Generalised Leukaemic Gingival Enlargement: a Case Report
Identifieur interne : 001B28 ( Main/Merge ); précédent : 001B27; suivant : 001B29Generalised Leukaemic Gingival Enlargement: a Case Report
Auteurs : Mechery Reenesh ; Singh Munishwar ; Saroj Kumar RathSource :
- Journal of Oral & Maxillofacial Research [ 2029-283X ] ; 2012.
Abstract
Acute myeloblastic leukaemia is a malignant bone marrow neoplasm of myeloid precursors of white blood cells. Due to its high morbidity rate, early diagnosis and appropriate medical therapy is essential.
The article highlights normal blood alterations like anaemia, thrombocytopenia, leukocytosis and advanced diagnostic aids like flow cytometry, special staining as a diagnostic modality as well as for prognostic information in acute leukaemia, particularly as a tool for assigning lineage and facilitating further pathologic classification which may be helpful in influencing treatment strategies.
On clinical examination the case presented with features of inflammatory gingival enlargement with presence of local deposits and calculus. Routine blood examination anaemia, thrombocytopenia, leukocytosis with haemoglobin 5.6 gm% and total leukocyte count of 1,12,000 / cu mm suggestive of leukaemia. Myeloperoxidase and leukocyte nonspecific esterase (NSE) special stain were used which showed presence of myeloblasts in the peripheral smear suggestive of acute myelocytic leukaemia. Flow cytometry were done which further helped in interpretation of these cells which showed to be strongly positive for CD45, CD13, CD14, and anti HLADR and moderately positive for CD4, CD34 and Anti MPO confirming to be case of AML-M4 with 57.73% gating.
Fact that gingival alterations are sometimes the first manifestations of the disease implies that dental professionals must be sufficiently familiarized with the clinical manifestations of systemic diseases. The timely referral by the general dentist for a suspicious lesion provided an early diagnosis and early intervention reducing the patient morbidity.
Url:
DOI: 10.5037/jomr.2012.3305
PubMed: 24422017
PubMed Central: 3886083
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<sec sec-type="background"><title>Background</title>
<p>Acute myeloblastic leukaemia is a malignant bone marrow neoplasm of myeloid
precursors of white blood cells. Due to its high morbidity rate, early
diagnosis and appropriate medical therapy is essential.</p>
</sec>
<sec sec-type="methods"><title>Methods</title>
<p>The article highlights normal blood alterations like anaemia,
thrombocytopenia, leukocytosis and advanced diagnostic aids like flow
cytometry, special staining as a diagnostic modality as well as for
prognostic information in acute leukaemia, particularly as a tool for
assigning lineage and facilitating further pathologic classification which
may be helpful in influencing treatment strategies.</p>
</sec>
<sec sec-type="results"><title>Results</title>
<p>On clinical examination the case presented with features of inflammatory
gingival enlargement with presence of local deposits and calculus. Routine
blood examination anaemia, thrombocytopenia, leukocytosis with haemoglobin
5.6 gm% and total leukocyte count of 1,12,000 / cu mm suggestive of
leukaemia. Myeloperoxidase and leukocyte nonspecific esterase (NSE) special
stain were used which showed presence of myeloblasts in the peripheral smear
suggestive of acute myelocytic leukaemia. Flow cytometry were done which
further helped in interpretation of these cells which showed to be strongly
positive for CD45, CD13, CD14, and anti HLADR and moderately positive for
CD4, CD34 and Anti MPO confirming to be case of AML-M4 with 57.73%
gating.</p>
</sec>
<sec sec-type="conclusions"><title>Conclusions</title>
<p>Fact that gingival alterations are sometimes the first manifestations of the
disease implies that dental professionals must be sufficiently familiarized
with the clinical manifestations of systemic diseases. The timely referral
by the general dentist for a suspicious lesion provided an early diagnosis
and early intervention reducing the patient morbidity.</p>
</sec>
</div>
</front>
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