Age-Dependent Associations Between Chronic Periodontitis/Edentulism and Risk of Coronary Heart Disease
Identifieur interne : 001F71 ( Main/Merge ); précédent : 001F70; suivant : 001F72Age-Dependent Associations Between Chronic Periodontitis/Edentulism and Risk of Coronary Heart Disease
Auteurs : Thomas Dietrich [États-Unis, Royaume-Uni] ; Monik Jimenez [États-Unis] ; Elizabeth A. Krall Kaye [États-Unis] ; Pantel S. Vokonas [États-Unis] ; Raul I. Garcia [États-Unis]Source :
- Circulation : (New York, N.Y.) [ 0009-7322 ] ; 2008.
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- Pascal (Inist)
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Abstract
Background-Several epidemiological studies have suggested periodontitis as a risk factor for coronary heart disease (CHD), but results have been inconsistent. Methods and Results-We evaluated the association between clinical and radiographic measures of periodontitis, edentulism, and incident CHD (angina, myocardial infarction, or fatal CHD) among 1203 men in the VA Normative Aging and Dental Longitudinal Studies who were followed up with triennial comprehensive medical and dental examinations up to 35 years (median 24 years). Cox proportional hazards models with time-varying effects of exposure and potential confounders were fit. We found a significant dose-dependent association between periodontitis and CHD incidence among men <60 years of age (hazard ratio 2.12, 95% confidence interval 1.26 to 3.60 comparing highest versus lowest category of radiographic bone loss, P for trend=0.02), independent of age, body mass index, smoking, alcohol intake, diabetes mellitus, fasting glucose, total cholesterol, high-density lipoprotein cholesterol, triglycerides, hypertension, systolic and diastolic blood pressure, education, marital status, income, and occupation. No association was found among men >60 years of age. Similar results were found when the sum of probing pocket depths was used as a measure of periodontitis. Among men ≥60 years of age, edentulous men tended to have a higher risk of CHD than dentate men in the lowest bone loss (hazard ratio 1.61, 95% confidence interval 0.95 to 2.73) and lowest pocket depth (hazard ratio 1.72, 95% confidence interval 1.03 to 2.85) categories, independent of confounders. Conclusions-Chronic periodontitis is associated with incidence of CHD among younger men, independent of established cardiovascular risk factors.
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Krall Kaye</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Health Policy and Health Services Research, Boston University Goldman School of Dental Medicine</s1><s2>Boston, Mass</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, Mass</wicri:noRegion></affiliation></author><author><name sortKey="Vokonas, Pantel S" sort="Vokonas, Pantel S" uniqKey="Vokonas P" first="Pantel S." last="Vokonas">Pantel S. Vokonas</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>VA Normative Aging Study, VA Boston Healthcare System</s1><s2>Boston, Mass</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Virginie</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Medicine Boston University School of Medicine</s1><s2>Boston, Mass</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Medicine Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Garcia, Raul I" sort="Garcia, Raul I" uniqKey="Garcia R" first="Raul I." last="Garcia">Raul I. Garcia</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Health Policy and Health Services Research, Boston University Goldman School of Dental Medicine</s1><s2>Boston, Mass</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, Mass</wicri:noRegion></affiliation><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>VA Dental Longitudinal Study, VA Boston Healthcare System</s1><s2>Boston, Mass</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Virginie</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Circulation : (New York, N.Y.)</title><title level="j" type="abbreviated">Circulation : (N. Y. N.Y.)</title><idno type="ISSN">0009-7322</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Circulation : (New York, N.Y.)</title><title level="j" type="abbreviated">Circulation : (N. Y. N.Y.)</title><idno type="ISSN">0009-7322</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cardiovascular disease</term><term>Chronic</term><term>Coronary heart disease</term><term>Edentulousness</term><term>Epidemiology</term><term>Infection</term><term>Inflammation</term><term>Periodontitis</term><term>Risk factor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parodontite</term><term>Edentation</term><term>Cardiopathie coronaire</term><term>Infection</term><term>Pathologie de l'appareil circulatoire</term><term>Chronique</term><term>Facteur risque</term><term>Epidémiologie</term><term>Inflammation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background-Several epidemiological studies have suggested periodontitis as a risk factor for coronary heart disease (CHD), but results have been inconsistent. Methods and Results-We evaluated the association between clinical and radiographic measures of periodontitis, edentulism, and incident CHD (angina, myocardial infarction, or fatal CHD) among 1203 men in the VA Normative Aging and Dental Longitudinal Studies who were followed up with triennial comprehensive medical and dental examinations up to 35 years (median 24 years). Cox proportional hazards models with time-varying effects of exposure and potential confounders were fit. We found a significant dose-dependent association between periodontitis and CHD incidence among men <60 years of age (hazard ratio 2.12, 95% confidence interval 1.26 to 3.60 comparing highest versus lowest category of radiographic bone loss, P for trend=0.02), independent of age, body mass index, smoking, alcohol intake, diabetes mellitus, fasting glucose, total cholesterol, high-density lipoprotein cholesterol, triglycerides, hypertension, systolic and diastolic blood pressure, education, marital status, income, and occupation. No association was found among men >60 years of age. Similar results were found when the sum of probing pocket depths was used as a measure of periodontitis. Among men ≥60 years of age, edentulous men tended to have a higher risk of CHD than dentate men in the lowest bone loss (hazard ratio 1.61, 95% confidence interval 0.95 to 2.73) and lowest pocket depth (hazard ratio 1.72, 95% confidence interval 1.03 to 2.85) categories, independent of confounders. Conclusions-Chronic periodontitis is associated with incidence of CHD among younger men, independent of established cardiovascular risk factors.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Midlands de l'Ouest</li><li>Virginie</li></region><settlement><li>Birmingham</li></settlement><orgName><li>Université de Birmingham</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Dietrich, Thomas" sort="Dietrich, Thomas" uniqKey="Dietrich T" first="Thomas" last="Dietrich">Thomas Dietrich</name></noRegion><name sortKey="Dietrich, Thomas" sort="Dietrich, Thomas" uniqKey="Dietrich T" first="Thomas" last="Dietrich">Thomas Dietrich</name><name sortKey="Garcia, Raul I" sort="Garcia, Raul I" uniqKey="Garcia R" first="Raul I." last="Garcia">Raul I. Garcia</name><name sortKey="Garcia, Raul I" sort="Garcia, Raul I" uniqKey="Garcia R" first="Raul I." last="Garcia">Raul I. Garcia</name><name sortKey="Jimenez, Monik" sort="Jimenez, Monik" uniqKey="Jimenez M" first="Monik" last="Jimenez">Monik Jimenez</name><name sortKey="Jimenez, Monik" sort="Jimenez, Monik" uniqKey="Jimenez M" first="Monik" last="Jimenez">Monik Jimenez</name><name sortKey="Jimenez, Monik" sort="Jimenez, Monik" uniqKey="Jimenez M" first="Monik" last="Jimenez">Monik Jimenez</name><name sortKey="Krall Kaye, Elizabeth A" sort="Krall Kaye, Elizabeth A" uniqKey="Krall Kaye E" first="Elizabeth A." last="Krall Kaye">Elizabeth A. Krall Kaye</name><name sortKey="Vokonas, Pantel S" sort="Vokonas, Pantel S" uniqKey="Vokonas P" first="Pantel S." last="Vokonas">Pantel S. Vokonas</name><name sortKey="Vokonas, Pantel S" sort="Vokonas, Pantel S" uniqKey="Vokonas P" first="Pantel S." last="Vokonas">Pantel S. Vokonas</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Dietrich, Thomas" sort="Dietrich, Thomas" uniqKey="Dietrich T" first="Thomas" last="Dietrich">Thomas Dietrich</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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