Differentiation of Human Skeletal Muscle Stem Cells into Odontoblasts Is Dependent on Induction of α1 Integrin Expression*
Identifieur interne : 000B68 ( Ncbi/Merge ); précédent : 000B67; suivant : 000B69Differentiation of Human Skeletal Muscle Stem Cells into Odontoblasts Is Dependent on Induction of α1 Integrin Expression*
Auteurs : Nobuaki Ozeki ; Makio Mogi [Japon] ; Hideyuki Yamaguchi ; Taiki Hiyama ; Rie Kawai ; Naoko Hase ; Kazuhiko Nakata ; Hiroshi Nakamura ; Randall H. Kramer [États-Unis]Source :
- The Journal of Biological Chemistry [ 0021-9258 ] ; 2014.
Abstract
Url:
DOI: 10.1074/jbc.M113.526772
PubMed: 24692545
PubMed Central: 4022904
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differentiation of Human Skeletal Muscle Stem Cells into Odontoblasts Is Dependent on Induction of α1 Integrin Expression<xref ref-type="fn" rid="FN1">*</xref></title><author><name sortKey="Ozeki, Nobuaki" sort="Ozeki, Nobuaki" uniqKey="Ozeki N" first="Nobuaki" last="Ozeki">Nobuaki Ozeki</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Mogi, Makio" sort="Mogi, Makio" uniqKey="Mogi M" first="Makio" last="Mogi">Makio Mogi</name><affiliation wicri:level="1"><nlm:aff wicri:cut=", and" id="aff2">Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya 464-8650, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya 464-8650</wicri:regionArea><wicri:noRegion>Nagoya 464-8650</wicri:noRegion></affiliation></author><author><name sortKey="Yamaguchi, Hideyuki" sort="Yamaguchi, Hideyuki" uniqKey="Yamaguchi H" first="Hideyuki" last="Yamaguchi">Hideyuki Yamaguchi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hiyama, Taiki" sort="Hiyama, Taiki" uniqKey="Hiyama T" first="Taiki" last="Hiyama">Taiki Hiyama</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Kawai, Rie" sort="Kawai, Rie" uniqKey="Kawai R" first="Rie" last="Kawai">Rie Kawai</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hase, Naoko" sort="Hase, Naoko" uniqKey="Hase N" first="Naoko" last="Hase">Naoko Hase</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Nakata, Kazuhiko" sort="Nakata, Kazuhiko" uniqKey="Nakata K" first="Kazuhiko" last="Nakata">Kazuhiko Nakata</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Nakamura, Hiroshi" sort="Nakamura, Hiroshi" uniqKey="Nakamura H" first="Hiroshi" last="Nakamura">Hiroshi Nakamura</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Kramer, Randall H" sort="Kramer, Randall H" uniqKey="Kramer R" first="Randall H." last="Kramer">Randall H. Kramer</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Cell and Tissue Biology, University of California, San Francisco, California 94143</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Cell and Tissue Biology, University of California, San Francisco</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24692545</idno><idno type="pmc">4022904</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022904</idno><idno type="RBID">PMC:4022904</idno><idno type="doi">10.1074/jbc.M113.526772</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000326</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000326</idno><idno type="wicri:Area/Pmc/Curation">000326</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000326</idno><idno type="wicri:Area/Pmc/Checkpoint">000365</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000365</idno><idno type="wicri:Area/Ncbi/Merge">000B68</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Differentiation of Human Skeletal Muscle Stem Cells into Odontoblasts Is Dependent on Induction of α1 Integrin Expression<xref ref-type="fn" rid="FN1">*</xref></title><author><name sortKey="Ozeki, Nobuaki" sort="Ozeki, Nobuaki" uniqKey="Ozeki N" first="Nobuaki" last="Ozeki">Nobuaki Ozeki</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Mogi, Makio" sort="Mogi, Makio" uniqKey="Mogi M" first="Makio" last="Mogi">Makio Mogi</name><affiliation wicri:level="1"><nlm:aff wicri:cut=", and" id="aff2">Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya 464-8650, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya 464-8650</wicri:regionArea><wicri:noRegion>Nagoya 464-8650</wicri:noRegion></affiliation></author><author><name sortKey="Yamaguchi, Hideyuki" sort="Yamaguchi, Hideyuki" uniqKey="Yamaguchi H" first="Hideyuki" last="Yamaguchi">Hideyuki Yamaguchi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hiyama, Taiki" sort="Hiyama, Taiki" uniqKey="Hiyama T" first="Taiki" last="Hiyama">Taiki Hiyama</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Kawai, Rie" sort="Kawai, Rie" uniqKey="Kawai R" first="Rie" last="Kawai">Rie Kawai</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hase, Naoko" sort="Hase, Naoko" uniqKey="Hase N" first="Naoko" last="Hase">Naoko Hase</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Nakata, Kazuhiko" sort="Nakata, Kazuhiko" uniqKey="Nakata K" first="Kazuhiko" last="Nakata">Kazuhiko Nakata</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Nakamura, Hiroshi" sort="Nakamura, Hiroshi" uniqKey="Nakamura H" first="Hiroshi" last="Nakamura">Hiroshi Nakamura</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Kramer, Randall H" sort="Kramer, Randall H" uniqKey="Kramer R" first="Randall H." last="Kramer">Randall H. Kramer</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Cell and Tissue Biology, University of California, San Francisco, California 94143</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Cell and Tissue Biology, University of California, San Francisco</wicri:cityArea></affiliation></author></analytic><series><title level="j">The Journal of Biological Chemistry</title><idno type="ISSN">0021-9258</idno><idno type="eISSN">1083-351X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> Human skeletal muscle stem cells (hSMSCs) can differentiate into bone and fat cells.</p><p><bold>Results:</bold> hSMSCs could also differentiate into odontoblasts but required an extracellular matrix scaffold and changes in their integrin profile.</p><p><bold>Conclusion:</bold> The present results identify an odontoblast differentiation pathway dependent on adhesion receptor expression.</p><p><bold>Significance:</bold> The data provide insight into how hSMSC adhesion receptors interact with the microenvironment to regulate lineage specification.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Biol Chem</journal-id><journal-id journal-id-type="iso-abbrev">J. Biol. Chem</journal-id><journal-id journal-id-type="hwp">jbc</journal-id><journal-id journal-id-type="pmc">jbc</journal-id><journal-id journal-id-type="publisher-id">JBC</journal-id><journal-title-group><journal-title>The Journal of Biological Chemistry</journal-title></journal-title-group><issn pub-type="ppub">0021-9258</issn><issn pub-type="epub">1083-351X</issn><publisher><publisher-name>American Society for Biochemistry and Molecular Biology</publisher-name><publisher-loc>9650 Rockville Pike, Bethesda, MD 20814, U.S.A.</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24692545</article-id><article-id pub-id-type="pmc">4022904</article-id><article-id pub-id-type="publisher-id">M113.526772</article-id><article-id pub-id-type="doi">10.1074/jbc.M113.526772</article-id><article-categories><subj-group subj-group-type="heading"><subject>Glycobiology and Extracellular Matrices</subject></subj-group></article-categories><title-group><article-title>Differentiation of Human Skeletal Muscle Stem Cells into Odontoblasts Is Dependent on Induction of α1 Integrin Expression<xref ref-type="fn" rid="FN1">*</xref></article-title><alt-title alt-title-type="short">Odontogenic Lineage Is Dependent on α1 Integrin Expression</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ozeki</surname><given-names>Nobuaki</given-names></name><xref ref-type="aff" rid="aff1"><sup>‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mogi</surname><given-names>Makio</given-names></name><xref ref-type="aff" rid="aff2"><sup>§</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yamaguchi</surname><given-names>Hideyuki</given-names></name><xref ref-type="aff" rid="aff1"><sup>‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hiyama</surname><given-names>Taiki</given-names></name><xref ref-type="aff" rid="aff1"><sup>‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kawai</surname><given-names>Rie</given-names></name><xref ref-type="aff" rid="aff1"><sup>‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hase</surname><given-names>Naoko</given-names></name><xref ref-type="aff" rid="aff1"><sup>‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nakata</surname><given-names>Kazuhiko</given-names></name><xref ref-type="aff" rid="aff1"><sup>‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nakamura</surname><given-names>Hiroshi</given-names></name><xref ref-type="aff" rid="aff1"><sup>‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kramer</surname><given-names>Randall H.</given-names></name><xref ref-type="aff" rid="aff3"><sup>¶</sup></xref><xref ref-type="corresp" rid="cor1"><sup>1</sup></xref></contrib><aff id="aff1">From the<label>‡</label>Department of Endodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464-8651, Japan,</aff><aff id="aff2"><label>§</label>Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya 464-8650, Japan, and</aff><aff id="aff3"><label>¶</label>Department of Cell and Tissue Biology, University of California, San Francisco, California 94143</aff></contrib-group><author-notes><corresp id="cor1"><label>1</label> To whom correspondence should be addressed. Tel.: <phone>415-476-3275</phone>; Fax: <fax>415-476-1499</fax>; E-mail: <email>randall.kramer@ucsf.edu</email>.</corresp></author-notes><pub-date pub-type="ppub"><day>16</day><month>5</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>1</day><month>4</month><year>2014</year></pub-date><volume>289</volume><issue>20</issue><fpage>14380</fpage><lpage>14391</lpage><history><date date-type="received"><day>11</day><month>10</month><year>2013</year></date><date date-type="rev-recd"><day>14</day><month>3</month><year>2014</year></date></history><permissions><copyright-statement>© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.</copyright-statement><copyright-year>2014</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zbc02014014380.pdf"></self-uri><abstract abstract-type="teaser"><p><bold>Background:</bold> Human skeletal muscle stem cells (hSMSCs) can differentiate into bone and fat cells.</p><p><bold>Results:</bold> hSMSCs could also differentiate into odontoblasts but required an extracellular matrix scaffold and changes in their integrin profile.</p><p><bold>Conclusion:</bold> The present results identify an odontoblast differentiation pathway dependent on adhesion receptor expression.</p><p><bold>Significance:</bold> The data provide insight into how hSMSC adhesion receptors interact with the microenvironment to regulate lineage specification.</p></abstract><abstract><p>Skeletal muscle stem cells represent an abundant source of autologous cells with potential for regenerative medicine that can be directed to differentiate into multiple lineages including osteoblasts and adipocytes. In the current study, we found that α7 integrin-positive human skeletal muscle stem cells (α7<sup>+</sup>hSMSCs) could differentiate into the odontoblast lineage under specific inductive conditions in response to bone morphogenetic protein-4 (BMP-4). Cell aggregates of FACS-harvested α7<sup>+</sup>hSMSCs were treated in suspension with retinoic acid followed by culture on a gelatin scaffold in the presence of BMP-4. Following this protocol, α7<sup>+</sup>hSMSCs were induced to down-regulate myogenic genes (<italic>MYOD</italic> and α7 integrin) and up-regulate odontogenic markers including dentin sialophosphoprotein, matrix metalloproteinase-20 (enamelysin), dentin sialoprotein, and alkaline phosphatase but not osteoblastic genes (osteopontin and osteocalcin). Following retinoic acid and gelatin scaffold/BMP-4 treatment, there was a coordinated switch in the integrin expression profile that paralleled odontoblastic differentiation where α1β1 integrin was strongly up-regulated with the attenuation of muscle-specific α7β1 integrin expression. Interestingly, using siRNA knockdown strategies revealed that the differentiation-related expression of the α1 integrin receptor positively regulates the expression of the odontoblastic markers dentin sialophosphoprotein and matrix metalloproteinase-20. These results strongly suggest that the differentiation of α7<sup>+</sup>hSMSCs along the odontogenic lineage is dependent on the concurrent expression of α1 integrin.</p></abstract><kwd-group><kwd>Bone Morphogenetic Protein (BMP)</kwd><kwd>Cell Adhesion</kwd><kwd>Cell Motility</kwd><kwd>Integrins</kwd><kwd>Stem Cells</kwd><kwd>Muscle</kwd><kwd>BMP-4</kwd><kwd>Odontoblast</kwd><kwd>Retinoic Acid</kwd></kwd-group><funding-group><award-group><funding-source id="CS100">National Institutes of Health</funding-source><award-id rid="CS100">R01DE015404</award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list><country><li>Japon</li><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><noCountry><name sortKey="Hase, Naoko" sort="Hase, Naoko" uniqKey="Hase N" first="Naoko" last="Hase">Naoko Hase</name><name sortKey="Hiyama, Taiki" sort="Hiyama, Taiki" uniqKey="Hiyama T" first="Taiki" last="Hiyama">Taiki Hiyama</name><name sortKey="Kawai, Rie" sort="Kawai, Rie" uniqKey="Kawai R" first="Rie" last="Kawai">Rie Kawai</name><name sortKey="Nakamura, Hiroshi" sort="Nakamura, Hiroshi" uniqKey="Nakamura H" first="Hiroshi" last="Nakamura">Hiroshi Nakamura</name><name sortKey="Nakata, Kazuhiko" sort="Nakata, Kazuhiko" uniqKey="Nakata K" first="Kazuhiko" last="Nakata">Kazuhiko Nakata</name><name sortKey="Ozeki, Nobuaki" sort="Ozeki, Nobuaki" uniqKey="Ozeki N" first="Nobuaki" last="Ozeki">Nobuaki Ozeki</name><name sortKey="Yamaguchi, Hideyuki" sort="Yamaguchi, Hideyuki" uniqKey="Yamaguchi H" first="Hideyuki" last="Yamaguchi">Hideyuki Yamaguchi</name></noCountry><country name="Japon"><noRegion><name sortKey="Mogi, Makio" sort="Mogi, Makio" uniqKey="Mogi M" first="Makio" last="Mogi">Makio Mogi</name></noRegion></country><country name="États-Unis"><region name="Californie"><name sortKey="Kramer, Randall H" sort="Kramer, Randall H" uniqKey="Kramer R" first="Randall H." last="Kramer">Randall H. 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