Association between short leukocyte telomere length, endotoxemia, and severe periodontitis in people with diabetes: a cross-sectional survey.
Identifieur interne : 000A06 ( Main/Merge ); précédent : 000A05; suivant : 000A07Association between short leukocyte telomere length, endotoxemia, and severe periodontitis in people with diabetes: a cross-sectional survey.
Auteurs : Stefano Masi [Royaume-Uni] ; Nikolaos Gkranias ; Kawa Li ; Klelia D. Salpea ; Mohamed Parkar ; Marco Orlandi ; Jean E. Suvan ; Heng L. Eng ; Stefano Taddei ; Kalpesh Patel ; Ulpee Darbar ; Nikos Donos ; John E. Deanfield ; Steve Hurel ; Steve E. Humphries ; Francesco D'AiutoSource :
- Diabetes care [ 1935-5548 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Diabète de type 1 (), Diabète de type 1 (immunologie), Diabète de type 2 (), Endotoxémie (), Femelle, Humains, Leucocytes (métabolisme), Mâle, Parodontite (), Raccourcissement des télomères, Réaction de polymérisation en chaine en temps réel, Sujet âgé, Études transversales.
- MESH :
English descriptors
- KwdEn :
- Adult, Aged, Cross-Sectional Studies, Diabetes Mellitus, Type 1 (complications), Diabetes Mellitus, Type 1 (immunology), Diabetes Mellitus, Type 2 (complications), Endotoxemia (complications), Female, Humans, Leukocytes (metabolism), Male, Middle Aged, Periodontitis (complications), Real-Time Polymerase Chain Reaction, Telomere Shortening.
- MESH :
- complications : Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Endotoxemia, Periodontitis.
- immunology : Diabetes Mellitus, Type 1.
- metabolism : Leukocytes.
- Adult, Aged, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Real-Time Polymerase Chain Reaction, Telomere Shortening.
Abstract
OBJECTIVE Shortened leukocyte telomere length (LTL) and diagnosis of periodontitis are associated with an increased risk of complications and mortality in diabetes. This study investigated the association between LTL, endotoxemia, and severity of periodontitis in a large cohort of people with diabetes. RESEARCH DESIGN AND METHODS Six hundred thirty individuals (371 with type 2 and 259 with type 1 diabetes) were recruited from the University College Hospital in London, U.K. During a baseline visit, blood was collected for standard biochemical tests and DNA extraction, while a dental examination was performed to determine diagnosis and extent of periodontitis. LTL was measured by real-time PCR, and endotoxemia was assessed by the limulus amoebocyte lysate method. RESULTS Two hundred fifty-five individuals were diagnosed with gingivitis, 327 with periodontitis (114 with moderate and 213 with severe disease), and 48 with edentulous. Diagnosis of periodontitis was associated with shorter LTL (P = 0.04). A negative association between LTL and endotoxemia was found in the severe periodontitis and type 2 diabetes groups (P = 0.01 for both). Shorter LTL was associated with increased extent of periodontitis (P = 0.01) and increased insulin resistance (homeostatic model assessment). Multiple adjustments for biochemical, anthropometric, and medication-use variables did not affect the results. CONCLUSIONS LTL is associated with endotoxemia and diagnosis of periodontitis in people with diabetes. LTL shortening might represent a novel biological pathway accounting for previous epidemiological data that documented higher prevalence of diabetes and its complications in people with periodontitis and vice versa.
DOI: 10.2337/dc13-2106
PubMed: 24652728
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Salpea</name></author><author><name sortKey="Parkar, Mohamed" sort="Parkar, Mohamed" uniqKey="Parkar M" first="Mohamed" last="Parkar">Mohamed Parkar</name></author><author><name sortKey="Orlandi, Marco" sort="Orlandi, Marco" uniqKey="Orlandi M" first="Marco" last="Orlandi">Marco Orlandi</name></author><author><name sortKey="Suvan, Jean E" sort="Suvan, Jean E" uniqKey="Suvan J" first="Jean E" last="Suvan">Jean E. Suvan</name></author><author><name sortKey="Eng, Heng L" sort="Eng, Heng L" uniqKey="Eng H" first="Heng L" last="Eng">Heng L. 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Salpea</name></author><author><name sortKey="Parkar, Mohamed" sort="Parkar, Mohamed" uniqKey="Parkar M" first="Mohamed" last="Parkar">Mohamed Parkar</name></author><author><name sortKey="Orlandi, Marco" sort="Orlandi, Marco" uniqKey="Orlandi M" first="Marco" last="Orlandi">Marco Orlandi</name></author><author><name sortKey="Suvan, Jean E" sort="Suvan, Jean E" uniqKey="Suvan J" first="Jean E" last="Suvan">Jean E. Suvan</name></author><author><name sortKey="Eng, Heng L" sort="Eng, Heng L" uniqKey="Eng H" first="Heng L" last="Eng">Heng L. Eng</name></author><author><name sortKey="Taddei, Stefano" sort="Taddei, Stefano" uniqKey="Taddei S" first="Stefano" last="Taddei">Stefano Taddei</name></author><author><name sortKey="Patel, Kalpesh" sort="Patel, Kalpesh" uniqKey="Patel K" first="Kalpesh" last="Patel">Kalpesh Patel</name></author><author><name sortKey="Darbar, Ulpee" sort="Darbar, Ulpee" uniqKey="Darbar U" first="Ulpee" last="Darbar">Ulpee Darbar</name></author><author><name sortKey="Donos, Nikos" sort="Donos, Nikos" uniqKey="Donos N" first="Nikos" last="Donos">Nikos Donos</name></author><author><name sortKey="Deanfield, John E" sort="Deanfield, John E" uniqKey="Deanfield J" first="John E" last="Deanfield">John E. Deanfield</name></author><author><name sortKey="Hurel, Steve" sort="Hurel, Steve" uniqKey="Hurel S" first="Steve" last="Hurel">Steve Hurel</name></author><author><name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E" last="Humphries">Steve E. Humphries</name></author><author><name sortKey="D Aiuto, Francesco" sort="D Aiuto, Francesco" uniqKey="D Aiuto F" first="Francesco" last="D'Aiuto">Francesco D'Aiuto</name></author></analytic><series><title level="j">Diabetes care</title><idno type="eISSN">1935-5548</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cross-Sectional Studies</term><term>Diabetes Mellitus, Type 1 (complications)</term><term>Diabetes Mellitus, Type 1 (immunology)</term><term>Diabetes Mellitus, Type 2 (complications)</term><term>Endotoxemia (complications)</term><term>Female</term><term>Humans</term><term>Leukocytes (metabolism)</term><term>Male</term><term>Middle Aged</term><term>Periodontitis (complications)</term><term>Real-Time Polymerase Chain Reaction</term><term>Telomere Shortening</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Diabète de type 1 ()</term><term>Diabète de type 1 (immunologie)</term><term>Diabète de type 2 ()</term><term>Endotoxémie ()</term><term>Femelle</term><term>Humains</term><term>Leucocytes (métabolisme)</term><term>Mâle</term><term>Parodontite ()</term><term>Raccourcissement des télomères</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Sujet âgé</term><term>Études transversales</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Diabetes Mellitus, Type 1</term><term>Diabetes Mellitus, Type 2</term><term>Endotoxemia</term><term>Periodontitis</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Diabète de type 1</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Diabetes Mellitus, Type 1</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Leukocytes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Leucocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Real-Time Polymerase Chain Reaction</term><term>Telomere Shortening</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Diabète de type 1</term><term>Diabète de type 2</term><term>Endotoxémie</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Parodontite</term><term>Raccourcissement des télomères</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Sujet âgé</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">OBJECTIVE Shortened leukocyte telomere length (LTL) and diagnosis of periodontitis are associated with an increased risk of complications and mortality in diabetes. This study investigated the association between LTL, endotoxemia, and severity of periodontitis in a large cohort of people with diabetes. RESEARCH DESIGN AND METHODS Six hundred thirty individuals (371 with type 2 and 259 with type 1 diabetes) were recruited from the University College Hospital in London, U.K. During a baseline visit, blood was collected for standard biochemical tests and DNA extraction, while a dental examination was performed to determine diagnosis and extent of periodontitis. LTL was measured by real-time PCR, and endotoxemia was assessed by the limulus amoebocyte lysate method. RESULTS Two hundred fifty-five individuals were diagnosed with gingivitis, 327 with periodontitis (114 with moderate and 213 with severe disease), and 48 with edentulous. Diagnosis of periodontitis was associated with shorter LTL (P = 0.04). A negative association between LTL and endotoxemia was found in the severe periodontitis and type 2 diabetes groups (P = 0.01 for both). Shorter LTL was associated with increased extent of periodontitis (P = 0.01) and increased insulin resistance (homeostatic model assessment). Multiple adjustments for biochemical, anthropometric, and medication-use variables did not affect the results. CONCLUSIONS LTL is associated with endotoxemia and diagnosis of periodontitis in people with diabetes. LTL shortening might represent a novel biological pathway accounting for previous epidemiological data that documented higher prevalence of diabetes and its complications in people with periodontitis and vice versa.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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