Genetic Variation on the BAT1-NFKBIL1-LTA Region of Major Histocompatibility Complex Class III Associates with Periodontitis
Identifieur interne : 000754 ( Main/Merge ); précédent : 000753; suivant : 000755Genetic Variation on the BAT1-NFKBIL1-LTA Region of Major Histocompatibility Complex Class III Associates with Periodontitis
Auteurs : K. A. Elisa Kallio [Finlande] ; Marja Marchesani [Finlande] ; Efthymia Vlachopoulou [Finlande] ; P Ivi M Ntyl [Finlande] ; Susanna Paju [Finlande] ; K Re Buhlin [Finlande, Suède] ; Anna L. Suominen [Finlande] ; Johanna Contreras [Chili] ; Matti Knuuttila [Finlande] ; Marcela Hernandez [Chili] ; Sisko Huumonen [Finlande] ; Markku S. Nieminen [Finlande] ; Markus Perola [Finlande] ; Juha Sinisalo [Finlande] ; Marja-Liisa Lokki [Finlande] ; Pirkko J. Pussinen [Finlande]Source :
- Infection and Immunity [ 0019-9567 ] ; 2014.
Abstract
Periodontitis is a chronic inflammatory disease with a multifactorial etiology. We investigated whether human major histocompatibility complex (MHC) polymorphisms (6p21.3) are associated with periodontal parameters. Parogene 1 population samples (
Url:
DOI: 10.1128/IAI.01681-13
PubMed: 24566624
PubMed Central: 3993418
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PMC:3993418Le document en format XML
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Region of Major Histocompatibility Complex Class III Associates with Periodontitis</title>
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Region of Major Histocompatibility Complex Class III Associates with Periodontitis</title>
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<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Infection and Immunity</title>
<idno type="ISSN">0019-9567</idno>
<idno type="eISSN">1098-5522</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Periodontitis is a chronic inflammatory disease with a multifactorial etiology. We investigated whether human major histocompatibility complex (MHC) polymorphisms (6p21.3) are associated with periodontal parameters. Parogene 1 population samples (<italic>n</italic>
= 169) were analyzed with 13,245 single nucleotide polymorphisms (SNPs) of the MHC region. Eighteen selected SNPs (<italic>P</italic>
≤ 0.001) were replicated in Parogene 2 population samples (<italic>n</italic>
= 339) and the Health 2000 Survey (<italic>n</italic>
= 1,420). All subjects had a detailed clinical and radiographic oral health examination. Serum lymphotoxin-α (LTA) concentrations were measured in the Parogene populations, and the protein was detected in inflamed periodontal tissue. In the Parogene 1 population, 10 SNPs were associated with periodontal parameters. The strongest associations emerged from the parameters bleeding on probing (BOP) and a probing pocket depth (PPD) of ≥6 mm with the genes <italic>BAT1</italic>
, <italic>NFKBIL1</italic>
, and <italic>LTA</italic>
. Six SNPs, rs11796, rs3130059, rs2239527, rs2071591, rs909253, and rs1041981 (<italic>r</italic>
<sup>2</sup>
, ≥0.92), constituted a risk haplotype. In the Parogene 1 population, the haplotype had the strongest association with the parameter BOP, a PPD of ≥6 mm, and severe periodontitis with odds ratios (95% confidence intervals) of 2.63 (2.21 to 3.20), 2.90 (2.37 to 3.52), and 3.10 (1.63 to 5.98), respectively. These results were replicated in the other two populations. High serum LTA concentrations in the Parogene population were associated with the periodontitis risk alleles of the <italic>LTA</italic>
SNPs (rs909253 and rs1041981) of the haplotype. In addition, the protein was expressed in inflamed gingival connective tissue. We identified a novel <italic>BAT1-NFKBIL1-LTA</italic>
haplotype as a significant contributor to the risk of periodontitis. The genetic polymorphisms in the MHC class III region may be functionally important in periodontitis susceptibility.</p>
</div>
</front>
</TEI>
</record>
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