Biomarkers of periodontitis and inflammation in ischemic stroke: A case-control study.
Identifieur interne : 000988 ( Main/Exploration ); précédent : 000987; suivant : 000989Biomarkers of periodontitis and inflammation in ischemic stroke: A case-control study.
Auteurs : Frederick Palm [Allemagne] ; Laura Lahdentausta [Finlande] ; Timo Sorsa [Finlande] ; Taina Tervahartiala [Finlande] ; Pia Gokel [Allemagne] ; Florian Buggle [Allemagne] ; Anton Safer [Allemagne] ; Heiko Becher [Allemagne] ; Armin J. Grau [Allemagne] ; Pirkko Pussinen [Finlande]Source :
- Innate immunity [ 1753-4267 ] ; 2014.
Descripteurs français
- KwdFr :
- Accident vasculaire cérébral (immunologie), Accident vasculaire cérébral (métabolisme), Aggregatibacter actinomycetemcomitans (), Bouche édentée, Encéphalopathie ischémique (immunologie), Encéphalopathie ischémique (métabolisme), Facteurs de risque, Femelle, Humains, Inflammation (anatomopathologie), Interleukine-1 bêta (analyse), Marqueurs biologiques (analyse), Matrix metalloproteinase 8 (analyse), Myeloperoxidase (analyse), Mâle, Parodontite (anatomopathologie), Porphyromonas gingivalis (), Salive (), Sujet âgé, Études cas-témoins.
- MESH :
- analyse : Interleukine-1 bêta, Marqueurs biologiques, Matrix metalloproteinase 8, Myeloperoxidase.
- anatomopathologie : Inflammation, Parodontite.
- immunologie : Accident vasculaire cérébral, Encéphalopathie ischémique.
- métabolisme : Accident vasculaire cérébral, Encéphalopathie ischémique.
- Aggregatibacter actinomycetemcomitans, Bouche édentée, Facteurs de risque, Femelle, Humains, Mâle, Porphyromonas gingivalis, Salive, Sujet âgé, Études cas-témoins.
English descriptors
- KwdEn :
- Aged, Aggregatibacter actinomycetemcomitans (chemistry), Biomarkers (analysis), Brain Ischemia (immunology), Brain Ischemia (metabolism), Case-Control Studies, Female, Humans, Inflammation (pathology), Interleukin-1beta (analysis), Male, Matrix Metalloproteinase 8 (analysis), Mouth, Edentulous, Periodontitis (pathology), Peroxidase (analysis), Porphyromonas gingivalis (chemistry), Risk Factors, Saliva (chemistry), Stroke (immunology), Stroke (metabolism).
- MESH :
- chemical , analysis : Biomarkers, Interleukin-1beta, Matrix Metalloproteinase 8, Peroxidase.
- chemistry : Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Saliva.
- immunology : Brain Ischemia, Stroke.
- metabolism : Brain Ischemia, Stroke.
- pathology : Inflammation, Periodontitis.
- Aged, Case-Control Studies, Female, Humans, Male, Mouth, Edentulous, Risk Factors.
Abstract
Periodontitis is a common infectious disease associated with increased risk for ischemic stroke though presently unclear mechanisms. In a case-control study, we investigated salivary levels of four periodontal pathogens, as well as systemic and local inflammatory markers. The population comprised 98 patients with acute ischemic stroke (mean ± SD, 68.2 ± 9.7 yrs; 45.9% women) and 100 healthy controls (69.1 ± 5.2 yrs; 47.0% women). Patients were more often edentulous and had fewer teeth than controls (13.8 ± 10.8 versus 16.6 ± 10.1). After adjusting for stroke risk factors and number of teeth, controls had higher saliva matrix metalloproteinase-8 (MMP-8), myeloperoxidase (MPO), IL-1β, Aggregatibacter actinomycetemcomitans, and serum LPS activity levels. Patients had higher serum MMP-8 and MPO, and they were more often qPCR-positive for A. actinomycetemcomitans (37.9% versus 19.0%) and for ≥3 periodontopathic species combined (50.0% versus 33.0%). We conclude that controls more often had evidence of current periodontal infection with higher periodontal pathogen amount, endotoxemia, local inflammation and tissue destruction. Stroke patients more often had evidence of end-stage periodontitis with edentulism and missing teeth. They were more often carriers of several periodontopathic pathogens in saliva, especially A. actinomycetemcomitans. Additionally, inflammatory burden may contribute to high systemic inflammation associated with elevated stroke susceptibility.
DOI: 10.1177/1753425913501214
PubMed: 24045341
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Periodontitis is a common infectious disease associated with increased risk for ischemic stroke though presently unclear mechanisms. In a case-control study, we investigated salivary levels of four periodontal pathogens, as well as systemic and local inflammatory markers. The population comprised 98 patients with acute ischemic stroke (mean ± SD, 68.2 ± 9.7 yrs; 45.9% women) and 100 healthy controls (69.1 ± 5.2 yrs; 47.0% women). Patients were more often edentulous and had fewer teeth than controls (13.8 ± 10.8 versus 16.6 ± 10.1). After adjusting for stroke risk factors and number of teeth, controls had higher saliva matrix metalloproteinase-8 (MMP-8), myeloperoxidase (MPO), IL-1β, Aggregatibacter actinomycetemcomitans, and serum LPS activity levels. Patients had higher serum MMP-8 and MPO, and they were more often qPCR-positive for A. actinomycetemcomitans (37.9% versus 19.0%) and for ≥3 periodontopathic species combined (50.0% versus 33.0%). We conclude that controls more often had evidence of current periodontal infection with higher periodontal pathogen amount, endotoxemia, local inflammation and tissue destruction. Stroke patients more often had evidence of end-stage periodontitis with edentulism and missing teeth. They were more often carriers of several periodontopathic pathogens in saliva, especially A. actinomycetemcomitans. Additionally, inflammatory burden may contribute to high systemic inflammation associated with elevated stroke susceptibility.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Finlande</li>
</country>
<region><li>Uusimaa</li>
</region>
<settlement><li>Helsinki</li>
</settlement>
<orgName><li>Université d'Helsinki</li>
</orgName>
</list>
<tree><country name="Allemagne"><noRegion><name sortKey="Palm, Frederick" sort="Palm, Frederick" uniqKey="Palm F" first="Frederick" last="Palm">Frederick Palm</name>
</noRegion>
<name sortKey="Becher, Heiko" sort="Becher, Heiko" uniqKey="Becher H" first="Heiko" last="Becher">Heiko Becher</name>
<name sortKey="Buggle, Florian" sort="Buggle, Florian" uniqKey="Buggle F" first="Florian" last="Buggle">Florian Buggle</name>
<name sortKey="Gokel, Pia" sort="Gokel, Pia" uniqKey="Gokel P" first="Pia" last="Gokel">Pia Gokel</name>
<name sortKey="Grau, Armin J" sort="Grau, Armin J" uniqKey="Grau A" first="Armin J" last="Grau">Armin J. Grau</name>
<name sortKey="Safer, Anton" sort="Safer, Anton" uniqKey="Safer A" first="Anton" last="Safer">Anton Safer</name>
</country>
<country name="Finlande"><region name="Uusimaa"><name sortKey="Lahdentausta, Laura" sort="Lahdentausta, Laura" uniqKey="Lahdentausta L" first="Laura" last="Lahdentausta">Laura Lahdentausta</name>
</region>
<name sortKey="Pussinen, Pirkko" sort="Pussinen, Pirkko" uniqKey="Pussinen P" first="Pirkko" last="Pussinen">Pirkko Pussinen</name>
<name sortKey="Sorsa, Timo" sort="Sorsa, Timo" uniqKey="Sorsa T" first="Timo" last="Sorsa">Timo Sorsa</name>
<name sortKey="Tervahartiala, Taina" sort="Tervahartiala, Taina" uniqKey="Tervahartiala T" first="Taina" last="Tervahartiala">Taina Tervahartiala</name>
</country>
</tree>
</affiliations>
</record>
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