Would nitric oxide be an effective marker for earlier stages of peri-implant disease? An analysis in human peri-implant sulcular fluid.
Identifieur interne : 000149 ( Ncbi/Merge ); précédent : 000148; suivant : 000150Would nitric oxide be an effective marker for earlier stages of peri-implant disease? An analysis in human peri-implant sulcular fluid.
Auteurs : Andreia Espindola Vieira [Brésil] ; Camilla Christian Gomes Moura ; Maria Aparecida De Souza ; Darceny Zanetta-Barbosa ; Paula DechichiSource :
- The Journal of oral implantology [ 0160-6972 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- diagnostic : Péri-implantite.
- effets indésirables : Implants dentaires.
- étiologie : Péri-implantite.
- Adulte, Adulte d'âge moyen, Exsudat gingival, Femelle, Humains, Monoxyde d'azote, Mâle, Études transversales.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Dental Implants.
- chemistry : Gingival Crevicular Fluid.
- diagnosis : Peri-Implantitis.
- etiology : Peri-Implantitis.
- Adult, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Nitric Oxide.
Abstract
Nitric oxide has an important effect on host immune response. However, little has been studied in relation to its potential as a possible diagnostic tool in peri-implant disease. The present study analyzed nitrite levels in the peri-implant sulcular fluid (PISF) of implants with mucositis and the correlation of these nitrite levels with clinical parameters using a simplified fluid collection methodology. Twenty-five partially edentulous patients showing peri-implant mucositis were evaluated, and the peri-implant status was determined based on current clinical parameters: probing depth (PD) and bleeding on probing (BOP). The sulcular fluid (SF) around teeth (control) and implants were collected, and the nitrite levels were evaluated using the Griess method. The mean probing depth (mm) was significantly higher (P < .0001) in implants (2.852 ± 0.6484) than in control teeth (1.585 ± 0.3636). The mean total nitrite level (μM) was statistically higher (P = .0069) in implants with mucositis (14.34 ± 11.83) than in control teeth (9.316 ± 5.534). No correlation was observed between the total nitrite levels and the PD mean in the control group (P = .2558, r = -0.2361) or in the implant group (P = .1160, r = -0.3224), as well as the number of faces showing bleeding on probing (P = .8747, r = 0.0332). These results demonstrated that the nitrite levels were higher in inflamed areas. According to the methodology applied and results obtained, the higher nitrite levels in inflamed areas suggest that, in the future, nitrite could be used as a marker of peri-implant mucositis associated with clinical data to monitor the cure or evolution of the disease.
DOI: 10.1563/AAID-JOI-D-11-00158
PubMed: 23402357
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An analysis in human peri-implant sulcular fluid.</title><author><name sortKey="Vieira, Andreia Espindola" sort="Vieira, Andreia Espindola" uniqKey="Vieira A" first="Andreia Espindola" last="Vieira">Andreia Espindola Vieira</name><affiliation wicri:level="2"><nlm:affiliation>Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Universidade Federal de Uberlândia, Uberlândia, Minas Gerais</wicri:regionArea><placeName><region type="state">Minas Gerais</region></placeName></affiliation></author><author><name sortKey="Moura, Camilla Christian Gomes" sort="Moura, Camilla Christian Gomes" uniqKey="Moura C" first="Camilla Christian Gomes" last="Moura">Camilla Christian Gomes Moura</name></author><author><name sortKey="De Souza, Maria Aparecida" sort="De Souza, Maria Aparecida" uniqKey="De Souza M" first="Maria Aparecida" last="De Souza">Maria Aparecida De Souza</name></author><author><name sortKey="Zanetta Barbosa, Darceny" sort="Zanetta Barbosa, Darceny" uniqKey="Zanetta Barbosa D" first="Darceny" last="Zanetta-Barbosa">Darceny Zanetta-Barbosa</name></author><author><name sortKey="Dechichi, Paula" sort="Dechichi, Paula" uniqKey="Dechichi P" first="Paula" last="Dechichi">Paula Dechichi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23402357</idno><idno type="pmid">23402357</idno><idno type="doi">10.1563/AAID-JOI-D-11-00158</idno><idno type="wicri:Area/PubMed/Corpus">000483</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000483</idno><idno type="wicri:Area/PubMed/Curation">000483</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000483</idno><idno type="wicri:Area/PubMed/Checkpoint">000483</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000483</idno><idno type="wicri:Area/Ncbi/Merge">000149</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Would nitric oxide be an effective marker for earlier stages of peri-implant disease? An analysis in human peri-implant sulcular fluid.</title><author><name sortKey="Vieira, Andreia Espindola" sort="Vieira, Andreia Espindola" uniqKey="Vieira A" first="Andreia Espindola" last="Vieira">Andreia Espindola Vieira</name><affiliation wicri:level="2"><nlm:affiliation>Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Universidade Federal de Uberlândia, Uberlândia, Minas Gerais</wicri:regionArea><placeName><region type="state">Minas Gerais</region></placeName></affiliation></author><author><name sortKey="Moura, Camilla Christian Gomes" sort="Moura, Camilla Christian Gomes" uniqKey="Moura C" first="Camilla Christian Gomes" last="Moura">Camilla Christian Gomes Moura</name></author><author><name sortKey="De Souza, Maria Aparecida" sort="De Souza, Maria Aparecida" uniqKey="De Souza M" first="Maria Aparecida" last="De Souza">Maria Aparecida De Souza</name></author><author><name sortKey="Zanetta Barbosa, Darceny" sort="Zanetta Barbosa, Darceny" uniqKey="Zanetta Barbosa D" first="Darceny" last="Zanetta-Barbosa">Darceny Zanetta-Barbosa</name></author><author><name sortKey="Dechichi, Paula" sort="Dechichi, Paula" uniqKey="Dechichi P" first="Paula" last="Dechichi">Paula Dechichi</name></author></analytic><series><title level="j">The Journal of oral implantology</title><idno type="ISSN">0160-6972</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Cross-Sectional Studies</term><term>Dental Implants (adverse effects)</term><term>Female</term><term>Gingival Crevicular Fluid (chemistry)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nitric Oxide</term><term>Peri-Implantitis (diagnosis)</term><term>Peri-Implantitis (etiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Exsudat gingival ()</term><term>Femelle</term><term>Humains</term><term>Implants dentaires (effets indésirables)</term><term>Monoxyde d'azote</term><term>Mâle</term><term>Péri-implantite (diagnostic)</term><term>Péri-implantite (étiologie)</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Dental Implants</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Gingival Crevicular Fluid</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Peri-Implantitis</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Péri-implantite</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Implants dentaires</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Peri-Implantitis</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Péri-implantite</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nitric Oxide</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Exsudat gingival</term><term>Femelle</term><term>Humains</term><term>Monoxyde d'azote</term><term>Mâle</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nitric oxide has an important effect on host immune response. However, little has been studied in relation to its potential as a possible diagnostic tool in peri-implant disease. The present study analyzed nitrite levels in the peri-implant sulcular fluid (PISF) of implants with mucositis and the correlation of these nitrite levels with clinical parameters using a simplified fluid collection methodology. Twenty-five partially edentulous patients showing peri-implant mucositis were evaluated, and the peri-implant status was determined based on current clinical parameters: probing depth (PD) and bleeding on probing (BOP). The sulcular fluid (SF) around teeth (control) and implants were collected, and the nitrite levels were evaluated using the Griess method. The mean probing depth (mm) was significantly higher (P < .0001) in implants (2.852 ± 0.6484) than in control teeth (1.585 ± 0.3636). The mean total nitrite level (μM) was statistically higher (P = .0069) in implants with mucositis (14.34 ± 11.83) than in control teeth (9.316 ± 5.534). No correlation was observed between the total nitrite levels and the PD mean in the control group (P = .2558, r = -0.2361) or in the implant group (P = .1160, r = -0.3224), as well as the number of faces showing bleeding on probing (P = .8747, r = 0.0332). These results demonstrated that the nitrite levels were higher in inflamed areas. According to the methodology applied and results obtained, the higher nitrite levels in inflamed areas suggest that, in the future, nitrite could be used as a marker of peri-implant mucositis associated with clinical data to monitor the cure or evolution of the disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23402357</PMID><DateCompleted><Year>2013</Year><Month>04</Month><Day>02</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0160-6972</ISSN><JournalIssue CitedMedium="Print"><Volume>39</Volume><Issue>1</Issue><PubDate><Year>2013</Year><Month>Feb</Month></PubDate></JournalIssue><Title>The Journal of oral implantology</Title><ISOAbbreviation>J Oral Implantol</ISOAbbreviation></Journal><ArticleTitle>Would nitric oxide be an effective marker for earlier stages of peri-implant disease? An analysis in human peri-implant sulcular fluid.</ArticleTitle><Pagination><MedlinePgn>37-43</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1563/AAID-JOI-D-11-00158</ELocationID><Abstract><AbstractText>Nitric oxide has an important effect on host immune response. However, little has been studied in relation to its potential as a possible diagnostic tool in peri-implant disease. The present study analyzed nitrite levels in the peri-implant sulcular fluid (PISF) of implants with mucositis and the correlation of these nitrite levels with clinical parameters using a simplified fluid collection methodology. Twenty-five partially edentulous patients showing peri-implant mucositis were evaluated, and the peri-implant status was determined based on current clinical parameters: probing depth (PD) and bleeding on probing (BOP). The sulcular fluid (SF) around teeth (control) and implants were collected, and the nitrite levels were evaluated using the Griess method. The mean probing depth (mm) was significantly higher (P < .0001) in implants (2.852 ± 0.6484) than in control teeth (1.585 ± 0.3636). The mean total nitrite level (μM) was statistically higher (P = .0069) in implants with mucositis (14.34 ± 11.83) than in control teeth (9.316 ± 5.534). No correlation was observed between the total nitrite levels and the PD mean in the control group (P = .2558, r = -0.2361) or in the implant group (P = .1160, r = -0.3224), as well as the number of faces showing bleeding on probing (P = .8747, r = 0.0332). These results demonstrated that the nitrite levels were higher in inflamed areas. According to the methodology applied and results obtained, the higher nitrite levels in inflamed areas suggest that, in the future, nitrite could be used as a marker of peri-implant mucositis associated with clinical data to monitor the cure or evolution of the disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vieira</LastName><ForeName>Andreia Espindola</ForeName><Initials>AE</Initials><AffiliationInfo><Affiliation>Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moura</LastName><ForeName>Camilla Christian Gomes</ForeName><Initials>CC</Initials></Author><Author ValidYN="Y"><LastName>de Souza</LastName><ForeName>Maria Aparecida</ForeName><Initials>MA</Initials></Author><Author ValidYN="Y"><LastName>Zanetta-Barbosa</LastName><ForeName>Darceny</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Dechichi</LastName><ForeName>Paula</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Oral Implantol</MedlineTA><NlmUniqueID>7801086</NlmUniqueID><ISSNLinking>0160-6972</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015921">Dental Implants</NameOfSubstance></Chemical><Chemical><RegistryNumber>31C4KY9ESH</RegistryNumber><NameOfSubstance UI="D009569">Nitric Oxide</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015921" MajorTopicYN="N">Dental Implants</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005883" MajorTopicYN="N">Gingival Crevicular Fluid</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009569" MajorTopicYN="Y">Nitric Oxide</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057873" MajorTopicYN="N">Peri-Implantitis</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>2</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>2</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>4</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23402357</ArticleId><ArticleId IdType="doi">10.1563/AAID-JOI-D-11-00158</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Brésil</li></country><region><li>Minas Gerais</li></region></list><tree><noCountry><name sortKey="De Souza, Maria Aparecida" sort="De Souza, Maria Aparecida" uniqKey="De Souza M" first="Maria Aparecida" last="De Souza">Maria Aparecida De Souza</name><name sortKey="Dechichi, Paula" sort="Dechichi, Paula" uniqKey="Dechichi P" first="Paula" last="Dechichi">Paula Dechichi</name><name sortKey="Moura, Camilla Christian Gomes" sort="Moura, Camilla Christian Gomes" uniqKey="Moura C" first="Camilla Christian Gomes" last="Moura">Camilla Christian Gomes Moura</name><name sortKey="Zanetta Barbosa, Darceny" sort="Zanetta Barbosa, Darceny" uniqKey="Zanetta Barbosa D" first="Darceny" last="Zanetta-Barbosa">Darceny Zanetta-Barbosa</name></noCountry><country name="Brésil"><region name="Minas Gerais"><name sortKey="Vieira, Andreia Espindola" sort="Vieira, Andreia Espindola" uniqKey="Vieira A" first="Andreia Espindola" last="Vieira">Andreia Espindola Vieira</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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