Lessons learned and unlearned in periodontal microbiology
Identifieur interne : 000242 ( Ncbi/Checkpoint ); précédent : 000241; suivant : 000243Lessons learned and unlearned in periodontal microbiology
Auteurs : Ricardo Teles [États-Unis] ; Flavia Teles [États-Unis] ; Jorge Frias-Lopez [États-Unis] ; Bruce Paster [États-Unis] ; Anne Haffajee [États-Unis]Source :
- Periodontology 2000 [ 0906-6713 ] ; 2013.
Abstract
Periodontal diseases are initiated by bacterial species living in polymicrobial biofilms at or below the gingival margin and progress largely as a result of the inflammation initiated by specific subgingival species. In the past few decades, efforts to understand the microbiota of periodontal diseases have led to an exponential increase in information about biofilms associated with periodontal health and disease. In fact, the oral microbiota is one of the best characterized microbiomes that colonize the human body. Despite this increased knowledge, one has to ask if our fundamental concepts of the etiology and pathogenesis of periodontal diseases have really changed. In this chapter we will review how our comprehension of the structure and function of the subgingival microbiota evolved over the years in search of lessons learned and unlearned in periodontal microbiology. More specifically, this review focuses on: 1) how the data obtained through molecular techniques has impacted our knowledge of the etiology of periodontal infections; 2) the potential role of viruses in the etiopathogenesis of periodontal diseases; 3) how concepts of microbial ecology have expanded our understanding of host microbial interactions that might lead to periodontal diseases; 4) the role of inflammation in the pathogenesis of periodontal diseases; and 5) the impact of these evolving concepts on treatment and preventive approaches to periodontal infections. We will conclude by reviewing how novel systems biology approaches promise to unravel new details of the pathogenesis of periodontal diseases and, hopefully, lead to a better understanding of periodontal disease mechanisms.
Url:
DOI: 10.1111/prd.12010
PubMed: 23574465
PubMed Central: 3912758
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000428
- to stream Pmc, to step Curation: 000428
- to stream Pmc, to step Checkpoint: 000640
- to stream Ncbi, to step Merge: 000242
- to stream Ncbi, to step Curation: 000242
Links to Exploration step
PMC:3912758Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lessons learned and unlearned in periodontal microbiology</title>
<author><name sortKey="Teles, Ricardo" sort="Teles, Ricardo" uniqKey="Teles R" first="Ricardo" last="Teles">Ricardo Teles</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Teles, Flavia" sort="Teles, Flavia" uniqKey="Teles F" first="Flavia" last="Teles">Flavia Teles</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Frias Lopez, Jorge" sort="Frias Lopez, Jorge" uniqKey="Frias Lopez J" first="Jorge" last="Frias-Lopez">Jorge Frias-Lopez</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Microbiology, The Forsyth Institute, Cambridge, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Microbiology, The Forsyth Institute, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Paster, Bruce" sort="Paster, Bruce" uniqKey="Paster B" first="Bruce" last="Paster">Bruce Paster</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Microbiology, The Forsyth Institute, Cambridge, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Microbiology, The Forsyth Institute, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Haffajee, Anne" sort="Haffajee, Anne" uniqKey="Haffajee A" first="Anne" last="Haffajee">Anne Haffajee</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23574465</idno>
<idno type="pmc">3912758</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912758</idno>
<idno type="RBID">PMC:3912758</idno>
<idno type="doi">10.1111/prd.12010</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000428</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000428</idno>
<idno type="wicri:Area/Pmc/Curation">000428</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000428</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000640</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000640</idno>
<idno type="wicri:Area/Ncbi/Merge">000242</idno>
<idno type="wicri:Area/Ncbi/Curation">000242</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000242</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lessons learned and unlearned in periodontal microbiology</title>
<author><name sortKey="Teles, Ricardo" sort="Teles, Ricardo" uniqKey="Teles R" first="Ricardo" last="Teles">Ricardo Teles</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Teles, Flavia" sort="Teles, Flavia" uniqKey="Teles F" first="Flavia" last="Teles">Flavia Teles</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Frias Lopez, Jorge" sort="Frias Lopez, Jorge" uniqKey="Frias Lopez J" first="Jorge" last="Frias-Lopez">Jorge Frias-Lopez</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Microbiology, The Forsyth Institute, Cambridge, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Microbiology, The Forsyth Institute, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Paster, Bruce" sort="Paster, Bruce" uniqKey="Paster B" first="Bruce" last="Paster">Bruce Paster</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Microbiology, The Forsyth Institute, Cambridge, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Microbiology, The Forsyth Institute, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Haffajee, Anne" sort="Haffajee, Anne" uniqKey="Haffajee A" first="Anne" last="Haffajee">Anne Haffajee</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Periodontology 2000</title>
<idno type="ISSN">0906-6713</idno>
<idno type="eISSN">1600-0757</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Periodontal diseases are initiated by bacterial species living in polymicrobial biofilms at or below the gingival margin and progress largely as a result of the inflammation initiated by specific subgingival species. In the past few decades, efforts to understand the microbiota of periodontal diseases have led to an exponential increase in information about biofilms associated with periodontal health and disease. In fact, the oral microbiota is one of the best characterized microbiomes that colonize the human body. Despite this increased knowledge, one has to ask if our fundamental concepts of the etiology and pathogenesis of periodontal diseases have really changed. In this chapter we will review how our comprehension of the structure and function of the subgingival microbiota evolved over the years in search of lessons learned and unlearned in periodontal microbiology. More specifically, this review focuses on: 1) how the data obtained through molecular techniques has impacted our knowledge of the etiology of periodontal infections; 2) the potential role of viruses in the etiopathogenesis of periodontal diseases; 3) how concepts of microbial ecology have expanded our understanding of host microbial interactions that might lead to periodontal diseases; 4) the role of inflammation in the pathogenesis of periodontal diseases; and 5) the impact of these evolving concepts on treatment and preventive approaches to periodontal infections. We will conclude by reviewing how novel systems biology approaches promise to unravel new details of the pathogenesis of periodontal diseases and, hopefully, lead to a better understanding of periodontal disease mechanisms.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Teles, Ricardo" sort="Teles, Ricardo" uniqKey="Teles R" first="Ricardo" last="Teles">Ricardo Teles</name>
</region>
<name sortKey="Frias Lopez, Jorge" sort="Frias Lopez, Jorge" uniqKey="Frias Lopez J" first="Jorge" last="Frias-Lopez">Jorge Frias-Lopez</name>
<name sortKey="Haffajee, Anne" sort="Haffajee, Anne" uniqKey="Haffajee A" first="Anne" last="Haffajee">Anne Haffajee</name>
<name sortKey="Paster, Bruce" sort="Paster, Bruce" uniqKey="Paster B" first="Bruce" last="Paster">Bruce Paster</name>
<name sortKey="Teles, Flavia" sort="Teles, Flavia" uniqKey="Teles F" first="Flavia" last="Teles">Flavia Teles</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000242 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 000242 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= EdenteV1 |flux= Ncbi |étape= Checkpoint |type= RBID |clé= PMC:3912758 |texte= Lessons learned and unlearned in periodontal microbiology }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:23574465" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a EdenteV1
This area was generated with Dilib version V0.6.33. |