Application of mesenchymal stem cells in bone regenerative procedures in oral implantology. A literature review
Identifieur interne : 000A28 ( Ncbi/Merge ); précédent : 000A27; suivant : 000A29Application of mesenchymal stem cells in bone regenerative procedures in oral implantology. A literature review
Auteurs : Jose A. Vi A [Espagne] ; Marya El-Alami [Espagne] ; Juan Gambini [Espagne] ; Consuelo Borras [Espagne] ; Jose Vi A [Espagne] ; María A. Pe Arrocha [Espagne]Source :
- Journal of Clinical and Experimental Dentistry [ 1989-5488 ] ; 2014.
Abstract
Objective: The aim of this work was to review de literature about the role of mesenchymal stem cells in bone regenerative procedures in oral implantology, specifically, in the time require to promote bone regeneration. Study Design: A bibliographic search was carried out in PUBMED with a combination of different key words. Animal and human studies that assessed histomorphometrically the influence of mesenchymal stem cells on bone regeneration procedures in oral implantology surgeries were examined. Reults: - Alveolar regeneration: Different controlled histomorphometric animal studies showed that bone regeneration is faster using stem cells seeded in scaffolds than using scaffolds or platelet rich plasma alone. Human studies revealed that stem cells increase bone regeneration. - Maxillary sinus lift: Controlled studies in animals and in humans showed higher bone regeneration applying stem cells compared with controls. - Periimplantary bone regeneration and alveolar distraction: Studies in animals showed higher regeneration when stem cells are used. In humans, no evidence of applying mesenchymal stem cells in these regeneration procedures was found. Conclusion: Stem cells may promote bone regeneration and be useful in bone regenerative procedures in oral implantology, but no firm conclusions can be drawn from the rather limited clinical studies so far performed.
Url:
DOI: 10.4317/jced.51186
PubMed: 24596637
PubMed Central: 3935907
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in oral implantology. A literature review</title><author><name sortKey="Vi A, Jose A" sort="Vi A, Jose A" uniqKey="Vi A J" first="Jose A." last="Vi A">Jose A. Vi A</name><affiliation wicri:level="1"><nlm:aff id="A1">Master of Oral Surgery and Implantology. Valencia University Medical and Dental School. Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Master of Oral Surgery and Implantology. Valencia University Medical and Dental School. Valencia</wicri:regionArea></affiliation></author><author><name sortKey="El Alami, Marya" sort="El Alami, Marya" uniqKey="El Alami M" first="Marya" last="El-Alami">Marya El-Alami</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of physiology. Valencia University Medical School. Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of physiology. Valencia University Medical School. Valencia</wicri:regionArea></affiliation></author><author><name sortKey="Gambini, Juan" sort="Gambini, Juan" uniqKey="Gambini J" first="Juan" last="Gambini">Juan Gambini</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of physiology. Valencia University Medical School. Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of physiology. Valencia University Medical School. Valencia</wicri:regionArea></affiliation></author><author><name sortKey="Borras, Consuelo" sort="Borras, Consuelo" uniqKey="Borras C" first="Consuelo" last="Borras">Consuelo Borras</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of physiology. Valencia University Medical School. Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of physiology. Valencia University Medical School. Valencia</wicri:regionArea></affiliation></author><author><name sortKey="Vi A, Jose" sort="Vi A, Jose" uniqKey="Vi A J" first="Jose" last="Vi A">Jose Vi A</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of physiology. Valencia University Medical School. Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of physiology. Valencia University Medical School. Valencia</wicri:regionArea></affiliation></author><author><name sortKey="Pe Arrocha, Maria A" sort="Pe Arrocha, Maria A" uniqKey="Pe Arrocha M" first="María A." last="Pe Arrocha">María A. Pe Arrocha</name><affiliation wicri:level="1"><nlm:aff id="A3">Assistant professor of Oral Surgery. University Medical and Dental School. Professor of Master of Oral Surgery and Implantology. Valencia University Medical and Dental School. Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Assistant professor of Oral Surgery. University Medical and Dental School. Professor of Master of Oral Surgery and Implantology. Valencia University Medical and Dental School. Valencia</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24596637</idno><idno type="pmc">3935907</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935907</idno><idno type="RBID">PMC:3935907</idno><idno type="doi">10.4317/jced.51186</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000028</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000028</idno><idno type="wicri:Area/Pmc/Curation">000028</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000028</idno><idno type="wicri:Area/Pmc/Checkpoint">000468</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000468</idno><idno type="wicri:Area/Ncbi/Merge">000A28</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Application of mesenchymal stem cells in bone regenerative procedures
in oral implantology. A literature review</title><author><name sortKey="Vi A, Jose A" sort="Vi A, Jose A" uniqKey="Vi A J" first="Jose A." last="Vi A">Jose A. Vi A</name><affiliation wicri:level="1"><nlm:aff id="A1">Master of Oral Surgery and Implantology. Valencia University Medical and Dental School. Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Master of Oral Surgery and Implantology. Valencia University Medical and Dental School. Valencia</wicri:regionArea></affiliation></author><author><name sortKey="El Alami, Marya" sort="El Alami, Marya" uniqKey="El Alami M" first="Marya" last="El-Alami">Marya El-Alami</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of physiology. Valencia University Medical School. Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of physiology. Valencia University Medical School. Valencia</wicri:regionArea></affiliation></author><author><name sortKey="Gambini, Juan" sort="Gambini, Juan" uniqKey="Gambini J" first="Juan" last="Gambini">Juan Gambini</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of physiology. Valencia University Medical School. Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of physiology. Valencia University Medical School. Valencia</wicri:regionArea></affiliation></author><author><name sortKey="Borras, Consuelo" sort="Borras, Consuelo" uniqKey="Borras C" first="Consuelo" last="Borras">Consuelo Borras</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of physiology. Valencia University Medical School. Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of physiology. Valencia University Medical School. Valencia</wicri:regionArea></affiliation></author><author><name sortKey="Vi A, Jose" sort="Vi A, Jose" uniqKey="Vi A J" first="Jose" last="Vi A">Jose Vi A</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of physiology. Valencia University Medical School. Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of physiology. Valencia University Medical School. Valencia</wicri:regionArea></affiliation></author><author><name sortKey="Pe Arrocha, Maria A" sort="Pe Arrocha, Maria A" uniqKey="Pe Arrocha M" first="María A." last="Pe Arrocha">María A. Pe Arrocha</name><affiliation wicri:level="1"><nlm:aff id="A3">Assistant professor of Oral Surgery. University Medical and Dental School. Professor of Master of Oral Surgery and Implantology. Valencia University Medical and Dental School. Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Assistant professor of Oral Surgery. University Medical and Dental School. Professor of Master of Oral Surgery and Implantology. Valencia University Medical and Dental School. Valencia</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Clinical and Experimental Dentistry</title><idno type="eISSN">1989-5488</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Objective: The aim of this work was to review de literature about the role of mesenchymal stem cells in bone regenerative procedures in oral implantology, specifically, in the time require to promote bone regeneration.
Study Design: A bibliographic search was carried out in PUBMED with a combination of different key words. Animal and human studies that assessed histomorphometrically the influence of mesenchymal stem cells on bone regeneration procedures in oral implantology surgeries were examined.
Reults:
- Alveolar regeneration: Different controlled histomorphometric animal studies showed that bone regeneration is faster using stem cells seeded in scaffolds than using scaffolds or platelet rich plasma alone. Human studies revealed that stem cells increase bone regeneration.
- Maxillary sinus lift: Controlled studies in animals and in humans showed higher bone regeneration applying stem cells compared with controls.
- Periimplantary bone regeneration and alveolar distraction: Studies in animals showed higher regeneration when stem cells are used. In humans, no evidence of applying mesenchymal stem cells in these regeneration procedures was found.
Conclusion: Stem cells may promote bone regeneration and be useful in bone regenerative procedures in oral implantology, but no firm conclusions can be drawn from the rather limited clinical studies so far performed.
</p><p><bold> Key words:</bold>Mesenchymal stem cells, bone regeneration, dental implants, oral surgery, tissue engineering.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Thomson, Ja" uniqKey="Thomson J">JA Thomson</name></author><author><name sortKey="Itskovitz Eldor, J" uniqKey="Itskovitz Eldor J">J Itskovitz-Eldor</name></author><author><name sortKey="Shapiro, Ss" uniqKey="Shapiro S">SS Shapiro</name></author><author><name sortKey="Waknitz, Ma" uniqKey="Waknitz M">MA Waknitz</name></author><author><name sortKey="Swiergiel, Jj" uniqKey="Swiergiel J">JJ Swiergiel</name></author><author><name sortKey="Marshall, Vs" uniqKey="Marshall V">VS Marshall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, A" uniqKey="Smith A">A Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caplan, Ai" uniqKey="Caplan A">AI 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Exp Dent</journal-id><journal-id journal-id-type="iso-abbrev">J Clin Exp Dent</journal-id><journal-id journal-id-type="publisher-id">Medicina Oral S.L.</journal-id><journal-title-group><journal-title>Journal of Clinical and Experimental Dentistry</journal-title></journal-title-group><issn pub-type="epub">1989-5488</issn><publisher><publisher-name>Medicina Oral S.L.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24596637</article-id><article-id pub-id-type="pmc">3935907</article-id><article-id pub-id-type="publisher-id">51186</article-id><article-id pub-id-type="doi">10.4317/jced.51186</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject><subj-group><subject>Implantology</subject></subj-group></subj-group></article-categories><title-group><article-title>Application of mesenchymal stem cells in bone regenerative procedures
in oral implantology. A literature review</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Viña</surname><given-names>Jose A.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>El-Alami</surname><given-names>Marya</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Gambini</surname><given-names>Juan</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Borras</surname><given-names>Consuelo</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Viña</surname><given-names>Jose</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Peñarrocha</surname><given-names>María A.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>Master of Oral Surgery and Implantology. Valencia University Medical and Dental School. Valencia, Spain</aff><aff id="A2"><label>2</label>Department of physiology. Valencia University Medical School. Valencia, Spain</aff><aff id="A3"><label>3</label>Assistant professor of Oral Surgery. University Medical and Dental School. Professor of Master of Oral Surgery and Implantology. Valencia University Medical and Dental School. Valencia, Spain</aff><author-notes><corresp> Cirugía Bucal. Clínicas Odontológicas
Facultad de Medicina y Odontología
Universidad de Valencia
Gascó Oliag 1
46021, Valencia
, E-mail: <email>maria.penarrocha@uv.es</email></corresp><fn id="FN1" fn-type="conflict"><p><bold>Conflict of interest statement:</bold>The authors declare that they have no conflict of interest.</p></fn></author-notes><pub-date pub-type="epub"><day>1</day><month>2</month><year>2014</year></pub-date><pub-date pub-type="collection"><month>2</month><year>2014</year></pub-date><volume>6</volume><issue>1</issue><fpage>e60</fpage><lpage>e65</lpage><history><date date-type="accepted"><day>26</day><month>9</month><year>2013</year></date><date date-type="received"><day>27</day><month>6</month><year>2013</year></date></history><permissions><copyright-statement>Copyright: © 2014 Medicina Oral S.L.</copyright-statement><copyright-year>2014</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.5/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Objective: The aim of this work was to review de literature about the role of mesenchymal stem cells in bone regenerative procedures in oral implantology, specifically, in the time require to promote bone regeneration.
Study Design: A bibliographic search was carried out in PUBMED with a combination of different key words. Animal and human studies that assessed histomorphometrically the influence of mesenchymal stem cells on bone regeneration procedures in oral implantology surgeries were examined.
Reults:
- Alveolar regeneration: Different controlled histomorphometric animal studies showed that bone regeneration is faster using stem cells seeded in scaffolds than using scaffolds or platelet rich plasma alone. Human studies revealed that stem cells increase bone regeneration.
- Maxillary sinus lift: Controlled studies in animals and in humans showed higher bone regeneration applying stem cells compared with controls.
- Periimplantary bone regeneration and alveolar distraction: Studies in animals showed higher regeneration when stem cells are used. In humans, no evidence of applying mesenchymal stem cells in these regeneration procedures was found.
Conclusion: Stem cells may promote bone regeneration and be useful in bone regenerative procedures in oral implantology, but no firm conclusions can be drawn from the rather limited clinical studies so far performed.
</p><p><bold> Key words:</bold>Mesenchymal stem cells, bone regeneration, dental implants, oral surgery, tissue engineering.</p></abstract></article-meta></front></pmc><affiliations><list><country><li>Espagne</li></country></list><tree><country name="Espagne"><noRegion><name sortKey="Vi A, Jose A" sort="Vi A, Jose A" uniqKey="Vi A J" first="Jose A." last="Vi A">Jose A. Vi A</name></noRegion><name sortKey="Borras, Consuelo" sort="Borras, Consuelo" uniqKey="Borras C" first="Consuelo" last="Borras">Consuelo Borras</name><name sortKey="El Alami, Marya" sort="El Alami, Marya" uniqKey="El Alami M" first="Marya" last="El-Alami">Marya El-Alami</name><name sortKey="Gambini, Juan" sort="Gambini, Juan" uniqKey="Gambini J" first="Juan" last="Gambini">Juan Gambini</name><name sortKey="Pe Arrocha, Maria A" sort="Pe Arrocha, Maria A" uniqKey="Pe Arrocha M" first="María A." last="Pe Arrocha">María A. Pe Arrocha</name><name sortKey="Vi A, Jose" sort="Vi A, Jose" uniqKey="Vi A J" first="Jose" last="Vi A">Jose Vi A</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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