Expression of MMP-2, 9 and 13 in newly formed bone after sinus augmentation using inorganic bovine bone in human
Identifieur interne : 001C94 ( Main/Exploration ); précédent : 001C93; suivant : 001C95Expression of MMP-2, 9 and 13 in newly formed bone after sinus augmentation using inorganic bovine bone in human
Auteurs : J. Bassil [Liban] ; K. Senni [France] ; S. Changotade [France] ; B. Baroukh [France] ; C. Kassis [Liban] ; N. Naaman [Liban] ; G. Godeau [France]Source :
- Journal of periodontal research [ 0022-3484 ] ; 2011.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Bone, Bone graft, Bovine, Human, Stomatology.
- mix :
Abstract
Background and Objective: The aim of the present study was to analyse the expression of MMP-2, MMP-9 and MMP-13 in newly formed bone following maxillary sinus augmentation using inorganic bovine bone substitute, because these MMPs play a major role in bone remodeling and bone resorption. Material and Methods: Deproteinized bovine bone (Bio-Oss®) was used to fill cavities after elevating the sinus mucosa. Twenty patients with edentulous posterior maxilla were treated with 20 sinus-augmentation procedures using a two-stage technique. Forty-nine Straumann® endosseous implants were used to complete the implant-prosthetic rehabilitation. One cylinder-shaped bone biopsy from each patient was taken from the augmented maxillary region using trephine burs at the second stage of surgery, 8 months after grafting. A biopsy was also taken as a control from the upper molar region from six different patients who did not undergo the sinus procedure. All biopsies were subjected to biochemical analysis and staining for TRAP. Results: No implant losses or failures occurred. The large number of TRAP-positive multinucleated osteoclasts in resorption lacunae indicated that the resorption was very active in all grafts, in contrast with the control group. Zymography and western blot analysis demonstrated a significantly increased expression of MMP-2, MMP-9 and MMP-13 in the newly formed bone compared with controls (p < 0.05). Conclusion: The quantity of osteoclastic cells and the increased expression of proteolytic enzymes suggest that 8 months after grafting, inorganic bovine bone is slowly resorbing and is the site of important remodeling of the newly formed bone by means of resorption and synthesis.
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Affiliations:
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Le document en format XML
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<term>GELATINASE</term>
<term>INTERSTITIAL COLLAGENASE</term>
<term>MATRIX METALLOPROTEINASES</term>
<term>MAXILLARY</term>
<term>OSSIFICATION</term>
<term>OSTEOCLASTS</term>
<term>RESORPTION</term>
<term>RIDGE AUGMENTATION</term>
<term>TISSUE</term>
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<front><div type="abstract" xml:lang="en">Background and Objective: The aim of the present study was to analyse the expression of MMP-2, MMP-9 and MMP-13 in newly formed bone following maxillary sinus augmentation using inorganic bovine bone substitute, because these MMPs play a major role in bone remodeling and bone resorption. Material and Methods: Deproteinized bovine bone (Bio-Oss®) was used to fill cavities after elevating the sinus mucosa. Twenty patients with edentulous posterior maxilla were treated with 20 sinus-augmentation procedures using a two-stage technique. Forty-nine Straumann® endosseous implants were used to complete the implant-prosthetic rehabilitation. One cylinder-shaped bone biopsy from each patient was taken from the augmented maxillary region using trephine burs at the second stage of surgery, 8 months after grafting. A biopsy was also taken as a control from the upper molar region from six different patients who did not undergo the sinus procedure. All biopsies were subjected to biochemical analysis and staining for TRAP. Results: No implant losses or failures occurred. The large number of TRAP-positive multinucleated osteoclasts in resorption lacunae indicated that the resorption was very active in all grafts, in contrast with the control group. Zymography and western blot analysis demonstrated a significantly increased expression of MMP-2, MMP-9 and MMP-13 in the newly formed bone compared with controls (p < 0.05). Conclusion: The quantity of osteoclastic cells and the increased expression of proteolytic enzymes suggest that 8 months after grafting, inorganic bovine bone is slowly resorbing and is the site of important remodeling of the newly formed bone by means of resorption and synthesis.</div>
</front>
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