Inorganic polyphosphate adsorbed onto hydroxyapatite for guided bone regeneration: an animal study.
Identifieur interne : 000669 ( Main/Curation ); précédent : 000668; suivant : 000670Inorganic polyphosphate adsorbed onto hydroxyapatite for guided bone regeneration: an animal study.
Auteurs : Kazuya Doi ; Takayasu Kubo ; Ryou Takeshita ; Shiho Kajihara ; Shinichi Kato ; Yumi Kawazoe ; Toshikazu Shiba ; Yasumasa AkagawaSource :
- Dental materials journal [ 1881-1361 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Durapatite, Inorganic Chemicals, Polyphosphates.
- Adsorption, Animals, Bone Regeneration, Dogs, Microscopy, Electron, Scanning.
Abstract
Inorganic polyphosphate (poly(P)) is recognized as a therapeutic agent that promotes fibroblast growth factor and enhances osteogenic differentiation, and in vivo, when adsorbed onto interconnected porous calcium hydroxyapatite (IP-CHA) enhances bone regeneration. The present study focused on the effect of poly(P) adsorbed onto IP-CHA granules (Poly(P)/IP-CHA) in guided bone regeneration (GBR). Dental implants were placed into the edentulous mandibular areas of five Beagle-Labrador hybrid dogs with screw expose on the buccal side, and then bone defects were filled Poly(P)/IP-CHA (test) or IP-CHA (control). After 12 weeks, histological evaluation and histomorphometrical analysis were performed. Newly-bone formation around exposed implant screw was clearly detected in the test-group. The ratio for regenerated bone height in the test group versus the control-group was 85.6±20.2 and 62.6±23.8, respectively, with no significant difference, while, that for bone implant contact was significantly higher (67.9±11.8 and 48.8±14.1, respectively). These findings indicate that Poly(P)/IP-CHA enhances bone regeneration in GBR.
PubMed: 24500369
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Kazuya Doi<affiliation><nlm:affiliation>Department of Advanced Prosthodontics, Hiroshima University Graduate School of Biomedical and Health Sciences.</nlm:affiliation>
<wicri:noCountry code="subField">Hiroshima University Graduate School of Biomedical and Health Sciences</wicri:noCountry>
</affiliation>
Le document en format XML
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<front><div type="abstract" xml:lang="en">Inorganic polyphosphate (poly(P)) is recognized as a therapeutic agent that promotes fibroblast growth factor and enhances osteogenic differentiation, and in vivo, when adsorbed onto interconnected porous calcium hydroxyapatite (IP-CHA) enhances bone regeneration. The present study focused on the effect of poly(P) adsorbed onto IP-CHA granules (Poly(P)/IP-CHA) in guided bone regeneration (GBR). Dental implants were placed into the edentulous mandibular areas of five Beagle-Labrador hybrid dogs with screw expose on the buccal side, and then bone defects were filled Poly(P)/IP-CHA (test) or IP-CHA (control). After 12 weeks, histological evaluation and histomorphometrical analysis were performed. Newly-bone formation around exposed implant screw was clearly detected in the test-group. The ratio for regenerated bone height in the test group versus the control-group was 85.6±20.2 and 62.6±23.8, respectively, with no significant difference, while, that for bone implant contact was significantly higher (67.9±11.8 and 48.8±14.1, respectively). These findings indicate that Poly(P)/IP-CHA enhances bone regeneration in GBR.</div>
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