Serveur d'exploration sur le patient édenté (maquette)

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Efficacy of growth factor in promoting early osseointegration.

Identifieur interne : 000826 ( Main/Merge ); précédent : 000825; suivant : 000827

Efficacy of growth factor in promoting early osseointegration.

Auteurs : Khalid Al-Hezaimi [Arabie saoudite] ; Myron Nevins ; Soo-Woo Kim ; Ardavan Fateh ; David M. Kim

Source :

RBID : pubmed:24946082

Descripteurs français

English descriptors

Abstract

A preclinical study was conducted to evaluate the feasibility of 2 different topical formulations of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) to promote early osseointegration and enhanced bone-to-implant contact (BIC) for dental implants placed in an edentulous ridge. Six female beagle dogs were divided into 3 groups. The control group included 4 implants with no coating; test group A included 10 implants with commercially available rhPDGF-BB formulation coating; and second test group B included 10 implants with prototype viscous rhPDGF-BB coating. Three dogs were sacrificed at 3 weeks (12 implants) and the remaining 3 dogs at 6 weeks after implant placement (12 implants). The specimens were retrieved for histological evaluation, and revealed an uneventful healing of all implants without any sign of an inflammatory response at the different time intervals. Furthermore, the bone was in very close contact with the implants' surfaces with no evidence of intervening fibrous tissue layers. At 3 weeks, new bone formation between most implant threads on rhPDGF-BB coated implants was evident, whereas in the control group only a thin and sparse amount of new bone was noted. At 6 weeks, the commercially available rhPDGF-BB formulation coated implant group (Group A) showed more trabecular bone and higher BIC compared to the other 2 groups. Histologically, the results in this study showed that use of conventionally available rhPDGF-BB formulation as the implant surface treatment may accelerate the process of osseointegration and enhance BIC.

DOI: 10.1563/aaid-joi-D-13-00304
PubMed: 24946082

Links toward previous steps (curation, corpus...)


Links to Exploration step

pubmed:24946082

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Efficacy of growth factor in promoting early osseointegration.</title>
<author>
<name sortKey="Al Hezaimi, Khalid" sort="Al Hezaimi, Khalid" uniqKey="Al Hezaimi K" first="Khalid" last="Al-Hezaimi">Khalid Al-Hezaimi</name>
<affiliation wicri:level="1">
<nlm:affiliation>1  Department of Periodontology, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>1  Department of Periodontology, College of Dentistry, King Saud University, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Nevins, Myron" sort="Nevins, Myron" uniqKey="Nevins M" first="Myron" last="Nevins">Myron Nevins</name>
</author>
<author>
<name sortKey="Kim, Soo Woo" sort="Kim, Soo Woo" uniqKey="Kim S" first="Soo-Woo" last="Kim">Soo-Woo Kim</name>
</author>
<author>
<name sortKey="Fateh, Ardavan" sort="Fateh, Ardavan" uniqKey="Fateh A" first="Ardavan" last="Fateh">Ardavan Fateh</name>
</author>
<author>
<name sortKey="Kim, David M" sort="Kim, David M" uniqKey="Kim D" first="David M" last="Kim">David M. Kim</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="RBID">pubmed:24946082</idno>
<idno type="pmid">24946082</idno>
<idno type="doi">10.1563/aaid-joi-D-13-00304</idno>
<idno type="wicri:Area/PubMed/Corpus">000B95</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B95</idno>
<idno type="wicri:Area/PubMed/Curation">000B95</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000B95</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000B95</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B95</idno>
<idno type="wicri:Area/Ncbi/Merge">000E40</idno>
<idno type="wicri:Area/Ncbi/Curation">000E40</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000E40</idno>
<idno type="wicri:doubleKey">0160-6972:2014:Al Hezaimi K:efficacy:of:growth</idno>
<idno type="wicri:Area/Main/Merge">000826</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">Efficacy of growth factor in promoting early osseointegration.</title>
<author>
<name sortKey="Al Hezaimi, Khalid" sort="Al Hezaimi, Khalid" uniqKey="Al Hezaimi K" first="Khalid" last="Al-Hezaimi">Khalid Al-Hezaimi</name>
<affiliation wicri:level="1">
<nlm:affiliation>1  Department of Periodontology, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>1  Department of Periodontology, College of Dentistry, King Saud University, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Nevins, Myron" sort="Nevins, Myron" uniqKey="Nevins M" first="Myron" last="Nevins">Myron Nevins</name>
</author>
<author>
<name sortKey="Kim, Soo Woo" sort="Kim, Soo Woo" uniqKey="Kim S" first="Soo-Woo" last="Kim">Soo-Woo Kim</name>
</author>
<author>
<name sortKey="Fateh, Ardavan" sort="Fateh, Ardavan" uniqKey="Fateh A" first="Ardavan" last="Fateh">Ardavan Fateh</name>
</author>
<author>
<name sortKey="Kim, David M" sort="Kim, David M" uniqKey="Kim D" first="David M" last="Kim">David M. Kim</name>
</author>
</analytic>
<series>
<title level="j">The Journal of oral implantology</title>
<idno type="ISSN">0160-6972</idno>
<imprint>
<date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Angiogenesis Inducing Agents (therapeutic use)</term>
<term>Animals</term>
<term>Coated Materials, Biocompatible (therapeutic use)</term>
<term>Dental Implants</term>
<term>Dental Prosthesis Design</term>
<term>Dogs</term>
<term>Feasibility Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Mandible (diagnostic imaging)</term>
<term>Mandible (drug effects)</term>
<term>Mandible (pathology)</term>
<term>Osseointegration (drug effects)</term>
<term>Osteogenesis (drug effects)</term>
<term>Proto-Oncogene Proteins c-sis (therapeutic use)</term>
<term>Radiography, Bitewing</term>
<term>Random Allocation</term>
<term>Recombinant Proteins</term>
<term>Surface Properties</term>
<term>Time Factors</term>
<term>Viscosity</term>
<term>Wound Healing (drug effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Agents angiogéniques (usage thérapeutique)</term>
<term>Animaux</term>
<term>Attribution aléatoire</term>
<term>Chiens</term>
<term>Cicatrisation de plaie ()</term>
<term>Conception de prothèse dentaire</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Implants dentaires</term>
<term>Mandibule ()</term>
<term>Mandibule (anatomopathologie)</term>
<term>Mandibule (imagerie diagnostique)</term>
<term>Matériaux revêtus, biocompatibles (usage thérapeutique)</term>
<term>Ostéo-intégration ()</term>
<term>Ostéogenèse ()</term>
<term>Propriétés de surface</term>
<term>Protéines proto-oncogènes c-sis (usage thérapeutique)</term>
<term>Protéines recombinantes</term>
<term>Radiographie rétrocoronaire</term>
<term>Viscosité</term>
<term>Études de faisabilité</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en">
<term>Angiogenesis Inducing Agents</term>
<term>Coated Materials, Biocompatible</term>
<term>Proto-Oncogene Proteins c-sis</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr">
<term>Mandibule</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en">
<term>Mandible</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en">
<term>Mandible</term>
<term>Osseointegration</term>
<term>Osteogenesis</term>
<term>Wound Healing</term>
</keywords>
<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr">
<term>Mandibule</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Mandible</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr">
<term>Agents angiogéniques</term>
<term>Matériaux revêtus, biocompatibles</term>
<term>Protéines proto-oncogènes c-sis</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Animals</term>
<term>Dental Implants</term>
<term>Dental Prosthesis Design</term>
<term>Dogs</term>
<term>Feasibility Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Radiography, Bitewing</term>
<term>Random Allocation</term>
<term>Recombinant Proteins</term>
<term>Surface Properties</term>
<term>Time Factors</term>
<term>Viscosity</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Animaux</term>
<term>Attribution aléatoire</term>
<term>Chiens</term>
<term>Cicatrisation de plaie</term>
<term>Conception de prothèse dentaire</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Implants dentaires</term>
<term>Mandibule</term>
<term>Ostéo-intégration</term>
<term>Ostéogenèse</term>
<term>Propriétés de surface</term>
<term>Protéines recombinantes</term>
<term>Radiographie rétrocoronaire</term>
<term>Viscosité</term>
<term>Études de faisabilité</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">A preclinical study was conducted to evaluate the feasibility of 2 different topical formulations of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) to promote early osseointegration and enhanced bone-to-implant contact (BIC) for dental implants placed in an edentulous ridge. Six female beagle dogs were divided into 3 groups. The control group included 4 implants with no coating; test group A included 10 implants with commercially available rhPDGF-BB formulation coating; and second test group B included 10 implants with prototype viscous rhPDGF-BB coating. Three dogs were sacrificed at 3 weeks (12 implants) and the remaining 3 dogs at 6 weeks after implant placement (12 implants). The specimens were retrieved for histological evaluation, and revealed an uneventful healing of all implants without any sign of an inflammatory response at the different time intervals. Furthermore, the bone was in very close contact with the implants' surfaces with no evidence of intervening fibrous tissue layers. At 3 weeks, new bone formation between most implant threads on rhPDGF-BB coated implants was evident, whereas in the control group only a thin and sparse amount of new bone was noted. At 6 weeks, the commercially available rhPDGF-BB formulation coated implant group (Group A) showed more trabecular bone and higher BIC compared to the other 2 groups. Histologically, the results in this study showed that use of conventionally available rhPDGF-BB formulation as the implant surface treatment may accelerate the process of osseointegration and enhance BIC.</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000826 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000826 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    EdenteV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     pubmed:24946082
   |texte=   Efficacy of growth factor in promoting early osseointegration.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i   -Sk "pubmed:24946082" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a EdenteV1 

Wicri

This area was generated with Dilib version V0.6.33.
Data generation: Mon Dec 4 11:02:15 2017. Site generation: Tue Sep 29 19:14:38 2020