Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients—Case Report and Research
Identifieur interne : 000D91 ( Ncbi/Merge ); précédent : 000D90; suivant : 000D92Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients—Case Report and Research
Auteurs : Johann Lechner [Allemagne] ; Volker Von Baehr [Allemagne]Source :
- Breast Cancer : Basic and Clinical Research [ 1178-2234 ] ; 2014.
Abstract
Hollow spaces in the jawbone have been defined as fatty degenerative osteonecrosis of jawbone (FDOJ) and have been linked with a dysregulated immune system. Little is known about the underlying relationship.
Samples of FDOJ were analyzed to assess expression of cytokines which can play a role in the pathogenesis of breast cancer (MaCa).
Samples of FDOJ extracted from 23 patients with MaCa and 19 healthy control jawbone samples were analyzed for 7 immune messengers.
RANTES was found to be highly overexpressed in disease samples. No change was observed in expression levels of the other immune mediators.
This data provides a compelling confirmation that FDOJ produces high levels of RANTES, a cytokine implicated in MaCa and metastasis. Levels detected in FDOJ are five-fold higher than that previously reported for MaCa tissue suggesting its role as a cytokine source in MaCa.
We thus hypothesize that FDOJ may serve as an expeditor of MaCa progression, through RANTES production.
Url:
DOI: 10.4137/BCBCR.S15119
PubMed: 24899812
PubMed Central: 4039184
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<author><name sortKey="Lechner, Johann" sort="Lechner, Johann" uniqKey="Lechner J" first="Johann" last="Lechner">Johann Lechner</name>
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<author><name sortKey="Von Baehr, Volker" sort="Von Baehr, Volker" uniqKey="Von Baehr V" first="Volker" last="Von Baehr">Volker Von Baehr</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients—Case Report and Research</title>
<author><name sortKey="Lechner, Johann" sort="Lechner, Johann" uniqKey="Lechner J" first="Johann" last="Lechner">Johann Lechner</name>
<affiliation wicri:level="3"><nlm:aff id="af1-bcbcr-8-2014-089">Head of Clinic for Integrative Dentistry, Munich, Germany.</nlm:aff>
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<author><name sortKey="Von Baehr, Volker" sort="Von Baehr, Volker" uniqKey="Von Baehr V" first="Volker" last="Von Baehr">Volker Von Baehr</name>
<affiliation wicri:level="3"><nlm:aff id="af2-bcbcr-8-2014-089">Medical Head of Compartment of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin, Germany.</nlm:aff>
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<series><title level="j">Breast Cancer : Basic and Clinical Research</title>
<idno type="eISSN">1178-2234</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><sec><title>BACKGROUND</title>
<p>Hollow spaces in the jawbone have been defined as fatty degenerative osteonecrosis of jawbone (FDOJ) and have been linked with a dysregulated immune system. Little is known about the underlying relationship.</p>
</sec>
<sec><title>OBJECTIVES</title>
<p>Samples of FDOJ were analyzed to assess expression of cytokines which can play a role in the pathogenesis of breast cancer (MaCa).</p>
</sec>
<sec><title>MATERIAL AND METHODS</title>
<p>Samples of FDOJ extracted from 23 patients with MaCa and 19 healthy control jawbone samples were analyzed for 7 immune messengers.</p>
</sec>
<sec><title>RESULTS</title>
<p>RANTES was found to be highly overexpressed in disease samples. No change was observed in expression levels of the other immune mediators.</p>
</sec>
<sec><title>DISCUSSION</title>
<p>This data provides a compelling confirmation that FDOJ produces high levels of RANTES, a cytokine implicated in MaCa and metastasis. Levels detected in FDOJ are five-fold higher than that previously reported for MaCa tissue suggesting its role as a cytokine source in MaCa.</p>
</sec>
<sec><title>CONCLUSION</title>
<p>We thus hypothesize that FDOJ may serve as an expeditor of MaCa progression, through RANTES production.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Breast Cancer (Auckl)</journal-id>
<journal-id journal-id-type="iso-abbrev">Breast Cancer (Auckl)</journal-id>
<journal-title-group><journal-title>Breast Cancer : Basic and Clinical Research</journal-title>
</journal-title-group>
<issn pub-type="epub">1178-2234</issn>
<publisher><publisher-name>Libertas Academica</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24899812</article-id>
<article-id pub-id-type="pmc">4039184</article-id>
<article-id pub-id-type="doi">10.4137/BCBCR.S15119</article-id>
<article-id pub-id-type="publisher-id">bcbcr-8-2014-089</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject>
</subj-group>
</article-categories>
<title-group><article-title>Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients—Case Report and Research</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Lechner</surname>
<given-names>Johann</given-names>
</name>
<xref ref-type="aff" rid="af1-bcbcr-8-2014-089">1</xref>
<xref ref-type="corresp" rid="c1-bcbcr-8-2014-089"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>von Baehr</surname>
<given-names>Volker</given-names>
</name>
<xref ref-type="aff" rid="af2-bcbcr-8-2014-089">2</xref>
</contrib>
</contrib-group>
<aff id="af1-bcbcr-8-2014-089"><label>1</label>
Head of Clinic for Integrative Dentistry, Munich, Germany.</aff>
<aff id="af2-bcbcr-8-2014-089"><label>2</label>
Medical Head of Compartment of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin, Germany.</aff>
<author-notes><corresp id="c1-bcbcr-8-2014-089">CORRESPONDENCE: <email>drlechner@aol.com</email>
</corresp>
</author-notes>
<pub-date pub-type="collection"><year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>21</day>
<month>5</month>
<year>2014</year>
</pub-date>
<volume>8</volume>
<fpage>89</fpage>
<lpage>96</lpage>
<history><date date-type="received"><day>02</day>
<month>3</month>
<year>2014</year>
</date>
<date date-type="rev-recd"><day>27</day>
<month>4</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>28</day>
<month>4</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>© 2014 the author(s), publisher and licensee Libertas Academica Ltd.</copyright-statement>
<copyright-year>2014</copyright-year>
<license license-type="open-access"><license-p>This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 license.</license-p>
</license>
</permissions>
<abstract><sec><title>BACKGROUND</title>
<p>Hollow spaces in the jawbone have been defined as fatty degenerative osteonecrosis of jawbone (FDOJ) and have been linked with a dysregulated immune system. Little is known about the underlying relationship.</p>
</sec>
<sec><title>OBJECTIVES</title>
<p>Samples of FDOJ were analyzed to assess expression of cytokines which can play a role in the pathogenesis of breast cancer (MaCa).</p>
</sec>
<sec><title>MATERIAL AND METHODS</title>
<p>Samples of FDOJ extracted from 23 patients with MaCa and 19 healthy control jawbone samples were analyzed for 7 immune messengers.</p>
</sec>
<sec><title>RESULTS</title>
<p>RANTES was found to be highly overexpressed in disease samples. No change was observed in expression levels of the other immune mediators.</p>
</sec>
<sec><title>DISCUSSION</title>
<p>This data provides a compelling confirmation that FDOJ produces high levels of RANTES, a cytokine implicated in MaCa and metastasis. Levels detected in FDOJ are five-fold higher than that previously reported for MaCa tissue suggesting its role as a cytokine source in MaCa.</p>
</sec>
<sec><title>CONCLUSION</title>
<p>We thus hypothesize that FDOJ may serve as an expeditor of MaCa progression, through RANTES production.</p>
</sec>
</abstract>
<kwd-group><kwd>RANTES/CCL5</kwd>
<kwd>breast cancer</kwd>
<kwd>jawbone</kwd>
<kwd>osteonecrosis</kwd>
<kwd>metastasis</kwd>
<kwd>signaling pathways</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group><fig id="f1-bcbcr-8-2014-089" position="float"><label>Figure 1</label>
<caption><p>FDOJ sample completely converted the marrow of the JB to fatty tissue.</p>
</caption>
<graphic xlink:href="bcbcr-8-2014-089f1"></graphic>
</fig>
<fig id="f2-bcbcr-8-2014-089" position="float"><label>Figure 2</label>
<caption><p>Pathohistological structure of typical FDOJ—inconspicuous tissue in direct comparison with degenerative changed fatty tissue (Hematoxylin eosin stain HE 400-fold).</p>
</caption>
<graphic xlink:href="bcbcr-8-2014-089f2"></graphic>
</fig>
<fig id="f3-bcbcr-8-2014-089" position="float"><label>Figure 3</label>
<caption><p>Tumor cells in the retromolar area of FDOJ tissue (HE 400-fold).</p>
</caption>
<graphic xlink:href="bcbcr-8-2014-089f3"></graphic>
</fig>
<fig id="f4-bcbcr-8-2014-089" position="float"><label>Figure 4</label>
<caption><p>Analysis of seven cytokines in excised FDOJ tissue (retromolar area of the right mandible) from a MaCa patient in comparison to a normal JB.</p>
</caption>
<graphic xlink:href="bcbcr-8-2014-089f4"></graphic>
</fig>
<fig id="f5-bcbcr-8-2014-089" position="float"><label>Figure 5</label>
<caption><p>Bead-based processing of FDOJ samples.</p>
</caption>
<graphic xlink:href="bcbcr-8-2014-089f5"></graphic>
</fig>
<fig id="f6-bcbcr-8-2014-089" position="float"><label>Figure 6</label>
<caption><p>Distribution of seven cytokines in FDOJ in MaCa cases and in a normal JB (n = 23 and n = 19, respectively) (pg/mL).</p>
</caption>
<graphic xlink:href="bcbcr-8-2014-089f6"></graphic>
</fig>
<fig id="f7-bcbcr-8-2014-089" position="float"><label>Figure 7</label>
<caption><p>Distribution of individual RANTES values in FDOJ MaCa cases compared to the normal JB (in green; baseline) (n = 23 and n = 19, respectively) (pg/mL).</p>
</caption>
<graphic xlink:href="bcbcr-8-2014-089f7"></graphic>
</fig>
<fig id="f8-bcbcr-8-2014-089" position="float"><label>Figure 8</label>
<caption><p>Comparison of RANTES expression in MaCa tissues taken from the literature and in FDOJ among 23 MaCa patients.</p>
</caption>
<graphic xlink:href="bcbcr-8-2014-089f8"></graphic>
</fig>
<fig id="f9-bcbcr-8-2014-089" position="float"><label>Figure 9</label>
<caption><p>RANTES in the serum of 13 MaCa patients compared to normal values.</p>
</caption>
<graphic xlink:href="bcbcr-8-2014-089f9"></graphic>
</fig>
<fig id="f10-bcbcr-8-2014-089" position="float"><label>Figure 10</label>
<caption><p>Matched correlations of RANTES in FDOJ and in serum.</p>
</caption>
<graphic xlink:href="bcbcr-8-2014-089f10"></graphic>
</fig>
</floats-group>
</pmc>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Bavière</li>
<li>Berlin</li>
<li>District de Haute-Bavière</li>
</region>
<settlement><li>Berlin</li>
<li>Munich</li>
</settlement>
</list>
<tree><country name="Allemagne"><region name="Bavière"><name sortKey="Lechner, Johann" sort="Lechner, Johann" uniqKey="Lechner J" first="Johann" last="Lechner">Johann Lechner</name>
</region>
<name sortKey="Von Baehr, Volker" sort="Von Baehr, Volker" uniqKey="Von Baehr V" first="Volker" last="Von Baehr">Volker Von Baehr</name>
</country>
</tree>
</affiliations>
</record>
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