Stem Cells in the Face: Tooth Regeneration and Beyond
Identifieur interne : 000046 ( Ncbi/Merge ); précédent : 000045; suivant : 000047Stem Cells in the Face: Tooth Regeneration and Beyond
Auteurs : Jeremy J. Mao [États-Unis] ; Pamela G. Robey [États-Unis] ; Darwin J. Prockop [États-Unis]Source :
- Cell stem cell [ 1934-5909 ] ; 2012.
Abstract
Postnatal orofacial tissues contain rare cells that exhibit stem/progenitor cell properties. Despite a tremendous unmet clinical need for regeneration of tissues lost in congenital anomalies, infections, trauma or tumor resection, how orofacial stem/progenitor cells contribute to tissue development, pathogenesis and regeneration is largely a mystery. This perspective article critically analyzes the current status of orofacial stem/progenitor cells, identifies gaps in our understanding and highlights pathways for the development of regenerative therapies.
Url:
DOI: 10.1016/j.stem.2012.08.010
PubMed: 22958928
PubMed Central: 4093804
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PMC:4093804Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">Postnatal orofacial tissues contain rare cells that exhibit stem/progenitor cell properties. Despite a tremendous unmet clinical need for regeneration of tissues lost in congenital anomalies, infections, trauma or tumor resection, how orofacial stem/progenitor cells contribute to tissue development, pathogenesis and regeneration is largely a mystery. This perspective article critically analyzes the current status of orofacial stem/progenitor cells, identifies gaps in our understanding and highlights pathways for the development of regenerative therapies.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101311472</journal-id>
<journal-id journal-id-type="pubmed-jr-id">34100</journal-id>
<journal-id journal-id-type="nlm-ta">Cell Stem Cell</journal-id>
<journal-id journal-id-type="iso-abbrev">Cell Stem Cell</journal-id>
<journal-title-group><journal-title>Cell stem cell</journal-title>
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<title-group><article-title>Stem Cells in the Face: Tooth Regeneration and Beyond</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Mao</surname>
<given-names>Jeremy J.</given-names>
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<contrib contrib-type="author"><name><surname>Prockop</surname>
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<aff id="A1"><label>1</label>
Center for Craniofacial Regeneration, Columbia University Medical Center 630 W. 168 Street – PH7E, New York, NY 10032</aff>
<aff id="A2"><label>2</label>
Craniofacital and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892</aff>
<aff id="A3"><label>3</label>
Institute for Regenerative Medicine at Scott and White, Texas A&M University Health Science Center, Temple TX 76502</aff>
<author-notes><corresp id="cor1"><label>*</label>
<bold>Corresponding author</bold>
, Jeremy J. Mao, DDS, PhD, Professor and Edwin S. Robinson Endowed Chair, Co-Director, Center for Craniofacial Regeneration, Columbia University Medical Center, 630 W. 168 St. - PH7E, New York, NY 10032 Phone: 212-305-4475, <email>jmao@columbia.edu</email>
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<pub-date pub-type="nihms-submitted"><day>8</day>
<month>6</month>
<year>2014</year>
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<pub-date pub-type="ppub"><day>7</day>
<month>9</month>
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<pub-date pub-type="pmc-release"><day>11</day>
<month>7</month>
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<volume>11</volume>
<issue>3</issue>
<fpage>291</fpage>
<lpage>301</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.stem.2012.08.010</pmc-comment>
<permissions><copyright-statement>© 2012 ll Press. All rights reserved.</copyright-statement>
<copyright-year>2012</copyright-year>
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<abstract><p id="P1">Postnatal orofacial tissues contain rare cells that exhibit stem/progenitor cell properties. Despite a tremendous unmet clinical need for regeneration of tissues lost in congenital anomalies, infections, trauma or tumor resection, how orofacial stem/progenitor cells contribute to tissue development, pathogenesis and regeneration is largely a mystery. This perspective article critically analyzes the current status of orofacial stem/progenitor cells, identifies gaps in our understanding and highlights pathways for the development of regenerative therapies.</p>
</abstract>
<kwd-group><kwd>dental stem cells</kwd>
<kwd>dental pulp stem cells</kwd>
<kwd>periodontal ligament stem cells</kwd>
<kwd>alveolar bone stem cells</kwd>
<kwd>bone regeneration</kwd>
<kwd>tooth regeneration</kwd>
<kwd>periodontal regeneration</kwd>
<kwd>scaffolds</kwd>
<kwd>growth factors</kwd>
<kwd>animal models</kwd>
</kwd-group>
</article-meta>
</front>
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