Bisphosphonate-induced osteoradionecrosis
Identifieur interne : 000A06 ( Ncbi/Curation ); précédent : 000A05; suivant : 000A07Bisphosphonate-induced osteoradionecrosis
Auteurs : Ruchi Bhuyan ; Sanat Bhuyan ; Rajat G. Panigrahi ; Antarmayee PanigrahiSource :
- Journal of Oral and Maxillofacial Pathology : JOMFP [ 0973-029X ] ; 2013.
Abstract
Bisphosphonates (BPs) are a class of agents used to treat osteoporosis and malignant bone metastasis. Despite these benefits, osteonecrosis of the jaws has recently emerged as a significant complication in a subset of patients receiving these drugs.
This case presentation focuses on a 62-year-old man with a 3-year history of monthly use of Zometa (zolendronic acid) for treatment of multiple myeloma, resulting in BP-related osteoradionecrosis of the jaws (BRONJ). This new entity remains a challenge with diagnosis as well as treatment. The goal of this paper is to improve clinicians understanding and provide a guideline for establishing a stage-specific diagnosis and prevention of BRONJ.
Url:
DOI: 10.4103/0973-029X.125221
PubMed: 24574674
PubMed Central: 3927357
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Panigrahi</name><affiliation><nlm:aff id="aff2"><italic>Department of Oral Medicine and Radiology, Institute of Dental Sciences and Hospital, Siksha O Anusandhan University, Bhubaneswar, Odisha, India</italic></nlm:aff></affiliation></author><author><name sortKey="Panigrahi, Antarmayee" sort="Panigrahi, Antarmayee" uniqKey="Panigrahi A" first="Antarmayee" last="Panigrahi">Antarmayee Panigrahi</name><affiliation><nlm:aff id="aff3"><italic>Departments of Pedodontia and Preventive Dentistry, Jagadguru Sri Shivarathreeshwara Dental College, Mysore, Karnataka, India</italic></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24574674</idno><idno type="pmc">3927357</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927357</idno><idno type="RBID">PMC:3927357</idno><idno type="doi">10.4103/0973-029X.125221</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000219</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000219</idno><idno type="wicri:Area/Pmc/Curation">000219</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000219</idno><idno type="wicri:Area/Pmc/Checkpoint">000704</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000704</idno><idno type="wicri:Area/Ncbi/Merge">000A06</idno><idno type="wicri:Area/Ncbi/Curation">000A06</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bisphosphonate-induced osteoradionecrosis</title><author><name sortKey="Bhuyan, Ruchi" sort="Bhuyan, Ruchi" uniqKey="Bhuyan R" first="Ruchi" last="Bhuyan">Ruchi Bhuyan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Bhuyan, Sanat" sort="Bhuyan, Sanat" uniqKey="Bhuyan S" first="Sanat" last="Bhuyan">Sanat Bhuyan</name><affiliation><nlm:aff id="aff2"><italic>Department of Oral Medicine and Radiology, Institute of Dental Sciences and Hospital, Siksha O Anusandhan University, Bhubaneswar, Odisha, India</italic></nlm:aff></affiliation></author><author><name sortKey="Panigrahi, Rajat G" sort="Panigrahi, Rajat G" uniqKey="Panigrahi R" first="Rajat G" last="Panigrahi">Rajat G. Panigrahi</name><affiliation><nlm:aff id="aff2"><italic>Department of Oral Medicine and Radiology, Institute of Dental Sciences and Hospital, Siksha O Anusandhan University, Bhubaneswar, Odisha, India</italic></nlm:aff></affiliation></author><author><name sortKey="Panigrahi, Antarmayee" sort="Panigrahi, Antarmayee" uniqKey="Panigrahi A" first="Antarmayee" last="Panigrahi">Antarmayee Panigrahi</name><affiliation><nlm:aff id="aff3"><italic>Departments of Pedodontia and Preventive Dentistry, Jagadguru Sri Shivarathreeshwara Dental College, Mysore, Karnataka, India</italic></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Oral and Maxillofacial Pathology : JOMFP</title><idno type="ISSN">0973-029X</idno><idno type="eISSN">1998-393X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Bisphosphonates (BPs) are a class of agents used to treat osteoporosis and malignant bone metastasis. Despite these benefits, osteonecrosis of the jaws has recently emerged as a significant complication in a subset of patients receiving these drugs.</p><p>This case presentation focuses on a 62-year-old man with a 3-year history of monthly use of Zometa (zolendronic acid) for treatment of multiple myeloma, resulting in BP-related osteoradionecrosis of the jaws (BRONJ). This new entity remains a challenge with diagnosis as well as treatment. 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