented local and systemic bone loss with no effect on alveolar crest height.</p></sec><sec><title>Conclusions</title><p>Our results indicate that simvastatin has the potential of promoting bone formation and reducing alveolar bone loss in maxillary following ovariectomy (OVX) and ligature placement in rats.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Pihlstrom, Bl" uniqKey="Pihlstrom B">BL Pihlstrom</name></author><author><name sortKey="Michalowicz, Bs" uniqKey="Michalowicz B">BS Michalowicz</name></author><author><name sortKey="Johnson, Nw" uniqKey="Johnson N">NW Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wactawski Wende, J" uniqKey="Wactawski Wende J">J Wactawski-Wende</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Passos, Js" uniqKey="Passos J">JS Passos</name></author><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Transl Med</journal-id><journal-id journal-id-type="iso-abbrev">J Transl Med</journal-id><journal-title-group><journal-title>Journal of Translational Medicine</journal-title></journal-title-group><issn pub-type="epub">1479-5876</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25269614</article-id><article-id pub-id-type="pmc">4192445</article-id><article-id pub-id-type="publisher-id">284</article-id><article-id pub-id-type="doi">10.1186/s12967-014-0284-0</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>Simvastatin prevents alveolar bone loss in an experimental rat model of periodontitis after ovariectomy</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Xin-chen</given-names></name><address><email>xuxinchen88@163.com</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Hui</given-names></name><address><email>amychen.dentist@gmail.com</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Xi</given-names></name><address><email>summerflowergarden@126.com</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Zhai</surname><given-names>Zan-jing</given-names></name><address><email>eryijiuyuan@163.com</email></address><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Xu-qiang</given-names></name><address><email>shliuxuqiang@163.com</email></address><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Qin</surname><given-names>An</given-names></name><address><email>dr.qinan@gmail.com</email></address><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Lu</surname><given-names>Er-yi</given-names></name><address><email>lueryi222@126.com</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><aff id="Aff1"><label></label>Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai, 200011 China</aff><aff id="Aff2"><label></label>Department of Orthopaedic, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant, 639 Zhizaoju Road, Shanghai, 200011 China</aff></contrib-group><pub-date pub-type="epub"><day>1</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="collection"><year>2014</year></pub-date><volume>12</volume><elocation-id>284</elocation-id><history><date date-type="received"><day>15</day><month>7</month><year>2014</year></date><date date-type="accepted"><day>25</day><month>9</month><year>2014</year></date></history><permissions><copyright-statement>© Xu et al.; licensee BioMed Central Ltd. 2014</copyright-statement><license license-type="open-access"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0">http://creativecommons.org/licenses/by/4.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p>Periodontitis is an inflammatory disease characterized by the loss of connective tissue and alveolar bone. There is an increasing evidence that periodontitis is associated with a number of chronic disease, including osteoporosis. Periodontitis and osteoporosis are both bone destructive diseases and of high prevalence in adult population. Osteoporosis could increase some inflammatory factors that also participate in the progression of periodontitis, so as to facilitate the alveolar bone resorption. Simvastatin, specific inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme reductase, is of pleiotropic effects including anti-catabolic and anabolic effect on bone metabolism. This study aimed to explore the local and systemic effect of simvastatin on maxillary in rats with both osteoporosis and periodontitis.</p></sec><sec><title>Methods</title><p>Thirty-six 4-month-old female Sprague Dawley rats were randomly assigned to six groups: sham group, ligature group, ovariectomized (OVX) + ligature group, local simvastatin administration to OVX + ligature rats (local simvastatin group), oral simvastatin administration to OVX + ligature rats (oral simvastatin group), local and oral simvastatin administration to OVX + ligature rats (L&O simvastatin group). One month after OVX, ligatures were placed on the maxillary first (M1) and second molars (M2) for 4 weeks on all rats except those in the sham group, followed by simvastatin treatment for 2 months. The maxillae, serum, and femurs were collected for further examination including micro-computed (micro-CT) tomography, hematoxylin and eosin (H&E) staining, tartrate-resistant acid phosphatase (TRAP) staining, enzyme-linked immunosorbent assays (ELISA), and the three-point bending test.</p></sec><sec><title>Results</title><p>Local simvastatin administration increased alveolar crest height and prevented local alveolar bone loss without alteration of systemic bone loss. Oral administration prevented local and systemic bone loss with no effect on alveolar crest height.</p></sec><sec><title>Conclusions</title><p>Our results indicate that simvastatin has the potential of promoting bone formation and reducing alveolar bone loss in maxillary following ovariectomy (OVX) and ligature placement in rats.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Simvastatin</kwd><kwd>Alveolar bone loss</kwd><kwd>Periodontitis</kwd><kwd>Osteoporosis</kwd><kwd>Maxillary</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2014</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Xu, Xin Chen" sort="Xu, Xin Chen" uniqKey="Xu X" first="Xin-Chen" last="Xu">Xin-Chen Xu</name></noRegion><name sortKey="Chen, Hui" sort="Chen, Hui" uniqKey="Chen H" first="Hui" last="Chen">Hui Chen</name><name sortKey="Liu, Xu Qiang" sort="Liu, Xu Qiang" uniqKey="Liu X" first="Xu-Qiang" last="Liu">Xu-Qiang Liu</name><name sortKey="Lu, Er Yi" sort="Lu, Er Yi" uniqKey="Lu E" first="Er-Yi" last="Lu">Er-Yi Lu</name><name sortKey="Qin, An" sort="Qin, An" uniqKey="Qin A" first="An" last="Qin">An Qin</name><name sortKey="Zhai, Zan Jing" sort="Zhai, Zan Jing" uniqKey="Zhai Z" first="Zan-Jing" last="Zhai">Zan-Jing Zhai</name><name sortKey="Zhang, Xi" sort="Zhang, Xi" uniqKey="Zhang X" first="Xi" last="Zhang">Xi Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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