The effects of ErhBMP‐2‐/EGCG‐coated BCP bone substitute on dehiscence around dental implants in dogs
Identifieur interne : 000817 ( Istex/Corpus ); précédent : 000816; suivant : 000818The effects of ErhBMP‐2‐/EGCG‐coated BCP bone substitute on dehiscence around dental implants in dogs
Auteurs : Y-S Shin ; J-Y Seo ; S-H Oh ; J-H Kim ; S-T Kim ; Y-B Park ; H-S MoonSource :
- Oral Diseases [ 1354-523X ] ; 2014-04.
Abstract
The purpose was to evaluate the effect of Escherichia coli‐derived recombinant human bone morphogenetic protein‐2 (ErhBMP‐2)‐/epigallocatechin‐3‐gallate (EGCG)‐coated biphasic calcium phosphate (BCP) and titanium barrier membrane on dehiscence defects in dogs.
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DOI: 10.1111/odi.12109
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Iksan, Korea</mods:affiliation></affiliation></author><author><name sortKey="Kim, J" sort="Kim, J" uniqKey="Kim J" first="J-H" last="Kim">J-H Kim</name><affiliation><mods:affiliation>Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Kim, S" sort="Kim, S" uniqKey="Kim S" first="S-T" last="Kim">S-T Kim</name><affiliation><mods:affiliation>Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: kst72@snu.ac.kr</mods:affiliation></affiliation></author><author><name sortKey="Park, Y" sort="Park, Y" uniqKey="Park Y" first="Y-B" last="Park">Y-B Park</name><affiliation><mods:affiliation>Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Moon, H" sort="Moon, H" uniqKey="Moon H" first="H-S" last="Moon">H-S Moon</name><affiliation><mods:affiliation>Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Korea</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D6073C8F3E9E99AE96BB77DB3855558729EE0F71</idno><date when="2014" year="2014">2014</date><idno type="doi">10.1111/odi.12109</idno><idno type="url">https://api.istex.fr/document/D6073C8F3E9E99AE96BB77DB3855558729EE0F71/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000817</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000817</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">The effects of Erh<hi rend="fc">BMP</hi>‐2‐/<hi rend="fc">EGCG</hi>‐coated <hi rend="fc">BCP</hi> bone substitute on dehiscence around dental implants in dogs</title><author><name sortKey="Shin, Y" sort="Shin, Y" uniqKey="Shin Y" first="Y-S" last="Shin">Y-S Shin</name><affiliation><mods:affiliation>Department of Conservative Dentistry, Oral Science Research Center, Yonsei University College of Dentistry, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Seo, J" sort="Seo, J" uniqKey="Seo J" first="J-Y" last="Seo">J-Y Seo</name><affiliation><mods:affiliation>Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Oh, S" sort="Oh, S" uniqKey="Oh S" first="S-H" last="Oh">S-H Oh</name><affiliation><mods:affiliation>Department of Dental Biomaterials, Institute of Biomaterials‐Implant, Wonkwang University School of Dentistry, Iksan, Korea</mods:affiliation></affiliation></author><author><name sortKey="Kim, J" sort="Kim, J" uniqKey="Kim J" first="J-H" last="Kim">J-H Kim</name><affiliation><mods:affiliation>Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Kim, S" sort="Kim, S" uniqKey="Kim S" first="S-T" last="Kim">S-T Kim</name><affiliation><mods:affiliation>Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: kst72@snu.ac.kr</mods:affiliation></affiliation></author><author><name sortKey="Park, Y" sort="Park, Y" uniqKey="Park Y" first="Y-B" last="Park">Y-B Park</name><affiliation><mods:affiliation>Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Moon, H" sort="Moon, H" uniqKey="Moon H" first="H-S" last="Moon">H-S Moon</name><affiliation><mods:affiliation>Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Korea</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Oral Diseases</title><title level="j" type="alt">ORAL DISEASES</title><idno type="ISSN">1354-523X</idno><idno type="eISSN">1601-0825</idno><imprint><biblScope unit="vol">20</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="281">281</biblScope><biblScope unit="page" to="287">287</biblScope><biblScope unit="page-count">7</biblScope><date type="published" when="2014-04">2014-04</date></imprint><idno type="ISSN">1354-523X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1354-523X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The purpose was to evaluate the effect of Escherichia coli‐derived recombinant human bone morphogenetic protein‐2 (ErhBMP‐2)‐/epigallocatechin‐3‐gallate (EGCG)‐coated biphasic calcium phosphate (BCP) and titanium barrier membrane on dehiscence defects in dogs.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Y‐S Shin</name><affiliations><json:string>Department of Conservative Dentistry, Oral Science Research Center, Yonsei University College of Dentistry, Seoul, Korea</json:string></affiliations></json:item><json:item><name>J‐Y Seo</name><affiliations><json:string>Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Korea</json:string></affiliations></json:item><json:item><name>S‐H Oh</name><affiliations><json:string>Department of Dental Biomaterials, Institute of Biomaterials‐Implant, Wonkwang University School of Dentistry, Iksan, Korea</json:string></affiliations></json:item><json:item><name>J‐H Kim</name><affiliations><json:string>Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Korea</json:string></affiliations></json:item><json:item><name>S‐T Kim</name><affiliations><json:string>Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea</json:string><json:string>E-mail: kst72@snu.ac.kr</json:string></affiliations></json:item><json:item><name>Y‐B Park</name><affiliations><json:string>Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Korea</json:string></affiliations></json:item><json:item><name>H‐S Moon</name><affiliations><json:string>Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Korea</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>GBR</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>biphasic calcium phosphate</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dehiscence defect</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>epigallocatechin‐3‐gallate</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>ErhBMP‐2</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>titanium barrier membrane</value></json:item></subject><articleId><json:string>ODI12109</json:string></articleId><arkIstex>ark:/67375/WNG-K21LN493-H</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The purpose was to evaluate the effect of Escherichia coli‐derived recombinant human bone morphogenetic protein‐2 (ErhBMP‐2)‐/epigallocatechin‐3‐gallate (EGCG)‐coated biphasic calcium phosphate (BCP) and titanium barrier membrane on dehiscence defects in 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substitute on dehiscence around dental implants in dogs</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Publishing Ltd</publisher><availability><licence>© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</licence></availability><date type="published" when="2014-04"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">The effects of Erh<hi rend="fc">BMP</hi>‐2‐/<hi rend="fc">EGCG</hi>‐coated <hi rend="fc">BCP</hi> bone substitute on dehiscence around dental implants in dogs</title><author xml:id="author-0000"><persName><forename type="first">Y‐S</forename><surname>Shin</surname></persName><affiliation><orgName>Department of Conservative Dentistry</orgName><orgName>Oral Science Research Center</orgName><orgName>Yonsei University College of Dentistry</orgName><address><settlement type="city">Seoul</settlement><country key="KP">Korea</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">J‐Y</forename><surname>Seo</surname></persName><affiliation><orgName>Department of Prosthodontics</orgName><orgName>Yonsei University College of Dentistry</orgName><address><settlement type="city">Seoul</settlement><country key="KP">Korea</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">S‐H</forename><surname>Oh</surname></persName><affiliation><orgName>Department of Dental Biomaterials</orgName><orgName>Institute of Biomaterials‐Implant</orgName><orgName>Wonkwang University School of Dentistry</orgName><address><settlement type="city">Iksan</settlement><country key="KP">Korea</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">J‐H</forename><surname>Kim</surname></persName><affiliation><orgName>Department of Prosthodontics</orgName><orgName>Yonsei University College of Dentistry</orgName><address><settlement type="city">Seoul</settlement><country key="KP">Korea</country></address></affiliation></author><author xml:id="author-0004" role="corresp"><persName><forename type="first">S‐T</forename><surname>Kim</surname></persName><affiliation><orgName>Department of Periodontology</orgName><orgName>Dental Research Institute</orgName><orgName>Seoul National University School of Dentistry</orgName><address><settlement type="city">Seoul</settlement><country key="KP">Korea</country></address></affiliation><affiliation>Correspondence: Sungtae Kim, Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, 101 Daehak‐ro, Jongno‐gu, Seoul 110‐774, Korea. Tel: +82 2 2072 4712, Fax: +82 2 744 0051, E‐mail: kst72@snu.ac.kr</affiliation></author><author xml:id="author-0005"><persName><forename type="first">Y‐B</forename><surname>Park</surname></persName><affiliation><orgName>Department of Prosthodontics</orgName><orgName>Yonsei University College of Dentistry</orgName><address><settlement type="city">Seoul</settlement><country key="KP">Korea</country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">H‐S</forename><surname>Moon</surname></persName><affiliation><orgName>Department of Prosthodontics</orgName><orgName>Yonsei University College of Dentistry</orgName><address><settlement type="city">Seoul</settlement><country key="KP">Korea</country></address></affiliation></author><idno type="istex">D6073C8F3E9E99AE96BB77DB3855558729EE0F71</idno><idno type="ark">ark:/67375/WNG-K21LN493-H</idno><idno type="DOI">10.1111/odi.12109</idno><idno type="unit">ODI12109</idno><idno type="toTypesetVersion">file:ODI.ODI12109.pdf</idno></analytic><monogr><title level="j" type="main">Oral Diseases</title><title level="j" type="alt">ORAL DISEASES</title><idno type="pISSN">1354-523X</idno><idno type="eISSN">1601-0825</idno><idno type="book-DOI">10.1111/(ISSN)1601-0825</idno><idno type="book-part-DOI">10.1111/odi.2014.20.issue-3</idno><idno type="product">ODI</idno><imprint><biblScope unit="vol">20</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="281">281</biblScope><biblScope unit="page" to="287">287</biblScope><biblScope unit="page-count">7</biblScope><date type="published" when="2014-04"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract style="main" xml:id="odi12109-abs-0001">
Objectives
<p>The purpose was to evaluate the effect of <hi rend="italic"><hi rend="fc">E</hi>scherichia coli</hi>‐derived recombinant human bone morphogenetic protein‐2 (Erh<hi rend="fc">BMP</hi>‐2)‐/epigallocatechin‐3‐gallate (<hi rend="fc">EGCG</hi>)‐coated biphasic calcium phosphate (<hi rend="fc">BCP</hi>) and titanium barrier membrane on dehiscence defects in dogs.</p>
Materials and Methods
<p>In five mongrel dogs, the dehiscence bony defects around dental implants were surgically created and in total three implants were placed at edentulous ridge of which teeth had been extracted 12 weeks before. For the control group, <hi rend="fc">BCP</hi> was applied to the dehiscence defect. For experimental groups, Erh<hi rend="fc">BMP</hi>‐2‐coated <hi rend="fc">BCP</hi> and Erh<hi rend="fc">BMP</hi>‐2‐/<hi rend="fc">EGCG</hi>‐coated <hi rend="fc">BCP</hi> were applied. The newly designed titanium barrier membrane was used to apply all the defects. The defects were evaluated histologically and histometrically after 12 weeks. The comparative statistics of the groups were obtained through Kruskal–Wallis test.</p>
Results
<p>In bone‐to‐implant contact (<hi rend="fc">BIC</hi>), bone density (<hi rend="fc">BD</hi>), bone regeneration height (<hi rend="fc">BRH</hi>), and bone mineralization apposition rate (<hi rend="fc">BMAR</hi>), differences among groups were not found. Erh<hi rend="fc">BMP</hi>‐2/<hi rend="fc">EGCG</hi> group appeared to have higher value. In fluorescence analysis, bone remodeling around graft material was more active in the Erh<hi rend="fc">BMP</hi>‐2/<hi rend="fc">EGCG</hi> group.</p>
Conclusion
<p>Within the limit of this study, it is reasonable to assume that <hi rend="fc">BMP</hi>‐2‐/<hi rend="fc">EGCG</hi>‐coated biphasic <hi rend="fc">BCP</hi> and the newly designed titanium membrane were more beneficial in dehiscence defect healing with increased bone remodeling.</p></abstract><textClass><keywords><term xml:id="odi12109-kwd-0001"><hi rend="fc">GBR</hi></term><term xml:id="odi12109-kwd-0002">biphasic calcium phosphate</term><term xml:id="odi12109-kwd-0003">dehiscence defect</term><term xml:id="odi12109-kwd-0004">epigallocatechin‐3‐gallate</term><term xml:id="odi12109-kwd-0005">Erh<hi rend="fc">BMP</hi>‐2</term><term xml:id="odi12109-kwd-0006">titanium barrier membrane</term></keywords><keywords rend="articleCategory"><term>Original Article</term></keywords><keywords rend="tocHeading1"><term>Original Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="odi12109" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1601-0825</doi><issn type="print">1354-523X</issn><issn type="electronic">1601-0825</issn><idGroup><id type="product" value="ODI"></id></idGroup><titleGroup><title sort="ORAL DISEASES" type="main">Oral Diseases</title><title type="short">Oral Dis</title></titleGroup></publicationMeta><publicationMeta level="part" position="30"><doi origin="wiley">10.1111/odi.2014.20.issue-3</doi><copyright ownership="publisher">Copyright © 2014 John Wiley & Sons A/S. Published
by John Wiley & Sons Ltd</copyright><numberingGroup><numbering type="journalVolume" number="20">20</numbering><numbering type="journalIssue">3</numbering></numberingGroup><coverDate startDate="2014-04">April 2014</coverDate></publicationMeta><publicationMeta level="unit" position="80" status="forIssue" type="article"><doi>10.1111/odi.12109</doi><idGroup><id type="unit" value="ODI12109"></id></idGroup><countGroup><count number="7" type="pageTotal"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Articles</title></titleGroup><copyright ownership="publisher">© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</copyright><eventGroup><event date="2012-12-31" type="manuscriptReceived"></event><event date="2013-03-11" type="manuscriptRevised"></event><event date="2013-04-01" type="manuscriptAccepted"></event><event agent="SPS" date="2013-04-08" type="xmlCreated"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.3.0 mode:FullText" date="2014-03-16"></event><event type="publishedOnlineAccepted" date="2013-04-08"></event><event type="publishedOnlineEarlyUnpaginated" date="2013-05-07"></event><event type="publishedOnlineFinalForm" date="2014-03-14"></event><event type="firstOnline" date="2013-05-07"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-07"></event></eventGroup><numberingGroup><numbering type="pageFirst">281</numbering><numbering type="pageLast">287</numbering></numberingGroup><correspondenceTo>Correspondence: Sungtae Kim, Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, 101 Daehak‐ro, Jongno‐gu, Seoul 110‐774, Korea. Tel: +82 2 2072 4712, Fax: +82 2 744 0051, E‐mail: <email>kst72@snu.ac.kr</email></correspondenceTo><selfCitationGroup><citation type="self" xml:id="odi12109-cit-1001"><journalTitle>Oral Diseases</journalTitle> (<pubYear year="2014">2014</pubYear>) <vol>20</vol>, <pageFirst>281</pageFirst>–<pageLast>287</pageLast></citation></selfCitationGroup><linkGroup><link type="toTypesetVersion" href="file:ODI.ODI12109.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">The effects of Erh<fc>BMP</fc>‐2‐/<fc>EGCG</fc>‐coated <fc>BCP</fc> bone substitute on dehiscence around dental implants in dogs</title><title type="shortAuthors">Y‐S Shin <i>et al</i></title></titleGroup><creators><creator affiliationRef="#odi12109-aff-0001" creatorRole="author" xml:id="odi12109-cr-0001"><personName><givenNames>Y‐S</givenNames> <familyName>Shin</familyName></personName></creator><creator affiliationRef="#odi12109-aff-0002" creatorRole="author" xml:id="odi12109-cr-0002"><personName><givenNames>J‐Y</givenNames> <familyName>Seo</familyName></personName></creator><creator affiliationRef="#odi12109-aff-0003" creatorRole="author" xml:id="odi12109-cr-0003"><personName><givenNames>S‐H</givenNames> <familyName>Oh</familyName></personName></creator><creator affiliationRef="#odi12109-aff-0002" creatorRole="author" xml:id="odi12109-cr-0004"><personName><givenNames>J‐H</givenNames> <familyName>Kim</familyName></personName></creator><creator affiliationRef="#odi12109-aff-0004" corresponding="yes" creatorRole="author" xml:id="odi12109-cr-0005"><personName><givenNames>S‐T</givenNames> <familyName>Kim</familyName></personName></creator><creator affiliationRef="#odi12109-aff-0002" creatorRole="author" xml:id="odi12109-cr-0006"><personName><givenNames>Y‐B</givenNames> <familyName>Park</familyName></personName></creator><creator affiliationRef="#odi12109-aff-0002" creatorRole="author" xml:id="odi12109-cr-0007"><personName><givenNames>H‐S</givenNames> <familyName>Moon</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="KP" type="organization" xml:id="odi12109-aff-0001"><orgDiv>Department of Conservative Dentistry</orgDiv> <orgName>Oral Science Research Center</orgName> <orgName>Yonsei University College of Dentistry</orgName> <address><city>Seoul</city><country>Korea</country></address></affiliation><affiliation countryCode="KP" type="organization" xml:id="odi12109-aff-0002"><orgDiv>Department of Prosthodontics</orgDiv> <orgName>Yonsei University College of Dentistry</orgName> <address><city>Seoul</city><country>Korea</country></address></affiliation><affiliation countryCode="KP" type="organization" xml:id="odi12109-aff-0003"><orgDiv>Department of Dental Biomaterials</orgDiv> <orgName>Institute of Biomaterials‐Implant</orgName> <orgName>Wonkwang University School of Dentistry</orgName> <address><city>Iksan</city><country>Korea</country></address></affiliation><affiliation countryCode="KP" type="organization" xml:id="odi12109-aff-0004"><orgDiv>Department of Periodontology</orgDiv> <orgName>Dental Research Institute</orgName> <orgName>Seoul National University School of Dentistry</orgName> <address><city>Seoul</city> <country>Korea</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="odi12109-kwd-0001"><fc>GBR</fc></keyword><keyword xml:id="odi12109-kwd-0002">biphasic calcium phosphate</keyword><keyword xml:id="odi12109-kwd-0003">dehiscence defect</keyword><keyword xml:id="odi12109-kwd-0004">epigallocatechin‐3‐gallate</keyword><keyword xml:id="odi12109-kwd-0005">Erh<fc>BMP</fc>‐2</keyword><keyword xml:id="odi12109-kwd-0006">titanium barrier membrane</keyword></keywordGroup><fundingInfo><fundingAgency>National Research Foundation of Korea (NRF)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Ministry of Education, Science and Technology</fundingAgency><fundingNumber>2012‐0001818</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:id="odi12109-abs-0001"><section xml:id="odi12109-sec-0001"><title type="main">Objectives</title><p>The purpose was to evaluate the effect of <i><fc>E</fc>scherichia coli</i>‐derived recombinant human bone morphogenetic protein‐2 (Erh<fc>BMP</fc>‐2)‐/epigallocatechin‐3‐gallate (<fc>EGCG</fc>)‐coated biphasic calcium phosphate (<fc>BCP</fc>) and titanium barrier membrane on dehiscence defects in dogs.</p></section><section xml:id="odi12109-sec-0002"><title type="main">Materials and Methods</title><p>In five mongrel dogs, the dehiscence bony defects around dental implants were surgically created and in total three implants were placed at edentulous ridge of which teeth had been extracted 12 weeks before. For the control group, <fc>BCP</fc> was applied to the dehiscence defect. For experimental groups, Erh<fc>BMP</fc>‐2‐coated <fc>BCP</fc> and Erh<fc>BMP</fc>‐2‐/<fc>EGCG</fc>‐coated <fc>BCP</fc> were applied. The newly designed titanium barrier membrane was used to apply all the defects. The defects were evaluated histologically and histometrically after 12 weeks. The comparative statistics of the groups were obtained through Kruskal–Wallis test.</p></section><section xml:id="odi12109-sec-0003"><title type="main">Results</title><p>In bone‐to‐implant contact (<fc>BIC</fc>), bone density (<fc>BD</fc>), bone regeneration height (<fc>BRH</fc>), and bone mineralization apposition rate (<fc>BMAR</fc>), differences among groups were not found. Erh<fc>BMP</fc>‐2/<fc>EGCG</fc> group appeared to have higher value. In fluorescence analysis, bone remodeling around graft material was more active in the Erh<fc>BMP</fc>‐2/<fc>EGCG</fc> group.</p></section><section xml:id="odi12109-sec-0004"><title type="main">Conclusion</title><p>Within the limit of this study, it is reasonable to assume that <fc>BMP</fc>‐2‐/<fc>EGCG</fc>‐coated biphasic <fc>BCP</fc> and the newly designed titanium membrane were more beneficial in dehiscence defect healing with increased bone remodeling.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The effects of ErhBMP‐2‐/EGCG‐coated BCP bone substitute on dehiscence around dental implants in dogs</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The effects of ErhBMP‐2‐/EGCG‐coated BCP bone substitute on dehiscence around dental implants in dogs</title></titleInfo><name type="personal"><namePart type="given">Y‐S</namePart><namePart type="family">Shin</namePart><affiliation>Department of Conservative Dentistry, Oral Science Research Center, Yonsei University College of Dentistry, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J‐Y</namePart><namePart type="family">Seo</namePart><affiliation>Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S‐H</namePart><namePart type="family">Oh</namePart><affiliation>Department of Dental Biomaterials, Institute of Biomaterials‐Implant, Wonkwang University School of Dentistry, Iksan, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J‐H</namePart><namePart type="family">Kim</namePart><affiliation>Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S‐T</namePart><namePart type="family">Kim</namePart><affiliation>Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea</affiliation><affiliation>E-mail: kst72@snu.ac.kr</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y‐B</namePart><namePart type="family">Park</namePart><affiliation>Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H‐S</namePart><namePart type="family">Moon</namePart><affiliation>Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2014-04</dateIssued><dateCreated encoding="w3cdtf">2013-04-08</dateCreated><dateCaptured encoding="w3cdtf">2012-12-31</dateCaptured><dateValid encoding="w3cdtf">2013-04-01</dateValid><edition>Oral Diseases (2014) 20, 281–287</edition><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>The purpose was to evaluate the effect of Escherichia coli‐derived recombinant human bone morphogenetic protein‐2 (ErhBMP‐2)‐/epigallocatechin‐3‐gallate (EGCG)‐coated biphasic calcium phosphate (BCP) and titanium barrier membrane on dehiscence defects in dogs.</abstract><abstract>In five mongrel dogs, the dehiscence bony defects around dental implants were surgically created and in total three implants were placed at edentulous ridge of which teeth had been extracted 12 weeks before. For the control group, BCP was applied to the dehiscence defect. For experimental groups, ErhBMP‐2‐coated BCP and ErhBMP‐2‐/EGCG‐coated BCP were applied. The newly designed titanium barrier membrane was used to apply all the defects. The defects were evaluated histologically and histometrically after 12 weeks. The comparative statistics of the groups were obtained through Kruskal–Wallis test.</abstract><abstract>In bone‐to‐implant contact (BIC), bone density (BD), bone regeneration height (BRH), and bone mineralization apposition rate (BMAR), differences among groups were not found. ErhBMP‐2/EGCG group appeared to have higher value. In fluorescence analysis, bone remodeling around graft material was more active in the ErhBMP‐2/EGCG group.</abstract><abstract>Within the limit of this study, it is reasonable to assume that BMP‐2‐/EGCG‐coated biphasic BCP and the newly designed titanium membrane were more beneficial in dehiscence defect healing with increased bone remodeling.</abstract><note type="funding">National Research Foundation of Korea (NRF)</note><note type="funding">Ministry of Education, Science and Technology - No. 2012‐0001818; </note><subject><genre>keywords</genre><topic>GBR</topic><topic>biphasic calcium phosphate</topic><topic>dehiscence defect</topic><topic>epigallocatechin‐3‐gallate</topic><topic>ErhBMP‐2</topic><topic>titanium barrier membrane</topic></subject><relatedItem type="host"><titleInfo><title>Oral Diseases</title></titleInfo><titleInfo type="abbreviated"><title>Oral Dis</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Original Article</topic></subject><identifier type="ISSN">1354-523X</identifier><identifier type="eISSN">1601-0825</identifier><identifier type="DOI">10.1111/(ISSN)1601-0825</identifier><identifier type="PublisherID">ODI</identifier><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>281</start><end>287</end><total>7</total></extent></part></relatedItem><identifier type="istex">D6073C8F3E9E99AE96BB77DB3855558729EE0F71</identifier><identifier type="ark">ark:/67375/WNG-K21LN493-H</identifier><identifier type="DOI">10.1111/odi.12109</identifier><identifier type="ArticleID">ODI12109</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2014 John Wiley & Sons A/S. 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