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Inorganic polyphosphate adsorbed onto hydroxyapatite for guided bone regeneration: an animal study.

Identifieur interne : 000669 ( Main/Curation ); précédent : 000668; suivant : 000670

Inorganic polyphosphate adsorbed onto hydroxyapatite for guided bone regeneration: an animal study.

Auteurs : Kazuya Doi ; Takayasu Kubo ; Ryou Takeshita ; Shiho Kajihara ; Shinichi Kato ; Yumi Kawazoe ; Toshikazu Shiba ; Yasumasa Akagawa

Source :

Dental materials journal [ 1881-1361 ] ; 2014.

RBID : pubmed:24500369

Descripteurs français

KwdFr :
- Adsorption, Animaux, Chiens, Durapatite (), Microscopie électronique à balayage, Polyphosphates (), Produits chimiques inorganiques (), Régénération osseuse.
MESH :
- Adsorption, Animaux, Chiens, Durapatite, Microscopie électronique à balayage, Polyphosphates, Produits chimiques inorganiques, Régénération osseuse.

English descriptors

KwdEn :
- Adsorption, Animals, Bone Regeneration, Dogs, Durapatite (chemistry), Inorganic Chemicals (chemistry), Microscopy, Electron, Scanning, Polyphosphates (chemistry).
MESH :
- chemical , chemistry : Durapatite, Inorganic Chemicals, Polyphosphates.
- Adsorption, Animals, Bone Regeneration, Dogs, Microscopy, Electron, Scanning.

Abstract

Inorganic polyphosphate (poly(P)) is recognized as a therapeutic agent that promotes fibroblast growth factor and enhances osteogenic differentiation, and in vivo, when adsorbed onto interconnected porous calcium hydroxyapatite (IP-CHA) enhances bone regeneration. The present study focused on the effect of poly(P) adsorbed onto IP-CHA granules (Poly(P)/IP-CHA) in guided bone regeneration (GBR). Dental implants were placed into the edentulous mandibular areas of five Beagle-Labrador hybrid dogs with screw expose on the buccal side, and then bone defects were filled Poly(P)/IP-CHA (test) or IP-CHA (control). After 12 weeks, histological evaluation and histomorphometrical analysis were performed. Newly-bone formation around exposed implant screw was clearly detected in the test-group. The ratio for regenerated bone height in the test group versus the control-group was 85.6±20.2 and 62.6±23.8, respectively, with no significant difference, while, that for bone implant contact was significantly higher (67.9±11.8 and 48.8±14.1, respectively). These findings indicate that Poly(P)/IP-CHA enhances bone regeneration in GBR.

PubMed: 24500369

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pubmed:24500369

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Kazuya Doi

<affiliation><nlm:affiliation>Department of Advanced Prosthodontics, Hiroshima University Graduate School of Biomedical and Health Sciences.</nlm:affiliation>
<wicri:noCountry code="subField">Hiroshima University Graduate School of Biomedical and Health Sciences</wicri:noCountry>
</affiliation>

Le document en format XML

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<author><name sortKey="Shiba, Toshikazu" sort="Shiba, Toshikazu" uniqKey="Shiba T" first="Toshikazu" last="Shiba">Toshikazu Shiba</name>
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<term>Inorganic Chemicals (chemistry)</term>
<term>Microscopy, Electron, Scanning</term>
<term>Polyphosphates (chemistry)</term>
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<term>Animaux</term>
<term>Chiens</term>
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<front><div type="abstract" xml:lang="en">Inorganic polyphosphate (poly(P)) is recognized as a therapeutic agent that promotes fibroblast growth factor and enhances osteogenic differentiation, and in vivo, when adsorbed onto interconnected porous calcium hydroxyapatite (IP-CHA) enhances bone regeneration. The present study focused on the effect of poly(P) adsorbed onto IP-CHA granules (Poly(P)/IP-CHA) in guided bone regeneration (GBR). Dental implants were placed into the edentulous mandibular areas of five Beagle-Labrador hybrid dogs with screw expose on the buccal side, and then bone defects were filled Poly(P)/IP-CHA (test) or IP-CHA (control). After 12 weeks, histological evaluation and histomorphometrical analysis were performed. Newly-bone formation around exposed implant screw was clearly detected in the test-group. The ratio for regenerated bone height in the test group versus the control-group was 85.6±20.2 and 62.6±23.8, respectively, with no significant difference, while, that for bone implant contact was significantly higher (67.9±11.8 and 48.8±14.1, respectively). These findings indicate that Poly(P)/IP-CHA enhances bone regeneration in GBR.</div>
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Inorganic polyphosphate adsorbed onto hydroxyapatite for guided bone regeneration: an animal study.

Inorganic polyphosphate adsorbed onto hydroxyapatite for guided bone regeneration: an animal study.

Source :

Descripteurs français

English descriptors

Abstract

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Curation

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