Dental status, dental treatment procedures and radiotherapy as risk factors for infected osteoradionecrosis (IORN) in patients with oral cancer – a comparison of two 10 years’ observation periods
Identifieur interne : 000877 ( Main/Merge ); précédent : 000876; suivant : 000878Dental status, dental treatment procedures and radiotherapy as risk factors for infected osteoradionecrosis (IORN) in patients with oral cancer – a comparison of two 10 years’ observation periods
Auteurs : Marcus Niewald [Allemagne] ; Kristina Mang [Allemagne] ; Oliver Barbie [Allemagne] ; Jochen Fleckenstein [Allemagne] ; Henrik Holtmann [Allemagne] ; Wolfgang J. Spitzer [Allemagne] ; Christian Rübe [Allemagne]Source :
- SpringerPlus [ 2193-1801 ] ; 2014.
Abstract
Dental status, dental treatment procedures and radiotherapy dosage as potential risk factors for an infected osteoradionecrosis (IORN) in patients with oral cancers: Retrospective evaluation of 204 patients treated in two observation periods of approximately ten years each.
In group A, 90 patients were treated in the years 1993-2003, in group B 114 patients in the years 1983-1992 (data in brackets). All patients had histopathologically proven squamous cell cancers, mainly UICC stages III and IV. 70% (85%, n.s.) had undergone surgery before radiotherapy. All patients were referred to the oral and maxillofacial surgeon for dental rehabilitation before further treatment.
Radiotherapy was performed using a 3D-conformal technique with 4-6MV photons of a linear accelerator (Co-60 device up to 1987). The majority of patients were treated using conventional fractionation with total doses of 60-70 Gy in daily fractions of 2 Gy. Additionally, in group A, hyperfractionation was used applying a total dose of 72 Gy in fractions of 1.2 Gy twice daily (time interval > 6 hours). In group B, a similar schedule was used up to a total dose of 82.8 Gy (time interval 4-6 hours). 14 (0) patients had radiochemotherapy simultaneously. After therapy, the patients were seen regularly by the radiooncologist and – if necessary – by the oral and maxillofacial surgeon. The duration of follow-up was 3.64 years (5 years, p = 0.004).
Before radiotherapy, the dental health status was very poor. On average, 21.5 (21.2, n.s.) teeth were missing. Further 2.04 teeth (2.33, n.s.) were carious, 1.4 (0.3, p = 0.002) destroyed.
Extractions were necessary in 3.6 teeth (5.8, p = 0.008), conserving treatment in 0.4 (0.1, p = 0.008) teeth. After dental treatment, 6.30 (4.8, n.s.) teeth remained.
IORN was diagnosed after conventionally fractionated radiotherapy in 15% (11%, n.s.), after hyperfractionation in 0% (34%, p = 0.01).
Within more than 20 years there was no improvement in dental status of oral cancer patients. Extensive dental treatment procedures remained necessary. There was an impressive reduction of the IORN frequency in patients treated in a hyperfractionated manner probably resulting from a dose reduction and an extension of the interfraction time.
Url:
DOI: 10.1186/2193-1801-3-263
PubMed: 24936388
PubMed Central: 4048661
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000083
- to stream Pmc, to step Curation: 000083
- to stream Pmc, to step Checkpoint: 000375
- to stream Ncbi, to step Merge: 000E28
- to stream Ncbi, to step Curation: 000E28
- to stream Ncbi, to step Checkpoint: 000E28
Links to Exploration step
PMC:4048661Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dental status, dental treatment procedures and radiotherapy as risk factors for infected osteoradionecrosis (IORN) in patients with oral cancer – a comparison of two 10 years’ observation periods</title><author><name sortKey="Niewald, Marcus" sort="Niewald, Marcus" uniqKey="Niewald M" first="Marcus" last="Niewald">Marcus Niewald</name><affiliation wicri:level="3"><nlm:aff id="Aff7">Department of Cranio-and-Maxillo Facial Surgery, Düsseldorf University Medical School, Düsseldorf, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cranio-and-Maxillo Facial Surgery, Düsseldorf University Medical School, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Mang, Kristina" sort="Mang, Kristina" uniqKey="Mang K" first="Kristina" last="Mang">Kristina Mang</name><affiliation wicri:level="1"><nlm:aff id="Aff6">Department of Oral and Maxillofacial Surgery, Saarland University Medical Center, Homburg/Saar, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Oral and Maxillofacial Surgery, Saarland University Medical Center, Homburg/Saar</wicri:regionArea><wicri:noRegion>Homburg/Saar</wicri:noRegion><wicri:noRegion>Homburg/Saar</wicri:noRegion><wicri:noRegion>Homburg/Saar</wicri:noRegion></affiliation></author><author><name sortKey="Barbie, Oliver" sort="Barbie, Oliver" uniqKey="Barbie O" first="Oliver" last="Barbie">Oliver Barbie</name><affiliation wicri:level="3"><nlm:aff id="Aff7">Department of Cranio-and-Maxillo Facial Surgery, Düsseldorf University Medical School, Düsseldorf, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cranio-and-Maxillo Facial Surgery, Düsseldorf University Medical School, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Fleckenstein, Jochen" sort="Fleckenstein, Jochen" uniqKey="Fleckenstein J" first="Jochen" last="Fleckenstein">Jochen Fleckenstein</name><affiliation wicri:level="3"><nlm:aff id="Aff7">Department of Cranio-and-Maxillo Facial Surgery, Düsseldorf University Medical School, Düsseldorf, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cranio-and-Maxillo Facial Surgery, Düsseldorf University Medical School, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Holtmann, Henrik" sort="Holtmann, Henrik" uniqKey="Holtmann H" first="Henrik" last="Holtmann">Henrik Holtmann</name><affiliation wicri:level="1"><nlm:aff id="Aff6">Department of Oral and Maxillofacial Surgery, Saarland University Medical Center, Homburg/Saar, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Oral and Maxillofacial Surgery, Saarland University Medical Center, Homburg/Saar</wicri:regionArea><wicri:noRegion>Homburg/Saar</wicri:noRegion><wicri:noRegion>Homburg/Saar</wicri:noRegion><wicri:noRegion>Homburg/Saar</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff7">Department of Cranio-and-Maxillo Facial Surgery, Düsseldorf University Medical School, Düsseldorf, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cranio-and-Maxillo Facial Surgery, Düsseldorf University Medical School, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Spitzer, Wolfgang J" sort="Spitzer, Wolfgang J" uniqKey="Spitzer W" first="Wolfgang J" last="Spitzer">Wolfgang J. Spitzer</name><affiliation wicri:level="1"><nlm:aff id="Aff6">Department of Oral and Maxillofacial Surgery, Saarland University Medical Center, Homburg/Saar, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Oral and Maxillofacial Surgery, Saarland University Medical Center, Homburg/Saar</wicri:regionArea><wicri:noRegion>Homburg/Saar</wicri:noRegion><wicri:noRegion>Homburg/Saar</wicri:noRegion><wicri:noRegion>Homburg/Saar</wicri:noRegion></affiliation></author><author><name sortKey="Rube, Christian" sort="Rube, Christian" uniqKey="Rube C" first="Christian" last="Rübe">Christian Rübe</name><affiliation wicri:level="3"><nlm:aff id="Aff7">Department of Cranio-and-Maxillo Facial Surgery, Düsseldorf University Medical School, Düsseldorf, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cranio-and-Maxillo Facial Surgery, Düsseldorf University Medical School, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24936388</idno><idno type="pmc">4048661</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048661</idno><idno type="RBID">PMC:4048661</idno><idno type="doi">10.1186/2193-1801-3-263</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000083</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000083</idno><idno type="wicri:Area/Pmc/Curation">000083</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000083</idno><idno type="wicri:Area/Pmc/Checkpoint">000375</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000375</idno><idno type="wicri:Area/Ncbi/Merge">000E28</idno><idno type="wicri:Area/Ncbi/Curation">000E28</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E28</idno><idno type="wicri:Area/Main/Merge">000877</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Dental status, dental treatment procedures and radiotherapy as risk factors for infected osteoradionecrosis (IORN) in patients with oral cancer – a comparison of two 10 years’ observation periods</title><author><name sortKey="Niewald, Marcus" sort="Niewald, Marcus" uniqKey="Niewald M" first="Marcus" last="Niewald">Marcus Niewald</name><affiliation wicri:level="3"><nlm:aff id="Aff7">Department of Cranio-and-Maxillo Facial Surgery, Düsseldorf University Medical School, Düsseldorf, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cranio-and-Maxillo Facial Surgery, Düsseldorf University Medical School, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Mang, Kristina" sort="Mang, Kristina" uniqKey="Mang K" first="Kristina" last="Mang">Kristina Mang</name><affiliation wicri:level="1"><nlm:aff id="Aff6">Department of Oral and Maxillofacial Surgery, Saarland University Medical Center, Homburg/Saar, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Oral and Maxillofacial Surgery, Saarland University Medical Center, Homburg/Saar</wicri:regionArea><wicri:noRegion>Homburg/Saar</wicri:noRegion><wicri:noRegion>Homburg/Saar</wicri:noRegion><wicri:noRegion>Homburg/Saar</wicri:noRegion></affiliation></author><author><name sortKey="Barbie, Oliver" sort="Barbie, Oliver" uniqKey="Barbie O" first="Oliver" last="Barbie">Oliver Barbie</name><affiliation wicri:level="3"><nlm:aff id="Aff7">Department of Cranio-and-Maxillo Facial Surgery, Düsseldorf University Medical School, Düsseldorf, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cranio-and-Maxillo Facial Surgery, Düsseldorf University Medical School, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Fleckenstein, Jochen" sort="Fleckenstein, Jochen" uniqKey="Fleckenstein J" first="Jochen" last="Fleckenstein">Jochen Fleckenstein</name><affiliation wicri:level="3"><nlm:aff id="Aff7">Department of Cranio-and-Maxillo Facial Surgery, Düsseldorf University Medical School, Düsseldorf, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cranio-and-Maxillo Facial Surgery, Düsseldorf University Medical School, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Holtmann, Henrik" sort="Holtmann, Henrik" uniqKey="Holtmann H" first="Henrik" last="Holtmann">Henrik Holtmann</name><affiliation wicri:level="1"><nlm:aff id="Aff6">Department of Oral and Maxillofacial Surgery, Saarland University Medical Center, Homburg/Saar, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Oral and Maxillofacial Surgery, Saarland University Medical Center, Homburg/Saar</wicri:regionArea><wicri:noRegion>Homburg/Saar</wicri:noRegion><wicri:noRegion>Homburg/Saar</wicri:noRegion><wicri:noRegion>Homburg/Saar</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff7">Department of Cranio-and-Maxillo Facial Surgery, Düsseldorf University Medical School, Düsseldorf, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cranio-and-Maxillo Facial Surgery, Düsseldorf University Medical School, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Spitzer, Wolfgang J" sort="Spitzer, Wolfgang J" uniqKey="Spitzer W" first="Wolfgang J" last="Spitzer">Wolfgang J. Spitzer</name><affiliation wicri:level="1"><nlm:aff id="Aff6">Department of Oral and Maxillofacial Surgery, Saarland University Medical Center, Homburg/Saar, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Oral and Maxillofacial Surgery, Saarland University Medical Center, Homburg/Saar</wicri:regionArea><wicri:noRegion>Homburg/Saar</wicri:noRegion><wicri:noRegion>Homburg/Saar</wicri:noRegion><wicri:noRegion>Homburg/Saar</wicri:noRegion></affiliation></author><author><name sortKey="Rube, Christian" sort="Rube, Christian" uniqKey="Rube C" first="Christian" last="Rübe">Christian Rübe</name><affiliation wicri:level="3"><nlm:aff id="Aff7">Department of Cranio-and-Maxillo Facial Surgery, Düsseldorf University Medical School, Düsseldorf, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cranio-and-Maxillo Facial Surgery, Düsseldorf University Medical School, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author></analytic><series><title level="j">SpringerPlus</title><idno type="eISSN">2193-1801</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objectives</title><p>Dental status, dental treatment procedures and radiotherapy dosage as potential risk factors for an infected osteoradionecrosis (IORN) in patients with oral cancers: Retrospective evaluation of 204 patients treated in two observation periods of approximately ten years each.</p></sec><sec><title>Patients and methods</title><p>In group A, 90 patients were treated in the years 1993-2003, in group B 114 patients in the years 1983-1992 (data in brackets). All patients had histopathologically proven squamous cell cancers, mainly UICC stages III and IV. 70% (85%, n.s.) had undergone surgery before radiotherapy. All patients were referred to the oral and maxillofacial surgeon for dental rehabilitation before further treatment.</p><p>Radiotherapy was performed using a 3D-conformal technique with 4-6MV photons of a linear accelerator (Co-60 device up to 1987). The majority of patients were treated using conventional fractionation with total doses of 60-70 Gy in daily fractions of 2 Gy. Additionally, in group A, hyperfractionation was used applying a total dose of 72 Gy in fractions of 1.2 Gy twice daily (time interval > 6 hours). In group B, a similar schedule was used up to a total dose of 82.8 Gy (time interval 4-6 hours). 14 (0) patients had radiochemotherapy simultaneously. After therapy, the patients were seen regularly by the radiooncologist and – if necessary – by the oral and maxillofacial surgeon. The duration of follow-up was 3.64 years (5 years, p = 0.004).</p></sec><sec><title>Results</title><p>Before radiotherapy, the dental health status was very poor. On average, 21.5 (21.2, n.s.) teeth were missing. Further 2.04 teeth (2.33, n.s.) were carious, 1.4 (0.3, p = 0.002) destroyed.</p><p>Extractions were necessary in 3.6 teeth (5.8, p = 0.008), conserving treatment in 0.4 (0.1, p = 0.008) teeth. After dental treatment, 6.30 (4.8, n.s.) teeth remained.</p><p>IORN was diagnosed after conventionally fractionated radiotherapy in 15% (11%, n.s.), after hyperfractionation in 0% (34%, p = 0.01).</p></sec><sec><title>Conclusion</title><p>Within more than 20 years there was no improvement in dental status of oral cancer patients. Extensive dental treatment procedures remained necessary. There was an impressive reduction of the IORN frequency in patients treated in a hyperfractionated manner probably resulting from a dose reduction and an extension of the interfraction time.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ahmed, M" uniqKey="Ahmed M">M Ahmed</name></author><author><name sortKey="Hansen, Vn" uniqKey="Hansen V">VN Hansen</name></author><author><name sortKey="Harrington, Kj" uniqKey="Harrington K">KJ Harrington</name></author><author><name sortKey="Nutting, Cm" uniqKey="Nutting C">CM Nutting</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barbie, O" uniqKey="Barbie O">O Barbie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ben David, Ma" uniqKey="Ben David M">MA Ben-David</name></author><author><name sortKey="Diamante, M" uniqKey="Diamante M">M Diamante</name></author><author><name sortKey="Radawski, Jd" uniqKey="Radawski J">JD Radawski</name></author><author><name sortKey="Vineberg, Ka" uniqKey="Vineberg K">KA Vineberg</name></author><author><name sortKey="Stroup, C" uniqKey="Stroup C">C Stroup</name></author><author><name sortKey="Murdoch Kinch, Ca" uniqKey="Murdoch Kinch C">CA Murdoch-Kinch</name></author><author><name sortKey="Zwetchkenbaum, Sr" uniqKey="Zwetchkenbaum S">SR Zwetchkenbaum</name></author><author><name sortKey="Eisbruch, A" uniqKey="Eisbruch A">A Eisbruch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berger, A" uniqKey="Berger A">A Berger</name></author><author><name sortKey="Bensadoun, Rj" uniqKey="Bensadoun R">RJ Bensadoun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bhide, Sa" uniqKey="Bhide S">SA Bhide</name></author><author><name sortKey="Ahmed, M" uniqKey="Ahmed M">M Ahmed</name></author><author><name sortKey="Newbold, K" uniqKey="Newbold K">K Newbold</name></author><author><name sortKey="Harrington, Kj" uniqKey="Harrington K">KJ Harrington</name></author><author><name sortKey="Nutting, Cm" uniqKey="Nutting C">CM Nutting</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chopra, S" uniqKey="Chopra S">S Chopra</name></author><author><name sortKey="Kamdar, D" uniqKey="Kamdar D">D Kamdar</name></author><author><name sortKey="Ugur, Oe" uniqKey="Ugur O">OE Ugur</name></author><author><name sortKey="Chen, G" uniqKey="Chen G">G Chen</name></author><author><name sortKey="Peshek, B" uniqKey="Peshek B">B Peshek</name></author><author><name sortKey="Marunick, M" uniqKey="Marunick M">M Marunick</name></author><author><name sortKey="Kim, H" uniqKey="Kim H">H Kim</name></author><author><name sortKey="Lin, Hs" uniqKey="Lin H">HS Lin</name></author><author><name sortKey="Jacobs, J" uniqKey="Jacobs J">J Jacobs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crombie, Ak" uniqKey="Crombie A">AK Crombie</name></author><author><name sortKey="Farah, C" uniqKey="Farah C">C Farah</name></author><author><name sortKey="Tripcony, L" uniqKey="Tripcony L">L Tripcony</name></author><author><name sortKey="Dickie, G" uniqKey="Dickie G">G Dickie</name></author><author><name sortKey="Batstone, Md" uniqKey="Batstone M">MD Batstone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Curi, Mm" uniqKey="Curi M">MM Curi</name></author><author><name sortKey="Dib, Ll" uniqKey="Dib L">LL Dib</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Curi, Mm" uniqKey="Curi M">MM Curi</name></author><author><name sortKey="Oliveira Dos Santos, M" uniqKey="Oliveira Dos Santos M">M Oliveira dos Santos</name></author><author><name sortKey="Feher, O" uniqKey="Feher O">O Feher</name></author><author><name sortKey="Faria, Jc" uniqKey="Faria J">JC Faria</name></author><author><name sortKey="Rodrigues, Ml" uniqKey="Rodrigues M">ML Rodrigues</name></author><author><name sortKey="Kowalski, Lp" uniqKey="Kowalski L">LP Kowalski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frydrych, Am" uniqKey="Frydrych A">AM Frydrych</name></author><author><name sortKey="Slack Smith, Lm" uniqKey="Slack Smith L">LM Slack-Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldwasser, Ba" uniqKey="Goldwasser B">BA Goldwasser</name></author><author><name sortKey="Chuang, S K" uniqKey="Chuang S">S-K Chuang</name></author><author><name sortKey="Kabal, Lb" uniqKey="Kabal L">LB Kabal</name></author><author><name sortKey="August, M" uniqKey="August M">M August</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gomez, Dr" uniqKey="Gomez D">DR Gomez</name></author><author><name sortKey="Zhung, Je" uniqKey="Zhung J">JE Zhung</name></author><author><name sortKey="Gomez, J" uniqKey="Gomez J">J Gomez</name></author><author><name sortKey="Chan, K" uniqKey="Chan K">K Chan</name></author><author><name sortKey="Wu, Aj" uniqKey="Wu A">AJ Wu</name></author><author><name sortKey="Wolden, Sl" uniqKey="Wolden S">SL Wolden</name></author><author><name sortKey="Pfister, Dg" uniqKey="Pfister D">DG Pfister</name></author><author><name sortKey="Shaha, A" uniqKey="Shaha A">A Shaha</name></author><author><name sortKey="Shah, Jp" uniqKey="Shah J">JP Shah</name></author><author><name sortKey="Kraus, Dh" uniqKey="Kraus D">DH Kraus</name></author><author><name sortKey="Wong, Rj" uniqKey="Wong R">RJ Wong</name></author><author><name sortKey="Lee, Ny" uniqKey="Lee N">NY Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gomez, Dr" uniqKey="Gomez D">DR Gomez</name></author><author><name sortKey="Estilo, Cl" uniqKey="Estilo C">CL Estilo</name></author><author><name sortKey="Wolden, Sl" uniqKey="Wolden S">SL Wolden</name></author><author><name sortKey="Zelefsky, Mj" uniqKey="Zelefsky M">MJ Zelefsky</name></author><author><name sortKey="Kraus, Dh" uniqKey="Kraus D">DH Kraus</name></author><author><name sortKey="Wong, Rj" uniqKey="Wong R">RJ Wong</name></author><author><name sortKey="Shaha, Ar" uniqKey="Shaha A">AR Shaha</name></author><author><name sortKey="Shah, Jp" uniqKey="Shah J">JP Shah</name></author><author><name sortKey="Mechalakos, Jg" uniqKey="Mechalakos J">JG Mechalakos</name></author><author><name sortKey="Lee, Ny" uniqKey="Lee N">NY Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guggenheimer, J" uniqKey="Guggenheimer J">J Guggenheimer</name></author><author><name sortKey="Hoffman, Rd" uniqKey="Hoffman R">RD Hoffman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jereczek Fossa, Ba" uniqKey="Jereczek Fossa B">BA Jereczek-Fossa</name></author><author><name sortKey="Orecchia, R" uniqKey="Orecchia R">R Orecchia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jham, Bc" uniqKey="Jham B">BC Jham</name></author><author><name sortKey="Reis, Pm" uniqKey="Reis P">PM Reis</name></author><author><name sortKey="Miranda, El" uniqKey="Miranda E">EL Miranda</name></author><author><name sortKey="Lopes, Rc" uniqKey="Lopes R">RC Lopes</name></author><author><name sortKey="Carvalho, Al" uniqKey="Carvalho A">AL Carvalho</name></author><author><name sortKey="Scheper, Ma" uniqKey="Scheper M">MA Scheper</name></author><author><name sortKey="Freire, Ar" uniqKey="Freire A">AR Freire</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katsura, K" uniqKey="Katsura K">K Katsura</name></author><author><name sortKey="Sasai, K" uniqKey="Sasai K">K Sasai</name></author><author><name sortKey="Sato, K" uniqKey="Sato K">K Sato</name></author><author><name sortKey="Saito, M" uniqKey="Saito M">M Saito</name></author><author><name sortKey="Hoshina, H" uniqKey="Hoshina H">H Hoshina</name></author><author><name sortKey="Hayashi, T" uniqKey="Hayashi T">T Hayashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kern, R" uniqKey="Kern R">R Kern</name></author><author><name sortKey="Kr Mer, J" uniqKey="Kr Mer J">J Krämer</name></author><author><name sortKey="Michaelis, W" uniqKey="Michaelis W">W Michaelis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name></author><author><name sortKey="Chu, Fc" uniqKey="Chu F">FC Chu</name></author><author><name sortKey="Pope, Ra" uniqKey="Pope R">RA Pope</name></author><author><name sortKey="Woodard, Hq" uniqKey="Woodard H">HQ Woodard</name></author><author><name sortKey="Bragg, Db" uniqKey="Bragg D">DB Bragg</name></author><author><name sortKey="Shidnia, H" uniqKey="Shidnia H">H Shidnia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Ja" uniqKey="Lee J">JA Lee</name></author><author><name sortKey="Huh, Sj" uniqKey="Huh S">SJ Huh</name></author><author><name sortKey="Oh, D" uniqKey="Oh D">D Oh</name></author><author><name sortKey="Bae, Ds" uniqKey="Bae D">DS Bae</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Ij" uniqKey="Lee I">IJ Lee</name></author><author><name sortKey="Koom, Ws" uniqKey="Koom W">WS Koom</name></author><author><name sortKey="Lee, Cg" uniqKey="Lee C">CG Lee</name></author><author><name sortKey="Kim, Yb" uniqKey="Kim Y">YB Kim</name></author><author><name sortKey="Yoo, Sw" uniqKey="Yoo S">SW Yoo</name></author><author><name sortKey="Keum, Kc" uniqKey="Keum K">KC Keum</name></author><author><name sortKey="Kim, Ge" uniqKey="Kim G">GE Kim</name></author><author><name sortKey="Choi, Ec" uniqKey="Choi E">EC Choi</name></author><author><name sortKey="Cha, Ih" uniqKey="Cha I">IH Cha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lockhart, Pb" uniqKey="Lockhart P">PB Lockhart</name></author><author><name sortKey="Clark, J" uniqKey="Clark J">J Clark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lozza, L" uniqKey="Lozza L">L Lozza</name></author><author><name sortKey="Cerrotta, A" uniqKey="Cerrotta A">A Cerrotta</name></author><author><name sortKey="Gardani, G" uniqKey="Gardani G">G Gardani</name></author><author><name sortKey="De Marie, M" uniqKey="De Marie M">M De Marie</name></author><author><name sortKey="Di Russo, A" uniqKey="Di Russo A">A Di Russo</name></author><author><name sortKey="Kenda, R" uniqKey="Kenda R">R Kenda</name></author><author><name sortKey="Tana, S" uniqKey="Tana S">S Tana</name></author><author><name sortKey="Valvo, F" uniqKey="Valvo F">F Valvo</name></author><author><name sortKey="Zucali, R" uniqKey="Zucali R">R Zucali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maier, H" uniqKey="Maier H">H Maier</name></author><author><name sortKey="Zoller, J" uniqKey="Zoller J">J Zoller</name></author><author><name sortKey="Herrmann, A" uniqKey="Herrmann A">A Herrmann</name></author><author><name sortKey="Kreiss, M" uniqKey="Kreiss M">M Kreiss</name></author><author><name sortKey="Heller, Wd" uniqKey="Heller W">WD Heller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mang, C" uniqKey="Mang C">C Mang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monnier, Y" uniqKey="Monnier Y">Y Monnier</name></author><author><name sortKey="Broome, M" uniqKey="Broome M">M Broome</name></author><author><name sortKey="Betz, M" uniqKey="Betz M">M Betz</name></author><author><name sortKey="Bouferrache, K" uniqKey="Bouferrache K">K Bouferrache</name></author><author><name sortKey="Ozsahin, M" uniqKey="Ozsahin M">M Ozsahin</name></author><author><name sortKey="Jaques, B" uniqKey="Jaques B">B Jaques</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nabil, S" uniqKey="Nabil S">S Nabil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Niewald, M" uniqKey="Niewald M">M Niewald</name></author><author><name sortKey="Barbie, O" uniqKey="Barbie O">O Barbie</name></author><author><name sortKey="Schnabel, K" uniqKey="Schnabel K">K Schnabel</name></author><author><name sortKey="Engel, M" uniqKey="Engel M">M Engel</name></author><author><name sortKey="Schedler, M" uniqKey="Schedler M">M Schedler</name></author><author><name sortKey="Nieder, C" uniqKey="Nieder C">C Nieder</name></author><author><name sortKey="Berberich, W" uniqKey="Berberich W">W Berberich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Niewald, M" uniqKey="Niewald M">M Niewald</name></author><author><name sortKey="Fleckenstein, J" uniqKey="Fleckenstein J">J Fleckenstein</name></author><author><name sortKey="Mang, K" uniqKey="Mang K">K Mang</name></author><author><name sortKey="Holtmann, H" uniqKey="Holtmann H">H Holtmann</name></author><author><name sortKey="Spitzer, Wj" uniqKey="Spitzer W">WJ Spitzer</name></author><author><name sortKey="Rube, C" uniqKey="Rube C">C Rube</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oh, Hk" uniqKey="Oh H">HK Oh</name></author><author><name sortKey="Chambers, Ms" uniqKey="Chambers M">MS Chambers</name></author><author><name sortKey="Garden, As" uniqKey="Garden A">AS Garden</name></author><author><name sortKey="Wong, Pf" uniqKey="Wong P">PF Wong</name></author><author><name sortKey="Martin, Jw" uniqKey="Martin J">JW Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reuther, T" uniqKey="Reuther T">T Reuther</name></author><author><name sortKey="Schuster, T" uniqKey="Schuster T">T Schuster</name></author><author><name sortKey="Mende, U" uniqKey="Mende U">U Mende</name></author><author><name sortKey="Kubler, A" uniqKey="Kubler A">A Kubler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schuurhuis, Jm" uniqKey="Schuurhuis J">JM Schuurhuis</name></author><author><name sortKey="Stokman, Ma" uniqKey="Stokman M">MA Stokman</name></author><author><name sortKey="Roodenburg, Jl" uniqKey="Roodenburg J">JL Roodenburg</name></author><author><name sortKey="Reintsema, H" uniqKey="Reintsema H">H Reintsema</name></author><author><name sortKey="Langendijk, Ja" uniqKey="Langendijk J">JA Langendijk</name></author><author><name sortKey="Vissink, A" uniqKey="Vissink A">A Vissink</name></author><author><name sortKey="Spijkervet, Fk" uniqKey="Spijkervet F">FK Spijkervet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwartz, Hc" uniqKey="Schwartz H">HC Schwartz</name></author><author><name sortKey="Kagan, Ar" uniqKey="Kagan A">AR Kagan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stenson, Km" uniqKey="Stenson K">KM Stenson</name></author><author><name sortKey="Kunnavakkam, R" uniqKey="Kunnavakkam R">R Kunnavakkam</name></author><author><name sortKey="Cohen, Ee" uniqKey="Cohen E">EE Cohen</name></author><author><name sortKey="Portugal, Ld" uniqKey="Portugal L">LD Portugal</name></author><author><name sortKey="Blair, E" uniqKey="Blair E">E Blair</name></author><author><name sortKey="Haraf, Dj" uniqKey="Haraf D">DJ Haraf</name></author><author><name sortKey="Salama, J" uniqKey="Salama J">J Salama</name></author><author><name sortKey="Vokes, Ee" uniqKey="Vokes E">EE Vokes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Store, G" uniqKey="Store G">G Store</name></author><author><name sortKey="Boysen, M" uniqKey="Boysen M">M Boysen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Storey, Mr" uniqKey="Storey M">MR Storey</name></author><author><name sortKey="Garden, As" uniqKey="Garden A">AS Garden</name></author><author><name sortKey="Morrison, Wh" uniqKey="Morrison W">WH Morrison</name></author><author><name sortKey="Eicher, Sa" uniqKey="Eicher S">SA Eicher</name></author><author><name sortKey="Schechter, Nr" uniqKey="Schechter N">NR Schechter</name></author><author><name sortKey="Ang, Kk" uniqKey="Ang K">KK Ang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Studer, G" uniqKey="Studer G">G Studer</name></author><author><name sortKey="Glanzmann, C" uniqKey="Glanzmann C">C Glanzmann</name></author><author><name sortKey="Studer, Sp" uniqKey="Studer S">SP Studer</name></author><author><name sortKey="Gratz, Kw" uniqKey="Gratz K">KW Gratz</name></author><author><name sortKey="Bredell, M" uniqKey="Bredell M">M Bredell</name></author><author><name sortKey="Locher, M" uniqKey="Locher M">M Locher</name></author><author><name sortKey="Lutolf, Um" uniqKey="Lutolf U">UM Lutolf</name></author><author><name sortKey="Zwahlen, Ra" uniqKey="Zwahlen R">RA Zwahlen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thiel, Hj" uniqKey="Thiel H">HJ Thiel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thorn, Jj" uniqKey="Thorn J">JJ Thorn</name></author><author><name sortKey="Hansen, Hs" uniqKey="Hansen H">HS Hansen</name></author><author><name sortKey="Specht, L" uniqKey="Specht L">L Specht</name></author><author><name sortKey="Bastholt, L" uniqKey="Bastholt L">L Bastholt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsai, Cj" uniqKey="Tsai C">CJ Tsai</name></author><author><name sortKey="Hofstede, Tm" uniqKey="Hofstede T">TM Hofstede</name></author><author><name sortKey="Sturgis, Em" uniqKey="Sturgis E">EM Sturgis</name></author><author><name sortKey="Garden, As" uniqKey="Garden A">AS Garden</name></author><author><name sortKey="Lindberg, Me" uniqKey="Lindberg M">ME Lindberg</name></author><author><name sortKey="Wei, Q" uniqKey="Wei Q">Q Wei</name></author><author><name sortKey="Tucker, Sl" uniqKey="Tucker S">SL Tucker</name></author><author><name sortKey="Dong, L" uniqKey="Dong L">L Dong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turner, Sl" uniqKey="Turner S">SL Turner</name></author><author><name sortKey="Slevin, Nj" uniqKey="Slevin N">NJ Slevin</name></author><author><name sortKey="Gupta, Nk" uniqKey="Gupta N">NK Gupta</name></author><author><name sortKey="Swindell, R" uniqKey="Swindell R">R Swindell</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000877 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000877 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV1
|flux= Main
|étape= Merge
|type= RBID
|clé= PMC:4048661
|texte= Dental status, dental treatment procedures and radiotherapy as risk factors for infected osteoradionecrosis (IORN) in patients with oral cancer – a comparison of two 10 years’ observation periods
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:24936388" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV1
| This area was generated with Dilib version V0.6.33. |  |