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Peroxisome proliferator‐activated receptor (PPAR) γ polymorphism, vitamin D, bone mineral density and periodontitis in postmenopausal women

Identifieur interne : 001573 ( Main/Exploration ); précédent : 001572; suivant : 001574

Peroxisome proliferator‐activated receptor (PPAR) γ polymorphism, vitamin D, bone mineral density and periodontitis in postmenopausal women

Auteurs : Y. Wang [Japon] ; N. Sugita [Japon] ; A. Yoshihara [Japon] ; M. Iwasaki [Japon] ; H. Miyazaki [Japon] ; K. Nakamura [Japon] ; H. Yoshie [Japon]

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RBID : ISTEX:CB6A613F2CAB4866DE9E78EEE99B5FB6D837CA38

English descriptors

Abstract

PPARg regulates bone metabolism and inflammation. Our previous study suggested PPARg Pro12Ala polymorphism to represent a susceptibility factor for periodontitis in pregnant Japanese women. Several recent papers have drawn attention to a possible link between low bone mineral density (BMD) and periodontitis in postmenopausal women. Since the pathogenesis for both involve bone remodeling, they might share common risk factors such as gene polymorphisms and vitamin D level. The present study investigated possible associations between the PPARgPro12Ala polymorphism, periodontitis, BMD and serum 25(OH)D in postmenopausal Japanese women.

Url:
DOI: 10.1111/odi.12032


Affiliations:


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Le document en format XML

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<div type="abstract">PPARg regulates bone metabolism and inflammation. Our previous study suggested PPARg Pro12Ala polymorphism to represent a susceptibility factor for periodontitis in pregnant Japanese women. Several recent papers have drawn attention to a possible link between low bone mineral density (BMD) and periodontitis in postmenopausal women. Since the pathogenesis for both involve bone remodeling, they might share common risk factors such as gene polymorphisms and vitamin D level. The present study investigated possible associations between the PPARgPro12Ala polymorphism, periodontitis, BMD and serum 25(OH)D in postmenopausal Japanese women.</div>
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